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My Friend Claims Her Second Round of Cancer

As my Italian father would say, since the house is burning      let us warm ourselves, and so




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Learning to Talk: Speaking the Language of Patients

In this narrative medicine essay, a resident physician recalls the joy she felt while learning the formal language of medicine as a student and anticipates the lifelong joy of learning to interpret that language in ways most helpful for her patients.




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Crossing Boundaries—Violation or Obligation?

In this narrative medicine essay, a physician reflects on the rise of professional boundaries; on the ways in which such boundaries can in some instances foster uncaring patient-physician relationships; and on ways physicians might balance providing objective medical care and addressing social and economic injustices in the lives of their patients.




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An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy

J. Mater. Chem. B, 2020, 8,3316-3326
DOI: 10.1039/C9TB02327E, Review Article
Jie Lin, Jianping Zheng, Aiguo Wu
Circulating tumor cells (CTCs) are circulating cancer cells that shed from tumor tissue into blood vessels and circulate in the blood to invade other organs, which results in fatal metastases. Surface-enhanced Raman scattering (SERS) has great potentials in CTCs detection.
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A dual-targeted CeO2–DNA nanosensor for real-time imaging of H2O2 to assess atherosclerotic plaque vulnerability

J. Mater. Chem. B, 2020, 8,3502-3505
DOI: 10.1039/C9TB02459J, Communication
Zhenhua Liu, Yujie Cao, Xiaona Zhang, Huazhen Yang, Yujie Zhao, Wen Gao, Bo Tang
A novel dual-targeted CeO2–DNA nanosensor by modifying with folic acid (FA) and CD36 antibody was designed.
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Biomolecular detection, tracking, and manipulation using a magnetic nanoparticle-quantum dot platform

J. Mater. Chem. B, 2020, 8,3534-3541
DOI: 10.1039/C9TB02481F, Paper
Kalpesh D. Mahajan, Gang Ruan, Greg Vieira, Thomas Porter, Jeffrey J. Chalmers, R. Sooryakumar, Jessica O. Winter
Fluorescent and magnetic materials play a significant role in biosensor technology, enabling sensitive quantification and separations with applications in diagnostics, purification, quality control, and therapeutics.
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Glutamate detection at the cellular level by means of polymer/enzyme multilayer modified carbon nanoelectrodes

J. Mater. Chem. B, 2020, 8,3631-3639
DOI: 10.1039/C9TB02461A, Paper
Miriam Marquitan, Melanie D. Mark, Andrzej Ernst, Anna Muhs, Stefan Herlitze, Adrian Ruff, Wolfgang Schuhmann
Carbon nanoelectrodes in the sub-micron range were modified with an enzyme cascade immobilized in a spatially separated polymer double layer system for the detection of glutamate at the cellular level.
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Boosting biomolecular interactions through DNA origami nano-tailored biosensing interfaces

J. Mater. Chem. B, 2020, 8,3606-3615
DOI: 10.1039/C9TB02439E, Paper
Iene Rutten, Devin Daems, Jeroen Lammertyn
Nano-tailored DNA origami designs nanostructure the bioreceptor layer of encoded microparticles in an innovative microfluidic platform, hereby boosting biomolecular interactions.
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Silver nanoprism-based plasmonic ELISA for sensitive detection of fluoroquinolones

J. Mater. Chem. B, 2020, 8,3667-3675
DOI: 10.1039/C9TB02776A, Paper
Meifang Yuan, Qirong Xiong, Ganggang Zhang, Zhijuan Xiong, Daofeng Liu, Hongwei Duan, Weihua Lai
Silver nanoprism-based plasmonic ELISA for qualitative and quantitative detection of fluoroquinolones.
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Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells

J. Mater. Chem. B, 2020, 8,3408-3422
DOI: 10.1039/C9TB02457C, Review Article
Pi Ding, Zhili Wang, Zeen Wu, Weipei Zhu, Lifen Liu, Na Sun, Renjun Pei
This paper summarizes various aptamer-functionalized nanostructured interfaces for the detection and release of circulating tumor cells.
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Novel perylene probe-encapsulated metal–organic framework nanocomposites for ratiometric fluorescence detection of ATP

J. Mater. Chem. B, 2020, 8,3661-3666
DOI: 10.1039/C9TB02319D, Paper
Xiaomeng Zhou, Juanmin Li, Li-Li Tan, Qiang Li, Li Shang
Schematic illustration of PDI@ZIF-8 nanocomposite synthesis and ratiometric fluorescence assay for ATP sensing. 2-MIm: 2-methylimidazole.
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A perylenetetracarboxylic dianhydride and aniline-assembled supramolecular nanomaterial with multi-color electrochemiluminescence for a highly sensitive label-free immunoassay

J. Mater. Chem. B, 2020, 8,3676-3682
DOI: 10.1039/C9TB02368B, Paper
Wei Zhang, Yue Song, Yunyun Wang, Shuijian He, Lei Shang, Rongna Ma, Liping Jia, Huaisheng Wang
A novel multi-color ECL nanomaterial assembled from 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) and aniline (An) was used for highly sensitive label-free CEA detection.
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Toehold-regulated competitive assembly to accelerate the kinetics of graphene oxide-based biosensors

J. Mater. Chem. B, 2020, 8,3683-3689
DOI: 10.1039/C9TB02454A, Paper
Huan Du, Junbo Chen, Jie Zhang, Rongxing Zhou, Peng Yang, Xiandeng Hou, Nansheng Cheng
With toehold-regulation, the kinetics of graphene oxide-based biosensors can be accelerated.
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A general strategy for designing NIR-II emissive silk for the in vivo monitoring of an implanted stent model beyond 1500 nm

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02685A, Paper
Zhiming Deng, Junqing Huang, Zhenluan Xue, Mingyang Jiang, Youbin Li, Songjun Zeng
The NIR-II emissive silk is explored by a general feeding strategy for NIR-II imaging guided in situ monitoring of the implanted biological stent model made from silk.
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Encapsulated DNase Improving the Killing Efficiency of Antibiotics in Staphylococcal Biofilms

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00441C, Communication
Chenhui Liu, Yu Zhao, Wanqi Su, Jingshan Chai, Lina Xu, Jingjing Cao, Yang Liu
We developed a polymer-encapsulated DNase, n(DNase), which can efficiently accumulate in biofilm and expose the DNase to cleave the eDNA of biofilm. CLSM and crystal violet results demonstrated an effective...
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Development of mucoadhesive cationic polypeptide micelles for sustained cabozantinib release and inhibition of corneal neovascularization

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00874E, Paper
Haijie Han, Qichuan Yin, Xiajing Tang, Xiaoning Yu, Qiang Gao, Yelei Tang, Andrzej Grzybowski, Ke Yao, Jian Ji, Xingchao Shentu
Corneal neovascularization (CNV) is one of the leading risk factors for vision loss. Anti-angiogenic drugs can theoretically be extended to the treatment of CNV. However, the application of these drugs...
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The rise of bio-inspired polymer compartments responding to pathology related signals

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00475H, Perspective
Open Access
Luisa Zartner, Moritz Sylvester Muthwill, Ionel Adrian Dinu, Cora-Ann Schoenenberger, Cornelia G. Palivan
Self-organized nano- and microscale polymer compartments (polymersomes, GUVs, PICsomes and LbL capsules) have increasing potential in many sensing applications. In this review, we highlight the key role they play in...
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Biomimetic Immunomagnetic Gold Hybrid Nanoparticles Coupled with Inductively Coupled Plasma Mass Spectrometry for the Detection of Circulating Tumor Cells

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00403K, Paper
Zhimin Chang, Hang Zhou, Chao Yang, Rui Zhang, Qiannan You, Ruhong Yan, Li Li, Mingfeng Ge, Yuguo Tang, Wen-fei Dong, Zheng Wang
Immunomagnetic beads are important tools for the isolation and detection of circulating tumor cells (CTCs). However, the current immunomagnetic bead technique provides poor CTC separation purity due to nonspecific binding...
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Thin platelet-like COF nanocomposites for blood brain barrier transport and inhibition of brain metastasis from renal cancer

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00724B, Paper
Guiyang Zhang, Bo Jiang, Chunyong Wu, Yanfeng Liu, Yidan He, Xin Huang, Wei Chen, Kai Xi, Hongqian Guo, Xiaozhi Zhao, Xudong Jia
A drug-loaded polymer–COF nanocomposite has been developed to cross the blood brain barrier and treat brain metastasis from renal cancer.
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Bioinspired polydopamine nanoparticles: synthesis, nanomechanical properties, and efficient PEGylation strategy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02769F, Paper
Islam Zmerli, Jean-Philippe Michel, Ali Makky
We established tightly controlled experimental conditions to synthesize polydopamine nanoparticles with well-defined and reproducible physicochemical properties such as size, yield and nanomechanics.
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Aqueous surface gels as low friction interfaces to mitigate implant-associated inflammation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00582G, Perspective
Allison L. Chau, Jonah Rosas, George D. Degen, Lisa K. Månsson, Jonathan Chen, Eric Valois, Angela A. Pitenis
Soft implant surfaces should be designed with an eye toward natural, healthy biointerfaces, which use high water content aqueous gel gradients to reduce contact pressures and frictional shear stresses and thus reduce inflammation and discomfort.
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A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02156F, Paper
Mohammad-Ali Shahbazi, Neha Shrestha, Malgorzata Karolina Pierchala, Firoz Babu Kadumudi, Mehdi Mehrali, Masoud Hasany, Véronique Préat, Sander Leeuwenburgh, Alireza Dolatshahi-Pirouz
A polymeric gum has been developed herein, which combines high stretchability and self-healing capacity with a bioactivity that can target and eliminate bacterial infections and inflammations.
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Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00875C, Paper
Lisa White, Jessica E. Boles, Nyasha Allen, Luke Alesbrook, J. Mark Sutton, Charlotte Hind, Kira Hilton, Laura R. Blackholly, Rebecca Ellaby, George Williams, Daniel P Mulvihill, Jennifer Ruth Hiscock
SSAs are a class of Supramolecular Self-associating Amphiphilic salt, the anionic component of which contains a covalently bound hydrogen bond donor-acceptor motif. This results in a monomeric unit which can...
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Unique Sequence-Dependent Properties of Trinucleotide Repeat Monolayers: Electrochemical, Electrical, and Topographic Characterization

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00507J, Paper
Narges Asefifeyzabadi, Motahareh Taki, Madison Funneman, Tingjie Song, Mohtashim Hassan Shamsi
Trinucleotide repeat (TNR) sequences widely exist in nature and their overgrowth is associated with two dozen neurodegenerative diseases in humans. These sequences have unique helical flexibility which affects their biophysical...
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In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00499E, Paper
Zhaowen Ding, Nana Luo, Hua Yue, Yongjun Gao, Guanghui Ma, Wei Wei
2D PEGylated graphene oxide showed stealth-but-immune-activating capacity on macrophages, along with specific intraperitoneal immunological response in vivo.
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A waterborne polyurethane 3D scaffold containing PLGA with a controllable degradation rate and an anti-inflammatory effect for potential applications in neural tissue repair

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00656D, Paper
Bohong Du, Hang Yin, Yue Chen, Weiwei Lin, Yanchao Wang, Daiguo Zhao, Gang Wang, Xueling He, Jiehua Li, Zhen Li, Feng Luo, Hong Tan, Qiang Fu
3D connected porous LGPU scaffolds with adjustable degradation and a strong anti-inflammatory effect were prepared for neural tissue repair.
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Nanoclay-functionalized 3D nanofibrous scaffolds promote bone regeneration

J. Mater. Chem. B, 2020, 8,3842-3851
DOI: 10.1039/C9TB02814E, Paper
Qingqing Yao, Kirby E. Fuglsby, Xiao Zheng, Hongli Sun
A nanoclay-enriched 3D nanofibrous biomimetic scaffold with strong bone regenerative ability by virtue of its improved mechanical properties, osteoconductivity, and drug binding capacity was developed.
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Macrocyclic polyamine [12]aneN3 modified triphenylamine-pyrazine derivatives as efficient non-viral gene vectors with AIE and two-photon imaging properties

J. Mater. Chem. B, 2020, 8,3869-3879
DOI: 10.1039/D0TB00321B, Paper
Le-Le Ma, Ming-Xuan Liu, Xu-Ying Liu, Wan Sun, Zhong-Lin Lu, Yong-Guang Gao, Lan He
[12]aneN3 modified triphenylamine-pyrazines as non-viral gene vectors with AIE and two-photon imaging properties.
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Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment

J. Mater. Chem. B, 2020, 8,3929-3938
DOI: 10.1039/D0TB00243G, Paper
Linhua Liao, Dong Cen, Yike Fu, Bin Liu, Chao Fang, Yifan Wang, Xiujun Cai, Xiang Li, Hao Bin Wu, Gaorong Han
Fine nanocapsules based on MnFe hydroxides, showing high loading capacity, O2 induction and biodegradation, were synthesized for effective synergistic therapies.
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Molecular simulations and understanding of antifouling zwitterionic polymer brushes

J. Mater. Chem. B, 2020, 8,3814-3828
DOI: 10.1039/D0TB00520G, Paper
Yonglan Liu, Dong Zhang, Baiping Ren, Xiong Gong, Lijian Xu, Zhang-Qi Feng, Yung Chang, Yi He, Jie Zheng
Zwitterionic materials demonstrate the strong surface hydration to empower their antifouling property.
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“Watson–Crick GC”-inspired supramolecular nanodrug of methotrexate and 5-fluorouracil for tumor microenvironment-activatable self-recognizing synergistic chemotherapy

J. Mater. Chem. B, 2020, 8,3829-3841
DOI: 10.1039/D0TB00468E, Paper
Meijin Chen, Shiduan Chen, Fukai Zhu, Fanfan Wang, Haina Tian, Zhongxiong Fan, Sunkui Ke, Zhenqing Hou, Yang Li
The “Watson–Crick G≡C”-inspired carrier-free nanodrug have excellent tumor microenvironment-triggered active self-targeting ability and enhanced synergistic chemotherapeutic effects.
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Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

J. Mater. Chem. B, 2020, 8,3880-3885
DOI: 10.1039/D0TB00407C, Paper
Sara Amorim, Iva Pashkuleva, Celso A. Reis, Rui L. Reis, Ricardo A. Pires
We developed hyaluronic acid (HA):poly-L-lysine (PLL) layer-by-layer (LbL) constructs whose viscoelastic properties and bioactivity can be finely tuned by using polyanions of different molecular weight and/or crosslinking.
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Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00735H, Paper
Long Wu, Wei Xie, Hui-Ming Zan, Zhongzhong Liu, Ganggang Wang, Yanfeng Wang, Wei Liu, Wenfei Dong
Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.
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Synthetic mycomelanin thin films as emergent bio-inspired interfaces controlling the fate of embryonic stem cells

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00623H, Paper
Paola Manini, Valeria Lucci, Valeria Lino, Stefania Sartini, Francesco Rossella, Geppino Falco, Cinzia Chiappe, Marco d’Ischia
Mycomelanin thin films from 1,8-dihydroxynaphthalene can serve as a biointerface inducing adhesion and proliferation of ESCs and promoting their differentiation towards endodermal lineages.
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A fiber-shaped neural probe with alterable elastic moduli for direct implantation and stable electronic–brain interfaces

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00508H, Communication
Chengqiang Tang, Songlin Xie, Mengying Wang, Jianyou Feng, Zhengqi Han, Xiaoying Wu, Liyuan Wang, Chuanrui Chen, Jiajia Wang, Liping Jiang, Peining Chen, Xuemei Sun, Huisheng Peng
A fiber-shaped neural probe with alterable elastic moduli allows direct implantation and enables adaptive electronic–tissue interfaces post implantation.
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A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00561D, Paper
Yu Zhang, Jun Yang, Jun Zhang, Shuangwen Li, Lisi Zheng, Yanlong Zhang, Huipeng Meng, Xinge Zhang, Zhongming Wu
A bio-inspired injectable hydrogel as a cell platform for real time glycemic regulation by mimicking the function of native islet β cells.
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Regulation of cell binding and entry by DNA origami mediated spatial distribution of aptamers

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00663G, Communication
Ke Liu, Cong Xu, Jinyao Liu
Customizing the spatial distribution of aptamers on DNA origami nanoboxes can regulate the internalization and proliferation of cancer cells.
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A decellularized scaffold derived from squid cranial cartilage for use in cartilage tissue engineering

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00483A, Paper
Thou Lim, Qian Tang, Zhen-Zhong Zhu, Yong Feng, Shi Zhan, Xiao-Juan Wei, Chang-Qing Zhang
Decellularized cartilage scaffold (DCS) is an emerging substitute for cartilage defect application.
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Preparation and biological evaluations of collagen-like hierarchical Ti surface with superior osteogenic capabilities

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00799D, Paper
Weiwei Lao, Qiaojie Luo, Yadong Chen, Wei Yao, Jiajia Xu, Lijie Fan, Xiaodong Li
The construction of multiscale Ti surfaces of high osteogenic ability always attracts numerous attentions in oral implantology and implantable biomaterial field. However, so far, the absence of solid understanding of...
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Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00620C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Conor C. Horgan, Anika Nagelkerke, Thomas E. Whittaker, Valeria Nele, Lucia Massi, Ulrike Kauscher, Jelle Penders, Mads S. Bergholt, Steve R. Hood, Molly M. Stevens
Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling.
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Surface functionalization strategies of extracellular vesicles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00744G, Review Article
Sagar Rayamajhi, Santosh Aryal
Physical, biological, and chemical strategies of surface functionalization can add vital functionality in extracellular vesicles (EVs) for diverse biomedical applications.
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The Praeger handbook of media literacy / Art Silverblatt, editor




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The interplay of influence : news, advertising, politics, and the Internet / Kathleen Hall Jamieson, Karlyn Kohrs Campbell

Jamieson, Kathleen Hall




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Social media law and marketing : fans, followers and online infamy / Geoffry Holland, Kathryn Crossley, Wenee Yap

Holland, Geoffrey M, author




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Confessions from correspondent-land : the dangers & delights of life as a foreign correspondent / Nick Bryant

Bryant, Nick (Nicholas Andrew), author




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Analyzing media messages : using quantitative content analysis in research / Daniel Riffe, Stephen Lacy and Frederick Fico

Riffe, Daniel




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Methods for analyzing social media / edited by Klaus Bredl, Julia Hunniger and Jakob Linaa Jensen




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Talking deadly [videorecording] : exploring language, identity and power in Aboriginal English




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The Oxford handbook of new audiovisual aesthetics / edited by John Richardson, Claudia Gorbman, Carol Vernallis




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The Johns Hopkins guide to digital media / edited by Marie-Laure Ryan, Lori Emerson, and Benjamin J. Robertson