Lab Chip, 2020, 20,1390-1397
DOI: 10.1039/D0LC00021C, Communication

Bo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi “Leo” Liu, Pei-Shan Chung, Harold G. Monbouquette, Pei-Yu Chiou, Nigel T. Maidment
PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.
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Lab Chip, 2020, 20,1461-1471
DOI: 10.1039/C9LC01097A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R. A. Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A. Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F. Tedde, Hans P. Kiener, Peter Ertl
We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.
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Lab Chip, 2020, 20,1398-1409
DOI: 10.1039/C9LC01103J, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van Steijn
We developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.
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Lab Chip, 2020, 20,1503-1512
DOI: 10.1039/D0LC00103A, Paper

Juan Hu, Xiangpeng Li, Robert L. Judd, Christopher J. Easley
High temporal resolution sampling and quantitative detection of glycerol secretion dynamics from adipose tissue using our automated, droplet-based microfluidic system.
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Lab Chip, 2020, 20,1493-1502
DOI: 10.1039/C9LC01039D, Paper

Zachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan Ozcan
A rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.
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Lab Chip, 2020, 20,1472-1492
DOI: 10.1039/C9LC01047E, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert Gough
The Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00051E, Paper

Jinxin Zhang, Jessica H. Hartman, Chuyi Chen, Shujie Yang, Qi Li, Zhenhua Tian, Po-Hsun Huang, Lin Wang, Joel N. Meyer, Tony Jun Huang
Acoustofluidic sorting of Caenorhabditis elegans in a high throughput manner.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00254B, Paper

Azusa Shimizu, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miura, Hiroaki Onoe
A perfusable and stretchable gelatin-based microfluidic system that can apply both simultaneous fluidic shear stress and stretch stress to in vitro endothelial 3D tissues is presented.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01209E, Paper

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

J. A. Crowe, A. El-Tamer, D. Nagel, A. V. Koroleva, J. Madrid-Wolff, O. E. Olarte, S. Sokolovsky, E. Estevez-Priego, A.-A. Ludl, J. Soriano, P. Loza-Alvarez, B. N. Chichkov, E. J. Hill, H. R. Parri, E. U. Rafailov
We identified photopolymers for 2-photon polymerisation with biocompatibility for human iPSC-derived neural network development. Generation of microscale scaffold topologies enabled neurite guidance, demonstrating use in reproducing aligned networks.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00122H, Paper

N. Garg, R. Tona, P. Martin, P. M. Martin-Soladana, G. Ward, N. Douillet, D. Lai
A microfluidic approach to seeded crystallization has been demonstrated using abacavir hemisulfate, a nucleoside analog reverse transcriptase inhibitor, in droplet reactors to control polymorphism and produce particles with a low particle size distribution.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00134A, Paper

Sayali Upasham, Shalini Prasad
SLOCK is a sweat based platform for monitoring circadian relevant biomarkers-cortisol and DHEA, using electrochemical detection modality.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01190K, Paper

Ting-Wen Lo, Ziwen Zhu, Emma Purcell, Daniel Watza, Joyful Wang, Yoon-Tae Kang, Shruti Jolly, Deepak Nagrath, Sunitha Nagrath
Immunoaffinity based EV isolation technologies use antibodies targeting surface markers on EVs to provide higher isolation specificity and purity compared to existing approaches.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00302F, Paper

Christopher Dixon, Julian Lamanna, Aaron R. Wheeler
The integration of 3D porous membranes in a digital microfluidic device enables the generation of cell-free plasma from finger-stick volumes of blood with in-line, on-chip analysis.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00001A, Paper

Kiing S. Wong, William T. H. Lim, Chien W. Ooi, Leslie Y. Yeo, Ming K. Tan
We demonstrate an efficient technique for in situ production and application of plasma-activated aerosols for surface disinfection.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC90036B, Correction

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ewa Guzniczak, Oliver Otto, Graeme Whyte, Nicholas Willoughby, Melanie Jimenez, Helen Bridle
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00071J, Paper

Vinitha T. U., Sthitodhi Ghosh, Alexander Milleman, Thinh Nguyen, Chong H. Ahn
A new polymer lab-on-a-chip with on-chip dried reagents for microfluidic capillary flow assay (MCFA) detection of unbound cortisol in saliva.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01268K, Paper

Bohee Maeng, Hyung-kwan Chang, Jungyul Park
A powerless smart contact lens enabling to monitor intraocular pressure (IOP) by checking the visual color change in photonic crystal structure with a microhydraulic amplification system has been realized.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00079E, Paper

Kenji Akama, Hiroyuki Noji
Homogeneous digital immunoassay is a powerful analytical method for highly sensitive biomarker detection with a simple protocol. By using this method, we demonstrated the simultaneous multiple protein detection.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00248H, Paper

Matthias Hermann, Kyle Bachus, Graham T. T. Gibson, Richard D. Oleschuk
This paper reports a portable viscometer that requires less than 10 μL of sample for a measurement.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01064E, Paper

Seungbeom Noh, Hanseup Kim
This paper reports in-air monitoring of in vitro monolayer cells under air-exposure utilizing electrochemical impedance spectroscopy (EIS).
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00318B, Paper

Ren Shen, Yanwei Jia, Pui-In Mak, Rui P. Martins
A proposed DNA amplification enhancer with a “clip-to-release on amplification” mechanism reduces dye-mediated inhibition to amplification, increases fluorescence signal up to 10-fold, and eliminates false-negative results for on-chip PCR.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00175A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Karl Olofsson, Björn Hammarström, Martin Wiklund
A novel, simple and robust route for binary separation of viable and dead cells using a density modified medium which takes advantage of the compromised cell membrane of dead cells.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00133C, Paper

George Banis, Luke Beardslee, Justin Stine, Rajendra Mayavan Sathyam, Reza Ghodssi
Ingestible capsule systems continue evolving to overcome drawbacks associated with traditional gastrointestinal (GI) diagnostic and therapeutic processes, such as location restrictions or insufficient sensitivity measures when obtaining information on local...
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00250J, Paper

Yuexiao Song, Feng Xin, Yongsheng Xu
This work develops a reliable method to achieve stratified flow in squared cross-section microchannels by endowing the four channel walls with very different wettabilities. The gas–liquid flows are studied experimentally...
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Lab Chip, 2020, 20,1531-1543
DOI: 10.1039/C9LC01010F, Critical Review

Yanan Zhao, Utkan Demirci, Yun Chen, Pu Chen
We report recent progress in applying innovative microfluidic chip-based neurotechnologies to promote multiscale brain research across the hierarchical organizations from the molecular, cellular, and tissue levels up to the whole organism level.
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Lab Chip, 2020, 20,1577-1585
DOI: 10.1039/D0LC00024H, Paper

Jingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong Yang
An automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.
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Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper

Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
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Lab Chip, 2020, 20,1544-1553
DOI: 10.1039/C9LC01230C, Communication

Jeffrey C. Y. Chiu, Joyce A. Teodoro, Jeong Hyun Lee, Kerryn Matthews, Simon P. Duffy, Hongshen Ma
Inverse gelation of methylcellulose enables hydrogel micropatterning to selectively propagate cells identified by microscopy.
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Lab Chip, 2020, 20,1586-1600
DOI: 10.1039/D0LC00099J, Paper

Karina M. Lugo-Cintrón, José M. Ayuso, Bridget R. White, Paul M. Harari, Suzanne M. Ponik, David J. Beebe, Max M. Gong, María Virumbrales-Muñoz
Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.
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Lab Chip, 2020, 20,1554-1561
DOI: 10.1039/D0LC00063A, Communication

Nianzuo Yu, Yongshun Liu, Bai Ji, Shuli Wang, Yunyun Chen, Tianmeng Sun, Junhu Zhang, Bai Yang
Blood pressure sensors are proposed to measure the value of central venous pressure, and diagnose the severity of hypertension, hypotension and arterial thrombosis.
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Lab Chip, 2020, 20,1621-1627
DOI: 10.1039/D0LC00304B, Paper

Fu Sun, Anurup Ganguli, Judy Nguyen, Ryan Brisbin, Krithika Shanmugam, David L. Hirschberg, Matthew B. Wheeler, Rashid Bashir, David M. Nash, Brian T. Cunningham
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00112K, Paper

Yuncheng Man, Erdem Kucukal, Ran An, Quentin Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A Little, Umut A. Gurkan
Abnormal red blood cells (RBC) deformability contributes to hemolysis, thrombophilia, inflammation, and microvascular occlusion in various circulatory diseases. A quantitative and objective assessment of microvascular occlusion mediated by RBCs with...
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00354A, Paper

Naotomo Tottori, Takasi Nisisako
We propose sheath-free microfluidic deterministic lateral displacement devices with inertially focused single straight input.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00142B, Paper

Sharif M. Rahman, Joshua M. Campbell, Rachael N. Coates, Katie M. Render, C. Ethan Byrne, Elizabeth C. Martin, Adam T. Melvin
Breast cancer cells co-cultured with adipose-derived stem cells (ASCs) in a microfluidic device exhibited enhanced growth, a more aggressive morphology and polarization towards the ASCs, and increased drug resistance.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00096E, Paper

Hanfei Shen, Tony Liu, Jesse Cui, Piyush Borole, Ari Benjamin, Konrad Kording, David Issadore
Liquid biopsy (LB) technologies continue to improve in sensitivity, specificity, and multiplexing and can measure an ever growing library of disease biomarkers. However, clinical interpretation of the increasingly large sets...
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00292E, Communication

Tao Wang, Cong Xu
Liquid-liquid-liquid three-phase microfluidics provides abundant flow patterns and attractive characteristics that substantially extend the applications of liquid-liquid two-phase microfluidics. Although the manipulation of stable interfaces between adjacent liquid phases is...
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DOI: 10.1021/acs.jcim.9b01107

DOI: 10.1021/acs.jcim.9b00927

DOI: 10.1021/acs.jcim.9b01073

DOI: 10.1021/acs.jcim.9b01111

DOI: 10.1021/acs.jcim.0c00024

DOI: 10.1021/acs.jcim.9b01110

DOI: 10.1021/acs.jcim.0c00087