li

[ASAP] Naphthacemycins from a <italic toggle="yes">Streptomyces</italic> sp. as Protein-Tyrosine Phosphatase Inhibitors

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00417




li

[ASAP] Bioactive <italic toggle="yes">seco</italic>-Sativene Sesquiterpenoids from an <italic toggle="yes">Artemisia desertorum</italic> Endophytic Fungus, <italic toggle="yes">Cochliobolus sativ

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01148




li

[ASAP] Irpexine, an Isoindolinone Alkaloid Produced by Coculture of Endophytic Fungi, <italic toggle="yes">Irpex lacteus</italic> and <italic toggle="yes">Phaeosphaeria oryzae</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00047




li

[ASAP] Kalparinol, a Salvialane (Isodaucane) Sesquiterpenoid Derived from Native Australian <italic toggle="yes">Dysphania</italic> Species That Suggests a Putative Biogenetic Link to Zerumbone

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01039




li

[ASAP] Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00561




li

[ASAP] Unprecedented Quassinoids from <italic toggle="yes">Eurycoma longifolia</italic>: Biogenetic Evidence and Antifeedant Effects

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00244




li

[ASAP] Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus <italic toggle="yes">Talaromyces</italic> sp.

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00024




li

[ASAP] Phenylpropanoid-Conjugated Triterpenoids from the Leaves of <italic toggle="yes">Actinidia arguta</italic> and Their Inhibitory Activity on a-Glucosidase

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00643




li

[ASAP] Sesquiterpenoids from Cultures of the Basidiomycetes <italic toggle="yes">Irpex lacteus</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01177




li

[ASAP] Cyperane-Type and Related (Nor)Sesquiterpenoids from the Root Bark of <italic toggle="yes">Acanthopanax gracilistylus</italic> and Their Inhibitory Effects on Nitric Oxide Production

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00913




li

[ASAP] Antitubercular Ilamycins from Marine-Derived <italic toggle="yes">Streptomyces atratus</italic> SCSIO ZH16 ?<italic toggle="yes">ilaR</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00151




li

[ASAP] Spiroseoflosterol, a Rearranged Ergostane-Steroid from the Fruiting Bodies of <italic toggle="yes">Butyriboletus roseoflavus</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01282




li

[ASAP] Resorcylic Acid Lactones from an <italic toggle="yes">Ilyonectria</italic> sp.

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01167




li

[ASAP] Psathyrins: Antibacterial Diterpenoids from <italic toggle="yes">Psathyrella candolleana</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00269




li

[ASAP] Isolation of Taste-Active Triterpenoids from <italic toggle="yes">Quercus robur</italic>: Sensory Assessment and Identification in Wines and Spirit

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00106




li

[ASAP] Phaeosphaones: Tyrosinase Inhibitory Thiodiketopiperazines from an Endophytic <italic toggle="yes">Phaeosphaeria fuckelii</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00046




li

[ASAP] Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01022




li

[ASAP] Total Synthesis of Isohericenone J via a Stille Coupling Reaction

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01251




li

[ASAP] Review of Biology and Ecology of Pharmaceutical Marine Sponges<source>Biology and Ecology of Pharmaceutical Marine Sponges</source>. Edited by Ramasamy Santhanam, Santhanam Ramesh, and Anbu Jeba Sunilson. <publisher-name>CRC Press

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00352




li

[ASAP] Iheyamides A–C, Antitrypanosomal Linear Peptides Isolated from a Marine <italic toggle="yes">Dapis</italic> sp. Cyanobacterium

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00250




li

[ASAP] Cytotoxic Monoterpenoid Indole Alkaloids from <italic toggle="yes">Tabernaemontana corymbosa</italic> as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00856




li

[ASAP] Cucurbitane-Type Triterpenoids from the Vines of <italic toggle="yes">Momordica charantia</italic> and Their Anti-inflammatory Activities

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00592




li

[ASAP] Bromo-spiroisoxazoline Alkaloids, Including an Isoserine Peptide, from the Caribbean Marine Sponge <italic toggle="yes">Aplysina lacunosa</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01286




li

[ASAP] Bioactive Compounds from the Aerial Parts of <italic toggle="yes">Evolvulus linarioides</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01189




li

[ASAP] Constituents of Two <italic toggle="yes">Dioscorea</italic> Species That Potentiate Antibiotic Activity against MRSA

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01006




li

[ASAP] Effect of Temperature on <sup>1</sup>H NMR Spectra, Antitrypanosomal Activity, Conformational Analysis, and Molecular Docking of Curine Derivatives from <italic toggle="yes">Berberis brevissima</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00397




li

[ASAP] <italic toggle="yes">Streptomyces albogriseolus</italic> SY67903 Produces Eunicellin Diterpenoids Structurally Similar to Terpenes of the Gorgonian <italic toggle="yes">Muricella sibogae</italic>, the Bac

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00147




li

[ASAP] A Grand Challenge. 3. Unbiased Phenotypic Function of Metabolites from Australia Plants <italic toggle="yes">Gloriosa superba</italic> and <italic toggle="yes">Alangium villosum</italic> against Parkinson

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00880




li

[ASAP] Advances in the Biosynthesis of Pyranocoumarins: Isolation and <sup>13</sup>C-Incorporation Analysis by High-Performance Liquid Chromatography–Ultraviolet–Solid-Phase Extraction–Nuclear Magnetic Resonance Data

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00607




li

[ASAP] Stoechanones A and B, Phytotoxic Copaane Sesquiterpenoids Isolated from <italic toggle="yes">Lavandula stoechas</italic> with Potential Herbicidal Activity against <italic toggle="yes">Amaranthus retroflexus<

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00182




li

Highlight.js 10, Node 14, and modern React in 20 minutes

#485 — April 24, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

Introducing Crank.js: A New JSX-Driven Framework — A new framework for creating JSX-driven components with functions, promises and generators. If you haven’t got time to read the creator’s lengthy (but well worth reading!) rationale for creating another framework, check out the GitHub repo or jump straight into a CodeSandbox example. I hope to see a lot more about this in the near future.

Brian Kim

The Cost of JavaScript Frameworks — Using data from the HTTP Archive, Tim explores the performance cost of using various popular frameworks as a starting point. Some good analysis here.

Tim Kadlec

You Hacked the Gibson? Yeah, They Built Their Own Login — Don't let Crash Override pwn your app. FusionAuth adds secure login, registration and user management to your app in minutes not months. Download our community edition for free.

FusionAuth sponsor

Node.js 14 Released — v14 now becomes the current ‘release’ line with it becoming a LTS (Long Term Support) release in October. Diagnostic reports are now a stable feature, it now uses V8 8.1, there's an experimental Async Local Storage API, and more.

Michael Dawson and Bethany Griggs

Vidact: A Compiler to Convert React-like Apps to Vanilla JS — Compiles pure React-compatible JavaScript (JSX) to vanilla JavaScript with no virtual DOM.. think similar to Svelte, but without introducing a new syntax. A curious idea.

Mohamad Mohebifar

Highlight.js 10.0: The Web Syntax Highlighter Library — I always laugh when I see a big release of a popular library and saw we last linked it 5 years ago ???? Nonetheless, this is a big release and Highlight.js continues to be a fantastic library for syntax highlighting code.

highlight.js

???? Jobs

Senior Full-stack Developer (Malmö/Sweden) — Every day is different from the next. Join our upbeat Team and work on exciting, major projects using a modern JavaScript stack.

Ortelius AB

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

▶  React: The Basics in 20 Minutes — A well presented, up to date (yep, it covers hooks) tutorial that doesn’t hang around, whether you’re new to React or just want a refresher.

Devistry

Creating Web Apps via TypeScript and webpack — The example app doesn’t use any front-end framework, just vanilla DOM APIs. Some knowledge of TypeScript, webpack, and npm are required, but this is a neat way to bring together a bunch of tools.

Axel Rauschmayer

What Is The toJSON() Function? — If an object has a toJSON function, JSON.stringify() calls toJSON() and serializes the return value from toJSON() instead.

Valeri Karpov

A Much Faster Way to Debug Code Than with Breakpoints or console.log — Move forward and backwards through your code to understand what led to a specific bug, view runtime values, edit-and-continue, and more.

Wallaby.js sponsor

How Does TypeScript Work? A Bird’s Eye View — Dr. Axel goes into depth on the structure of a typical TypeScript project, what gets compiled, and how can an IDE be used to write TypeScript. Aimed at people who haven’t yet picked TypeScript up.

Axel Rauschmayer

10 Lesser Known Angular Features You've Probably Never Used

W3Radar

You Might Not Need switch — Using an object of outcomes instead of switch suits many use cases, though take care over readability.

Valentino Gagliardi

???? Upcoming Online Events

  • Pick JS (May 8) — Aimed at intermediate to expert JS developers rather than beginners.
  • JavaScript Remote Conf 2020 (May 14-15) — Speakers lined up already include Douglas Crockford, Aimee Knight and Christian Heilmann.
  • ESNEXT CONF 2020 (May 18-22) — From the Pika folks (of Snowpack fame). 12 speakers over 5 days so it's a gradual pace.
  • ForwardJS (May 26-29) — A real world event (ForwardJS Ottawa) that has now become a virtual event.
  • CascadiaJS 2020 (September 1-2) — This upcoming online conference is set to take place in September, and the CFP is open now through May 15.

???? Code & Tools

Phelia: A Reactive Slack Application Framework — If you think Slack apps were all about text bots, think again.. you can now create apps complete with in-app UIs. Phelia brings the React approach to the task.

Max Chehab

Marked.js 1.0: A Fast Markdown Parser and Compiler — Got Markdown to render? Marked.js to the rescue. While the project is years old, 1.0 has dropped just this week. Here’s a live demo.

Christopher Jeffrey

Stream Chat API & JavaScript SDK for Custom Chat Apps — Build real-time chat in less time. Rapidly ship in-app messaging with our highly reliable chat infrastructure.

Stream sponsor

Alpine.js: A Minimal Framework for Composing JS Behavior in Your Markup — We only gave Alpine a brief link when it first dropped but with new versions coming out thick and fast, we think it’s well worth a look. Billed as “like Tailwind for JavaScript”, Alpine lets you keep the HTML you know and love and just pepper it with JavaScript as and where appropriate.

Alpine.js

enroute: A React Router with a Small Footprint for Modern Browsers

TJ Holowaychuk

Rosetta: A General Purpose Internationalization Library in 292 Bytes — Less than 300 bytes, but does have a few dependencies. Aims to be very simple and is targeted at basic string use cases.

Luke Edwards

NAB 2020 May Be Canceled, But The Full Bitmovin Experience Is Not

Bitmovin Inc. sponsor

Hotkey 1.4: Trigger an Action on an Element When a 'Hotkey' is Pressed — Use Hotkey, set the data-hotkey attribute on your elements, and you get keyboard shortcuts. GitHub built and uses it (look for the data-hotkey attributes on their pages).

GitHub

web-worker: Consistent Web Workers for the Browser and Node — In Node it works as a web-compatible Worker implementation atop worker_threads. In the browser it’s an alias for Worker.

Jason Miller




li

Jest 26, JS one liners, and comparing Ember to React

#487 — May 8, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

Jest 26 Released: The Popular Testing Framework — Jest is a popular testing framework that works with pretty much everything. This release focuses on getting the dependency count and install size down (this causes some breaking changes, unsurprisingly), adds a new fake timer implementation, drops Node 8 support, and initial, experimental ESM support to play with.

Christoph Nakazawa

1LOC: A Collection of One-Line JS Snippets — A neat little collection of vanilla JavaScript one-liners divided into various categories (arrays, date/time, checking objects, DOM work, etc.) You can submit your own for inclusion too.

Nguyen Huu Phuoc

Hardcore Functional Programming in JavaScript — Brian Lonsdorf teaches you functional programming concepts in JavaScript such as pure functions, currying, composition, functors, monads and more.

Frontend Masters sponsor

Debug Anything: The Basics — A six part series (all ready to read now) on debugging your JavaScript and TypeScript code with the debugger built into Visual Studio Code.

Charles Szilagyi

Comparing Ember Octane and React — This is about as detailed a comparison as you could hope for and a demonstration of just how much Ember contributes to the JavaScript ecosystem. Octane really kicks things up a notch for Ember, too.

Chris Garrett

Deno 1.0 is Due Next Week: Here's What You Need to Know — In 2018 Node's creator Ryan Dahl told us 10 Things I Regret About Node.js and revealed a prototype of Deno, a new V8-based runtime, and here's what you need to know about it. Short of time? This two-minute video sums up the biggest wins quickly.

David Else

Our newest newsletter..

Carrying on from the Deno item above, yes, we've started Deno Weekly, a new newsletter dedicated to the newest runtime in the JavaScript/TypeScript world. Issue 2 goes out just after 1.0 is released next week.

Even if you don't stick with Deno long term, feel free to subscribe then unsubscribe at any time — we won't take offence ????

Subscribe to Deno Weekly here or enjoy issue 1 here.

???? Jobs

JavaScript Developer at X-Team (Remote) — Join X-Team and work on projects for companies like Riot Games, FOX, Coinbase, and more. Work from anywhere.

X-Team

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

How To Build a Vue Survey App Using Firebase — A step-by-step guide to building a functional survey app using Vue.js and Firebase for both authentication and as a database.

David Atanda

A Brief Look at ES2020's Promise.any — When you need to know when at least 1 promise got resolved among an iterable of Promise objects, Promise.any() is the solution.

Marios Fakiolas

ES2020: Everything You Need to Know — An ES2020 roundup!

Martin McKeaveney

Building a Crossword Puzzle Generator — As a NY Times crossword addict, I love a good crossword, but if you’d rather figure out how to make your computer solve them, be my guest ???? This post guides you on how to approach the problem.

Mitchum

Git Best Practices for SOC 2 Compliance Quick Wins — Get quick wins for your SOC 2 compliance audit, and raise developer productivity at the same time.

Datree.io sponsor

Getting Started with Sapper and SvelteSapper is a Svelte-powered framework.

Chris Boakes

A ES2015+ Cheatsheet — A one-page guide to ES2015+ features based around brief example snippets.

Devhints.io

How to Fix ESLint Errors Upon Save in VS Code — A quick-fire tip.

David Walsh

How to Build a Blog with Next 9.3, Netlify, and Markdown — Learn how to build a Next.js-powered Markdown blog and deploy it to the Netlify platform.

Cassidy Williams

A Canvas Engine Comparison: PixiJS vs Two.js vs Paper.js — A benchmark of three popular 2D rendering engines/drawing APIs. Note: This will tax your system.

SlayLines

???? BTW, if you like videos, we need to shout out Florin Pop's YouTube channel as he's just passed 20k subscribers by posting neat JavaScript videos and live streams nearly every day for the past six months! ???? Lots of great stuff on there for JavaScript developers of all skill levels.

???? Code & Tools

Selecto.js: Make Elements Selectable Within an Area — Let’s say you have a number of elements that represent choices, data, whatever, and you want users to be able to select a subset of them by clicking/pointing and dragging. That’s what this does. Live examples here.

Daybrush (Younkue Choi)

Visual Studio Code April 2020 Released — Probably the most widely used editor in the JavaScript space now and April brings some neat new features like being able to work on GitHub issues within the editor.

Microsoft

Stream Chat API & JavaScript SDK for Custom Chat Apps — Build real-time chat in less time. Rapidly ship in-app messaging with our highly reliable chat infrastructure.

Stream sponsor

Majestic 1.7: A Zero Config GUI for Jest — A tool to help make your JavaScript testing life a little easier. Run npx majestic in the folder of any project that uses Jest to give it a quick try.

Raathi Kugarajan

Pico: Take Browser Screenshots Client-Side with JavaScript — Different from capturing a webpage using Puppeteer or a similar tool in that the screenshot taking happens entirely client side.

Gripeless

React Flow: A Library for Rendering Interactive Graphs — If you have a need to lay out graphs in a visual way and be able to smoothly pan and zoom around such graphs, this is an interesting new library. Live demo here.

Moritz Klack

MongoDB Is Easy. Now Make It Powerful. Free Download for 30 Days.

Studio 3T sponsor

NeutralinoJS: Build Cross-Platform Apps Using JS, HTML and CSS — Sounds just like Electron, right? Not quite. NeutralinoJS use less memory and are smaller as they don’t ship a full browser inside. 1.4.0 just dropped.

Neutralinojs

Slugify 1.0: Simply Turns Strings into URL/Filename-Friendly 'Slugs' — e.g. ‘I ♥ Dogs’ becomes ‘i-love-dogs’

Sindre Sorhus

RxJS Primitives: A Set of Libraries That Provide Operators for RxJS

Tane Piper

⚡️ Quick releases:




li

LIC listing may take about a year, says Finance Secretary Rajiv Kumar

Kumar said the idea behind the listing of LIC was to "bring in more transparency and allow the company to share gains with its stakeholders"




li

Budget 2020: Selling pressure on stock market may continue, say experts

On Saturday, the benchmark indices closed near their day's lows, indicating further selling pressure on the following trading day




li

Budget stimulus unlikely to revive India's growth from slowdown: Experts

Economists and industry leaders said the budget proposals would provide some support to growth over the longer term but were insufficient to give it an immediate boost




li

Budget: No tax relief for home buyers stuck in stalled projects, says FPCE

Real estate developers' apex bodies CREDAI and Naredco have also expressed disappointment over the Budget as their demand of one-time restructuring of builders' loan was not met




li

LIC disinvestment: 100,000 employees stage walk-out across country

There are 13 unions in LIC, and employees and officers affiliated to 11 unions were on protest




li

No timeline to remove income tax exemptions, says Nirmala Sitharaman

"We have not made up our minds as yet (on the removal of all exemptions)... We are trying step by step, move forward and no particular timeline given," she said




li

Putting the Public Back in Public Reporting of Health Care Quality

Interview with Tara Lagu, MD, MPH, author of Putting the Public Back in Public Reporting of Health Care Quality




li

Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment

Interview with Nora D. Volkow, MD, author of Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment




li

Improving Postdischarge Outcomes in Patients Hospitalized for Acute Heart Failure Syndromes

Interview with Mihai Gheorghiade, MD, author of Improving Postdischarge Outcomes in Patients Hospitalized for Acute Heart Failure Syndromes




li

Application of Electronic Health Records to the Joint Commission's 2011 National Patient Safety Goals

Interview with Ryan Radecki, MD, author of Application of Electronic Health Records to the Joint Commission's 2011 National Patient Safety Goals




li

Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage

Interview with J. Michael McWilliams, MD, Phd, author of Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage




li

Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service-Related PTSD

Interview with John H. Krystal, MD, author of Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service-Related PTSD




li

Effect of a Dietary Portfolio of Cholesterol-Lowering Foods Given at 2 Levels of Intensity of Dietary Advice on Serum Lipids in Hyperlipidemia: A Randomized Controlled Trial

Interview with David J. A. Jenkins, MD, author of Effect of a Dietary Portfolio of Cholesterol-Lowering Foods Given at 2 Levels of Intensity of Dietary Advice on Serum Lipids in Hyperlipidemia: A Randomized Controlled Trial




li

Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents

Interview with Colin P. West, MD, PhD, author of Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents




li

Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students

Interview with Julie A. Freischlag, MD, author of Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students




li

Graduated Driver Licensing and Fatal Crashes Involving 16- to 19-Year-Old Drivers

Interview with Scott V. Masten, PhD, author of Graduated Driver Licensing and Fatal Crashes Involving 16- to 19-Year-Old Drivers




li

Regional Variation in the Association Between Advance Directives and End-of-Life Medicare Expenditures

Interview with Lauren Hersch Nicholas, PhD, MPP, author of Regional Variation in the Association Between Advance Directives and End-of-Life Medicare Expenditures




li

Use of Electron-Beam Sterilized Hemodialysis Membranes and Risk of Thrombocytopenia

Interview with Mercedeh Kiaii, MD, author of Use of Electron-Beam Sterilized Hemodialysis Membranes and Risk of Thrombocytopenia