Dave Campbell of Thunder Bay, Ont., is resting his legs after taking the ride of his life through the Western Cape of South Africa in the 800-kilometre bikepacking 'Rhino Run.' Here are some of the photos he shared from his six-day expedition at the end of October.

Buenos Aires, Argentina :: Miembros de la comunidad japonesa encuentran amigos en un barco de visita y escuchan el evangelio en su lengua materna.

"Since my childhood, I have been anxious about missing out. I remember not wanting to sleep whenever I heard the adults chatting in the night. I wanted to be part of it all. Later on, in high school, I said “yes” to every event and outing, which ended up crashing so many times. I couldn’t choose. I wanted to be there to celebrate all the fun moments but also share all the tears in the low moments," says Ivy. "However, this lifestyle of being afraid of missing out could not continue when I joined missions. I have had to learn how to let go when I miss out on opportunities to create precious memories with family and friends in my home country."

La tripulación de técnicos del Logos Hope sabe que el mantenimiento del barco es una forma de hacer ministerio.

Headlines for November 01, 2024; Will Abortion Rights Decide 2024 Election? Amy Littlefield on Trump’s Misogyny & 10 Ballot Measures; Report from Wisconsin: John Nichols on Harris’s Madison Roots & Key Senate/House Races Nationwide; “Little Secret”? Elie Mystal on Trump’s Likely Plan to Steal Election with GOP House Speaker Johnson

Headlines for November 08, 2024; Democrats Deserted Working Poor: Bishop William Barber on Healthcare, Living Wages, Voting Rights; “Open Celebration of the Oligarchy”: Both Dems & GOP Sucked Up to Billionaires in 2024 Election; End the Arms: Humanitarian Chief Jan Egeland Urges U.S. to Stop Arming Israel Before Trump Takes Office

The Prince Edward Island Fire Marshals Office has concluded its investigation into a massive fire at Valley Truss and Metal in Kensington in October.

Some business owners in Charlottetown have made suggestions for increasing the city’s housing supply, but not everyone is happy with their recommendations when it comes to rental properties.

U.S. president-elect Donald Trump has promised sweeping global tariffs in his next term, but the Canadian Steel Producers Association remains confident that the industry can come out unscathed.

Wildland firefighters were at Queen’s Park on Wednesday to outline why they feel a new bill that extends protections for cancers, heart injuries and post-traumatic stress disorder linked to their occupation falls short.

Sault Ste. Marie has the highest rate of opioid deaths in Ontario so far this year, according to new numbers from the province's coroner's office.

The crowning achievement at last year's COP climate conference in Dubai was a global consensus on the need to "transition away from fossil fuels." This year, the conference had not even started yet before BBC News exposed senior organizers of using the event to arrange potential deals for fossil fuel expansion. The recent election of Donald Trump in the U.S. has added an additional layer of uncertainty to this year's meeting.

A Métis pad saddle from the early 1800s is on display at the Cantonal Museum of Archaeology and History in Lausanne, Switzerland, sitting alongside contemporary beadwork created by other Red River Métis artists. 

RCMP say a 23-year-old woman was found dead in a residence in central Manitoba on Tuesday. 

Ryan Dinwiddie and the Toronto Argonauts have been down this road before. Toronto will be minus starting quarterback Chad Kelly, the CFL's outstanding player last season, on Sunday when it faces the Winnipeg Blue Bombers in the Grey Cup.

Workers in Ontario are owed tens of millions of dollars in unpaid wages that the provincial government has yet to collect from employers, according to internal government records obtained by CBC Toronto.

The president of Mohawk College says a drop in international student enrolment at the Hamilton institution is facing a projected $50 million deficit in the 2025-2026 school year. That’s going to mean layoffs, he said.

Saskatchewan's police watchdog is investigating an incident that led to the suspension of five Saskatoon police officers and a sixth officer is also off work because of an unrelated incident.

The Winnipeg Blue Bombers will face the Toronto Argonauts in their fifth straight Grey Cup appearance. The Bombers advanced to the CFL title game after disposing of the Saskatchewan Roughriders 38-22 in the West final Saturday night in Winnipeg.

Across Canada, there’s a growing number of political leaders proposing to force people into treatment for drug addiction, despite inconclusive evidence about its effectiveness.

Head coach Corey Mace, quarterback Trevor Harris and linebacker Jameer Thurman talk about coming up short in the CFL West Final. The Roughriders lost the the Winnipeg Blue Bombers 38-22 sending the Bombers to their fifth straight Grey Cup.

A recent study out of the University of Calgary estimates that more than 10 million Canadians are being exposed to high levels of radon, an odourless, tasteless radioactive gas that is the second leading cause of lung cancer in the country.

A blaze at an apartment building has displaced residents and led to two injuries, almost two years after a fire at the same building displaced dozens.

The National Capital Commission says it opened the Rideau Canal Skateway below its usual stands for ice thickness a few times last season — and plans to do the same this year. 

Health officials say it’s the right time to get your seasonal flu and COVID-19 vaccines as levels of both viruses rise in Ottawa. The CBC’s Kimberley Molina reports.

Faster. Higher. Stronger. Together — and just don't test positive. That's the rallying cry for thousands of athletes as they prepare for the Olympics.

Figure skating pair Evelyn Walsh and Trennt Michaud didn't qualify for the 2022 Beijing Winter Olympics next month, their coach has all the faith that the pair will come back even stronger. 

Kamloops RCMP say they are investigating the fire that destroyed the Red Bridge Thursday as an arson.

Concerns are mounting over the potential environmental impact on fish populations following the destruction of Kamloops' historic Red Bridge, which collapsed into the South Thompson River during a fire.

Wade Cudmore told the jury at his first-degree murder trial that he was not present when brothers Carlo and Erick Fryer were killed during a drug deal in May 2021.

"People actually reached out and hugged it and they told their [stories] about residential school," master carver Stanley C. Hunt says.

A group of residential school survivors and their supporters are asking the federal government to reverse what they're calling a funding cut and come up with more money to help find the unmarked graves of students who went to these institutions.

A jury has found a Naramata, B.C., man guilty on two counts of second-degree murder in the deaths of two brothers. Wade Cudmore, 35, was one of two men accused in the May 2021 drug deal killings of Kamloops, B.C., brothers Erick and Carlo Fryer.

Garry Gottfriedson, who attended the Kamloops Indian Residential School for five years, drew on his own experience at residential school, as well as those of his siblings and parents, for the book. He describes the process of gathering their stories as "powerful."

A recent request to change the wording in a mandatory Indigenous intercultural course for lawyers in British Columbia led to a debate over whether the changes amounted to residential school denialism. 

The pay cut comes after city council had already taken a number of steps against the mayor, including stripping him of his duties as a city spokesperson, removing him from the Thompson Nicola Regional District board and Shuswap Watershed Council and relocating his office to the basement of city hall. 

Kimberly Murray has opened an uncomfortable and difficult but long overdue conversation about justice for Canada’s "disappeared" residential school children, Indigenous leaders say in response to the special interlocutor's two-volume final report.

The trade war that could stem from U.S. tariffs on steel and aluminum is unlikely to affect GDP, freeing the Fed to raise rates at its March 21 meeting.

Marc-André Fleury stopped 26 shots in what will likely be his final game in Pittsburgh as the Minnesota Wild beat the Penguins 5-3 on Tuesday night. He spent 13 seasons with Pittsburgh and won Stanley Cups in 2009, 2016 and 2017.

Connor McDavid retured from injury — well ahead of schedule. The Oilers captain re-entered the lineup when Edmonton hosted the Vegas Golden Knights on Wednesday.

Israeli airstrikes have killed at least 46 people in the Gaza Strip over the past 24 hours — including 11 in an Israeli-declared humanitarian zone, medics said — as the country missed a deadline set by Washington to allow more humanitarian aid into the Palestinian enclave. 

Toronto's redesigned vacant home tax rollout has begun, with over 59,000 people filing their paperwork in the first week. Some councillors say they were left responding to complaints about the rollout, after the city's online declaration portal experienced technical problems shortly after launch.

The Ontario Liberal Party is pledging to reduce the income tax rate for middle class families and eliminate provincial sales tax on hydro bills, if they win in the 2026 election.

Ontario Provincial Police (OPP) have released dashcam footage of a crash that sent two people to hospital in life-threatening condition, linked to an ongoing investigation into rocks being thrown at moving vehicles in the GTA.

After Canada Post workers gave a 72-hour notice to strike early Tuesday, some Calgary business owners are worried about what this means for holiday season sales. 

CME Group, the world's leading derivatives marketplace, today declared a fourth-quarter dividend of $1.15 per share. The dividend is payable December 27, 2024, to shareholders of record as of...

The establishment of neural connectivity is a major part of neural development. The central nervous system (CNS) midline is the most characterized axon guidance choice point, and work in Drosophila has played a pivotal role in understanding the molecular mechanisms responsible. Axons respond to attractive cues such as Netrin via the Frazzled receptor, and repulsive cues such as Slit via Robo receptors. Both signals are expressed at the CNS midline, affect pioneer axons, and have dramatic effects on the axon scaffold as a whole. Here, we focus on previous research analyzing classic mutants in the Slit/Robo pathway, which can readily be detected with a dissecting microscope. We also discuss analyzing these mutants in a teaching lab situation. The combination of sophisticated genetics and reliable axonal markers in Drosophila allows phenotypic analysis to be performed at the single-cell level. The elaborate architecture of neurons is very sensitive to disruption by genetic mutations, allowing the effects of novel mutations to be easily detected and assessed.

CRISPR–Cas9 has revolutionized gene editing for traditional and nontraditional model organisms alike. This tool has opened the door to new mechanistic studies of basic mosquito biology as well as the development of novel vector control strategies based on CRISPR–Cas9, including gene drives that spread genetic elements in the population. Although the promise of the specificity, flexibility, and ease of deployment CRISPR is real, its implementation still requires empirical optimization for each new species of interest, as well as to each genomic target within a given species. Here, we provide an overview of designing and testing single-guide RNAs for the use of CRISPR-based gene editing tools.