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Assessing the range of enzymatic and oxidative tunability for biosensor design

J. Mater. Chem. B, 2020, 8,3460-3487
DOI: 10.1039/C9TB02666E, Review Article
Hattie C. Schunk, Derek S. Hernandez, Mariah J. Austin, Kabir S. Dhada, Adrianne M. Rosales, Laura J. Suggs
This review aims to inspire novel biosensor design by addressing materials chemistries through the lense of enzymatic and oxidative susceptibility in the spectra of inflammatory disease biomarkers.
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Introduction to Biosensors

J. Mater. Chem. B, 2020, 8,3168-3170
DOI: 10.1039/D0TB90051F, Editorial
Ning Gu, Shaoqin Liu
Shaoqin Liu and Ning Gu, Journal of Materials Chemistry B themed issue on Biosensors.
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Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00629G, Paper
Alexander Morlando, Marcela Chaki Borrás, Yaser Rehman, Shahnaz Bakand, Philip Barker, Ronald Sluyter, Konstantin Konstantinov
Low photocatalytic CeO2/TiO2 nanocomposite particles with high UV attenuation and reduced ROS generation for application in sunscreen products.
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Functional peptide-based drug delivery systems

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00713G, Highlight
Zheng Lian, Tianjiao Ji
Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.
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Encapsulated DNase Improving the Killing Efficiency of Antibiotics in Staphylococcal Biofilms

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00441C, Communication
Chenhui Liu, Yu Zhao, Wanqi Su, Jingshan Chai, Lina Xu, Jingjing Cao, Yang Liu
We developed a polymer-encapsulated DNase, n(DNase), which can efficiently accumulate in biofilm and expose the DNase to cleave the eDNA of biofilm. CLSM and crystal violet results demonstrated an effective...
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Design principles and fundamental understanding of biosensors for amyloid-β detection

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00344A, Review Article
Yanxian Zhang, Baiping Ren, Dong Zhang, Yonglan Liu, Mingzhen Zhang, Chao Zhao, Jie Zheng
Aβ as biomarker in Alzheimer’s disease (AD) drives the significant research efforts for developing different biosensors with different sensing strategies, materials, and mechanisms for Aβ detection.
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Development of mucoadhesive cationic polypeptide micelles for sustained cabozantinib release and inhibition of corneal neovascularization

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00874E, Paper
Haijie Han, Qichuan Yin, Xiajing Tang, Xiaoning Yu, Qiang Gao, Yelei Tang, Andrzej Grzybowski, Ke Yao, Jian Ji, Xingchao Shentu
Corneal neovascularization (CNV) is one of the leading risk factors for vision loss. Anti-angiogenic drugs can theoretically be extended to the treatment of CNV. However, the application of these drugs...
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The rise of bio-inspired polymer compartments responding to pathology related signals

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00475H, Perspective
Open Access
Luisa Zartner, Moritz Sylvester Muthwill, Ionel Adrian Dinu, Cora-Ann Schoenenberger, Cornelia G. Palivan
Self-organized nano- and microscale polymer compartments (polymersomes, GUVs, PICsomes and LbL capsules) have increasing potential in many sensing applications. In this review, we highlight the key role they play in...
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Biomimetic Immunomagnetic Gold Hybrid Nanoparticles Coupled with Inductively Coupled Plasma Mass Spectrometry for the Detection of Circulating Tumor Cells

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00403K, Paper
Zhimin Chang, Hang Zhou, Chao Yang, Rui Zhang, Qiannan You, Ruhong Yan, Li Li, Mingfeng Ge, Yuguo Tang, Wen-fei Dong, Zheng Wang
Immunomagnetic beads are important tools for the isolation and detection of circulating tumor cells (CTCs). However, the current immunomagnetic bead technique provides poor CTC separation purity due to nonspecific binding...
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Thin platelet-like COF nanocomposites for blood brain barrier transport and inhibition of brain metastasis from renal cancer

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00724B, Paper
Guiyang Zhang, Bo Jiang, Chunyong Wu, Yanfeng Liu, Yidan He, Xin Huang, Wei Chen, Kai Xi, Hongqian Guo, Xiaozhi Zhao, Xudong Jia
A drug-loaded polymer–COF nanocomposite has been developed to cross the blood brain barrier and treat brain metastasis from renal cancer.
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Bioinspired polydopamine nanoparticles: synthesis, nanomechanical properties, and efficient PEGylation strategy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02769F, Paper
Islam Zmerli, Jean-Philippe Michel, Ali Makky
We established tightly controlled experimental conditions to synthesize polydopamine nanoparticles with well-defined and reproducible physicochemical properties such as size, yield and nanomechanics.
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Aqueous surface gels as low friction interfaces to mitigate implant-associated inflammation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00582G, Perspective
Allison L. Chau, Jonah Rosas, George D. Degen, Lisa K. Månsson, Jonathan Chen, Eric Valois, Angela A. Pitenis
Soft implant surfaces should be designed with an eye toward natural, healthy biointerfaces, which use high water content aqueous gel gradients to reduce contact pressures and frictional shear stresses and thus reduce inflammation and discomfort.
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A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02156F, Paper
Mohammad-Ali Shahbazi, Neha Shrestha, Malgorzata Karolina Pierchala, Firoz Babu Kadumudi, Mehdi Mehrali, Masoud Hasany, Véronique Préat, Sander Leeuwenburgh, Alireza Dolatshahi-Pirouz
A polymeric gum has been developed herein, which combines high stretchability and self-healing capacity with a bioactivity that can target and eliminate bacterial infections and inflammations.
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Phosphates-responsive 2D-Metal─Organic-Framework-Nanozymes for Colorimetric Detection of Alkaline Phosphatase

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/C9TB02542A, Paper
Xiaoyu Wang, Xiaoqian Jiang, Hui Wei
In this study, a simple colorimetric method with tunable dynamic range for alkaline phosphatase (ALP) activity assay was developed by using peroxidase-mimicking two-dimensional-metal─organic-framework (2D-MOF). Phosphates including pyrophosphate (PPi), ATP, and...
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Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00875C, Paper
Lisa White, Jessica E. Boles, Nyasha Allen, Luke Alesbrook, J. Mark Sutton, Charlotte Hind, Kira Hilton, Laura R. Blackholly, Rebecca Ellaby, George Williams, Daniel P Mulvihill, Jennifer Ruth Hiscock
SSAs are a class of Supramolecular Self-associating Amphiphilic salt, the anionic component of which contains a covalently bound hydrogen bond donor-acceptor motif. This results in a monomeric unit which can...
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Unique Sequence-Dependent Properties of Trinucleotide Repeat Monolayers: Electrochemical, Electrical, and Topographic Characterization

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00507J, Paper
Narges Asefifeyzabadi, Motahareh Taki, Madison Funneman, Tingjie Song, Mohtashim Hassan Shamsi
Trinucleotide repeat (TNR) sequences widely exist in nature and their overgrowth is associated with two dozen neurodegenerative diseases in humans. These sequences have unique helical flexibility which affects their biophysical...
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In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00499E, Paper
Zhaowen Ding, Nana Luo, Hua Yue, Yongjun Gao, Guanghui Ma, Wei Wei
2D PEGylated graphene oxide showed stealth-but-immune-activating capacity on macrophages, along with specific intraperitoneal immunological response in vivo.
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A waterborne polyurethane 3D scaffold containing PLGA with a controllable degradation rate and an anti-inflammatory effect for potential applications in neural tissue repair

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00656D, Paper
Bohong Du, Hang Yin, Yue Chen, Weiwei Lin, Yanchao Wang, Daiguo Zhao, Gang Wang, Xueling He, Jiehua Li, Zhen Li, Feng Luo, Hong Tan, Qiang Fu
3D connected porous LGPU scaffolds with adjustable degradation and a strong anti-inflammatory effect were prepared for neural tissue repair.
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Glutathione- and light-controlled generation of singlet oxygen for triggering drug release in mesoporous silica nanoparticles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00636J, Paper
Roy C. H. Wong, Dennis K. P. Ng, Wing-Ping Fong, Pui-Chi Lo
An activatable phthalocyanine-based photosensitiser and a singlet-oxygen-triggered doxorubicin releasing system have been incorporated into mesoporous silica nanoparticles, which can release the encapsulated doxorubicin in a controllable manner.
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Multivalent cationic dendrofullerenes for gene transfer: synthesis and DNA complexation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00113A, Paper
Beatriz M. Illescas, Alfonso Pérez-Sánchez, Araceli Mallo, Ángel Martín-Domenech, Ignacio Rodríguez-Crespo, Nazario Martín
Non-viral nucleic acid vectors able to display high transfection efficiencies with low toxicity and overcoming the multiple biological barriers are needed to further develop the clinical applications of gene therapy.
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Progress in biomimetic leverages for marine antifouling using nanocomposite coatings

J. Mater. Chem. B, 2020, 8,3701-3732
DOI: 10.1039/C9TB02119A, Review Article
Mohamed S. Selim, Sherif A. El-Safty, Mohamed A. Shenashen, Shimaa A. Higazy, Ahmed Elmarakbi
Because of the environmental and economic casualties of biofouling on maritime navigation, modern studies have been devoted toward formulating advanced nanoscale composites in the controlled development of effective marine antifouling self-cleaning surfaces.
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Nanoclay-functionalized 3D nanofibrous scaffolds promote bone regeneration

J. Mater. Chem. B, 2020, 8,3842-3851
DOI: 10.1039/C9TB02814E, Paper
Qingqing Yao, Kirby E. Fuglsby, Xiao Zheng, Hongli Sun
A nanoclay-enriched 3D nanofibrous biomimetic scaffold with strong bone regenerative ability by virtue of its improved mechanical properties, osteoconductivity, and drug binding capacity was developed.
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Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics

J. Mater. Chem. B, 2020, 8,3852-3868
DOI: 10.1039/D0TB00064G, Paper
John D. Schneible, Kaihang Shi, Ashlyn T. Young, Srivatsan Ramesh, Nanfei He, Clay E. Dowdey, Jean Marie Dubnansky, Radina L. Lilova, Wei Gao, Erik Santiso, Michael Daniele, Stefano Menegatti
Composite material enabling the delivery of synergistic combination of doxorubicin and gemcitabine against breast cancer with molar and kinetic precision.
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Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment

J. Mater. Chem. B, 2020, 8,3929-3938
DOI: 10.1039/D0TB00243G, Paper
Linhua Liao, Dong Cen, Yike Fu, Bin Liu, Chao Fang, Yifan Wang, Xiujun Cai, Xiang Li, Hao Bin Wu, Gaorong Han
Fine nanocapsules based on MnFe hydroxides, showing high loading capacity, O2 induction and biodegradation, were synthesized for effective synergistic therapies.
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A near-infrared light-responsive multifunctional nanocomposite hydrogel for efficient and synergistic antibacterial wound therapy and healing promotion

J. Mater. Chem. B, 2020, 8,3908-3917
DOI: 10.1039/D0TB00361A, Paper
Na Yang, Ming Zhu, Guochao Xu, Ning Liu, Cong Yu
A multifunctional nanocomposite hydrogel for synergistic antibacterial wound therapy and healing promotion.
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Molecular simulations and understanding of antifouling zwitterionic polymer brushes

J. Mater. Chem. B, 2020, 8,3814-3828
DOI: 10.1039/D0TB00520G, Paper
Yonglan Liu, Dong Zhang, Baiping Ren, Xiong Gong, Lijian Xu, Zhang-Qi Feng, Yung Chang, Yi He, Jie Zheng
Zwitterionic materials demonstrate the strong surface hydration to empower their antifouling property.
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Unravelling the nucleation, growth, and faceting of magnetite–gold nanohybrids

J. Mater. Chem. B, 2020, 8,3886-3895
DOI: 10.1039/C9TB02721A, Paper
Yulia A. Nalench, Igor V. Shchetinin, Alexander S. Skorikov, Pavel S. Mogilnikov, Michael Farle, Alexander G. Savchenko, Alexander G. Majouga, Maxim A. Abakumov, Ulf Wiedwald
The nucleation, growth and faceting of Fe3O4–Au nanoparticles is systematically monitored using liquid probes during reaction. Two consecutive processes are obtained, the growth of Fe3O4 spheres on Au seeds and faceting towards octahedral motifs.
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New forms of electrospun nanofiber materials for biomedical applications

J. Mater. Chem. B, 2020, 8,3733-3746
DOI: 10.1039/D0TB00271B, Review Article
Shixuan Chen, Johnson V. John, Alec McCarthy, Jingwei Xie
This review article discusses new forms of electrospun nanofiber materials and their biomedical applications.
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Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

J. Mater. Chem. B, 2020, 8,3880-3885
DOI: 10.1039/D0TB00407C, Paper
Sara Amorim, Iva Pashkuleva, Celso A. Reis, Rui L. Reis, Ricardo A. Pires
We developed hyaluronic acid (HA):poly-L-lysine (PLL) layer-by-layer (LbL) constructs whose viscoelastic properties and bioactivity can be finely tuned by using polyanions of different molecular weight and/or crosslinking.
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Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

J. Mater. Chem. B, 2020, 8,3939-3948
DOI: 10.1039/D0TB00327A, Paper
Boya Zhang, Shiyu Wan, Xinyu Peng, Mingying Zhao, Sai Li, Yuji Pu, Bin He
A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.
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H2S-Donating trisulfide linkers confer unexpected biological behaviour to poly(ethylene glycol)–cholesteryl conjugates

J. Mater. Chem. B, 2020, 8,3896-3907
DOI: 10.1039/C9TB02614B, Paper
Francesca Ercole, Yuhuan Li, Michael R. Whittaker, Thomas P. Davis, John F. Quinn
A comprehensive in vitro study into trisulfide-bearing PEG-conjugates was conducted. For these materials the combination of a cholesteryl group and an H2S donating moiety is required to confer cytoprotective and ROS-mitigating effects.
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Synthetic mycomelanin thin films as emergent bio-inspired interfaces controlling the fate of embryonic stem cells

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00623H, Paper
Paola Manini, Valeria Lucci, Valeria Lino, Stefania Sartini, Francesco Rossella, Geppino Falco, Cinzia Chiappe, Marco d’Ischia
Mycomelanin thin films from 1,8-dihydroxynaphthalene can serve as a biointerface inducing adhesion and proliferation of ESCs and promoting their differentiation towards endodermal lineages.
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A fiber-shaped neural probe with alterable elastic moduli for direct implantation and stable electronic–brain interfaces

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00508H, Communication
Chengqiang Tang, Songlin Xie, Mengying Wang, Jianyou Feng, Zhengqi Han, Xiaoying Wu, Liyuan Wang, Chuanrui Chen, Jiajia Wang, Liping Jiang, Peining Chen, Xuemei Sun, Huisheng Peng
A fiber-shaped neural probe with alterable elastic moduli allows direct implantation and enables adaptive electronic–tissue interfaces post implantation.
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Discrimination of cysteamine from mercapto amino acids through isoelectric point-mediated surface ligand exchange of β-cyclodextrin-modified gold nanoparticles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00462F, Paper
Quanbao Ma, Xun Fang, Junting Zhang, Lili Zhu, Xiabing Rao, Qi Lu, Zhijun Sun, Huan Yu, Qunlin Zhang
A pI-mediated R6G-β-CD@AuNPs system was designed for the first time for the discrimination of CA from GSH/Cys/Hcy in human serum samples.
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Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00357C, Paper
Shuiling Jin, Lanling Weng, Zhi Li, Zhenzhen Yang, Lili Zhu, Jianxiang Shi, Wenxue Tang, Wang Ma, Hong Zong, Wei Jiang
Chemodynamic therapy (CDT) has been critically challenged by insufficient H2O2 in cancer tissues and inefficient reactive oxygen species (ROS) production.
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A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00561D, Paper
Yu Zhang, Jun Yang, Jun Zhang, Shuangwen Li, Lisi Zheng, Yanlong Zhang, Huipeng Meng, Xinge Zhang, Zhongming Wu
A bio-inspired injectable hydrogel as a cell platform for real time glycemic regulation by mimicking the function of native islet β cells.
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Regulation of cell binding and entry by DNA origami mediated spatial distribution of aptamers

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00663G, Communication
Ke Liu, Cong Xu, Jinyao Liu
Customizing the spatial distribution of aptamers on DNA origami nanoboxes can regulate the internalization and proliferation of cancer cells.
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Preparation and biological evaluations of collagen-like hierarchical Ti surface with superior osteogenic capabilities

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00799D, Paper
Weiwei Lao, Qiaojie Luo, Yadong Chen, Wei Yao, Jiajia Xu, Lijie Fan, Xiaodong Li
The construction of multiscale Ti surfaces of high osteogenic ability always attracts numerous attentions in oral implantology and implantable biomaterial field. However, so far, the absence of solid understanding of...
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Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00052C, Paper
Javad Foroughi, Sepehr Talebian , In Kyoung Shim, Kara Vine, Song Cheol Kim, Geoffrey M Spinks
Biopolymer-based hydrogels have emerged as promising platforms for drug delivery systems (DDSs) due to their inherent biocompatibility, tunable physical properties and controllable degradability. Yet, drug release in majority of these...
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Surface functionalization strategies of extracellular vesicles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00744G, Review Article
Sagar Rayamajhi, Santosh Aryal
Physical, biological, and chemical strategies of surface functionalization can add vital functionality in extracellular vesicles (EVs) for diverse biomedical applications.
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Ag@S-nitrosothiols core-shell nanoparticles for chemo and photothermal synergistic tumor target therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00734J, Paper
Xinlin Yang, Tuanwei Liu, Xiao Li, Jinan Wang, Ping Zhang, Xiaoying Huang, Zhide Zhang, Dian-Shun Guo
Along with development of the controlled delivery systems for target therapy, ‘single-strategy’ therapy often fails to achieve the desired performance in real body internal environment. In such case, it is...
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Hydrogels toughened by biominerals as energy-dissipative sacrificial bonds

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00833H, Communication
Kazuki Fukao, Kazuki Tanaka, Ryuji Kiyama, Takayuki Nonoyama, Jian Ping Gong
Inspired by bone tissues, hydrogels toughened by hydroxyapatite (HAp) working as energy-dissipative sacrifical bonds is created. The contribution of dissipated energy from HAp mineral was over 500 % higher than...
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Diblock Copolypeptoids: A Review of Phase Separation, Self-Assembly and Biological Applications

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00477D, Review Article
Sunting Xuan, Ronald N Zuckermann
Polypeptoids are biocompatible, synthetically accessible, chemically and enzymatically stable, chemically diverse, and structurally controllable. As a bioinspired and biomimetic material, it has attracted considerable attention due to its great potential...
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High-performance non-enzymatic glucose detection: using conductive Ni-MOF as an electrocatalyst

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00131G, Communication
Yanxia Qiao, Qian Liu, Siyu Lu, Guang Chen, Shuyan Gao, Wenbo Lu, Xuping Sun
Conductive metal−organic frameworks (MOFs) are studied extensively in applications like water electrolysis, gas storage, and supercapacitors due to their high conductivity and large pore volume, etc. In this communication, we...
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Psychoanalysis and ethics in documentary film / Agnieszka Piotrowska

Piotrowska, Agnieszka, author




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Herding cats : the evolution of the ADF's media embedding program in operational areas / by Jason Logue

Logue, Jason, author




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Confessions from correspondent-land : the dangers & delights of life as a foreign correspondent / Nick Bryant

Bryant, Nick (Nicholas Andrew), author




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Digital innovations for mass communications : engaging the user / Paul Martin Lester

Lester, Paul Martin, author




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Documentary, world history, and national power in the PRC : global rise in Chinese eyes / Gotelind Müller

Müller, Gotelind




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Engaging with reality : documentary and globalization / Ib Bondebjerg

Bondebjerg, Ib