In patients with renal impairment (n = 22 of 39), the median serum concentrations of linezolid, PNU-142300, and PNU-142586 were 1.6-, 3.3-, 2.8-fold higher, respectively, than in patients without renal impairment. Metabolite concentrations in paired samples were poorly correlated with linezolid concentrations (r² = 0.26 for PNU-142300 and 0.06 for PNU-142586). Linezolid and its metabolites share potential toxicophores that deserve characterization to mitigate higher myelosuppression risk in patients with renal impairment.

Tens of thousands of new apartments enter the Ho Chi Minh City market every year, putting pressure on investors who want to reap returns from rental apartments.

Robots are replacing manufacturing workers in France, making companies more productive and reducing employment across the industry

Get an all day breakfast on a pizza before you go on your killing spree. Only psychopaths will order this, is what I'm saying.

Alison Roman’s latest comments about Marie Kondo have not sparked joy.

In an interview with The New Consumer about her increased popularity and the avenues she might pursue to capitalize on it, the popular food columnist discussed her hesitance to put her name on a product line—citing the Japanese organization maven and Chrissy Teigen as examples of what she did not foresee in her own future.

“I have a collaboration coming out with [the cookware startup] Material, a capsule collection,” Roman said. “It’s limited edition, a few tools that I designed that are based on tools that I use that aren’t in production anywhere—vintage spoons and very specific things that are one-offs that I found at antique markets that they have made for me.”

Read more at The Daily Beast.

BRITAIN'S summer holiday destinations will face some of the biggest economic hits of the coronavirus pandemic with fears of massive job losses in coastal communities, a study has claimed.

Big Oil Companies Face Tough Comparisons as Earnings Near American and European oil giants spend a lot of time talking about their differentiated strategies and approaches to hot-button issues such as climate change. But their bottom lines are still primarily driven by the same common factor: commodity prices. That shared reality doesn’t bode well for […]

Saudi Aramco’s IPO saga has turned into “A Tale of Two Princes.” As Saudi Arabia’s day-to-day ruler Crown Prince Mohammed bin Salman has guided the IPO far from public view, his half-brother Prince Abdulaziz bin Salman stepped onto center stage in Vienna last week, presiding over a crucial gathering of OPEC and its oil-producing allies […]

Tottenham will need to be creative in the transfer market this summer.

Liverpool are looking to make Sadio Mane an offer that would tarnish Real Madrid's hopes of signing him.

The summer transfer window is nearly upon us as Manchester United, Chelsea, Liverpool, Arsenal and the rest of the Premier League look to strengthen for whenever the new season starts. Express Sport brings you the latest updates throughout the day.

There’s nothing like crash-landing on an alien planet. Journey to the Savage Planet doesn't always get it right, but it has echoes of classic Metroid Prime, says Jacob Aron

If he can win the battle for our screens, he can benefit from the death of the traditional presidential campaign.

John Deere, the nearly 200-year-old tractor manufacturer, now considers itself a software company

MIT conference considers companies that have implemented job-friendly AI

This is a video from Russia's Zapad-2017 military exercises where a KA-52 Alligator helicopter accidentally fired two missiles towards a group of journalists covering the event (allegedly as a result of a short-circuit in the helicopter's electric system according to the Russian military *eyebarrelroll*). Three of the journalists were injured in the incident (amazingly not critically either), including the one seen strolling along the highway to the danger zone the video. Man, those missiles come QUICK. If you think you're gonna outrun one of those things like a tarantula in Animal Crossing, think again. I mean sure The Flash could do it, but he could also pleasure himself infinitely in the time it took you to read this article. "Huh?" How his penis doesn't catch fire is beyond me, there must be other superpowers at play too. Keep going for a couple versions of the video (the second with slow-mos), as well as a news report which includes the copter's gun view.

New Pokemon Go Throwback challenges start today for the Johto region. Here's a recap of all field research tasks and rewards on offer for the next seven days.

Square Enix decides to just make FFXV a constantly updated demo. NISA decides that you really should play The Witch and the Hundred Knight. Female...

With barbers closed, actors and footballers have resorted to shaving off their hair - but experts warn it isn’t for everyone

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With salons closed due to physical distancing guidelines, many men have resorted to cutting their hair at home. And instead of opting for a short back and sides, male celebrities have decided to just shave all their hair off.

Riz Ahmed, the Rogue One and Four Lions actor, has labelled it the #stayathome haircut, and Line of Duty actor Stephen Graham posted footage of his son clipping off his hair with the caption “lockdown locks!”

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Sustainable fashion collaboration featuring only biodegradable fabrics will be sold online

John Lewis and the fashion brand Mother of Pearl have chosen Earth Day for the launch of their sustainable fashion collaboration, specifically for its geopolitical symbolism.

Earth Day, which celebrates its 50th anniversary on 22 April, seemed an appropriate day to launch a collection bringing rigorous standards of ethical design to mass market fashion. A launch date that pays homage to the planet rather than the artificial seasons of fashion, and dovetails with the concept of timeless, seasonless clothes designed for wardrobe longevity.

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Gregory McMichael and his son, Travis, were both charged with murder and aggravated assault.

Despite having made 130 more films – including six Tarantinos – Jackson trails king of the curse word Hill. But then he wasn’t in The Wolf of Wall Street …

With the movie industry shut down due to coronavirus, now is a valuable time for us to look back and properly examine the attraction that we have to certain figures. Are we drawn to Tom Hanks because he exudes a sense of benevolent paternalism that we tend to find subconsciously appealing? Do we flock to Marvel films because we seek the clarity of a good-v-evil dynamic in a world where those are becoming increasingly opaque?

And why do people go and see Jonah Hill films? Seriously, why?

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Ad-Rock and Mike D host a convivial trip down memory lane in this filmed record of a live show staged in tribute to third member Adam Yauch

The release of this documentary coincides with #MeAt20, a heart-twisting craze on social media for posting pictures of yourself at 20 years old. Middle-aged people’s timelines are speckled with funny, sweet and sometimes unbearably sad images of themselves in unlined, unformed youth, doing goofy things in milky analogue pictures from back when you had 12 or 24 exposures on your roll-film camera and getting them developed at Boots was a pricey business. That’s what I thought of while watching this engaging, oddly moving film from Spike Jonze: a record of the live stage show he devised at the Kings Theatre in Brooklyn, New York, in tribute to white hip-hop stars and tongue-in-cheek party-libertarian activists the Beastie Boys. It is presented by the two surviving members, Adam Horovitz and Michael Diamond, in tribute to the third member, Adam Yauch, who died of cancer in 2012. Jonze is reuniting with the band after having directed a string of their music videos, including the crime-TV spoof for their single Sabotage in 1994.

Horovitz and Diamond amble on stage, apparently dressed head-to-toe in Gap, and appear for all the world to be about to unveil the iPhone 4S, although actually their jokey anecdotalism makes the show in some ways like the regional tours once presented by George Best and Rodney Marsh. With amiably rehearsed back-and-forth banter, they introduce the embarrassing photos and excruciating TV clips that are shown on a big screen. And the effect of seeing them juxtaposed with the plump-faced frizzy-haired imps of 1986 is startling and bizarre. In the present day, the advancing years seem to have boiled away the badass attitude, leaving behind the quirky humour.

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Elizabeth Sankey’s fine documentary on the genre, premiering on Mubi, could be the perfect spark for your own romantic comedy love-in

Romantic comedies are a perennially undervalued genre: even very fine ones are often described as “guilty pleasures”. That’s always a nonsense term, given that no pleasure is without value or grace – least of all these days. Under lockdown, don’t you find yourself more inclined towards romantic comedies both great and mediocre, to sink yourself in the familiar warmth of stories driven by love and tenderness, where everything tends to turn out fine?

Mubi has thus chosen an opportune moment to premiere Romantic Comedy, a spry, affectionate documentary by musician turned film-maker Elizabeth Sankey that gives this maligned genre its due. A short, accessible film essay that did the festival rounds last year, it cuts to the heart of why romcoms have to work harder to be taken seriously – hint: they tend to prioritise the female viewer – and unpicks their history of flawed gender politics and heteronormative bias. But it’s a loving exercise, overlaid with droll personal commentary, and one that will have you jotting down a playlist of films to watch right after.

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Jodian Self is hanging out with some of the biggest names in pro sports these days — all from the comfort of her south Winnipeg home. The 52-year-old former physical education ...

Go ahead and applaud taking down a group of boorish hockey “bros” for their despicable behaviour. But you might want to hold off on a full-fledged victory lap. Brendan Leipsic said ...

More than 20 million Americans lost their jobs in the last month, and unemployment among African-Americans has hit 16.7 percent.

In fact, why not join them?

Multiwavelength observations from the NASA/ESA Hubble Space Telescope and Gemini Observatory combined with close-up views from NASA’s Juno spacecraft reveal that lightning strikes and huge storm systems that create them in Jupiter’s atmosphere are formed in and around large convective cells over deep clouds of water ice and liquid; the observations also confirm that dark [...]

The U.S. government reported more catastrophic economic fallout from the coronavirus crisis on Friday as the pandemic pierced the very walls of the White House and California gave the green light for its factories to restart after a seven-week lockdown.

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week.

The Tokyo Olympics was postponed for a year to 2021 in the aftermath of the coronavirus pandemic.

If Judy Becker is forced to pick a side in “Feud: Bette and Joan,” the production designer for the FX series says she’s team Bette Davis, but she’d rather live in Joan Crawford’s house. “We designed an amazing closet for her and I can’t deny that I would love to have that,” she says. The […]

The Roses are Red Challenge has caught the internet and has become a fad now as the netizens are coming up with a hilarious line which rhyme with roses are red. It is the netizens who have started this trend amid lockdown and most of them are making their own versions of their poems. Most of them tickle your funny bone with the one-liners which have caught the attention of the Internet users.

The Portuguese midfielder is settling into life in east London well after his loan move.

ROGER FEDERER has explained why he gets injured less than rivals Rafael Nadal and Novak Djokovic..

Arsenal and England midfielder Jordan Nobbs will be a columnist for 90min & BBC Sport pundit at the Women's World Cup in France this summer, as Phil Neville's Lionesses' look to secure a maiden World Cup triumph. Two wins from our first two games is obviously what we were all hoping for. The first game of a World Cup, or any other major tournament, is never going to be one where you're playing at your absolute best. But the 2-1 win over was Scotland was great given the pre-match hype, the..

Singer Lance Bass turned 41 on 4 May.

John Legend joins Zane Lowe on Apple Music to run through his ‘At Home With’ playlist. He talks about how he’s coping at home

At present, Friends star Courteney Cox is staying at home in Malibu, California.

Ciara is already mum to daughter Sienna, three, and five-year-old son Future.

The 87-year-old record producer - who worked extensively with Michael at the height of his pop career - was originally awarded

Prosecutor Tom Durden has vowed to convene a grand jury to discuss possible charges against the suspects - but only when coronavirus pandemic restrictions are eased, which could take several weeks.

Ciara also opened up about the challenges of co-parenting with her husband, National Football League quarterback Russell Wilson, during the COVID-19 lockdown.

Nicki wed Kenneth Petty last year.

Nobody does it like Mr Jordan. Let it be on...

The post Michael Jordan’s ‘The Last Dance’ Is Currently The World’s Most Famous Documentary appeared first on Man's World India.

Actor Nicolas Cage has played some colourful characters throughout his...

The post Nicolas Cage To Play Joe Exotic In Upcoming ‘Tiger King’ TV Series appeared first on Man's World India.

Stranger Things has grown to become one of the most...

The post Stranger Things Season 4 Will Be “A Lot Scarier,” Says Joe Keery appeared first on Man's World India.