on Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome By feedproxy.google.com Published On :: 2020-04-01 Xien Yu ChuaApr 1, 2020; 19:730-743Technological Innovation and Resources Full Article
on Organellar maps through proteomic profiling - a conceptual guide By feedproxy.google.com Published On :: 2020-04-28 Georg H H BornerApr 28, 2020; 0:R120.001971v1-mcp.R120.001971Review Full Article
on Peptide-based interaction proteomics By feedproxy.google.com Published On :: 2020-04-28 Katrina MeyerApr 28, 2020; 0:R120.002034v1-mcp.R120.002034Review Full Article
on The DNA sensor cGAS is decorated by acetylation and phosphorylation modifications in the context of immune signaling By feedproxy.google.com Published On :: 2020-04-28 Bokai SongApr 28, 2020; 0:RA120.001981v1-mcp.RA120.001981Research Full Article
on Modulation of natural HLA-B*27:05 ligandome by ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 (ERAP2) By feedproxy.google.com Published On :: 2020-04-07 Elena LorenteApr 7, 2020; 0:RA120.002014v1-mcp.RA120.002014Research Full Article
on HIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV By feedproxy.google.com Published On :: 2020-04-21 Daniella H HockApr 21, 2020; 0:RA120.002076v1-mcp.RA120.002076Research Full Article
on Characterization of Prenylated C-terminal Peptides Using a Thiopropyl-based Capture Technique and LC-MS/MS By feedproxy.google.com Published On :: 2020-04-13 James A. WilkinsApr 13, 2020; 0:RA120.001944v1-mcp.RA120.001944Research Full Article
on Flow-induced reorganization of laminin-integrin networks within the endothelial basement membrane uncovered by proteomics By feedproxy.google.com Published On :: 2020-04-24 Eelke P. BéguinApr 24, 2020; 0:RA120.001964v1-mcp.RA120.001964Research Full Article
on Seminal Plasma Proteome as an Indicator of Sperm Dysfunction and Low Sperm Motility By feedproxy.google.com Published On :: 2020-04-20 Yunlei LiApr 20, 2020; 0:RA120.002017v1-mcp.RA120.002017Research Full Article
on Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics By feedproxy.google.com Published On :: 2020-04-01 Patrick HerrApr 1, 2020; 19:608-623Research Full Article
on Proteaphagy in mammalian cells can function independent of ATG5/ATG7 By feedproxy.google.com Published On :: 2020-04-16 Tatjana GoebelApr 16, 2020; 0:RA120.001983v1-mcp.RA120.001983Research Full Article
on Robust summarization and inference in proteome-wide label-free quantification By feedproxy.google.com Published On :: 2020-04-22 Adriaan StickerApr 22, 2020; 0:RA119.001624v1-mcp.RA119.001624Research Full Article
on Investigation of inter- and intra-tumoral heterogeneity of glioblastoma using TOF-SIMS By feedproxy.google.com Published On :: 2020-04-06 Samvel K GularyanApr 6, 2020; 0:RA120.001986v1-mcp.RA120.001986Research Full Article
on Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-Induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses By feedproxy.google.com Published On :: 2020-04-15 Sonia PodvinApr 15, 2020; 0:RA120.002079v1-mcp.RA120.002079Research Full Article
on Developments and Applications of Functional Protein Microarrays By feedproxy.google.com Published On :: 2020-04-17 Guan-Da SyuApr 17, 2020; 0:R120.001936v1-mcp.R120.001936Review Full Article
on Identification of an Unconventional Subpeptidome Bound to the Behcet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) By feedproxy.google.com Published On :: 2020-05-01 Liye ChenMay 1, 2020; 19:871-883Research Full Article
on Human Hepatocyte Nuclear Factor 4-{alpha} Encodes Isoforms with Distinct Transcriptional Functions By feedproxy.google.com Published On :: 2020-05-01 Élie LambertMay 1, 2020; 19:808-827Research Full Article
on Quantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation By feedproxy.google.com Published On :: 2020-04-14 Nora LinscheidApr 14, 2020; 0:RA119.001878v1-mcp.RA119.001878Research Full Article
on Immediate adaptation analysis implicates BCL6 as an EGFR-TKI combination therapy target in NSCLC By feedproxy.google.com Published On :: 2020-03-31 Yan Zhou TranMar 31, 2020; 0:RA120.002036v1-mcp.RA120.002036Research Full Article
on A cross-linking mass spectrometry approach defines protein interactions in yeast mitochondria By feedproxy.google.com Published On :: 2020-04-24 Andreas LindenApr 24, 2020; 0:RA120.002028v1-mcp.RA120.002028Research Full Article
on Characterization of signaling pathways associated with pancreatic {beta}-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice By feedproxy.google.com Published On :: 2020-04-07 Taewook KangApr 7, 2020; 0:RA119.001882v1-mcp.RA119.001882Research Full Article
on Discovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism By feedproxy.google.com Published On :: 2020-05-01 Xing-Huang GaoMay 1, 2020; 19:852-870Research Full Article
on Large-scale Identification of N-linked Intact Glycopeptides in Human Serum using HILIC Enrichment and Spectral Library Search By feedproxy.google.com Published On :: 2020-04-01 Qingbo ShuApr 1, 2020; 19:672-689Research Full Article
on Selection of features with consistent profiles improves relative protein quantification in mass spectrometry experiments By feedproxy.google.com Published On :: 2020-03-31 Tsung-Heng TsaiMar 31, 2020; 0:RA119.001792v1-mcp.RA119.001792Research Full Article
on Profiling Cell Signaling Networks at Single-cell Resolution By feedproxy.google.com Published On :: 2020-05-01 Xiao-Kang LunMay 1, 2020; 19:744-756Review Full Article
on DEqMS: a method for accurate variance estimation in differential protein expression analysis By feedproxy.google.com Published On :: 2020-03-23 Yafeng ZhuMar 23, 2020; 0:TIR119.001646v1-mcp.TIR119.001646Technological Innovation and Resources Full Article
on Virtual Issue: Technological Innovations By feedproxy.google.com Published On :: 2020-04-01 Anne-Claude GingrasApr 1, 2020; 19:572-573Editorial Full Article
on Compliance Checklists No Longer Required at Initial Manuscript Submission By feedproxy.google.com Published On :: 2020-04-01 Alma L. BurlingameApr 1, 2020; 19:571-571Editorial Full Article
on Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker By feedproxy.google.com Published On :: 2020-04-01 Karl A. T. MakepeaceApr 1, 2020; 19:624-639Research Full Article
on MaxQuant software for ion mobility enhanced shotgun proteomics By feedproxy.google.com Published On :: 2020-03-10 Nikita PrianichnikovMar 10, 2020; 0:TIR119.001720v1-mcp.TIR119.001720Technological Innovation and Resources Full Article
on Acquiring and Analyzing Data Independent Acquisition Proteomics Experiments without Spectrum Libraries By feedproxy.google.com Published On :: 2020-04-20 Lindsay K PinoApr 20, 2020; 0:P119.001913v1-mcp.P119.001913Perspective Full Article
on Proximity Dependent Biotinylation: Key Enzymes and Adaptation to Proteomics Approaches By feedproxy.google.com Published On :: 2020-05-01 Payman Samavarchi-TehraniMay 1, 2020; 19:757-773Review Full Article
on XG Firewall is now available on AWS By feedproxy.google.com Published On :: Mon, 20 Apr 2020 15:47:21 +0000 We are extremely pleased to announce the availability of XG Firewall on Amazon Web Services (AWS) public cloud infrastructure. Full Article Network Amazon Web Services AWS XG Firewall XG Firewall v18
on Following the money in a massive “sextortion” spam scheme By feedproxy.google.com Published On :: Wed, 22 Apr 2020 12:30:08 +0000 Cryptocurrency profits from sextortion spam funneled into wallets tied to other cybercrime and dark web market activity. Full Article SophosLabs Uncut
on Making the most of attending conferences By blogs.ams.org Published On :: Tue, 08 Oct 2019 16:54:02 +0000 In this blog by Julianne Vega, graduate student at University of Kentucky, Julianne tells us how to make the most of attending math conferences. If you are heading to a conference, challenge yourself! Your first conference may not be the … Continue reading → Full Article career advancement General Graduate School Uncategorized Undegraduates
on Mathematical light shines blindly on us By blogs.ams.org Published On :: Mon, 09 Dec 2019 18:57:58 +0000 By William Yslas Vélez Professor Emeritus University of Arizona “When I go to a Mexican restaurant I would gladly pay the musicians to stop playing.” John (not his real name) did not like the noise level. This statement came up … Continue reading → Full Article Changing Graduate Programs General Uncategorized
on Bank of REU/Grad Fair Questions By blogs.ams.org Published On :: Fri, 24 Jan 2020 19:14:06 +0000 By Lucy Martinez and Eduardo Torres Davila We attended the Joint Math Meetings (JMM) conference in Denver to present our research from our work at the Mathematical Sciences Research Institute Undergraduate Program. At JMM, there was a fair of graduate … Continue reading → Full Article career advancement Changing Graduate Programs General Going to graduate school Graduate School Uncategorized Undegraduates
on Finding belonging through mentorship By blogs.ams.org Published On :: Fri, 17 Apr 2020 19:45:03 +0000 Guest blog by Stephen McKean On my first day of college, I showed up an hour early to my very first class. The class was Math 2210, multivariable calculus. For some reason, I thought this was the highest math class … Continue reading → Full Article General Going to graduate school Graduate School Outreach Uncategorized Undegraduates
on A mathematician’s mission statement By blogs.ams.org Published On :: Thu, 23 Apr 2020 18:58:29 +0000 By Pamela E. Harris and Julianne Vega Companies and organizations are driven by their mission statements. These mission statements provide a concrete summary of what they value and what they work to achieve. Take for example the following mission statements: … Continue reading → Full Article career advancement General Uncategorized
on Cybersecurity in the Commonwealth: Building the Foundations of Effective National Responses in the Caribbean By feedproxy.google.com Published On :: Thu, 07 Feb 2019 14:20:01 +0000 Invitation Only Research Event 8 March 2019 - 9:00am to 5:30pm Bridgetown, Barbados Event participants Joyce Hakmeh, Cyber Research Fellow, International Security Department, Chatham House This workshop is the second in a series in the 'Implementing the Commonwealth Cybersecurity Agenda' project. The workshop aims to provide a multi-stakeholder pan-Commonwealth platform to discuss how to take the implementation of the 'Commonwealth Cyber Declaration' forward with a focus on the second pillar of the declaration – building the foundations of an effective national cybersecurity response with eight action points. As such, the workshop gathers different project implementers under the UK Foreign and Commonwealth Office’s Cyber Programme, in addition to other key relevant stakeholders from the global level, to explore ongoing initiatives which aim to deliver one or more of pillar two’s action points.The workshop addresses issues from a global perspective and a Commonwealth perspective and will include presentations from selected partners from different Commonwealth countries. Department/project International Security Programme Calum Inverarity Research Analyst and Coordinator, International Security Department +44 (0) 207 957 5751 Email Full Article
Calum Inverarity Research Analyst and Coordinator, International Security Department +44 (0) 207 957 5751 Email
on Transparency and Accountability for Drone Use: European Approaches By feedproxy.google.com Published On :: Thu, 07 Mar 2019 17:35:01 +0000 Invitation Only Research Event 11 March 2019 - 9:30am to 12 March 2019 - 12:30pm Chatham House With increased use of military drones in recent years there have also been many calls for greater transparency and accountability with regards to drone operations.This would allow for greater public understanding, particularly as the complex nature of military operations today intensifies difficulties in sustaining perceptions of the legitimate use of force.For example, in Europe, leading states rely on the US for drone platforms and for the infrastructure - such as military communication networks - that enable those operations, while the US also relies on airbases in European states to operate its drone programme.In addition, with reports that the US is loosening the rules on the use of drones, it is important to understand how European approaches to transparency and accountability may be affected by these developments.This workshop focuses on how European states can facilitate transparency to ensure accountability for drone use, as well as what the limits might be, considering both the complexity of military operations today and the need for achieving operational goals.With the US easing restrictions on export controls, the discussion also considers the role of regulation in ensuring accountability and prospects for developing common standards.Attendance at this event is by invitation only. Nilza Amaral Project Manager, International Security Programme Email Department/project International Security Programme, Policy Implications of Armed Drone Use Full Article
on How Regulation Could Break the Internet: In Conversation with Andrew Sullivan By feedproxy.google.com Published On :: Mon, 29 Apr 2019 13:30:01 +0000 Research Event 19 June 2019 - 6:00pm to 7:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Andrew Sullivan, President and CEO Internet SocietyChair: Emily Taylor, Associate Fellow, International Security Department, Chatham House; Editor, Journal of Cyber Policy Internet regulation is increasing around the world creating positive obligations on internet providers and exerting negative unintended consequences on the internet infrastructure. In some ways, most of this regulatory activity is justifiable. Governments are concerned about the increased risk that the use of the internet brings to societies. As a response, many governments have been enacting regulations as their main approach to dealing with these concerns. The main challenge is that most of the current regulations are either ill-defined or unworkable. On the one hand, several governments have established procedures that seek to analyze the impacts of new regulatory proposals before they were adopted. However, there hasn’t been enough attention aimed at analyzing regulations after they have been adopted and only a few have measures in place to evaluate the impacts of the procedures and practices that govern the regulatory process itself.On the other hand, much of the regulation creates unintended consequences to the internet itself. It undermines many of its fundamental properties and challenges the integrity and resiliency of its infrastructure. This event discusses current practices in internet-related regulation and the related challenges. Panellists will discuss how governments can enforce regulations that achieve their intended purpose while at the same time protecting the internet’s core infrastructure and its properties, including its openness, interoperability and global reach. Department/project International Security Programme, Internet Governance Calum Inverarity Research Analyst and Coordinator, International Security Department +44 (0) 207 957 5751 Email Full Article
Calum Inverarity Research Analyst and Coordinator, International Security Department +44 (0) 207 957 5751 Email
on The Implications of Drone Proliferation in Europe By feedproxy.google.com Published On :: Wed, 01 May 2019 10:55:01 +0000 Invitation Only Research Event 20 May 2019 - 9:30am to 21 May 2019 - 12:30pm Chatham House, London Several countries in Europe are currently developing, increasing or arming their drone capabilities. This increase in drone capability is taking place through procurement by individual states, bilateral projects – such as the French-German Future Combat Air Systems – and multinational efforts that include the development of the Eurodrone – a project by Germany, France, Italy and Spain – and the nEUROn which involves France, Greece, Italy, Spain, Sweden and Switzerland. In addition, the EU has recently approved the European Defence Fund which, along with funds for joint development of defence equipment and technology and for defence research, also includes direct funding to support the development of the Eurodrone. Other recent developments include the UK obtaining the MQ−9B SkyGuardian – an updated variant of the MQ-9 Reaper – and Germany signing a leasing agreement for the Israeli-made Heron TP. Also, in March 2019, the US State Department approved the sale of the MQ-9B SkyGuardian to Belgium and announced the provision of MQ-9 Reaper drones to the Netherlands. While the UK and France are the only countries in Europe so far to possess armed drones, Italy is on track to acquire armed drones in the near future. However, out of the European countries currently seeking to obtain unarmed drones – including Spain, Poland and Greece – only Switzerland has so far ruled out weaponizing its drones in the future. This Chatham House workshop will examine key issues pertaining to drone proliferation in Europe including: The risks and challenges of the increasing number and arming of drones. The risks for countries of not doing so in terms of geostrategic interests and the future battlefield.Opportunities for developing common standards on drone transfers and deployment across EU member states.Sharing and cooperation on drone use.What legal and policy implications might arise for European states as a result.With Brexit on the horizon, participants will also consider what impact this may have on future drone developments in Europe.Attendance at this event is by invitation only. Nilza Amaral Project Manager, International Security Programme Email Department/project International Security Programme, Policy Implications of Armed Drone Use Full Article
on Protecting Children in Conflict: See Me Safe Symposium By feedproxy.google.com Published On :: Wed, 01 May 2019 14:55:01 +0000 Invitation Only Research Event 7 May 2019 - 10:00am to 5:00pm Chatham House, London Today there are 420 million children, or one-fifth of children worldwide, who live in conflict zones and are at risk of being killed or injured and denied access to education, healthcare and humanitarian assistance. From Myanmar and Syria, to South Sudan and Yemen, the impact of conflict on children and their families is devastating. With conflicts becoming more protracted and urbanized, and the undermining of international rules and norms, the risk to civilians is rapidly increasing. The impact of the crisis in civilian protection is not only devastating children’s lives and risking a lost generation, it threatens global stability and prosperity, contributing to the degradation of the international rules-based system and its institutions and undermining the ability to hold perpetrators accountable and prevent these atrocities from happening. This symposium will bring together practitioners, policymakers, business leaders, philanthropists and academics for a day of panel discussions on the protection of children in conflict. The aim of the event is to generate an informed debate and to deepen engagement with issues around protecting children in conflict as well as to inspire support to help rebuild children’s lives. This event will be followed by a reception from 17:00-18:30. Attendance is by invitation only. Celebrating its centenary in 2020, Chatham House is partnering with Save the Children on this core area of their work, in their anniversary year. Department/project International Security Programme Nilza Amaral Project Manager, International Security Programme Email Full Article
on Understanding Cybercrime for Better Policing: Regional and Global Challenges By feedproxy.google.com Published On :: Fri, 24 May 2019 15:25:01 +0000 Research Event 18 June 2019 - 9:00am to 5:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE In recent years, cybercrime has evolved from a niche technological concern into a prominent global issue with substantial preventative and remedial costs for businesses and governments alike. Despite heavy investment in sophisticated cybersecurity measures and the adoption of several legal, organizational and capacity-building measures, cybercrime remains a major threat which is evolving on a daily basis. Today’s cybercrime is more aggressive, more complex, more organized and – importantly – more unpredictable than ever before.The challenges posed by cybercrime are experienced acutely by countries undergoing digital transformations: as the level of connectivity rises, so too does the potential for online theft, fraud and abuse. Cybercrime is pervasive but governments can work to limit its impact by creating a resilient overall economy and robust institution, and appropriately equipping law enforcement and the justice system to navigate its novel challenges.To advance the discourse surrounding these issues, this workshop will assess the current cyber threat landscape and how it is evolving. It will identify the main obstacles encountered by law enforcement, the judiciary and prosecutors in their fight against cybercrime. It will also compare national, regional and global approaches that countries can use to effectively curb cybercrime and tackle its emerging challenges. Department/project International Security Programme Calum Inverarity Research Analyst and Coordinator, International Security Department +44 (0) 207 957 5751 Email Full Article
Calum Inverarity Research Analyst and Coordinator, International Security Department +44 (0) 207 957 5751 Email
on Create a Global Code of Conduct for Outer Space By feedproxy.google.com Published On :: Thu, 06 Jun 2019 12:24:56 +0000 12 June 2019 Dr Patricia Lewis Research Director, Conflict, Science & Transformation; Director, International Security Programme @PatriciaMary The rules governing human activity in space have been in place for only a few decades, and yet they are already out of date. They need to be built on and extended to reflect the dramatic and rapid changes in the use of space. 2016-09-27-Space2.jpg Nighttime view of the strait of Gibraltar. Photo by NASA. The 1967 Outer Space Treaty (OST) is the mainframe for space law. It recognizes the importance of the use and scientific exploration of outer space for the benefit and in the interests of all countries. It also prohibits national sovereignty in space, including of the Moon and other celestial bodies.The OST prohibits all weapons of mass destruction in space – in orbit or on other planets and moons – and does not allow the establishment of military infrastructure, manoeuvres or the testing of any type of weapon on planets or moons. As the treaty makes clear, outer space is for peaceful purposes only. Except of course, it is not – nor has it ever been so.The very first satellite, Sputnik, was a military satellite which kicked off the Cold War space race between the US and the USSR. The militaries of many countries followed suit, and space is now used for military communication, signals intelligence, imaging, targeting, arms control verification and so on.However, in keeping with international aspirations, space is also being used for all kinds of peaceful purposes such as environmental monitoring, broadcast communications, delivering the internet, weather prediction, navigation, scientific exploration and – very importantly – monitoring the ‘space weather’ (including the activity from the Sun).There are several other international agreements on space, such as on the rescue of astronauts, the registration of satellites and liability for damage caused by space objects. There is also the Moon Treaty, which governs activities on the Moon and other moons, asteroids and planets.[i]More recently, states at the UN Committee on the Peaceful Uses of Outer Space (COPUOS) in Vienna have agreed on guidelines to deal with the worrying situation of space debris which is cluttering up orbits and posing a danger to satellites, the space station and astronauts.The problem the international community now faces is that the use of space is changing dramatically and rapidly. There are more satellites than ever – well over 1,000 – and more owners of satellites – almost every country uses information generated from space. Increasingly, however, those owners are not countries, militaries or international organizations but the commercial sector. Very soon, the owners will even include individuals.Small ‘mini-satellites’ or ‘cube-sats’ are poised to be deployed in space. These can act independently or in ‘swarms’, and are so small that they piggy-back on the launching of other satellites and so are very cheap to launch. This is changing the cost–benefit equation of satellite ownership and use. Developing countries are increasingly dependent on space for communications, the internet and information on, for example, weather systems, coastal activities and agriculture. Another major development is the advent of asteroid mining. Asteroids contain a wide range of metals and minerals – some asteroids are more promising than others, and some are closer to Earth than others. Several companies have been set up and registered around the world to begin the exploitation of asteroids for precious metals (such as platinum) and compounds (such as rare-earth minerals).Legally, however, this will be a murky venture. The current international treaty regime prohibits the ownership of a celestial body by a country – space is for all. But does international law prohibit the ownership or exploitation of a celestial body by a private company? The law has yet to be tested, but there are space lawyers who think that companies are exempt. Luxembourg and Australia are two countries that have already begun the registration of interest for space-mining companies.As humanity becomes more dependent on information that is generated in or transmitted through space, the vulnerability to the manipulation of space data is increasing. The demands on the use of communications frequencies (the issue of spectrum availability and rights), managed by the International Telecommunication Union (ITU),[ii] need to be urgently addressed.There are now constant cyberattacks in space and on the digital information on which our systems rely. For example, position, navigation and timing information such as from GPS or Galileo is not only vital for getting us safely from A to B, but also for fast-moving financial transactions that require accurate timing signals.Almost all of our electronic systems depend on those timing signals for synchronization and basic functioning. Cyber hacks, digital spoofing and ‘fake’ information are now a real possibility. There is no rules-based order in place that is fit to deal with these types of attacks.Cyberweapons are only part of the problem. It is assumed that states, if they haven’t already done so, will be positioning ‘defensive’ space weaponry to protect their satellites. The protection may be intended to be against space debris – nets, grabber bars and harpoons, for example, are all being investigated.All of these ideas, however, could be used as offensive weapons. Once one satellite operator decides to equip its assets with such devices, many others will follow. The weaponization of space is in the horizon.There are no international rules or agreements to manage these developments. Attempts in Geneva to address the arms race in space have floundered alongside the inability of the Conference on Disarmament to negotiate any instrument since 1996.Attempts to develop rules of the road and codes of conduct, or even to begin negotiations to prohibit weapons in space, have failed again and again. There are no agreed rules to govern cyber activity. The Tallinn Manuals[iii] that address how international law is applicable to cyberwarfare also address the laws of armed conflict in space, but data spoofing and cyber hacking in space exist in far murkier legal frameworks.The current system of international space law – which does not even allow for a regular review and consideration of the OST – is struggling to keep up. Space is the inheritance of humankind, yet the current generation of elders – as they have done with so many other parts of our global environment – have let things go and failed to shepherd in the much-needed system of rules to protect space for future generations.It is not too late, but it will require international cooperation among the major space players: Russia, the US, China, India and Europe – hardly a promising line-up of collaborators in the current political climate.Filling the governance gapsNorms of behaviour and rules of the road need to be established for space before it becomes a 21st-century ‘wild west’ of technology and activity. Issues such as cleaning up space debris, the principle of non-interference, and how close satellites can manoeuvre to each other (proximity rules) need to be agreed as a set of international norms for space behaviour.A cross-regional group of like-minded countries (for example Algeria, Canada, Chile, France, India, Kazakhstan, Malaysia, Nigeria, Sweden, the UAE and the UK) should link up with UN bodies, including the Office for Outer Space Affairs (UNOOSA), COPUOS and ITU, and key private-sector companies to kick-start a new process for a global code of conduct to establish norms and regulate behaviour in space.The UN could be the host entity for this new approach – or it could be established in the way the Ottawa process for landmines was established, by a group of like-minded states with collective responsibility for, and collective hosting and funding of, the negotiations.A new approach should also cover cybersecurity in space. The UN processes on space and cyber should intersect more to find ways to create synergies in their endeavours. And the problems ahead as regards spectrum management – particularly given the large number of small satellites and constellations that are to be launched in the near future – need urgent attention in ITU.What needs to happenThe international rules-based order for space – enshrined in particular in the 1967 Outer Space Treaty – has not kept pace with the rapid and dramatic changes in the use of space. New norms of behaviour and rules of the road are needed.These norms and rules need to address a host of contemporary or prospective developments, including asteroid mining, increased numbers of satellite owners, the emergence of ‘mini-satellites’, cyberwarfare, and the potential deployment of ‘defensive’ space weaponry to protect satellites.A cross-regional group of like-minded countries should link up with UN bodies – including UNOOSA, COPUOS and ITU – and key private-sector companies to kick-start a new process for developing a global code of conduct.Problems related to radio spectrum management – given the large number of small satellites and constellations to be launched in the near future – need urgent attention in ITU.Notes[i] All of these treaties and other documents can be found at UN Office for Outer Space Affairs (2002), United Nations Treaties and Principles on Outer Space, http://www.unoosa.org/pdf/publications/STSPACE11E.pdf.[ii] ITU (undated), ‘ITU Radiocommunication Sector’, https://www.itu.int/en/ITU-R/Pages/default.aspx.[iii] The NATO Cooperative Cyber Defence Centre of Excellence (CCDCOE), ‘Tallinn Manual 2.0’, https://ccdcoe.org/research/tallinn-manual/.This essay was produced for the 2019 edition of Chatham House Expert Perspectives – our annual survey of risks and opportunities in global affairs – in which our researchers identify areas where the current sets of rules, institutions and mechanisms for peaceful international cooperation are falling short, and present ideas for reform and modernization. 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on The Destabilizing Danger of Cyberattacks on Missile Systems By feedproxy.google.com Published On :: Tue, 02 Jul 2019 08:40:06 +0000 2 July 2019 Dr Patricia Lewis Research Director, Conflict, Science & Transformation; Director, International Security Programme @PatriciaMary Dr Beyza Unal Senior Research Fellow, International Security Programme @beyzaunal Google Scholar ‘Left-of-launch’ attacks that aim to disable enemy missile systems may increase the chance of them being used, not least because the systems are so vulnerable. 2019-07-02-NKMissile.jpg This undated photo released by North Korea's news agency in March 2017 shows the launch of four ballistic missiles during a military drill at an undisclosed location in North Korea. Photo: STR/AFP/Getty Images. After President Trump decided to halt a missile attack on Iran in response to the downing of a US drone, it was revealed that the US had conducted cyberattacks on Iranian weapons systems to prevent Iran launching missiles against US assets in the region.This ‘left-of-launch’ strategy – the pre-emptive action to prevent an adversary launch missiles – has been part of the US missile defence strategy for some time now. President George W Bush asked the US military and intelligence community to infiltrate the supply chain of North Korean missiles. It was claimed that the US hacked the North Korean ballistic missile programme, causing a failed ballistic missile test, in 2012.It was not clear then – or now – whether these ‘left-of-launch’ cyberattacks aimed at North Korea were successful as described or whether they were primarily a bluff. But that is somewhat irrelevant; the belief in the possibility and the understanding of the potential impact of such cyber capabilities undermines North Korean or Iranian confidence in their abilities to launch their missiles. In times of conflict, loss of confidence in weapons systems may lead to escalation.In other words, the adversary may be left with no option but to take the chance to use these missiles or to lose them in a conflict setting. ‘Left of launch’ is a dangerous game. If it is based on a bluff, it could be called upon and lead to deterrence failure. If it is based on real action, then it could create an asymmetrical power struggle. If the attacker establishes false confidence in the power of a cyber weapon, then it might lead to false signalling and messaging.This is the new normal. The cat-and-mouse game has to be taken seriously, not least because missile systems are so vulnerable.There are several ways an offensive cyber operation against missile systems might work. These include exploiting missile designs, altering software or hardware, or creating clandestine pathways to the missile command and control systems.They can also be attacked in space, targeting space assets and their link to strategic systems.Most missile systems rely, at least in part, on digital information that comes from or via space-based or space-dependent assets such as: communication satellites; satellites that provide position, navigation and timing (PNT) information (for example GPS or Galileo); weather satellites to help predict flight paths, accurate targeting and launch conditions; and remote imagery satellites to assist with information and intelligence for the planning and targeting.Missile launches themselves depend on 1) the command and control systems of the missiles, 2) the way in which information is transmitted to the missile launch facilities and 3) the way in which information is transmitted to the missiles themselves in flight. All these aspects rely on space technology.In addition, the ground stations that transmit and receive data to and from satellites are also vulnerable to cyberattack – either through their known and unknown internet connectivity or through malicious use of flash drives that contain a deliberate cyber infection.Non-space-based communications systems that use cable and ground-to-air-to-ground masts are likewise under threat from cyberattacks that find their way in via internet connectivity, proximity interference or memory sticks. Human error in introducing connectivity via phones, laptops and external drives, and in clicking on malicious links in sophisticated phishing lures, is common in facilitating inadvertent connectivity and malware infection.All of these can create a military capacity able to interfere with missile launches. Malware might have been sitting on the missile command and control system for months or even years, remaining inactivated until a chosen time or by a trigger that sets in motion a disruption either to the launch or to the flight path of the missile. The country that launches the missile that either fails to launch or fails to reach the target may never know if this was the result of a design flaw, a common malfunction or a deliberate cyberattack.States with these capabilities must exercise caution: cyber offence manoeuvres may prevent the launch of missile attacks against US assets in the Middle East or in the Pacific regions, but they may also interfere with US missile launches in the future. Even, as has recently been revealed, US cyber weapons targeting an adversary may blow back and inadvertently infect US systems. Nobody is invulnerable. Full Article
on Policy Implications of Armed Drone Use By feedproxy.google.com Published On :: Thu, 01 Aug 2019 13:15:02 +0000 This project brings together experts on the use of armed drones, including current and former military officials, academia, think-tanks and NGOs, to discuss and exchange perspectives based on their different experiences, with the aim of sharing knowledge and increasing understanding on these issues, and to inform and provide input into the European debate. With the increased use of armed drones in recent years, ethical and legal concerns have been raised in regard to civilian casualties, secrecy and lack of transparency and accountability for drone strikes.This project brings together experts on the use of armed drones, including current and former military officials, academia, think-tanks and NGOs, to discuss and exchange perspectives based on their different experiences, with the aim of sharing knowledge and increasing understanding on these issues, and to inform and provide input into the European debate. The experts explore the issues and controversies surrounding the use of drones outside formal armed conflict and study the broader policy implications in detail, particularly with regards to what this means for the UK and other European countries.Building on the findings from the workshops, this project will hold a simulation exercise to stress test critical areas of concern around the use of armed drones that are relevant for the UK and other EU member states.The discussions and the simulation exercise will provide opportunities for policy input on areas of mutual concern and feed into practical policy recommendations on the use of armed drones.This project builds on previous work on armed drones by the International Security Department and is funded by the Open Society Foundations. Past events (2) Research Event The Implications of Drone Proliferation in Europe 20 May 2019 Research Event Transparency and Accountability for Drone Use: European Approaches 11 March 2019 More on Policy Implications of Armed Drone Use Full Article
on Dorothy Gordon By feedproxy.google.com Published On :: Thu, 01 Aug 2019 15:21:32 +0000 Associate Fellow, International Security Programme and Global Economy and Finance Programme Biography Dorothy was the founding director general of the Ghana-India Kofi Annan Centre of Excellence in ICT, a position which she held for over a decade.She works globally as a policy adviser, evaluator, project manager and organizational management consultant.Over the course of her 30-year career in international development and technology she has held management positions with the UN and global management consulting firms on four continents.As a strong advocate of the importance of building robust local innovation ecosystems based on open source technologies, she serves on the board and as a mentor to a number of start-ups and NGOs focused on women in tech. Full Article
on Cyber Governance in the Commonwealth: Towards Stability and Responsible State Behaviour in Cyberspace By feedproxy.google.com Published On :: Mon, 05 Aug 2019 14:05:02 +0000 Invitation Only Research Event 7 October 2019 - 10:30am to 5:30pm Addis Ababa, Ethiopia This roundtable is part of a series under the project, 'Implementing the Commonwealth Cybersecurity Agenda', funded by the UK Foreign and Commonwealth Office (FCO). The roundtable aims to provide a multi-stakeholder, pan-Commonwealth platform to discuss how to implement the Commonwealth Cyber Declaration with a focus on its third pillar 'To promote stability in cyberspace through international cooperation'.In particular, the roundtable focuses on points 3 and 4 of the third pillar which revolve around the commitment to promote frameworks for stability in cyberspace including the applicability of international law, agreed voluntary norms of responsible state behaviour and the development and implementation of confidence-building measures consistent with the 2015 report of the UNGGE. The workshop also focuses on the commitment to advance discussions on how existing international law, including the Charter of the United Nations and applicable international humanitarian law, applies in cyberspace.The roundtable addresses the issue of global cyber governance from a Commonwealth perspective and will also include a discussion around the way forward, the needed capacity of the different Commonwealth countries and the cooperation between its members for better cyber governance.Participants include UNGGE members from Commonwealth countries in addition to representatives to the UN Open-Ended Working Group from African countries as well as members from academia, civil society and industry. Department/project International Security Programme Calum Inverarity Research Analyst and Coordinator, International Security Department +44 (0) 207 957 5751 Email Full Article
Calum Inverarity Research Analyst and Coordinator, International Security Department +44 (0) 207 957 5751 Email