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In a Letter to the United Nations – AUA Secretary General Co...

In a Letter to the United Nations – AUA Secretary General Conveys the Assyrian Nation’s Demands for an Assyrian State/Region in a Federalized Iraq



  • Assyrian Government Network

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Moon Story, First Assyrian Interactive Children's iPad Book

Moon Story, First Assyrian Interactive Children's iPad Book



  • Assyrian Education Network

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Persia at the beginning of Eastern Christianity: Impressions...

Persia at the beginning of Eastern Christianity: Impressions and Reflections



  • Assyrian Education Network

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Perspective: Letter: Speaking? Words? Where once I sang?

Perspective: Letter: Speaking? Words? Where once I sang?



  • Perspective: Editorials | Guest-Editorials | Letters

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Mor Augin Monastery’s Land in Tur-Abdin seized by Kurds

Mor Augin Monastery’s Land in Tur-Abdin seized by Kurds



  • Perspective: Editorials | Guest-Editorials | Letters

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Syriacs react to minister’s wording regarding Mor Gabriel Mo...

Syriacs react to minister’s wording regarding Mor Gabriel Monastery




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Left Exposed By Middle Eastern Upheaval, Christians Are Flee...

Left Exposed By Middle Eastern Upheaval, Christians Are Fleeing Region




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Spanish reporter Ferran Barber detained for weeks without ch...

Spanish reporter Ferran Barber detained for weeks without charge, deported from Iraqi Kurdistan




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New Maryland program to help residents with water bill debt

(The Center Square) – The state of Maryland is investing $20 million in taxpayer fudning into the Water Assistance Relief Program to support those residents with water bill debt that is directly related to the COVID-19 pandemic, Gov. Larry Hogan said.




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Review: Elgato Prompter

The $279 Elgato Prompter is a unique product that performs well in its namesake role but offers a range of functionality that extends far beyond script reading. You'll find Prompter highly useful if you're a frequent video conference participant, if you create screencams or recorded product demonstrations, and even if you produce webinars.




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Managing Teleprompter Scrolling Speed with Elgato Stream Deck and Pedal

One of the most challenging aspects of reading from a teleprompter has always been speed control. Unless you get the speed just right, you either have to rush or slow down your narration, and either adjustment adds stress to your delivery that can force a glitch and another retake. Fortunately, Elgato has two hardware options you can use to control scrolling speed; the Stream Deck+ ($199.99) and Stream Deck Pedal ($89.99). Elgato was kind enough to send both options for me to try, and I'll briefly recount my experience here.




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Q&A: Simon Crownshaw, Microsoft?s Worldwide Media and Entertainment Strategy Director, Talks Gen AI

In this expansive interview with Simon Crownshaw, Microsoft's worldwide media and entertainment strategy director, we discuss how Microsoft customers are leveraging generative AI in all stages of the streaming workflow and how they're using it in content delivery and to enhance user experiences in a range of use cases. Crownshaw also digs deep into how Microsoft is building asset management architecture and the critical role metadata plays in effective large-language models (LLMs), maximizing the value of available data.




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WMX Americas closes doors after two days of super-charged debate, collaboration and deal-making

WMX Americas closed its doors after a successful two days. One clear key message from the conference was there has to be a better focus on the customer. Customer experience, customer journey and customer feedback were all key takeaways.




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Yodel’s new investment “underscores long-term commitment to more sustainable deliveries”

UK independent parcel carrier, Yodel, has opened a brand-new 162,000 sq. ft. depot in Huyton, Liverpool.




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Amazon Pharmacy: These faster delivery speeds will be a game changer

Amazon Pharmacy has launched Same-Day Delivery of prescription medication in New York City and the greater L.A. area, with plans to expand the service to more than a dozen U.S. cities by the end of the year.




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DHL Express new facility to accommodate customers international shipping needs in Virginia

DHL recently expanded its vast network of U.S. retail locations by introducing a new company owned and operated retail shipping store in Fairfax, Virginia. The 1,152 sq. ft. store is the sixth DHL Service Point in Virginia, offering convenient access to its industry-leading shipping services in the D.C. area. 




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DHL Express to “accommodate growing international shipping needs” in Texas

DHL has recently expanded its vast network of U.S. retail locations with a new company owned and operated retail shipping store in Bellaire, Texas




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WMX Europe in Madrid closes its doors after an inspiring event

Last week WMX Europe, organised by Triangle Management Services, closed its doors after two successful days of idea-sharing and partnerships not to mention all the celebrations at the World Post & Parcel Awards 2024.




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Ochama to meet the evolving needs of consumers in Amsterdam with new offering

Ochama, an omni-channel retailer, recently announced the launch of “ochama 1h delivery,” providing  free one-hour delivery for selected products across most of Amsterdam. 




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Yodel to cater for XXL parcels

 Yodel has launched Xpect XXL, following a strong year of growth, as it looks to build on its irregular dimensions and weights service offering.




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GLS “to offer SMEs greater visibility and growth opportunities”

Polish marketplace ERLI, has partnered with DPD Poland,  expanding ERLI's Delivery Methods offer. 




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Upholstery Tech II

Savannah, GA United States - High School Diploma or GED required. 2 years experience using commercial sewing machines, sergers and/or various hand tools used in upholstery and carpet trades. Experience in aerospace industry preferred. Position Purpose : Under minimal supervision fabricate and ... View




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Material Control Spec II

Savannah, GA United States - High School Diploma or GED required. 2 years material experience expediting and/or warehouse operations. Position Purpose : Under direct supervision, performs a variety of activities within the Material Logistics process: DC/Warehouse distribution and shop floor c... View




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Giant 'God of Darkness' Asteroid May Not Escape Earth Unscathed




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Driver dies after crashing on hurricane-damaged highway in North Carolina




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Driver jumps from overpass into Trinity River after crash on I-35 in Fort Worth, causing heavy traffic




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U.S. serviceman finally laid to rest, more than 50 years after being killed in Vietnam




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White Emperor: China reveals mysterious jet that could be its first 6th-gen fighter




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See it: Vehicle falls into North Carolina gorge after driver disregards I-40 closure following Helene




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Man escapes from SUV after driving into Canandaigua Lake from City Pier




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Artsakh Uprooted: Aftermaths of Displacement

Artsakh Uprooted: Aftermaths of Displacement



  • Armenian
  • Assyrian and Hellenic Genocide News

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Azerbaijan is Utterly Unfit to Host the UN’s Climate Change ...

Azerbaijan is Utterly Unfit to Host the UN’s Climate Change Conference



  • Armenian
  • Assyrian and Hellenic Genocide News

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Kluane Lake map-area Yukon Territory (115g and F e1/2)

Re-release; Muller, J E. no. 58-9, 1958, 12 pages (1 sheet), https://doi.org/10.4095/101211




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Geology of Terrace map-area, British Columbia (103 I E1/2)

Re-release; Duffell, S; Souther, J G. 329, 1964, 131 pages (3 sheets), https://doi.org/10.4095/100553




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Stratigraphy, facies and paleogeography of Mesozoic and Tertiary rocks of northern Yukon and northwest Mackenzie District, N.W.T. (NTS-107B, 106M, 117A, 116O (N1/2), 116I, 116H, 116J, 116K (E1/2))

Re-release; Jeletzky, J A. 1972, 72 pages (3 sheets), https://doi.org/10.4095/129163




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Regional stream sediment and water geochemical reconnaissance data, Yukon [NTS 115J, 115K (E1/2)]

Re-release; Geological Survey of Canada. 1987, 142 pages (25 sheets); 1 diskette/disquette, https://doi.org/10.4095/130284




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Regional stream sediment and water geochemical reconnaissance data, Yukon [NTS 115F(E1/2)]

Re-release; Geological Survey of Canada. 1987, 130 pages (25 sheets); 1 diskette/disquette, https://doi.org/10.4095/130283




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Regional stream sediment and water geochemical reconnaissance data, Yukon [NTS 115N (E1/2), 115O]

Re-release; Department of Indian Affairs & Northern Development; Yukon Government. 1987, 146 pages (25 sheets); 1 diskette/disquette, https://doi.org/10.4095/130285
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_130285.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_130285.jpg" title=" 1987, 146 pages (25 sheets); 1 diskette/disquette, https://doi.org/10.4095/130285" height="150" border="1" /></a>




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Regional Stream Sediment and Water Geochemical Reconnaissance Data, New Brunswick [21o/8 [E1/2], 21p/5 [W1/2]

Re-release; Geological Survey of Canada. 1989, 60 pages, https://doi.org/10.4095/130703




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Airborne gamma ray spectrometric maps, Prosperous Lake - Hidden Lake area, Northwest Territories [85i/12, J/9 [E1/2], parts of 85i/11, 5, 6, 13, 14, J/8]

Re-release; Geological Survey of Canada. 1989, 81 pages, https://doi.org/10.4095/130681
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of_1978.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of_1978.jpg" title=" 1989, 81 pages, https://doi.org/10.4095/130681" height="150" border="1" /></a>




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Geology, Mount St. Elias map area [115B & C[E1/2]], Yukon Territory

Re-release; Dodds, C J; Campbell, R B. 1992, 85 pages (1 sheet), https://doi.org/10.4095/133475
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2189_e_1992_mn01.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2189_e_1992_mn01.jpg" title=" 1992, 85 pages (1 sheet), https://doi.org/10.4095/133475" height="150" border="1" /></a>




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Geology, SW Kluane Lake map area [115G & F [E1/2]], Yukon Territory

Re-release; Dodds, C J; Campbell, R B. 1992, 85 pages (1 sheet), https://doi.org/10.4095/133474
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2188_e_1992_mn01.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2188_e_1992_mn01.jpg" title=" 1992, 85 pages (1 sheet), https://doi.org/10.4095/133474" height="150" border="1" /></a>




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CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion.

This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. 

Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. 

Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. 

Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. 

The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. 

CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years.

 Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.

sb admin Thu, 02/06/2020 - 14:52
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Terrifying the public about COVID or other health concerns is bad for their health

Back around 2010, just before Halloween, a reporter friend retweeted a local police department’s warning to check your kids’ candy for drugs or razor blades or something like that. I asked, “Is there any evidence of something like that ever happening?”




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John Fetterman says social media was an 'accelerant' that made depression worse

Sen. John Fetterman (D-PA) said Sunday that social media served as "an accelerant" for his clinical depression, to the point that doctors advised him to stay off of it.




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Home economics: The alternative to mortgages with sky-high rates

Mortgage rates are at their highest levels in 22 years and house prices are at record highs. Hardworking people cannot get on the property ladder, and retirees are struggling to sell in order to downsize. The Biden administration has done little to help alleviate the problem. This Washington Examiner series, Home Economics, will investigate how we got here, the toll on people around the country, and the alternatives people are embracing to survive the market. The last part of this four-part series focuses on the alternatives to traditional fixed-rate mortgages gaining new consideration among prospective home buyers.




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Historic Langston to enter National Black Golf Hall of Fame

Langston Golf Course in Washington, D.C., the first golf course built specifically for African-American golfers, will be inducted into the National Black Golf Hall of Fame. The ceremony will take place March 23 in Tampa.




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Caves Valley to host new LPGA international event in 2014

Caves Valley Country Club in Owings Mills, Md. will be the host of a first-of-its-kind event next year on the LPGA Tour. On Friday the tour announced it will establish the International Crown, a biennial, global match-play competition.




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Army removes Confederate Memorial put up in 1914 from Arlington National Cemetery

Army removes Confederate Memorial from Arlington National Cemetery as Civil War-era controversies continue to roil national and local politics.




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Jury finds stone companies at fault in lawsuit by countertop cutter sick with silicosis

L.A. County jurors decided largely in favor of a man with silicosis who had to undergo a double lung transplant after years of cutting engineered stone countertops.