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On an adventurous quest




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Exploring the self-assembly dynamics of novel steroid–coumarin conjugates: a comprehensive spectroscopic and solid-state investigation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00192C, Paper
Open Access
Claudia M. Ramírez-Lozano, Ma. Eugenia Ochoa, Pablo Labra-Vázquez, Arturo Jiménez-Sánchez, Norberto Farfán, Rosa Santillan
The design, synthesis, and characterization of seven novel steroid–coumarin conjugates with diverse steroidal nuclei as lipophilic fluorescent materials for bioimaging applications are presented.
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Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00312H, Paper
I. Caroline Vaaland Holmgard, Aday González-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández-Bolaños, José M. Padrón, Óscar López, Emil Lindbäck
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.
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On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00241E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Julia A. Turner, Hendrik Zipse, Mark S. Taylor
Computational analysis of the HAT-induced expulsion of carboxylic acids from monoacylated pyranosides implicates concerted elimination through a hydrogen-bonded transition state.
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Generation of sulfones utilizing β-sulfinyl esters as masked aryl sulfinates under redox-neutral conditions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00238E, Communication
Yixin Zhang, Zhu Yang, Hongjun Yang, Xuefeng Li, Lu Yang
A method for generation of SVI sulfones from β-sulfinyl esters (SIV) under transition-metal-free non-oxidative mild conditions is presented.
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DFT investigation of the DDQ-catalytic mechanism for constructing C–O bonds

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00346B, Paper
Xiu-Fang Zheng, Da-Gang Zhou, Li-Jun Yang
The DDQ-catalytic mechanisms for constructing C–O bonds via H2O and CH3OH as oxygen sources have been investigated with DFT.
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Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum

Org. Biomol. Chem., 2024, 22,3019-3024
DOI: 10.1039/D4OB00334A, Paper
Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
Six unusual pyridine-containing bisnor- (C23), tetranor- (C21) and pentanor- (C20) sesterterpenoids were obtained from the medicinal plant Leucosceptrum canum of Tibetan origin. The immunosuppressive activities of these sesterterpenoids were observed.
The content of this RSS Feed (c) The Royal Society of Chemistry




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DevTools Digest - Chrome 35: Updates to the Developer Tools in Chrome 35

Updates to the Chrome Developer Tools: CSS property quick search, memory stats for heap snapshots, CodeMirror upgrade and more.




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History API: Scroll Restoration




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Why Mount Everest is a no-fly zone

Hurricane-force winds and frequent snowstorms are obstacles




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Where an aircraft goes to rest




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Domestic air travel leads airline recovery: Boeing

Low-cost carriers aid market with point-to-point structure and affordable rates




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As India builds its newest airports, it needs robust, fail-proof SOPs

A near air mishap on Bengaluru skies that put the lives of 430 people in danger shows safety risk norms require constant refresh




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Domestic airline industry may face a rejig

The pandemic laid bare fault-lines within India’s airlines




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Airlines test willingness to pay higher airfares

Key reasons behind the move include rising fuel prices, rupee’s weakness and losses incurred due to the pandemic 




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Yoke vs. sidestick: Jury still out on what works best for pilots

Why do Airbus commercial aircraft have sidesticks and Boeing have yokes as control units?




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Chicken gun test: Saving jets from bird strikes

According to ICAO, at least 34 bird strikes happen every day, causing around $1 billion worth damages every year




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OpenAI chair's AI startup Sierra gets $4.5 billion valuation in latest funding round

One-year-old Sierra focuses on selling artificial intelligence-powered customer service chatbots to enterprises




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As Bitcoin nears all-time high, WazirX investors are in pain over their locked crypto funds

Bitcoin was inching towards its March 2024 all-time-high price of $73,750.07, but those whose crypto assets are locked with the WazirX exchange after a cyberattack are anxious about missing out




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Amazon's improving retail sales boost third-quarter profit, revenue beats estimates

Like its tech peers, Amazon said it expected higher capital expenditures for the foreseeable future to help develop artificial intelligence software




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Out-of-pocket expenditure on health in Kerala is highest in country despite increased State investments

National Health Accounts figures show the per capita out-of-pocket expenditure on health in Kerala stands at ₹7,889. However, Kerala also tops the list when it comes to the per capita government spending on health, at ₹4,338




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Dietary restriction or good genes: new study tries to unpack which has greater impact on lifespan

If we know that genetics and lifestyle affect how long you live, which one is more important? And how do they interact?




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Over 77 per cent of India’s children lack WHO-suggested diversity in diet, study finds

The states of Uttar Pradesh, Rajasthan, Gujarat, Maharashtra and Madhya Pradesh reported the highest levels of inadequate diversity in children's diets -- all above 80 per cent -- while Sikkim and Meghalaya were the only two to report an under-50 per cent prevalence




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National Mental Health Festival 2024 kicks off in Bengaluru




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Doctors stress healthy lifestyle, regular check-up to prevent strokes in young adults

The webinar was held as part of The Hindu’s Wellness Series




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Ayushman Bharat: All seniors above 70 can avail health coverage except those in Delhi, West Bengal

Senior citizens eligible for PM-JAY regardless of income; Ayushman Vaya Vandana card will help cut out-of-pocket health spends; on Ayurveda Day, PM launches initiatives to validate traditional herbal medicine, promote Indian medical systems




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Lifestyle changes a major cause for stroke, say doctors

Speaking at a public awareness meeting organised at GRH on the occasion of World Stroke Day on Tuesday, Dr. Murugan, attributed these negative factors to a sedentary lifestyle because of the youth’s job nature and location




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ICMR invites expression of interest from firms for making anaemia detection device

The council wants to expand the effective screening network of anaemia among different age populations across India





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'The biggest risk I took was...'

'Life had its own plans and now I have learnt to go with the flow.'




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'I was the highest paid actress'

'I never had any nakhras, never threw tantrums, so I got along with all my heroes.'




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'My face is my greatest USP'

'My tool is the way I look. This is the only thing that distinguishes me.''Most of us dress similarly. What sets you apart is your face. If you change that also, you're like anybody else.'




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The Busiest Firang Actor In India

'There have been and will continue to be, so many captivating stories in colonial India.''Obviously, most of the white people were British, so if I am going to take on a role in a film set in one of the most turbulent periods of Indian history, then it only stands to reason that my character would be of British descent.''But that doesn't mean all my roles are negative.'





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Changing content type of a file in a FormData request with cURL

The other day I had to test an API response based on a file having the incorrect Content-Type of a FormData PUT request. After some digging in cURL I found the -F & --form flag to set the file and its content type. If you don’t specify the content type it will be inferred from … Continue reading "Changing content type of a file in a FormData request with cURL"




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Flipkart Big Diwali Sale 2024: Best deals on iPhone 16 Pro Max, others; buy Apple iPad 9th Gen for just Rs...

The iPhone 16 series made its debut in India in September, with the flagship iPhone 16 Pro Max starting at Rs. 1,44,900 for the 256GB variant.




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Annual festive treat to rasikas

The music, dance and drama festival gave a taste of talents from various artistes.




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Alarmel Valli answers readers questions

She talks about the eternal appeal of margam




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Why threats are not your best bet in negotiation

Threats are over-utilised but often under-rewarded tactics




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Investing in leadership pays off




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Be curious, spend time on important stuff, says Ericsson CEO Vestberg




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Onion auction to remain closed indefinitely in Nashik wholesale markets to protest 40% duty on export: Traders

Traders claimed the central government's decision to impose 40% duty on the export of onions till December 31, 2023 will adversely affect the onion growers and its export




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Government imposes restrictions on export of Basmati rice

Basmati rice below $1200 per tonne will not be allowed to export




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Restore incentive for cashew exports: Tamil Nadu Cashew Processors and Exporters Association

The association also urged APEDA to exempt imported raw cashew nuts from Food Safety and Standards Authority of India (FSSAI) clearance in customs.




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Centre bans onion export till March; Nashik farmers protest

On August 19, the Union government imposed a 40% duty on the export of onions until December 31,




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Govt hopeful of 'bountiful harvest' amid food inflation headwinds

The government subsidised the sale of a few commodities to improve domestic supply and arrest the sharp spikes in retail prices of wheat, rice, edible oils, pulses, tomato, and onion




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Supreme Court questions Centre on GM mustard

Centre says the Genetic Engineering Appraisal Committee is a statutory body and the committee had examined relevant scientific data before giving the go-ahead for the environmental release




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Wheat, rapeseed crops ravaged by rain days before harvesting

A poor harvest could force the Centre to import wheat, palm oil, sunflower oil and soybean oil




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Centre estimates dip in onion, potato production this year

Agriculture Ministry releases advance production estimates for 2023-24 and final estimates for the year 2022-23




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Farmers struggle to dry harvested cotton and fear drop in price