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Antibody free ELISA-like assay for the detection of transcription factors based on double-stranded DNA thermostability

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Analyst, 2020, 145,3339-3344
DOI: 10.1039/C9AN02631B, Paper
Yue Sun, Zhiyan Li, Choiwan Lau, Jianzhong Lu
Transcription factors (TFs) play critical roles in gene expression regulation and disease development. Herein we report a chemiluminescence assay for the detection of transcription factor based on double-stranded DNA thermostability.
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Trace manganese detection via differential pulse cathodic stripping voltammetry using disposable electrodes: additively manufactured nanographite electrochemical sensing platforms

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Analyst, 2020, 145,3424-3430
DOI: 10.1039/D0AN00018C, Paper
Open Access
Diego P. Rocha, Christopher W. Foster, Rodrigo A. A. Munoz, Gary A. Buller, Edmund M. Keefe, Craig E. Banks
Additive manufacturing is a promising technology for the rapid and economical fabrication of portable electroanalytical devices.
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Highly sensitive and selective optosensing of quercetin based on novel complexation with yttrium ions

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Analyst, 2020, 145,3376-3384
DOI: 10.1039/D0AN00117A, Paper
Nguyen Ngoc Nghia, Bui The Huy, Yong-Ill Lee
A simple and fast method was developed for the determination of quercetin using a Arduino-based portable device.
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An ionic-based carbon dot for enantioselective discrimination of nonaromatic amino alcohols

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Analyst, 2020, 145,3395-3400
DOI: 10.1039/D0AN00399A, Paper
Datong Wu, Fei Pan, Li Gao, Yongxin Tao, Yong Kong
An ionic chiral carbon dot was designed and synthesized for the chiral recognition of nonaromatic amino alcohols.
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Why ammonium detection is particularly challenging but insightful with ionophore-based potentiometric sensors – an overview of the progress in the last 20 years

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Analyst, 2020, 145,3188-3210
DOI: 10.1039/D0AN00327A, Critical Review
Open Access
María Cuartero, Noemi Colozza, Bibiana M. Fernández-Pérez, Gastón A. Crespo
An overview of ionophore-based electrodes for ammonium sensing critically analyzing contributions in the last 20 years and with focus in analytical applications.
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Time-resolved in situ monitoring of photocatalytic reactions by probe electrospray ionization mass spectrometry

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Analyst, 2020, 145,3313-3319
DOI: 10.1039/D0AN00305K, Paper
Zhongbao Han, Xiaoyu Gu, Shirong Wang, Liyan Liu, Ying Wang, Zhen Zhao, Zhan Yu
We report the application of PESI-MS to in situ monitoring of photocatalytic reactions of cationic dyes in suspensions in real-time.
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Model independent peak fitting and uncertainty assignment for high-precision time-of-flight mass spectrometry

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Analyst, 2020, 145,3401-3406
DOI: 10.1039/D0AN00325E, Paper
Aleksey Vladimirovich Chudinov, Marco Rosenbusch, Vyacheslav Ivanovich Kozlovskiy, Valeriy Vladislavovich Raznikov, Peter Schury, Michiharu Wada, Hermann Wollnik
Logarithmic scale splines for smooth extraction of a native peak shape, and uncertainty estimation using direct trials.
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Paper-based platforms with coulometric readout for ascorbic acid determination in fruit juices

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Analyst, 2020, 145,3431-3439
DOI: 10.1039/D0AN00477D, Paper
Estefanía Nunez-Bajo, M. Teresa Fernández-Abedul
Paper-based electrochemical platforms with coulometric readout are employed for fast and low cost determination of ascorbic acid in commercial juice samples.
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Recent developments of nanoenzyme-based colorimetric sensors for heavy metal detection and the interaction mechanism

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Analyst, 2020, 145,3173-3187
DOI: 10.1039/D0AN00339E, Critical Review
Zhengquan Yan, Hua Yuan, Qi Zhao, Lin Xing, Xiaoyu Zheng, Weiguo Wang, Yulei Zhao, Yang Yu, Lei Hu, Wenli Yao
This work highlights the application and interaction mechanism of metal nanoparticles, metal oxides, metal sulfides, graphene-based nanomaterials and G-quadruplex, etc. in nanoenzyme-based colorimetric sensors.
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In situ multiplex detection of serum exosomal microRNAs using an all-in-one biosensor for breast cancer diagnosis

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Analyst, 2020, 145,3289-3296
DOI: 10.1039/D0AN00393J, Paper
Huizhen Wang, Dinggeng He, Kejing Wan, Xiaowu Sheng, Hong Cheng, Jin Huang, Xiao Zhou, Xiaoxiao He, Kemin Wang
Herein, a simple all-in-one biosensor based on a DNA three-way junction has been constructed for in situ simultaneous detection of multiple miRNAs by competitive strand displacement.
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Novel ratiometric electrochemical sensor for no-wash detection of fluorene-9-bisphenol based on combining CoN nanoarrays with molecularly imprinted polymers

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Analyst, 2020, 145,3320-3328
DOI: 10.1039/D0AN00345J, Paper
Zhaoyi Liu, Yong Zhang, Bing Li, Xiang Ren, Hongmin Ma, Qin Wei
A ratiometric molecularly imprinted polymers electrochemical sensor was fabricated based on the direct electrochemical oxidation of BHPF on CoN nanoarray electrode.
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Using the interfacial barrier effects of p–n junction on electrochemistry for detection of phosphate

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Analyst, 2020, 145,3217-3221
DOI: 10.1039/C9AN02579K, Communication
Yu Ding, Minggang Zhao, Jiatuo Yu, Xiaomin Zhang, Zhengming Li, Hui Li
The electrochemical response to phosphate was produced by the induced change of the interfacial barrier of the NiO/ZnO p–n junction foam.
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Rapid detection of 21 β-lactams using an immunochromatographic assay based on the mutant BlaR-CTD protein from Bacillus Licheniformis

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Analyst, 2020, 145,3257-3265
DOI: 10.1039/D0AN00421A, Paper
Yue Li, Xinxin Xu, Liqiang Liu, Hua Kuang, Liguang Xu, Chuanlai Xu
In this study, a gold immunochromatographic assay (GICA) based on a penicillin receptor protein (PBP) is proposed to simultaneously detect penicillin, cephalosporin, and carbapenem antibiotics in milk and chicken.
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Colorimetric identification of lanthanide ions based on two carboxylic acids as an artificial tongue

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Analyst, 2020, 145,3359-3363
DOI: 10.1039/D0AN00357C, Paper
Chi Zhang, Juan Huang, Wei Wei, Zhengbo Chen
We report a colorimetric array, which consists of two carboxylic acids (quinolinic acid (QA), tannic acid (TCA)) as the sensor element and Eriochrome Black T (EBT) as the colorimetric signal readout.
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Synthesis of a manganese dioxide nanorod-anchored graphene oxide composite for highly sensitive electrochemical sensing of dopamine

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Analyst, 2020, 145,3283-3288
DOI: 10.1039/D0AN00348D, Paper
Juan Li, Huifang Shen, Suhua Yu, Geshan Zhang, Chuanli Ren, Xiaoya Hu, Zhanjun Yang
A novel manganese dioxide nanorod-anchored graphene oxide (MnO2 NRs/GO) composite was synthesized by a simple hydrothermal method for the development of a highly sensitive electrochemical sensor for dopamine.
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Nano-crystalline cellulose-coated magnetic nanoparticles for affinity adsorption of glycoproteins

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Analyst, 2020, 145,3407-3413
DOI: 10.1039/D0AN00442A, Paper
Jiaying Zhang, Xiangyu Feng, Jing Wang, Guozhen Fang, Jifeng Liu, Shuo Wang
A new core–shell structured nanomaterial based on Fe3O4 nanoparticles and 2,3-dialdehyde nanocrystalline cellulose (DAC) coatings and its high efficiency in the preconcentration of glycoproteins were described in this work.
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The fingerprint of essential bio-oils by Fourier transform ion cyclotron resonance mass spectrometry

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Analyst, 2020, 145,3414-3423
DOI: 10.1039/C9AN02492A, Paper
Claudia X. Ramírez, Diana Catalina Palacio Lozano, Hugh E. Jones, Rafael Cabanzo Hernández, Mark P. Barrow, Enrique Mejia-Ospino
Six essential oils were analyzed by Fourier transform ion cyclotron resonance mass spectrometry coupled to negative electrospray ionization (ESI(–)/FT-ICR MS).
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Development of a chromophore-solid phase peptide reaction assay (C-SPRA) for assessing skin sensitization in vitro

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Analyst, 2020, 145,3211-3216
DOI: 10.1039/C9AN02514F, Communication
Hiroshi Miyazaki, Yoshio Hamada, Hikaru Takaishi, Yuuki Minamino, Hidefumi Ikeda, Hideaki Mekata, Masayuki Takaishi, Kunihiko Yamashita, Kenji Usui
We developed an in vitro chromophore-solid phase peptide reaction assay (C-SPRA) using chromophores and immobilized peptides on microbeads. C-SPRA would enable accurate and high-throughput assessments of various chemicals.
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Detection and classification of fentanyl and its precursors by surface-enhanced Raman spectroscopy

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Analyst, 2020, 145,3440-3446
DOI: 10.1039/C9AN02568E, Paper
Rustin Mirsafavi, Martin Moskovits, Carl Meinhart
An analytical technique combining partial least squares-discriminant analysis, surface-enhanced Raman spectroscopy (SERS), and microfluidics for the detection and classification of fentanyl and its chemical precursors.
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Selective ratiometric red-emission detection of In3+ in aqueous solutions and in live cells using a fluorescent peptidyl probe and metal chelating agent

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00288G, Paper
Joohee Park, Hyeongseok Yu, See-Hyoung Park, Keun-Hyeung Lee
A ratiometric fluorescent detection method for In3+ in aqueous buffered solution, ground water, and live cells was developed.
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A highly efficient preconcentration route for rapid and sensitive detection of endotoxin based on an electrochemical biosensor

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00315H, Paper
Wenrui Ma, Lulu Liu, Yi Xu, Li Wang, Li Chen, Sheng Yan, Lingling Shui, Zhijun Wang, Shunbo Li
An impedimetric aptasensor for detection of endotoxin in a microfluidic chip was proposed, in which the Apt/AuNPs/SPCE sensing surface was fabricated in screen-printed electrode with good biological activity and stability....
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FRET based fluorescent ratiometric probes for rapid detection of endogenous hydrogen sulphide in living cells

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00531B, Paper
Yuming Zhang, Yuncong Chen, Bai Yang, Xueling Xue, Weijiang He, Zijian Guo
Real time monitor of hydrogen sulphide (H2S) level change is of crucial importance for the study of its complicated roles in physiology. Herein, we developed a FRET strategy for designing...
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Plasmonic Nanobiosensors for Detection of MicroRNA Cancer Biomarkers in Clinical Samples

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00193G, Paper
Bridget M Crawford, Hsin-Neng Wang, Christina Stolarchuk, Richard Von Furstenberg, Pietro Strobbia, dadong zhang, xiaodi qin, kouros owzar, katherine garman, Vo-Dinh Tuan
MicroRNA (miRNA) play an important role in the regulation of biological processes and have demonstrated great promise as biomarkers for the early detection of various diseases, including esophageal adenocarcinoma (EAC)...
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Laser-induced graphene hybrid photoelectrode for enhanced photoelectrochemical detection of glucose

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00252F, Paper
Hui Li, Chengxiang Guo, Changchun Liu, Lei Ge, Feng Li
The in situ and synchronous fabrication of Ni0/NiO–CdS–graphene hybrid photoelectrodes is developed using a facile and scalable direct-laser-writing method for photoelectrochemical detection of glucose.
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An electrochemical biosensor based on methylene blue-loaded nanocomposites as signal-amplifying tags to detect pathogenic bacteria

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00470G, Paper
Shengjun Bu, Kuiyu Wang, Zhongyi Li, Chengyu Wang, Zhuo Hao, Wensen Liu, Jiayu Wan
Synthesis of new methylene blue–magainin I organic–inorganic nanocomposites as electrochemical signal labels for the detection of bacteria.
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Liquid-crystal-based immunosensor for detection of cardiac troponin I

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00425A, Paper
Chunli Xia, dong Zhou, yueming Su, guangkai Zhou, Lishuang Yao, Weimin sun, yongjun Liu
Cardiac troponin I (cTnI) is one of the most sensitive and specific markers of myocardial cell injury, which can detect even minor myocardia damage. It is recognized as the main...
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Driving Force to Detect Alzheimer's Disease Biomarkers: The Application Of A Thioflavine T@Er-MOF Ratiometric Fluorescent Sensor for Smart Detection of Presenilin 1, amyloid β-protein and Acetyl Choline

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00440E, Paper
Xing Ze Wang, jing du, Nannan Xiao, Yan Zhang, Ling Fei, Jed D. LaCoste, Zhuo Huang, Qian wang, Xin Rui Wang, Bin Ding
Currently, the highly sensitive detection of Alzheimer's Disease (AD) biomarkers, namely presenilin 1, amyloid β-protein (Aβ), and acetylcholine (ACh), are vital to helping us prevent and diagnose AD. In this...
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A novel turn-on fluorescent sensor for sensitive detection of glutathione via gold nanoclusters preparation based on controllable ligand-induced etching

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00807A, Paper
Yun Chen, Xiawei Dong, Youkun Zheng, Yi-Han Wang, Zengchao Guo, Hui Jiang, Xuemei Wang
In this study, we report a facile one-pot chemical etching approach to simply and rapidly prepare gold nanoclusters capped with luminol (Lum-AuNCs) in alkaline aqueous solution at room temperature. A...
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Biocompatible Alkyne arms containing Schiff base Fluorescence Indicator for Duel detection of CdII and PbII at Physiological pH and its Application to Live Cell Imaging

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Published On ::

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00862A, Paper
Jebastin Andrews S.G, Benita Jeba Silviya S, Jeyanthi Dharmaraj, Winfred Jebaraj J, Sathya Devi E, C. Balakrishnan
An alkyne arms containing salen-type Schiff base ligand, 6,6'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(3-(prop-2-yn-1-yloxy)phenol) (H2L), is reported here as a dual chemosensor for CdII and PbII ions. The ligand, H2L was characterized by various spectral...
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Magnetic molecularly imprinted conducting polymer for determination of praziquantel enantiomers in milk

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00703J, Paper
Tienne Nascimento, Camilla Fonseca Silva, Hanna L Oliveira, Ricky Cássio Santos da Silva, Clébio Soares Nascimento, Keyller Bastos Borges
A new selective adsorbent based on magnetic molecularly imprinted conducting polymer was firstly synthetized and applied to the magnetic solid phase extraction (MSPE) for the determination of PZQ enantiomers in...
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A paper-supported sandwich immunosensor based on upconversion luminescence resonance energy transfer for the visual and quantitative determination of a cancer biomarker in human serum

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Published On ::

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/C9AN02307K, Paper
Mengyuan He, Ning Shang, Lin Shen, Zhi-hong Liu
In this paper, a paper-supported analytical device based on a sandwich immunoreaction and luminescence resonance energy transfer (LRET) was reported for the visual and quantitative determination of a cancer biomarker,...
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An Integrated Microfluidic Platform for Selective and Real-Time Detection of Thrombin Biomarkers using a Graphene FET

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00251H, Paper
Niazul Islam Khan, Mohammad Mousazadehkasin, Sujoy Ghosh, John G. Tsavalas, Edward Song
Lab-on-a-chip technology offers an ideal platform for low-cost, reliable, and easy-to-use diagnostics of key biomarkers needed for early screening of diseases and other health concerns. In this work, a graphene...
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Rapid on-site and naked-eye detection of common nitro pesticides with ionic liquids

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00452A, Paper
Kovida, Vikas Sharma, Apurba Lal Koner
Rapid ‘in-field’ detection of environmentally hazardous organophosphorus and nitro-containing pesticides is highly essential due to the lethal effects caused by the inhibition of the activity of acetylcholinesterase (AChE).
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Core–shell magnetic microporous covalent organic framework with functionalized Ti(IV) for selective enrichment of phosphopeptides

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00038H, Paper
Fengjuan Ding, Yameng Zhao, Haiyan Liu, Weibing Zhang
We fabricated a core-shell magnetic Ti4+-functionalized covalent organic framework composite to selectively capture phosphopeptides in biosamples. This method is applicable to achieve rapid, selective and efficient phosphopeptide analysis.
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Acid–base titration using a microfluidic thread-based analytical device (μTAD)

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00522C, Paper
Purim Jarujamrus, Akarapong Prakobkij, Sodsai Puchum, Sawida Chaisamdaeng, Rattapol Meelapsom, Wipark Anutrasakda, Maliwan Amatatongchai, Sanoe Chairam, Daniel Citterio
This work presents a novel analytical approach for precise and quick (within 2 minutes) determination of acid and base concentrations (of very small amount) by titration using a microfluidic thread-based analytical device (μTAD).
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A Simple and Ubiquitous Device for Picric Acid Detection in Latent Fingerprints using Carbon Dots

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00750A, Paper
Arunkumar Kathiravan, Annasamy Gowri, Srinivasan Venkatesan, Trevor Smith, Muthpandian Ashokkumar, Asha Jhonsi Mariadoss
This work addresses the synthetic optimization of carbon dots (CDs) and their application in sensing picric acid from latent fingerprint by exploiting a smartphone-based RGB tool. The optimization in the...
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Surface Polymer Imprinted Optical Fibre Sensor for Dose Detection of Dabrafenib

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00434K, Paper
Chenyang He , Ulises Hernandez Ledezma , Pratik Gurnani, Thais Fedatto Abelha, Kristofer James Thurecht, Ricardo Goncalves Correia , Steve Morgan, Poulam Patel, Cameron Alexander, Sergiy Korposh
Dabrafenib is one of the most widely used of the new generation of targeted anti-cancer drugs. However, its therapeutic window varies for different patients and so there is an unmet...
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An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00721H, Paper
Open Access
Xiaoxiao Guo, Jodie R Malcolm, Marrwa M Ali, Goreti Ribeiro Morais, Steve Shnyder, Paul Loadman, L H Patterson, Robert Andrew Falconer
The polysialyltransferases (polySTs) catalyse the polymerisation of polysialic acid, which plays an important role in tumour metastasis. While assays are available to assess polyST enzyme activity, there is no methodology...
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Phenyl doped graphitic carbon nitride nanosheets for sensing of copper ions in living cells

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00795A, Paper
Zhiping Song, Yuanteng Xu, Liangqia Guo
Copper (Cu) is a vital mental element for human and animals. Monitoring and evaluating the concentration level of Cu2+ in biological body is an effective way to prevent a variety...
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Influence of Hair Treatments on Detection of Antiretrovirals by Mass Spectrometry Imaging

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Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00478B, Paper
Mac Gilliland, Nicole R White, Bryan Yam, Joseph N Mwangi, Heather MA Prince, Ann Marie K Weideman, Angela DM Kashuba, Elias Rosen
Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair...
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[ASAP] Nucleic Acid Detection Using CRISPR/Cas Biosensing Technologies

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Published On :: Tue, 17 Mar 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00507


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[ASAP] A Coculture Based Tyrosine-Tyrosinase Electrochemical Gene Circuit for Connecting Cellular Communication with Electronic Networks

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00469


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[ASAP] <italic toggle="yes">In Vivo</italic> Production of Five Crocins in the Engineered <italic toggle="yes">Escherichia coli</italic>

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Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00039


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[ASAP] Efficient and Reproducible Multigene Expression after Single-Step Transfection Using Improved BAC Transgenesis and Engineering Toolkit

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00457


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[ASAP] Blue-Light-Switchable Bacterial Cell–Cell Adhesions Enable the Control of Multicellular Bacterial Communities

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00054


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[ASAP] A Novel Biosynthetic Pathway for the Production of Acrylic Acid through ß-Alanine Route in <italic toggle="yes">Escherichia coli</italic>

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00019


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[ASAP] Correction to EcoFlex: A Multifunctional MoClo Kit for <italic toggle="yes">E. coli</italic> Synthetic Biology

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Published On :: Fri, 17 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00177


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[ASAP] SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions

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Published On :: Fri, 17 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00059


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[ASAP] Engineering Prokaryotic Transcriptional Activator XylR as a Xylose-Inducible Biosensor for Transcription Activation in Yeast

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Published On :: Fri, 17 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00122


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[ASAP] Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production

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Published On :: Tue, 21 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00143


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