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Looking at 'repurposing' drugs: Biocon

We are working to repurpose our novel monoclonal antibody Itolizumab (used in psoriasis) to treat complications caused by Covid-19 infection. If we can successfully establish the potential role for our molecule in treating Covid-19 complications, it will enable us to address a critical unmet need, Kiran Mazumdar-Shaw said.




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Third lockdown is gradual de-escalation: VK Paul, Niti Aayog member

Paul, who also heads the medical emergency management plan on Covid, tells ET in an interview that the third phase of the lockdown should be seen as the country’s strategy of rational, gradual and cautious step-wise de-escalation of the lockdown.




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[ASAP] A Systematic Evaluation of Antibody Modification and <sup>89</sup>Zr-Radiolabeling for Optimized Immuno-PET

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00087




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[ASAP] Sulfonate Version of OHPAS Linker Has Two Distinct Pathways of Breakdown: Elimination Route Allows Para-Hydroxy-Protected Benzylsulfonate (PHP-BS) to Serve as an Alternative Self-Immolative Group

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00116




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[ASAP] Construction of Bispecific Aptamer–Drug Conjugate by a Hybrid Chemical and Biological Approach

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00071




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[ASAP] Intracellular Generation of Superoxide by TiO<sub>2</sub> Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00091




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[ASAP] Functionalized Pt(II) and Ir(III) NIR Emitters and Their Covalent Conjugates with Polymer-Based Nanocarriers

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00020




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[ASAP] SNAP/CLIP-Tags and Strain-Promoted Azide–Alkyne Cycloaddition (SPAAC)/Inverse Electron Demand Diels–Alder (IEDDA) for Intracellular Orthogonal/Bioorthogonal Labeling

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00107




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[ASAP] Anionic Polymers Promote Mitochondrial Targeting of Delocalized Lipophilic Cations

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00079




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[ASAP] Supramolecular ß-Sheet Forming Peptide Conjugated with Near-Infrared Chromophore for Selective Targeting, Imaging, and Dysfunction of Mitochondria

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00153




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[ASAP] Site-Selective Protein Chemical Modification of Exposed Tyrosine Residues Using Tyrosine Click Reaction

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00120




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[ASAP] Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00118




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[ASAP] Peptide-Functionalized Quantum Dots for Rapid Label-Free Sensing of 2,4,6-Trinitrotoluene

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00117




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[ASAP] Design Strategies and Medicinal Applications of Metal-Peptidic Bioconjugates

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00152




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[ASAP] Chemical Synthesis and Biological Application of Modified Oligonucleotides

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00060




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[ASAP] Noncovalent Indocyanine Green Conjugate of C-Phycocyanin: Preparation and Tumor-Associated Macrophages-Targeted Photothermal Therapeutics

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00139




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[ASAP] Fabrication of Patterned Hydrogel Interfaces: Exploiting the Maleimide Group as a Dual Purpose Handle for Cross-Linking and Bioconjugation

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00108




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[ASAP] Directing Quinone Methide-Dependent Alkylation and Cross-Linking of Nucleic Acids with Quaternary Amines

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00166




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[ASAP] Efficient Sortase-Mediated Ligation Using a Common C-Terminal Fusion Tag

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00156




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[ASAP] Two-Photon and Multicolor Fluorogenic Bioorthogonal Probes Based on Tetrazine-Conjugated Naphthalene Fluorophores

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00197




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[ASAP] A Bifunctional Nucleoside Probe for the Inhibition of the Human Immunodeficiency Virus-Type 1 Reverse Transcriptase

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00191




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[ASAP] Expanding the Scope of Antibody Rebridging with New Pyridazinedione–TCO Constructs

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00155




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[ASAP] Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00151




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[ASAP] Recent Advances in Nanomaterials with Inherent Optical and Magnetic Properties for Bioimaging and Imaging-Guided Nucleic Acid Therapy

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00126




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[ASAP] Installation of a Thermoswitchable Hydrophobic Domain into a Unimer Polyion Complex for Enhanced Cellular Uptake of siRNA

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00238




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[ASAP] Human Granulocyte-Macrophage Colony-Stimulating Factor Fused to Elastin-Like Polypeptides Assembles Biologically-Active Nanoparticles

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00204




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[ASAP] Supramolecular Encapsulation of Small-Ultrared Fluorescent Proteins in Virus-Like Nanoparticles for Noninvasive In Vivo Imaging Agents

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00190




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[ASAP] An Integrin Alpha 6-Targeted Radiotracer with Improved Receptor Binding Affinity and Tumor Uptake

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00170




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[ASAP] Enhancing the Carboxylation Efficiency of Silk Fibroin through the Disruption of Noncovalent Interactions

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00168




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[ASAP] Recent Advances in Carbon Dioxide Hydrogenation to Methanol via Heterogeneous Catalysis

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00723




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[ASAP] Exploring Anomalous Charge Storage in Anode Materials for Next-Generation Li Rechargeable Batteries

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00618




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[ASAP] Prebiotic Peptides: Molecular Hubs in the Origin of Life

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00664




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[ASAP] Biological and Bioinspired Inorganic N–N Bond-Forming Reactions

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00629




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[ASAP] Reduction of Substrates by Nitrogenases

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00556




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[ASAP] Heterogeneous Single-Atom Photocatalysts: Fundamentals and Applications

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00840




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[ASAP] Prebiotic Astrochemistry and the Formation of Molecules of Astrobiological Interest in Interstellar Clouds and Protostellar Disks

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00560




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[ASAP] Cyclic (Alkyl)- and (Aryl)-(amino)carbene Coinage Metal Complexes and Their Applications

Chemical Reviews
DOI: 10.1021/acs.chemrev.0c00043




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[ASAP] Multireference Electron Correlation Methods: Journeys along Potential Energy Surfaces

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00496




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[ASAP] Mobile Ions in Composite Solids

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00760




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[ASAP] Oxygen K-edge X-ray Absorption Spectra

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00439




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[ASAP] Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00814




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[ASAP] Microstructural and Dynamical Heterogeneities in Ionic Liquids

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00693




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[ASAP] Fundamentals and Applications of Photo-Cross-Linking in Bioprinting

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00812




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[ASAP] Correction to Small Molecule as Fluorescent Probes for Monitoring Intracellular Enzymatic Transformations

Chemical Reviews
DOI: 10.1021/acs.chemrev.0c00218




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[ASAP] Evolution of Dip-Pen Nanolithography (DPN): From Molecular Patterning to Materials Discovery

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00725




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[ASAP] Mass Spectrometry-Based Protein Footprinting for Higher-Order Structure Analysis: Fundamentals and Applications

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00815




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[ASAP] Photopolymerizable Biomaterials and Light-Based 3D Printing Strategies for Biomedical Applications

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00810




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[ASAP] Classical and Emerging Characterization Techniques for Investigation of Ion Transport Mechanisms in Crystalline Fast Ionic Conductors

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00747




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[ASAP] Catalytic N<sub>2</sub>-to-NH<sub>3</sub> (or -N<sub>2</sub>H<sub>4</sub>) Conversion by Well-Defined Molecular Coordination Complexes

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00638




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[ASAP] The Staudinger Ligation

Chemical Reviews
DOI: 10.1021/acs.chemrev.9b00665