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DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00383G, Paper
Debasish Bera, Rajib Sarkar, Tiyasa Dhar, Pinaki Saha, Prasanta Ghosh, Chhanda Mukhopadhyay
Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O coupling under oxidant-free conditions are outlined.
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Synthesis of alkenylphosphine oxides via Tf2O promoted addition–elimination of ketones and secondary phosphine oxides

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00318G, Communication
Jiangkai Ma, Lianjie Wang, Anjiang Qiao, Zhongxian Li, Fengqian Zhao, Junliang Wu
An efficient method for the synthesis of alkenylphosphine oxides via the addition-elimination of SPOs to ketones has been developed. The reaction exhibits good yields and compatibility. Several conversions have also proven the value of this method.
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Synthesis of alkynyl sulfides via base-promoted nucleophilic ring-opening of α-bromostyrene sulfonium salt

Org. Biomol. Chem., 2024, 22,2953-2957
DOI: 10.1039/D4OB00203B, Communication
Junqi Zhou, Ziyu Wang, Hanmiao Xu, Mengke Su, Jian Wen
An effective method for synthesizing various alkynyl sulfides has been developed using tetramethylene sulfoxide as a sulfur source through base-promoted nucleophilic ring-opening reactions.
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Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering

Org. Biomol. Chem., 2024, 22,3025-3034
DOI: 10.1039/D4OB00279B, Paper
Jouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
Evidence is presented that (6–4) photoproduct formation between two thymine residues in dinucleotide analogues is significantly and specifically enhanced when the 5''- and 3''-end sugar puckering are mainly north and south, respectively.
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Photochromism of phenazine-2,3-diol derivatives through excited state intermolecular proton transfer based on keto–enol tautomerization

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kazuki Ohira, Kumpei Kozuka, Naoki Kaneda, Masahiro Yamamoto, Keiichi Imato, Yousuke Ooyama
It was found that phenazine-2,3-diol derivatives exhibit photochromism through excited state intermolecular proton transfer (ESInterPT) processes based on keto–enol tautomerization.
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Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00380B, Communication
Shigeru Arai, Koichi Nakazawa, Xiao-Fei Yang, Masaya Nakajima, Shinji Harada, Atsushi Nishida
This work discloses the origin of regio- and stereoselectivity of hydrocyanation of alkynoates.
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Exploring the mechanism of the reductive amination of acetophenones via Borch approach: the role of the acid catalyst

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00160E, Paper
João Pedro Albuquerque Souza, Amanda Krauskopf Jacobs, Leandro Piovan, Renan Borsoi Campos
The energetic viability of several mechanistic variations of the reductive amination of acetophenones via the Borch approach was reexamined through density functional theory calculations. The crucial involvement of the acid...
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Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00397G, Paper
Angel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. Möller
Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...
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Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00236A, Review Article
Goverdhan Mehta, Saumitra Sengupta, Srihari Pabbaraja
Often referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...
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TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
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Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00167B, Paper
Open Access
Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. Smirnova
EPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.
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Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00479E, Communication
Cao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen
A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.
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2022 holds promise for the airline sector

Omicron might dent growth, but the long-term outlook seems promising




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As India builds its newest airports, it needs robust, fail-proof SOPs

A near air mishap on Bengaluru skies that put the lives of 430 people in danger shows safety risk norms require constant refresh




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Profits offer hope of soft landing to Spicejet

Apart from swift settlement with former owners, the airline urgently needs an immediate infusion of cash




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Air infrastructure plans should be future-proof

India’s aviation story is full of delayed, untapped and under-utilised potential




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Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




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Apple AirPods Pro’s new hearing aid feature could help people face a problem they’d rather ignore

Millions who could benefit from hearing aids have never tried them, but the Apple AirPods could change this




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Google’s moneymaking machine still pumping out massive profits despite multiple threats

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire




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Amazon's improving retail sales boost third-quarter profit, revenue beats estimates

Like its tech peers, Amazon said it expected higher capital expenditures for the foreseeable future to help develop artificial intelligence software




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Trachoma eliminated as a public health problem in India; what next?

The achievement marks a significant public health victory and has profound economic implications. Trachoma’s impact, through blindness and visual impairment, results in an estimated economic loss of $2.9 to 5.3 billion annually due to reduced productivity




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Drugs regulator finds 49 samples not of standard quality, manufacturers asked to withdraw their products

Four spurious drugs were also found and action has been initiated against the makers, the DCGI said




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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




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Roll back approval to import used medical devices, med-tech industry urges PM

The group said the move puts at risk patient safety and undermines the domestic med-tech sector. It said that refurbished machines are not subject to stringent quality checks applicable to new devices.




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Doctors urge National Medical Commission to simplify centralised registration process

The register is a centralised repository that contains the name, address, and qualifications of licensed medical practitioners; however the registration process is complex and cumbersome, say doctors




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Can mid-level healthcare providers compensate for physician shortages in rural India?

To make up for doctor shortages, several countries around the world have introduced a cadre of MLHPs into their health systems; however, in India, mainstreaming of MLHPs has time and again been met with resistance from organised medicine 




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'Can't Say Bigg Boss Promoting Polygamy'

'Ranvir will run out of steam pretty soon.''The way he is reacting or rather, overreacting to things, I am sure he will be exhausted soon.''You need to chill at times to play a game like Bigg Boss.'




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Meet Prashanth Rajendran: The product leader who's making big data safer for millions

Prashanth's inspiring journey began in Chennai, India, where he nurtured a passion for technology. He pursued his undergraduate degree in Electrical Engineering at NIT Trichy, before earning his master's degree from Duke University's esteemed Fuqua School of Business and Pratt School of Engineering.




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Flipkart Big Diwali Sale 2024: Best deals on iPhone 16 Pro Max, others; buy Apple iPad 9th Gen for just Rs...

The iPhone 16 series made its debut in India in September, with the flagship iPhone 16 Pro Max starting at Rs. 1,44,900 for the 256GB variant.




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How can AI, ML skills help sharpen problem-solving abilities in children?

As the world is rapidly moving towards the evolving digital space, skills like problem-solving have become more important than ever. The entire market size of AI is projected to grow from USD 214.6 billion in 2024 to 1,339.1 billion in 2030 with a CAGR of 35.7%. In Today's scenario, skills like problem-solving are not just limited to professionals, it becomes crucial to teach kids how to think critically and creatively to steer through the complexities of modern life. This not only sharpens their abilities but also boosts innovation and helps develop young minds to use tools needed to solve real-world problems.




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Role of soft skills in industrial and product design career success: Preparing next generation of designers

Kushal Karwa, a thought leader in design education, emphasizes the need for integrating soft skills training into career preparation programs to help young designers thrive in real-world environments.




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Expert clinic director successfully implements half-hour scheduling system, boosting therapist productivity

As word spread about the success of the half-hour schedule, some early adopters became curious after the clinic director and the team showcased the benefits.




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How entrepreneurial innovation is helping HR solve complex problems

Players like Mynoticeperiod, Hackerearth, e-poise and Merajob are expected to play a role in changing the HR start-up ecosystem




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Counselling: Overcoming the defences of your mind for peace, productivity

Learning to recognise the impact past experiences have on present behaviour can unlock your true potential




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Give employees appropriate strokes




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'Withholding' a problem in relationship building




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Leadership approach, a paradigm shift




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A new approach to visioning




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House panel tells government to ensure fertilizer availability, increase local production

Standing Committee also questions the high GST rate on components of fertilizers




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Onion auction to remain closed indefinitely in Nashik wholesale markets to protest 40% duty on export: Traders

Traders claimed the central government's decision to impose 40% duty on the export of onions till December 31, 2023 will adversely affect the onion growers and its export




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Farmers to approach Supreme Court against India-U.S. deal on poultry

Reduced import duty on produce and relaxed norms will affect farmers and traders here, they say




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Restore incentive for cashew exports: Tamil Nadu Cashew Processors and Exporters Association

The association also urged APEDA to exempt imported raw cashew nuts from Food Safety and Standards Authority of India (FSSAI) clearance in customs.




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Cabinet approves ₹22,303 cr subsidy on P&K fertilisers for Rabi crop season

The decision was informed by Information and Broadcasting Minister Anurag Thakur after the Cabinet meeting




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India’s smaller rice crop paves way for prolonged export curbs

Production in India, the world’s largest rice exporter, is under unusually intense focus after New Delhi banned exports of non-basmati white rice in July, sending global prices surging




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Centre bans onion export till March; Nashik farmers protest

On August 19, the Union government imposed a 40% duty on the export of onions until December 31,




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Amit Shah launches portal for procurement of pulses 

The Cooperation Minister said that before the sowing operation, tur farmers can register on the portal to sell their produce to NAFED and NCCF




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Centre estimates dip in onion, potato production this year

Agriculture Ministry releases advance production estimates for 2023-24 and final estimates for the year 2022-23




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Govt. should announce legally backed minimum procurement price for food crops, says Prakash Kammaradi

Karnataka Agriculture Price Commission headed by Prakash Kammaradi submitted a report on the legally backed MSP to the government in 2018




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RBI annual report 2023-2024: MSPs for kharif and rabi crops ensured minimum return of 50% over cost of production

Reserve Bank of India’s annual report highlights MSPs, foodgrain stocks, and challenges faced by agriculture in 2023-24




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India’s rising water stress can dent its sovereign credit profile: Moody’s Ratings

The country is among those most vulnerable to water management risks, and has the poorest access to basic services, including water, among G-20 economies, the rating major flagged