me

[ASAP] Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00101




me

[ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00339




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[ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00395




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[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00337




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[ASAP] Discovery of <italic toggle="yes">N</italic>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<italic toggle="yes">H</italic>-pyrrolo[2,3-<italic toggle=&q

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00628




me

[ASAP] Drug Research Meets Network Science: Where Are We?

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01989




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[ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00441




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[ASAP] Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00005




me

[ASAP] Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00664




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[ASAP] Inhibitors of Hypoxia-Inducible Factors as Treatment for Cancer

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00116




me

[ASAP] Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00665




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[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00045




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[ASAP] Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00039




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[ASAP] Structure Optimization of Gatastatin for the Development of ?-Tubulin-Specific Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00526




me

[ASAP] Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00111




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[ASAP] New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00561




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[ASAP] Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00117




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[ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00131




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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00095




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[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00192




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[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00106




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[ASAP] Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00109




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[ASAP] Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00066




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[ASAP] Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00009




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China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude

China’s first domestically designed large solar-powered unmanned plane reached above 20,000 meters in altitude on its test flight in the country’s northwest regions recently. The drone was developed by the China Academy of Aerospace Aerodynamics (CAAA), it’s developers kept the exact size of the drone as a secret, but it is believed to be about 14 …

The post China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude appeared first on LatestSolarNews.




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New Solar Plant In Chile To Power 13,000 Homes Per Year

Chile is building a brand new solar power plant that has some exciting outcome on the future. The plant is expected to provide energy on day and night as well as throughout inclement weather, to power up to 13,000 homes annually. This project will make Chile one of the top solar energy spots in the …

The post New Solar Plant In Chile To Power 13,000 Homes Per Year appeared first on LatestSolarNews.




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Spacing elements

So let’s say we have a “bar” with some items inside. Like a header or footer. Let’s also say we want those items to be spaced evenly, meaning they have the same gap everywhere. Shouldn’t be a big problem. Let’s take a look:

1. Margin

We can’t just add margin: 2rem to the elements since there is no margin collapsing on the horizontal axis. And it also doesn’t work when using Flexbox. Leaving a double sized gap in between. Wishing there is something like margin: 2rem collapse; where you can enable/disable it optionally.

See the Pen Spacing elements (no collapsing) by simurai (@simurai) on CodePen.

2. Pseudo classes

Using margin: 2rem 0 2rem 2rem and then a pseudo class like :last-child { margin-right: 2rem } to add the extra margin works as long as you don’t need to hide that element with display: none. Maybe a rare case, but I’ve been running into this issue once in a while. Would be cool if there is something like :last-displayed that would ignore elements that have display:none.

See the Pen Spacing elements (pseudo) by simurai (@simurai) on CodePen.

3. Margin + padding (best)

The easiest way I think, is to add margins to all elements (like in the first example), but then also add the same value as padding to the parent element. Like this:

.Header {
  padding: 1rem;
}
.Header-item {
  margin: 1rem;
}

That way all elements are evenly spaced and you still can use display:none without having to worry about breaking it. A little flaw is that you have to keep the 2 values in sync, but if you’re using a preprocessor, it can just be a single variable. Or maybe you could use REM’s to control it with font-size from the :root.

See the Pen Spacing elements by simurai (@simurai) on CodePen.

Other?

There are more ways but I’m not aware of a simple one that also let’s you use display: none. Let me know otherwise.

Update

A couple more options:

Hmmm.. gotta try some. I kinda like the 3rd one. Keeps it independent from the parent and is not “too” complicated.




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DuoTone themes

Double-hue syntax themes for Atom.

DuoTone themes use only 2 hues (7 shades in total). It tones down less important parts (like punctuation and brackets) and highlights only the important ones. This leads to a more calm color scheme, but still lets you find the stuff you’re looking for.

A big thanks goes to @braver who did most of the initial language support.

Color variations

And here some more color variations created by other theme authors.




me

17 Tools for Effective Customer Engagement

The one thing that every business that offers a service has in common is its customers. It doesn't matter if you are a freelancer with just one client or a small design agency with a few clients, you have to deal with customers on a day to day basis.




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Email Personalization: Your Secret To Better Engagement

One of the struggles that marketers face is how to send the right message at exactly the right time to target people in a way that will appeal to them. To solve the problem, businesses need to get themselves acquainted with new technologies and the power of personalization. In the past few years, digital marketing […]




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8 of the Top WP Multipurpose Themes That You Can Use

More than a few multipurpose WordPress themes have become big sellers in recent years, and for a reason. Actually, for several reasons. One reason is they serve as excellent toolkits for web designers who have large and varied clienteles. The best multipurpose themes, like those presented here, are popular for other reasons as well. They […]




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Women’s squad raises ₹20 lakh

The Indian women’s hockey team’s efforts to crowd-fund support for poor and migrant workers has raised ₹20,01,130 through an 18-day online challenge.T




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The matter of photography in the Americas / Natalia Brizuela and Jodi Roberts ; with contributions by Lisa Blackmore, Amy Sara Carroll, Marianela D'Aprile, María Fernanda Domínguez, Heloisa Espada, Rachel Price, Diana Ruiz, Tatiane Santa Ro

Rotch Library - TR184.B75 2018




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The women of Atelier 17: modernist printmaking in midcentury New York / Christina Weyl

Rotch Library - NE538.N5 W49 2019




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Mathias Goeritz: modernist art and architecture in Cold War Mexico / Jennifer Josten

Rotch Library - N6559.G64 J67 2018




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For your pleasure: Johannes Brus, photoworks and sculptures / with an essay by Clément Chéroux

Rotch Library - N6888.B745 A4 2018




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The Pre-Raphaelites and science / John Holmes

Hayden Library - NX454.5.P7 H65 2018




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Djordje Ozbolt: regaining memory loss / exhibition curator, Nicoletta Lambertucci

Rotch Library - N6488.I8 V433 2019 Y8




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New design, neoplasticism: Nieuwe beelding / Piet Mondrian ; English translation by Harry Holtzman and Martin S. James

Rotch Library - N6948.5.D42 M6613 2019




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I have forgotten the night / Joël Andrianomearisoa ; curated by Rina Ralay Ranaivo and Emmanuel Daydé

Rotch Library - N6488.I8 V433 2019 M28




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It's about time: Pavilion of Applied Arts / curator, Ralph Rugoff ; artist, Marysia Lewandowska

Rotch Library - N6488.I8 V433 2019 A67




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Altered states: Substanzen in der zeitgenössischen Kunst = substances in contemporary art / herausgegeben von = edited by Milena Mercer ; Texte = texts, Max Daly ... [and thirteen others]

Rotch Library - N8251.S555 A48 2018




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Women, art and money in late Victorian and Edwardian England: the hustle and the scramble / Maria Quirk

Rotch Library - N8354.Q57 2019




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Scott Vendes's Menice

Rotch Library - N6488.I8 V433 2019 B33




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Touch me / Johannes Frandsen ; text, Mattias Lundblad

Rotch Library - TR650.F73 2018




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Le modèle noir: de Géricault à Matisse: Musée d'Orsay / [éditeur, Claude Pommereau]

Rotch Library - N8232.M6325 2019




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Dorothy Iannone: a cookbook / Dorothy Iannone ; [edited by Clément Dirié]

Rotch Library - N6537.I26 A4 2018




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The stronger we become: the South African pavilion / Dineo Seshee Bopape, Tracey Rose, Mawande Ka Zenzile ; curated by Nkule Mabaso, Nomusa Makhubu

Rotch Library - N6488.I8 V433 2019 S6




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Biennale Arte 2019: may you live in interesting times: 11.05-24.11 Venezia Giardini/Arsenale

Rotch Library - N6488.I8 V433 2019 A1




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T.C. Cannon: at the edge of America / edited by Karen Kramer ; with contributions by heather ahtone, Sherwin Bitsui, Caitlin Cooper, Frank Buffalo Hyde, Trevor Fairbrother, Santee Frazier, Joy Harjo, Joan Naviyuk Kane, Karen Kramer, Deana McCloud, America

Rotch Library - NX512.C36 A4 2018