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The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors




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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




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NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




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Cell Death & Disease




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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Dermatophagoides pteronyssinus peptidase 1 (DERP1)

In vitro and rat studies suggest inhibiting the enzymatic activity of house dust mite (HDM) allergens could help treat allergic asthma.




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Glutathione peroxidase 4 (GPX4)

Mouse studies suggest inhibiting ferroptosis could help treat ischemia/reperfusion injury in the liver and kidney.




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Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




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Translational tidbits

Yabao and MRC Technology partner in PD; charities form Neuro-MAP to insource pharma's abandoned compounds; Singapore creates a diagnostic hub; a roundup of public-private partnerships.




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Translational balance

Moving discoveries from academia to industry requires a delicate balance of risk, reward, skill sets and personalities, according to a translational panel held at BIO-Europe's partnering conference.




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Neutralizing the negatives of RNAi

The siRNN technology that Solstice licensed from UCSD could take RNAi-based therapies to tissues outside the liver and expand their use to a host of new diseases.




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis




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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




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Nature Cell Biology




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Transcription factors in ferroptotic cell death




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




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UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53




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High-purity orbital angular momentum states from a visible metasurface laser




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The rise of integrated quantum photonics




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Superfluid coating




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Strain creates a trion factory




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Nature Photonics




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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




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An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




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Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




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Ex vivo pulsed dendritic cell vaccination against cancer




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Head-to-head trials in inflammatory bowel disease: past, present and future




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Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions




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Inducing senescence sensitizes pancreatic tumours to therapies




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Universal screening for hepatitis C virus infection should be linked to universal treatment access




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Nature Reviews Gastroenterology & Hepatology




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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys




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A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Nesfatin-1 puts the brakes on reward-based feeding




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




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Author Correction: Insights into parathyroid hormone secretion