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Defining the mechanism of the mitochondrial Atm1p [2Fe–2S] cluster exporter

Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00286C, Paper
Stephen A. Pearson, Christine Wachnowsky, J. A. Cowan
Atm1p mediated mitochondrial Fe–S cluster export is investigated, providing support for a [2Fe–2S](GS)4 cluster as a physiological substrate. A detailed mechanism of cluster export, combining kinetic, thermodynamic, and structural data is presented.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Enantiomeric Copper Based Anticancer Agents Promoting Sequence-Selective Cleavage of G-Quadruplex Telomeric DNA and non-random cleavage of plasmid DNA

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00084A, Paper
Sabiha Parveen, J. A. Cowan, Zhen Yu, Farukh Arjmand
Copper-based binuclear enantiomeric complexes 1S and 1R were synthesized as anticancer chemotherapeutic agents to target G-quadruplex rich region of DNA and thoroughly characterized by various spectroscopic and single X-ray crystal...
The content of this RSS Feed (c) The Royal Society of Chemistry




me

Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,474-490
DOI: 10.1039/C9MT00271E, Paper
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qinguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
BEOV activates PPARγ to affect JAK2/STAT3/SOCS1 signaling and eventually prevents Aβ generation. Meanwhile, BEOV inactivates PTP1B to affect PI3K/Akt/GSK3β signaling and finally reduces tau hyperphosphorylation.
The content of this RSS Feed (c) The Royal Society of Chemistry




me

Gene expression in mouse muscle over time after nickel pellet implantation

Metallomics, 2020, 12,528-538
DOI: 10.1039/C9MT00289H, Paper
Desmond I. Bannon, Wenjun Bao, Stephen D. Turner, Wilfred C. McCain, William Dennis, Russ Wolfinger, Ed Perkins, Roger Abounader
Implanted nickel becomes toxic when it exceeds homeostasis, initiating a range of global gene effects over time, including oxidative phosphorylation and immune responses, which are impacted in opposite directions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lanthanum chloride impairs spatial learning and memory by inducing [Ca2+]m overload, mitochondrial fission–fusion disorder and excessive mitophagy in hippocampal nerve cells of rats

Metallomics, 2020, 12,592-606
DOI: 10.1039/C9MT00291J, Paper
Miao Yu, Jinghua Yang, Xiang Gao, Wenchang Sun, Shiyu Liu, Yarao Han, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Cai
Lanthanum chloride damages hippocampal nerve cells of rats through inducing [Ca2+]m overload, mitochondrial fission–fusion disorder, and excessive mitophagy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Heterobimetallic Ru(II)/Fe(II) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

Metallomics, 2020, 12,547-561
DOI: 10.1039/C9MT00272C, Paper
Adriana Pereira Mundim Guedes, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Maria Alice Montes de Sousa, Paula Francinete Faustino da Silva, Mariana S. de Camargo, Hendryk Gemeiner, Menegário A. Amauri, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Elisângela de Paula Silveira-Lacerda, Alzir A. Batista
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(II) complexes attractive for the development of new chemotherapeutic agents for cancer treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Copper accumulation and the effect of chelation treatment on cerebral amyloid angiopathy compared to parenchymal amyloid plaques

Metallomics, 2020, 12,539-546
DOI: 10.1039/C9MT00306A, Paper
Xiayoue Zhu, Tiffany W. Victor, Ashwin Ambi, Joseph K. Sullivan, Joshua Hatfield, Feng Xu, Lisa M. Miller, William E. Van Nostrand
Multimodal imaging studies show that Aβ amyloid in brain vessels of Tg2576 mice (green) preferentially binds copper (red) – a pathology that can be reduced with copper chelators.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Comparative differential cuproproteomes of Rhodobacter capsulatus reveal novel copper homeostasis related proteins

Metallomics, 2020, 12,572-591
DOI: 10.1039/C9MT00314B, Paper
Nur Selamoglu, Özlem Önder, Yavuz Öztürk, Bahia Khalfaoui-Hassani, Crysten E. Blaby-Haas, Benjamin A. Garcia, Hans-Georg Koch, Fevzi Daldal
Cuproproteome of model bacterium Rhodobacter capsulatus reveals 75 Cu-responsive proteins that are strongly influenced (2–300 fold) by Cu availability.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Identification and determination of selenocysteine, selenosugar, and other selenometabolites in turkey liver

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT90015J, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarzyna Bierla, Rachel M. Taylor, Joanna Szpunar, Ryszard Lobinski, Roger A. Sunde
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The content of this RSS Feed (c) The Royal Society of Chemistry




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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper
Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00076K, Paper
Xinyang Li, Chao Zuo, Mei Wu, Zunzhen Zhang
Linc-ROR modulates the cell proliferation in arsenite-transformed keratinocytes via inhibiting P53 activity through the PI3K/AKT pathway.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00048E, Paper
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Sarah Kassab, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Metal findings in human Alzheimer brains are consistent despite differences in sample post-mortem delay, age, Braak stage and biobank location.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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In vitro selenium supplementation suppresses key mediators involved in myometrial activation and rupture of fetal membranes

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00063A, Paper
Dineli Matheesha Kalansuriya, Ratana Lim, Martha Lappas
Selenium suppresses key mediators involved in preterm birth in human fetal membranes and myometrium.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Reacher Said Nothing: Lee Child and the Making of Make Me


 
It had never been attempted before, and might never be done again. One man watching another man write a novel from beginning to end.
 
On September 1, 2014, in an 11th floor apartment in New York, Lee Child embarked on the twentieth book in his globally successful Jack Reacher series. Andy Martin was there to see him do it, sitting a couple of yards behind him, peering over his shoulder as the writer took another drag of a Camel cigarette and tapped

Read More...




me

Reacher Said Nothing: Lee Child and the Making of Make Me


 
It had never been attempted before, and might never be done again. One man watching another man write a novel from beginning to end.
 
On September 1, 2014, in an 11th floor apartment in New York, Lee Child embarked on the twentieth book in his globally successful Jack Reacher series. Andy Martin was there to see him do it, sitting a couple of yards behind him, peering over his shoulder as the writer took another drag of a Camel cigarette and tapped

Read More...




me

Bodies merged, new guidelines implemented

Bodies merged, new guidelines implemented




me

Disqualification case of 7 MLAs : Tribunal reserves judgement

Disqualification case of 7 MLAs : Tribunal reserves judgement




me

[ASAP] Development of Mischmetal–Fe–Co–B Permanent Magnet Alloys via High-Throughput Methods

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00190




me

[ASAP] Optimized Multimetal Sensitized Phosphor for Enhanced Red Up-Conversion Luminescence by Machine Learning

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00035




me

[ASAP] Experimental and Theoretical Investigation on Phase Formation and Mechanical Properties in Cr–Co–Ni Alloys Processed Using a Novel Thin-Film Quenching Technique

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00170




me

Annual Report to the Nation: Overall cancer mortality continues to decline; Special section on adults ages 20 to 49 shows higher cancer incidence and mortality for women than men

The 2019 Annual Report to the Nation on the Status of Cancer finds overall cancer death rates continue to decline and cancer incidence dropped in men and remained stable in women. A special section reports on recent cancer trends in younger adults.




me

NCI study finds long-term increased risk of cancer death following common treatment for hyperthyroidism

Findings from a new NCI study of patients who received radioactive iodine (RAI) treatment for hyperthyroidism show an association between the dose of treatment and long-term risk of death from solid cancers, including breast cancer.




me

Immunotherapy drug improves outcomes for some children with relapsed leukemia

For children and young adults with certain relapsed B-cell acute lymphoblastic leukemia (B-ALL), the immunotherapy drug blinatumomab is superior to standard chemotherapy, an NCI-sponsored Children’s Oncology Group trial shows.




me

Testing with combined biopsy method improves prostate cancer diagnosis in NCI study

Testing for prostate cancer with a combined biopsy method led to more accurate diagnosis and prediction of the course of the disease in an NCI study. The method is poised to reduce the risk of prostate cancer overtreatment and undertreatment.




me

In NIH trial, selumetinib shrinks tumors, provides clinical benefit for children with NF1

An NCI clinical trial finds the drug selumetinib improves outcomes for children with neurofibromatosis type 1 (NF1), shrinking inoperable tumors called plexiform neurofibromas, reducing pain, and improving function and overall quality of life.




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NCI statement on clinical trials during COVID-19 pandemic

Statement from the National Cancer Institute providing information regarding treatment of cancer patients and participation in clinical trials during the COVID-19 pandemic.




me

Remembered by heart / foreword by Sally Morgan




me

Meng Yuan di guo chu qi de zheng jiao guan xi / Hu Qide zhu

Hu, Qide




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Zhongguo Suzhou fa zhan bao gao : 2011 Suzhou lan pi shu = The development report of China's Suzhou / zhu bian, Yan Li ; fu zhu bian, Pu Ronggao




me

Zhan lüe xing xin xing chan ye xin cai liao bao gao = Report on advanced materials of strategic emerging industries / Zhong Yongheng zhu bian




me

Kai bian da jiang Meng Tian / Feng Zengxiu, Bai Yuanzhi zhu

Feng, Zengxiu, 1958-




me

Hiroshima : Heiwa Kinen Kōen = Hiroshima Memorial Peace Park / henshū Hiroshima Genbaku Shiryō Hozonkai




me

Wen hua ren lei xue yu ke cheng yan jiu : Fang fa lun de qi shi = Cultural anthropology and curriculum studies : methodological inspirations / Sang Guoyuan zhu

Sang, Guoyuan, 1975-




me

Bai yin : Jiang Jieshi wei shen me bai tui Taiwan? = The cause of failure / Wu Gengbin zhu

Wu, Gengbin




me

Mei you ying xiong de shi dai wo zhi xiang zuo yi ge ren / Da Ta zuo pin

Da Ta, 1955-




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Da xue sheng wan mei zhu yi te dian ji qi yu yi yu de guan xi yan jiu / Zhang Bin zhu

Zhang, Bin




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She hui ji xing wei ke xue yan jiu fa. San, Zi liao fen xi = Research methods in social and behavior science. III, Data analysis / Qu Haiyuan ... [et al.] zhu bian




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Zhongguo liu dong ren kou fa zhan bao gao. 2013 = Report on China's migrant population development / Guo jia wei sheng he ji hua sheng yu wei yuan hui liu dong ren kou si bian ; [zhu bian Wang Pei'an]




me

Min zu wen hua cun luo de kong jian yan jiu : yi Guizhou Sheng Liping Xian Dimen Cun wei li / You Xiaoju zhu

You, Xiaoju, 1978-




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Wo guo ping deng jiu ye ji hui bao zhang yan jiu = Study on equal employment opportunity security in China / Wang Liping zhu

Wang, Liping




me

Minguo shi qi Menggu jiao yu zheng ce yan jiu / Sun Yi zhu

Sun, Yi (Ethnologist), 1961- author




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Zhong jie yu fa zhan de hua ti tu chu lei xing xue yan jiu = Topic prominence in typological interlanguage development of Chinese students' English / Yang Lianrui zhu

Yang, Lianrui, 1963- author




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Chuang xin xing ren cai ji li ji zhi yan jiu : ji yu xin li qi yue de shi jiao = Study on incentive mechanism of innovative talent based on psychological contract perspective / Zhu Xiaomei zhu

Zhu, Xiaomei




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Tui fei zhi mei : tui fei zhu yi wen xue de fa sheng, liu bian ji te zheng yan jiu / Xue Wen zhu

Xue, Wen, 1971-




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Zhongguo di fang zheng fu ji xiao guan li yan jiu : yi Shenzhen de shi jian wei li = Research on performance management of local government in China : a case of Shenzhen practice / Zhu Yanqiang zhu

Zhu, Yanqiang




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Jiao shi jiao yu ji shu neng li fa zhan de cha yi xing yan jiu = Study on the differences of the development of teachers' educational technology ability / Qiu Jingling zhu

Qiu, Jingling, 1969-




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Zhongguo Cheng Zhen zhi gong shi ye bao xian wen ti yan jiu = The research for the problem of Chinese city officers and workers unemployment insurance / Shen Shuigen zhu

Shen, Shuigen




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Sheng yin = The reason for success : Mao Zedong kao shen me tong yi da lu? / Wu Gengbin zhu

Wu, Gengbin




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[ASAP] Lattice Strain Measurement of Core@Shell Electrocatalysts with 4D Scanning Transmission Electron Microscopy Nanobeam Electron Diffraction

ACS Catalysis
DOI: 10.1021/acscatal.0c00224