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Supreme head of Jacobite Syrian Christian Church Mor Baselios Thomas I passes away




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Temple firecrackers blast: Kerala cabinet sanctions Rs 4 lakh compensation for next of kin of deceased




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Kerala launches campaign against misuse of antibiotics




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A billion new developers thanks to AI?

This is a translation of my German article for the AI mag. At the WeAreDeveloper World Congress in Berlin in July, GitHub announced that the company will use artificial intelligence and assistants to turn a billion people into developers in a very short time. Amazon’s Cloud CEO, on the other hand, explained in an internal […]




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Big Upsets! Real Madrid, Bayern Munich lose

A first-half penalty earned Lille a shock 1-0 home victory over holders Real Madrid in the Champions League group phase on Wednesday.




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PIX: Manu, Vinesh, Babita, Bajrang Vote

Sports stars in Haryana stepped out to cast their vote on Saturday.




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Bihar to host Women's Asian Champions Trophy

'The design of the logo of this competition is a symbol of the rich cultural heritage and all-round progress of glorious Bihar.'




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Champions League PIX: Big wins for City, Barca

IMAGES from the UEFA Champions League matches played on Wednesday.




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PIX: Manchester United register big win!

United are six-times League Cup winners, most recently lifting the trophy in 2022-23 with Ten Hag at the helm.




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The basics of molecular biology / Alexander Vologodskii.

Cham : Springer, [2023]




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Can microbial communities regenerate? [electronic resource] : uniting ecology and evolutionary biology / S. Andrew Inkpen and W. Ford Doolittle.

Chicago, IL : The University of Chicago Press , 2022.




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India will be one of the biggest intelligence markets: Mukesh Ambani

Reliance would like to build AI infrastructure in the country that would make a similar impact like Jio did for telecom infrastructure, says Mukesh Ambani, speaking at the Nvidia AI summit in Mumbai




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Revolutionising data security: IBM introduces Guardium Data Security Centre with GenAI capabilities

The centre incorporates GenAI features for generating risk summaries and improving productivity among security teams.




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Apple ships $6 billion of iPhones from India in big China shift

Apple is expanding its manufacturing network in India at a rapid clip




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Tech giants are set to spend $200 billion this year chasing AI

Executives from each company warned investors this week that their splurge will continue next year, or even ramp up




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Progress targets $1 billion revenue with acquisition; expands Bangalore team

The ShareFile business the company is acquiring generates approximately $240 million in revenue




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Centre writes to Wikipedia over complaints of inaccuracies, biases

Sources said the Information and Broadcasting ministry has sent a notice to Wikipedia regarding complaints that it has received about alleged inaccuracies and bias of information on the site




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Sonata Software optimistic about revenue growth in H2FY25; eyes $1.5 billion revenue by FY27

The company’s international services revenue in the September-ended quarter stood at ₹707.9 crore




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Elon Musk’s broadband ambitions in India: Why Jio and Airtel are feeling the heat

Tech advancements have made it possible for satcom players to offer data services directly to the users’ smartphones, bypassing traditional cellular operators altogether




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AppLovin CEO once spurned by VC firms now worth $11 billion

Shares of Palo Alto, California-based AppLovin have surged seven-fold this year, giving co-founder Adam Foroughi a net worth of $10.9 billion




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In big trouble!

YW storyteller contest: We were flooded with stories for the YW Storyteller contest announced on June 24. Here are some entries that almost made it.




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Bird brained

YW storyteller contest: We were flooded with stories for the YW Storyteller contest announced on June 24. Here are some of the entries that almost made it… Congratulations!




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Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00312H, Paper
I. Caroline Vaaland Holmgard, Aday González-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández-Bolaños, José M. Padrón, Óscar López, Emil Lindbäck
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Catalytic asymmetric construction of helicenes via transformation of biaryls

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00012A, Review Article
Peiling Fan, Lun Li, Deyun Qian
Chiral helicenes can be built by catalytic asymmetric transformation of pre-existing, easily accessible biaryl precursors using conceptually novel strategies such as olefin metathesis, alkyne hydroarylation, C–X coupling, and C–H functionalization.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Kinetic resolution of 1,1'-binaphthyl-2,2'-diamine derivatives by chiral calcium phosphate-catalyzed acylation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00355A, Paper
Tatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama
Chiral calcium phosphate-catalyzed kinetic resolution of BINAM derivatives.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Friedel–Crafts reactions for biomolecular chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00406J, Review Article
Open Access
Jun Ohata
This review demonstrates advances in Friedel–Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Structural flexibility of favipiravir and its structural analogues in solutions: experimental and computational insight

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00404C, Paper
Tatiana P. Gerasimova, Almaz A. Zagidullin, Anastasiia N. Nikolaeva, Robert R. Fayzullin, Aliya M. Saitova, Vasili A. Miluykov, Stefan Grimme, Sergey A. Katsyuba
Keto-enol transformations of 6-R-3-hydroxy-2-pyrazinecarboxamides in solutions are accompanied by deprotonation of enol tautomers and the formation of corresponding anionic species. The key factors determining these processes have been identified.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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2-Azabicyclo[3.2.1]octane scaffold: synthesis and applications

Org. Biomol. Chem., 2024, 22,2902-2915
DOI: 10.1039/D4OB00199K, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mariana Crespo Monteiro, João Rafael Vale, Filipa Siopa
This review focuses on the preparation and applications in total synthesis of 2-azabicyclo[3.2.1]octane structures, a class of natural and synthetic compounds with a range of biological activities.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield

Org. Biomol. Chem., 2024, 22,3009-3018
DOI: 10.1039/D4OB00211C, Paper
Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
A single-point mutation of 7α-HSDH achieved the highest activity and synergistically improved substrate tolerance, thermal stability, cofactor affinity, and conversion rate.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective synthesis of an elusive C-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor

Org. Biomol. Chem., 2024, 22,3059-3067
DOI: 10.1039/D3OB02050A, Paper
Marie M. Le Roy, Sandra Claes, Nathalie Saffon-Merceron, Dominique Schols, Thibault Troadec, Raphaël Tripier
A rare example of C,C'-linked bis-cyclam has been synthesized with controlled manner in mild conditions thanks to the “bis-aminal” tool, and its good CXCR4-recognition properties could be demonstated in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Albumin–ruthenium catalyst conjugate for bio-orthogonal uncaging of alloc group

Org. Biomol. Chem., 2024, 22,2992-3000
DOI: 10.1039/D4OB00234B, Paper
Kimberly S. Taylor, Madison M. McMonagle, Schaelee C. Guy, Ariana M. Human-McKinnon, Shumpei Asamizu, Heidi J. Fletcher, Bradley W. Davis, Takashi L. Suyama
An organo–ruthenium catalyst conjugated to albumin efficiently unmasks an alloc group under physiologically relevant conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum

Org. Biomol. Chem., 2024, 22,3019-3024
DOI: 10.1039/D4OB00334A, Paper
Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
Six unusual pyridine-containing bisnor- (C23), tetranor- (C21) and pentanor- (C20) sesterterpenoids were obtained from the medicinal plant Leucosceptrum canum of Tibetan origin. The immunosuppressive activities of these sesterterpenoids were observed.
The content of this RSS Feed (c) The Royal Society of Chemistry




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BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00274A, Communication
Gaurav Jaiswal, Subhas Chandra Pan
BBr3 mediated dearomative spirocyclization of biaryl ynones has been reported for the direct synthesis of spiro[5.5]dienones with a tri-substituted double bond.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00272E, Paper
Brenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah Caldas
This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00040D, Paper
Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
Despite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00015C, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. Mendes
An effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00236A, Review Article
Goverdhan Mehta, Saumitra Sengupta, Srihari Pabbaraja
Often referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis, and biological application of A–D–A-type boranil fluorescent dyes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00297K, Paper
Wei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi Song
Acceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), were developed with strong red fluorescence and large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells and zebrafish.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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The Hobbit Experience 2014: Adding WebRTC gameplay to the Hobbit Experience

Learn how North Kingdom built an immersive multimedia experience optimized for modern mobile browsers using Web RTC




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As the price of aviation turbine fuel soars, airlines’ finances spin out of control




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IFSC: Aircraft leasing gets a big boost

Around 80 per cent of the total commercial fleet in India is leased against 53 per cent of the same, globally




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How cabin pressure plays a key role

Ensures adequate levels of oxygen in the air




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Electric aircraft set to transform urban mobility 

Investors are pouring in billions of dollars into eVTOL project (electric vertical take offs and landing aircraft) to ferry passengers




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Cabin crew with an invisible cape 

Being a cabin crew member is not a mere job, but an ineffable life experience




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Chicken gun test: Saving jets from bird strikes

According to ICAO, at least 34 bird strikes happen every day, causing around $1 billion worth damages every year




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Boeing bids farewell to ‘Queen of the skies’

The first Boeing 747 took off from New York on Jan 22, 1970 and now the final 747 freighter was delivered to Atlas Air on February 1, 2022.




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OpenAI chair's AI startup Sierra gets $4.5 billion valuation in latest funding round

One-year-old Sierra focuses on selling artificial intelligence-powered customer service chatbots to enterprises




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Meta builds AI search engine to cut Google, Bing reliance, the Information reports

The Facebook-owner currently relies on Google and Bing search engines to give users answers on news, stocks and sports




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Microsoft Teams to launch threaded conversations, combined chats and channels features

The app has also added other changes in the interface so users can organise their chats better




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OpenAI builds first chip with Broadcom and TSMC, scales back foundry ambition

OpenAI is working with Broadcom and TSMC to build its first in-house chip designed to support its artificial intelligence systems, per sources