la [ASAP] Imidazo[1,2-<italic toggle="yes">a</italic>]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells By feedproxy.google.com Published On :: Mon, 20 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01910 Full Article
la [ASAP] Synthesis and Structure–Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01961 Full Article
la [ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02164 Full Article
la [ASAP] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation By feedproxy.google.com Published On :: Wed, 22 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00035 Full Article
la [ASAP] Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands By feedproxy.google.com Published On :: Thu, 23 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01835 Full Article
la [ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma By feedproxy.google.com Published On :: Thu, 23 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02161 Full Article
la [ASAP] Molecular Interactions of Pyrazine-Based Compounds to Proteins By feedproxy.google.com Published On :: Fri, 24 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02021 Full Article
la [ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00227 Full Article
la [ASAP] Structure–Activity Relationship of SPOP Inhibitors against Kidney Cancer By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00161 Full Article
la [ASAP] Correction to Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00599 Full Article
la [ASAP] Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00015 Full Article
la [ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01936 Full Article
la [ASAP] Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions By feedproxy.google.com Published On :: Fri, 01 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01937 Full Article
la [ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00339 Full Article
la [ASAP] p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02038 Full Article
la [ASAP] Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via <sup>15</sup>N Direct Detection Nuclear Magnetic Resonance By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00231 Full Article
la [ASAP] Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00245 Full Article
la [ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00337 Full Article
la [ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme By feedproxy.google.com Published On :: Fri, 08 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00441 Full Article
la [ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma By feedproxy.google.com Published On :: Mon, 30 Mar 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00601 Full Article
la [ASAP] Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds By feedproxy.google.com Published On :: Mon, 30 Mar 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00664 Full Article
la [ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup> By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00641 Full Article
la [ASAP] Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00669 Full Article
la [ASAP] Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00039 Full Article
la [ASAP] Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening By feedproxy.google.com Published On :: Fri, 03 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00076 Full Article
la [ASAP] Assembling Pharma Resources to Tackle Diseases of Underserved Populations By feedproxy.google.com Published On :: Wed, 08 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00051 Full Article
la [ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents By feedproxy.google.com Published On :: Wed, 08 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00639 Full Article
la [ASAP] Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor By feedproxy.google.com Published On :: Thu, 09 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00681 Full Article
la [ASAP] New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00561 Full Article
la [ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00129 Full Article
la [ASAP] Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes By feedproxy.google.com Published On :: Mon, 13 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00117 Full Article
la [ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1 By feedproxy.google.com Published On :: Tue, 14 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00131 Full Article
la [ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00155 Full Article
la [ASAP] Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease By feedproxy.google.com Published On :: Fri, 01 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00109 Full Article
la [ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors By feedproxy.google.com Published On :: Fri, 01 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00025 Full Article
la [ASAP] Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase By feedproxy.google.com Published On :: Fri, 01 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00092 Full Article
la [ASAP] Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00009 Full Article
la [ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00022 Full Article
la [ASAP] Synthesis and Evaluation of <sup>11</sup>C- and <sup>18</sup>F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00127 Full Article
la [ASAP] Ligand Design for Cereblon Based Immunomodulatory Therapy By feedproxy.google.com Published On :: Fri, 08 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00214 Full Article
la Germany Facing Mass Blackouts Because The Wind And Solar Won’t Cooperate By latestsolarnews.com Published On :: Sat, 04 Mar 2017 19:59:09 +0000 Germany’s energy network nearly broken down in January because of poor execution from wind turbines and sun based boards, as indicated by information from a noteworthy exchange union. Wind and sunlight based power plants failed to meet expectations in January, 2017, as a result of shady climate with almost no wind, setting the phase for … The post Germany Facing Mass Blackouts Because The Wind And Solar Won’t Cooperate appeared first on LatestSolarNews. Full Article News
la Tanzania turns to solar power to increase electricity connectivity By latestsolarnews.com Published On :: Mon, 17 Apr 2017 22:05:48 +0000 As many as 60 percent of the Kenyan population now has access to electricity according to official data. But in neighbouring Tanzania, the penetration rate is less than half of that and sparsely populated rural communities are especially neglected. The post Tanzania turns to solar power to increase electricity connectivity appeared first on LatestSolarNews. Full Article News
la China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude By latestsolarnews.com Published On :: Tue, 06 Jun 2017 16:29:43 +0000 China’s first domestically designed large solar-powered unmanned plane reached above 20,000 meters in altitude on its test flight in the country’s northwest regions recently. The drone was developed by the China Academy of Aerospace Aerodynamics (CAAA), it’s developers kept the exact size of the drone as a secret, but it is believed to be about 14 … The post China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude appeared first on LatestSolarNews. Full Article News
la Solar Trees Powering The Park Of South Florida By latestsolarnews.com Published On :: Sun, 23 Jul 2017 23:58:07 +0000 Joining South Florida’s lush, green canopy of real trees are a new crop of solar trees. These “trees” have blue trunks and bear no fruit, but supply clean energy to whoever needs it. If you’re at the beach and your phone starts to die, you can charge it right here using Solar Power. Here’s how … The post Solar Trees Powering The Park Of South Florida appeared first on LatestSolarNews. Full Article News
la Solar Powered Lights For The Yard By latestsolarnews.com Published On :: Wed, 26 Jul 2017 21:41:45 +0000 Reading about the various sofas reviews here and choosing amongst them to match your patio is not that difficult when compared to doing the entire electrical work of the patio. When you are lighting your patio the exact opposite thing you need to do is to be stumbling over electrical lines and attempting to put … The post Solar Powered Lights For The Yard appeared first on LatestSolarNews. Full Article installations Why Solar
la Sono Motors Introduces The SION Solar Powered Car By latestsolarnews.com Published On :: Sat, 23 Sep 2017 18:45:01 +0000 The fantasy of having the capacity to drive to work in a solar-powered car is at last turning into a reality. Sono Motors simply uncovered the SION solar-powered electric car gives you the ability to travel up to 18 miles utilizing only energy from the sun. Best of all, the SION isn’t only for the … The post Sono Motors Introduces The SION Solar Powered Car appeared first on LatestSolarNews. Full Article News
la New Solar Plant In Chile To Power 13,000 Homes Per Year By latestsolarnews.com Published On :: Thu, 14 Dec 2017 01:36:55 +0000 Chile is building a brand new solar power plant that has some exciting outcome on the future. The plant is expected to provide energy on day and night as well as throughout inclement weather, to power up to 13,000 homes annually. This project will make Chile one of the top solar energy spots in the … The post New Solar Plant In Chile To Power 13,000 Homes Per Year appeared first on LatestSolarNews. Full Article solar news
la Construction has started on the largest solar project in Nepal By latestsolarnews.com Published On :: Tue, 01 May 2018 18:55:50 +0000 The reports say that the constructions of a 25MW largest solar PV project in Nepal has begun. The foundation stone was laid last week at Devighat in Nuwakot by Minister for Energy, Water Resources and Irrigation, Barsha Man Pun. The government plans to finish the construction of the project in a year. As stated by … The post Construction has started on the largest solar project in Nepal appeared first on LatestSolarNews. Full Article News
la 4 Benefits Of Solar LED Lights For Parking Lots By latestsolarnews.com Published On :: Sun, 08 Jul 2018 21:32:34 +0000 The future is solar LED lights. You will see them in the parking lots and other large areas around a city. They are cheap and save a good deal of money on electricity bills. Nowadays, the majority of parking lots feature the conventional lights that get their power from the grid. These products are not … The post 4 Benefits Of Solar LED Lights For Parking Lots appeared first on LatestSolarNews. Full Article Power Generation
la India is planning to achieve 50 GW of prodction from renewbale energy by 2028 By latestsolarnews.com Published On :: Tue, 08 Jan 2019 10:08:19 +0000 India is planning to achieve 50 gigawatt (GW) of production from renewable energy by 2028, in order to get to its goal of 40 per cent of electricity generation from non-fossil fuels by 2030, Ministry of New and Renewable Energy secretary, Anand Kumar said at the India-Norway Business Summit 2019 in New Delhi. Of this … The post India is planning to achieve 50 GW of prodction from renewbale energy by 2028 appeared first on LatestSolarNews. Full Article News india solar energy india
