By Michael Crowley The New York Times Company…

If you go to check how many people are hospitalized with COVID-19 in Spokane, the Spokane County Regional Health District website will give you an answer. Right now, it lists eight people as currently hospitalized with COVID-19, and that number has been trending downward.…

Two beloved Spokane-based entertainers are teaming up this weekend for a good cause.…

A catastrophic loss in biodiversity, reckless destruction of wildland and warming temperatures have allowed disease to explode. Ignoring the connection between climate change and pandemics would be “dangerous delusion,” one scientist said. The scientists who study how diseases emerge in a changing environment knew this moment was coming.…

As this issue goes to press, our city, our state, our country and our world are coping with the spread of a virus that's deadly to some, and not even noticed by others who have no symptoms but may spread it.…

"Are you curious?"…

As this issue goes to press we are all staying home to battle the coronavirus.…

If you've ever been compelled to visit Chewelah, it has likely been related to a trip to 49 Degrees North.…

Miang Goong Miang is the Thai version of lettuce wraps, in this case featuring goong, or shrimp.…

In one sense, SpoKast operates as your typical hang-out show, a shaggy space where a couple of affable friends riff on the news together and share their thoughts.…

If you've ever taken a stroll around downtown Spokane's west side, you may have come across Barrister Winery, tucked into a historic brick and timber building alongside the railroad tracks at 1213 Railroad Ave.…

Q: I recently read that a combination of the drugs hydroxychloroquine and azithromycin might be effective against COVID-19. I have diabetes and I am at risk for this viral infection.…

When I first moved to Spokane just over five years ago, I had no idea what kind of literary hotbed I was making my new home.…

Growing up, Luke Parker played sports.…

POMPEII, THE IMMORTAL CITY is on exhibit at the MAC. But galleries that should be thronged with visitors are empty, at least for a while.…

[IMAGE-1] Crystal Bertholic has been a leader in the region's craft cocktail revival since the beginning. Before she got her start shaking, stirring and straining mixed drinks, Bertholic was steaming milk and roasting coffee; then pouring craft beers.…

It's all right there in the name: "Community Pint."…

[IMAGE-1] If you think about it, the art of brewing beer is as visually interesting as it is delicious — the way the hops and the yeast and the grain all swirl together to create that sweet amber-colored goodness. Spokane's Genus Brewing has taken full advantage of that, and they've taken their passion for beer to the internet with great results.…

[IMAGE-1] Visiting Spokane Valley is a little like when a child visits their grandparents' place: At first you don't understand why you're there, but after you leave with new toys, clothes and a full stomach, you can't wait to go back. And the Spokane Valley Mall has all of that.…

The Showcase celebrity golf tournament attracts big-time athletes and pop stars each year.…

One great thing about seeing "oldies" acts on tour is the vivid reminder you get that groups in the old days really knew how to serve their fans. Take the Commodores, for example, a group with a 52-year-history that swung by Northern Quest Resort & Casino Thursday night.…

The kitchen is the undisputed hub of the household — not only a place for preparing food, but also the preferred spot for paying bills, the at-home office, homework and entertaining.…

Mosey on up to the bar at Lil Sumthin' Saloon for a sip of Southern hospitality by way of Texas, and a samplin' of some old-fashioned country vibes.…

Don't be caught empty-handed (or empty-hearted) this Valentine's Day, coming up Friday, Feb. 14.…

Weeks after being raped at a wedding — an experience already wrapped in feelings of self-blame and fear — the 18-year-old Eastern Washington University student realized something else was wrong.…

While its main goal is to introduce the humble breakfast taco to more Spokane eaters, owners of the new quick food stop Taco Vado say breakfast burritos have actually been its bestselling menu item since opening about a month ago.…

The '20s issue The '20s are back, baby.…

It’s March. The regular season is now in the rearview mirror.…

A little more than a year ago, local French-inspired bakery miFlavour moved into a building on East Sprague Avenue after two years in a shared commercial kitchen.…

ProPublica’s health reporter Caroline Chen explains what the conversation around asymptomatic coronavirus carriers is missing, and what we need to understand if we’re going to beat this nefarious virus together. By Caroline Chen, ProPublica In the early days of the coronavirus outbreak in the U.S., around the last week of February, I joked to a colleague that maybe now, finally, people would learn how to wash their hands properly.…

As soon as state Rep. Marcus Riccelli returned home from Olympia, he jumpstarted a community-wide effort to feed Spokane constituents deeply affected by the COVID-19 crisis.…

The Cannabis Issue In a normal year, cannabis stores would be cashing in this April.…

New TV ads that started airing on morning shows throughout the Spokane region are aimed at grocery shoppers, but they're not hawking deals on cabbage or Cap'n Crunch.…

Extraction was supposedly the most-watched new movie on Netflix last week, and yet it feels suspiciously like one you've already seen, possibly late at night on some obscure cable channel back in the '90s.…

At around 5:30 pm on Thursday, there were two camps of people set up in Coeur d'Alene Park in Browne's Addition.…

When Washington Gov. Jay Inslee solemnly looked into the camera on Friday, May 1, he wasn't ready to declare victory yet.…

Last week, the New York Times dropped a terrifying story: Asian Giant Hornets, or "murder hornets" as more J. Jonah Jameson-esque researchers like to call them, have been identified in Western Washington. These insects can grow up to 2 inches long, can rip the heads off an entire hive of honeybees in a matter of hours, and have dagger-like stingers that pierce beekeeper suits to deliver a sting that sears like molten acid.…

The present invention relates to a compound of formula A, wherein R is alkyl. Compound A may be used as an intermediate in the preparation of O-desmethyl venlafaxine or a salt thereof, and the present invention provides such a preparation, as well as a process for preparing the compound of formula A.

A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.

Disclosed is a method for producing graphene functionalized at its edge positions of graphite. Organic material having one or more functional groups is reacted with graphite in reaction medium comprising methanesulfonic acid and phosphorus pentoxide, or in reaction medium comprising trifluoromethanesulfonic acid, to produce graphene having organic material fuctionalized at edges. And then, high purity and large scaled graphene and film can be obtained by dispersing, centrifugal separating the functionalized graphene in a solvent and reducing, in particular heat treating the graphene. According to the present invention graphene can be produced inexpensively in a large amount with a minimum loss of graphite. (FIG. 1)

A nonmetallic compound having an ionic bond with a halide ion is used as a catalyst for living radical polymerization. Even if a radical initiator is not used, a monomer can be subjected to a radical polymerization to obtain a polymer having narrow molecular weight distribution. The cost of the living radical polymerization can be remarkably reduced, and it is made possible to prevent adverse effects of using a radical initiator (such as side reactions). The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst necessary, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor, etc. The catalyst can be applied to various monomers and enables synthesis of high molecular weight polymers.

A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R1 is H or a C1 to C16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R2 is H or a C1 to C16 alkyl group; R3 is H or a C1 to C16 alkyl group; R4 is a C1 to C16 alkyl group; X1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond;where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond;where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; andwhere part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

The present invention relates to a process for preparing a compound of formula wherein: R2 is cycloalkyl or alkyl, each of which may be optionally substituted; Y is —CONR3R4, —CN or CO2R5; R3, R4 and R5 are each independently H or alkyl; n is 1 to 6; wherein said process comprising the steps of: (i) treating a compound of formula (IV), where R1 is alkyl, with a compound of formula (V) and forming a compound of formula (IIIb); (ii) treating said compound of formula (IIIb) with a compound of formula (I1) to form a compound of formula (I).

The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.

Provided is a method for stably and economically producing xylylenediamine with a high yield and long catalyst service life by hydrogenating dicyanobenzene that is obtained by ammoxidating xylene. By bringing an aqueous basic solution into contact with a dicyanobenzene-absorbed liquid, which is obtained by bringing an ammoxidation reaction gas into contact with an organic solvent, under specified temperature conditions, and subjecting a base and a carboxylic acid in the dicyanobenzene-absorbed liquid to a neutralization reaction so as to form an aqueous phase that contains a water-soluble salt, and then subjecting an organic phase and the aqueous phase to liquid-liquid separation so as to remove the aqueous phase, it is possible to remove the carboxylic acid contained in the dicyanobenzene-absorbed liquid with high selectivity while inhibiting loss of the dicyanobenzene. By subjecting the raw material dicyanobenzene, which is obtained by separating low boiling point compounds from the post liquid-liquid separation organic phase by distillation under reduced pressure, to hydrogenation, xylylenediamine is produced with a high yield and the service life of the hydrogenation catalyst is extended.

A process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprising (1) providing a mixture of 1,3-cyanocyclohexane carboxaldehyde and/or 1,4-cyanocyclohexane carboxaldehyde; (2) contacting said mixture with a metal carbonate based solid bed or a weak base anion exchange resin bed at a temperature from 15 to 40 ° C. for a period of at least 1 minute; (3) thereby treating said mixture, wherein said treated mixture has a pH in the range of 6 to 9; (4) feeding said treated mixture, hydrogen, and ammonia into a continuous reductive amination reactor system; (6) contacting said treated mixture, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature from 80 ° C. to 160 ° C. and a pressure from 700 to 3500 psig; (7) thereby producing one or more cycloaliphatic diamines is provided.

The present invention provides a process for preparing a compound of formula (VI) or a salt thereof, the process comprising: (i) reacting 4-methoxyphenyl acetone with an amine of formula (VIII) under conditions of reductive amination to produce a compound of formula (II) or a salt thereof, wherein there is no isolation of an imine intermediate formed during the reductive amination; (ii) condensing the compound (II) or the acid addition salt thereof with an α-haloketone of formula (III) to produce the compound of formula (IV); (iii) reducing the compound (IV) to a compound of formula (V); and (iv) reducing the compound (V) to the compound of formula (VI), wherein the reduction is carried out in the presence of either (1) a hydrogen donating compound in the presence of a hydrogen transfer catalyst; or (2) ammonium formate using a hydrogenation catalyst, wherein R1 and R2 are independently optionally substituted arylalkyl, and Hal is selected from chloro or bromo.

A branched hetero polyfunctional polyoxyalkylene compound represented by the following formula (1): wherein Z represents a hydroxyl group-removed residue of pentaerythritol or dipentaerythritol, OA1 and OA2 represent an oxyalkylene group having 2 to 4 carbon atoms, L1, L2 and L3 represent an alkylene group or an alkylene group that contains an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group or a urea bond, X and Y are different from each other and represent a functional group capable of a chemical reaction; m and n are an average number of moles of the oxyalkylene group added, m represents 5 to 1,000, n represents 0 to 1,000, and p, q and r represent 0 or 1; and s1 is an integer of 2 or more and s1+s2=4 or 6.

The present invention provides a pest control agent, acaricide or fungicide that contains, as the active ingredient thereof, at least one type of compound selected from the aryloxyurea compounds represented by formula (V) (wherein R1 to R5 each independently represents an alkyl group or the like, X is a halogen atom or the like, n is an integer of 0 to 5, and Z is an oxygen atom or sulfur atom) or salts thereof.