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A photothermal-hypoxia sequentially activatable phase-change nanoagent for mitochondria-targeting tumor synergistic therapy

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00003E, Paper
Jia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui Wang
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.
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Long-term delivery of alendronate through an injectable tetra-PEG hydrogel to promote osteoporosis therapy

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00376J, Paper
Dawei Li, Jin Zhou, Mingming Zhang, Yuanzheng Ma, Yanyu Yang, Xue Han, Xing Wang
An alendronate-loaded tetra-PEG hydrogel, as an injectable and effective drug carrier, regulates the optimized release of therapeutic cargoes to promote osteoporosis therapy and bone regeneration.
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Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01872G, Review Article
Ratchapol Jenjob, Treethip Phakkeeree, Daniel Crespy
Core–shell particles offer significant advantages in their use for bioimaging and biosensors.
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Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6Al4V for treating methicillin-resistant Staphylococcus aureus bone infection and enhancing osteogenesis in a rabbit tibia osteomyelitis model

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01968E, Paper
Teng Zhang, Qingguang Wei, Hua Zhou, Wenhao Zhou, Daoyang Fan, Xinhong Lin, Zehao Jing, Hong Cai, Yan Cheng, Xiaoguang Liu, Weishi Li, Chunli Song, Yun Tian, Nanfang Xu, Yufeng Zheng, Zhongjun Liu
Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6A14V for treating MRSA bone infection and enhancing osteogenesis.
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A pH-responsive dissociable mesoporous silica-based nanoplatform enabling efficient dual-drug co-delivery and rapid clearance for cancer therapy

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00204F, Paper
Yongju He, Linjie Shao, Ibrahim Usman, Yao Hu, Anqiang Pan, Shuquan Liang, Hui Xu
The dilemma between tumor accumulation and renal clearance has severely limited the efficacy of mesoporous silica-based drug nanocarrier in cancer therapy. Herein, a pH-responsive dissociable mesoporous silica-based nanoplatform with efficient...
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Photothermal augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00549E, Paper
Tianhong Teng, Ronggui Lin, Ziguo Lin, Kun Ke, Xianchao Lin, Maoen Pan, Da Zhang, Heguang Huang
Preparation of Abraxane@MoSe2 and its PTT effect augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode.
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19 F magnetic resonance imaging enabled real-time, non-invasive and precise localization and quantification of the degradation rate of hydrogel scaffolds in vivo

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00278J, Paper
Qinghua Li, Zujian Feng, Huijuan Song, Jianhua Zhang, Anjie Dong, Deling Kong, Weiwei Wang, Pingsheng Huang
19 F MRI is able to precisely monitor the localization and quantify the degradation rate of implantable/injectable hydrogels in real-time and noninvasive manner, with no interference of endogenous background signals and limitation of penetration depth.
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ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00147C, Paper
Open Access
Junxiong Qiu, Peng Peng, Min Xin, Zhenkang Wen, Zhong Chen, Sipeng Lin, Manyuan Kuang, Yuan Fu, Guibin Fang, Shixun Li, Changchuan Li, Jiaji Mao, Ling Qin, Yue Ding
Aseptic loosening (AL) caused by wear particles released from implant surfaces is one of the main causes for the failure of artificial joints, which is initiated by macrophage inflammatory responses.
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Disulfiram-Gold-Nanorod Integrate for Effective Tumor Targeting and Photothermal-Chemical Synergistic Therapy

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00062K, Paper
Chaoli Xu, Ting Zhang, Guangming Lu, Kun Chen, Jun Tao, Yunlei Zhang, Zhaogang Teng, Bin Yang
Herein, we successfully constructed a combined therapeutic nanoplatform with high tumor targeting for cancer treatment by integrating gold nanorods with disulfiram (denoted Au-DSF). The Au-DSF integrates possess a uniform length...
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A disulfide based low molecular weight gel for the selective sustained release of biomolecules

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00508H, Paper
Nitin D. Bansode, Kotagudda Ranganath Sindhu, Chloe Morel, Murielle Rémy, Julien Verget, Claudine Boiziau, Philippe Barthélémy
Constructing biocompatible soft materials via supramolecular approaches remains an important challenge for in vivo applications.
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Multifunctional Antibacterial Dental Sealants Suppress Biofilms Derived from Children at High Risk of Caries

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00370K, Paper
Maria Salem Ibrahim, Isadora Martini Garcia, Taissa Vila, Abdulrahman A. Balhaddad, Fabricio Mezzomo Collares, Michael D Weir, Huakun Xu, Mary Anne Melo
Dental caries in children is a leading worldwide concern for oral health. Combining antibacterial and remineralizing additives within dental sealants is a promising approach for caries prevention. Saliva contains oral...
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Naturally available hypericin undergoes electron transfer for type I photodynamic and photothermal synergistic therapy

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Biomater. Sci., 2020, 8,2481-2487
DOI: 10.1039/D0BM00021C, Paper
Zhen Ke, Aize Xie, Jianjiao Chen, Zhenyuan Zou, Lei Shen, Yansong Dai, Dengfeng Zou
Hypericin undergoing electron transfer can be used for type I PDT and PTT.
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Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy

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Biomater. Sci., 2020, 8,2472-2480
DOI: 10.1039/D0BM00172D, Paper
Haishi Qiao, Xingmei Chen, Qiming Wang, Junmei Zhang, Dechun Huang, Enping Chen, Hongliang Qian, Yinan Zhong, Qi Tang, Wei Chen
Illustration of pH-degradable microgels (MGs) for the simultaneous encapsulation of OA and JQ1 for an enhanced oncolytic viral treatment with JQ1-meidated boosting viral replication and PD-L1 suppression.
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Spatial immobilization of endogenous growth factors to control vascularization in bone tissue engineering

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Biomater. Sci., 2020, 8,2577-2589
DOI: 10.1039/D0BM00087F, Paper
Marta R. Casanova, Catarina Oliveira, Emanuel M. Fernandes, Rui L. Reis, Tiago H. Silva, Albino Martins, Nuno M. Neves
An engineered biofunctional system comprises endogenous BMP-2 and VEGF bound in a parallel pattern. It successfully enabled obtaining the spatial osteogenic and angiogenic differentiation of human hBM-MSCs under basal culture conditions.
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H2S-releasing amphiphilic dipeptide hydrogels are potent S. aureus biofilm disruptors

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Biomater. Sci., 2020, 8,2564-2576
DOI: 10.1039/D0BM00241K, Paper
Yun Qian, Afnan Altamimi, Shaina Alston Yates, Santu Sarkar, Matthew Cochran, Mingjun Zhou, Nicole Levi-Polyachenko, John B. Matson
Hydrogen sulfide (H2S) is an endogenous signaling gas, and exogenous H2S administration has the potential for promoting wound healing. Here we investigate the antimicrobial effects of H2S-releasing hydrogels in the context of burn wound healing.
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Nanomedicine – a promising therapy for hematological malignancies

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Biomater. Sci., 2020, 8,2376-2393
DOI: 10.1039/D0BM00129E, Review Article
Lifen Huang, Jun Huang, Junbin Huang, Hongman Xue, Zhiqing Liang, Jun Wu, Chun Chen
Nanoparticles (NPs) are used for the diagnosis and treatment of hematological tumors by loading various pharmacodynamic molecules.
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A thermo-responsive, self-assembling biointerface for on demand release of surface-immobilised proteins

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Biomater. Sci., 2020, 8,2673-2681
DOI: 10.1039/C9BM01957J, Paper
Angela Saccardo, Mikhail Soloviev, Enrico Ferrari
Engineering of the neuronal SNARE proteins yields chimeric bio-materials that reversibly assemble and disassemble at set temperatures.
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Biodegradable nanocomposite fibrous scaffold mediated local delivery of vancomycin for the treatment of MRSA infected experimental osteomyelitis

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Biomater. Sci., 2020, 8,2653-2665
DOI: 10.1039/D0BM00140F, Paper
Amit G. Krishnan, Raja Biswas, Deepthy Menon, Manitha B. Nair
The study shows the development of a biodegradable bi-functional composite scaffold that can reduce bacterial infection, while promotes bone regeneration in osteomyelitis, without the need for revision surgery.
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An intelligent vancomycin release system for preventing surgical site infections of bone tissues

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00255K, Paper
Yuan Li, Guang Li, Xiaoling Sha, Litao Li, Kuo Zhang, Daohong Liu, Yanfei Hao, Xu Cui, Lei Wang, Hao Wang
An intelligent anti-bacterial system can be constructed on implants during surgery.
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Coupling PEG-LZM Polymer Network with Polyphenol Yields Suturable Biohydrogel for Tissue Patching

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00429D, Paper
Haoqi Tan, Junjie Sun, Dawei Jin, Jialin Song, Miao Lei, Artem Antoshin, Xin Chen, Meng Yin, Xue Qu, Changsheng Liu
Poor mechanical performances severely limit the application of hydrogel in vivo, for example, it is difficult to perform a very common suturing operation on hydrogel during surgery. There is a...
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A transport system based on a quantum dot-modified nanotracer is genetically and developmentally stable in pregnant mice

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00311E, Paper
Open Access
Hye Jin Kim, Ji Sun Park, Se Won Yi, Minyeon Go, Hye-Ryun Kim, Su Jin Lee, Jong Min Park, Dong Hyun Cha, Sung Han Shim, Keun-Hong Park
The use of nanoscale materials (NMs) could cause problems such as cytotoxicity, genomic aberration, but the impacts of NM exposure during pregnancy remain uncharacterized in the context of clinical applications.
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A biomimetic orally targeted delivery of Bindarit for immunotherapy of atherosclerosis

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00418A, Paper
Luqi Yin, Cuiping Peng, Yue Tang, Yuchuan Yuan, Jiaxing Liu, Tingting Xiang, Feila Liu, Zhou Xing, Xiaohui Li
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of atherosclerosis. However, the application of bindarit (a specific synthetic inhibitor of MCP-1) in atherosclerosis has not been confirmed...
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Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide

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Toxicol. Res., 2019, 8,850-861
DOI: 10.1039/C9TX00067D, Paper
Wei Huang, Chuanxin Liu, Lijuan Xie, Yuming Wang, Yanyan Xu, Yubo Li
Integrated network pharmacology and targeted metabolomics to reveal the nephrotoxicity mechanism of triptolide.
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Eco-friendly synthesis of glutathione-capped CdTe/CdSe/ZnSe core/double shell quantum dots: their cytotoxicity and genotoxicity effects on Chinese hamster ovary cells

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Toxicol. Res., 2019, 8,868-874
DOI: 10.1039/C9TX00113A, Paper
Neo Mervyn Monaheng, Sundararajan Parani, Mary Gulumian, Oluwatobi Samuel Oluwafemi
In this work, we report green one-pot synthesis, cytotoxicity and genotoxicity of glutathione-capped CdTe/CdSe/ZnSe heterostructured quantum dots (QDs) using a label-free xCELLigence RTCA system as well as the Cytokinesis Blocked Micronucleus assay.
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Tin thiocarbonohydrazone complexes: synthesis, crystal structures and biological evaluation

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Toxicol. Res., 2019, 8,862-867
DOI: 10.1039/C9TX00109C, Paper
Jin Wang, Yu-Ting Wang, Yan Fang, Yan-Li Lu, Ming-Xue Li
Three organotin thiocarbonohydrazone complexes have been synthesized, and growth inhibition assays indicated that complex 3 has the highest tumor cell selectivity.
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Kaempferol derivatives isolated from Lens culinaris Medik. reduce DNA damage induced by etoposide in peripheral blood mononuclear cells

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Toxicol. Res., 2019, 8,896-907
DOI: 10.1039/C9TX00176J, Paper
Magdalena Kluska, Michał Juszczak, Daniel Wysokiński, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak
Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy.
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Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use” by D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489

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Toxicol. Res., 2019, 8,1057-1058
DOI: 10.1039/C9TX00158A, Comment
Michael E. Mullins, Mark C. Yarema, Marco L. A. Sivilotti, Margaret Thompson, D. Adam Algren, Michael C. Beuhler, Christopher P. Holstege
We point out an acetylcysteine protocol that a previous article (D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489–498) overlooked.
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Characteristic synergistic cytotoxic effects toward cells in graphene oxide dressing with cadmium and copper ions

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Toxicol. Res., 2019, 8,908-917
DOI: 10.1039/C9TX00146H, Paper
Yiyang Dong, Yulin Chang, Haidi Gao, Victoria Arantza León Anchustegui, Qiang Yu, Haifang Wang, Jia-Hui Liu, Shihui Wang
Cadmium ions exerted synergistic toxic effects with graphene oxide on Hela cells.
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Gynura divaricata ameliorates hepatic insulin resistance by modulating insulin signalling, maintaining glycolipid homeostasis and reducing inflammation in type 2 diabetic mice

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Toxicol. Res., 2019, 8,928-938
DOI: 10.1039/C9TX00191C, Paper
Xuan Dong, Shu-Xiang Zhao, Bing-Qing Xu, Yu-Qing Zhang
Oral lyophilized powder of Gynura divaricata, an edible medicinal plant, can alleviate both hyperglycaemia and hepatic insulin resistance in type 2 diabetic mice.
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Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics

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Toxicol. Res., 2019, 8,953-963
DOI: 10.1039/C9TX00147F, Paper
Fatemeh Amereh, Akbar Eslami, Simin Fazelipour, Mohammad Rafiee, Mohammad Ismail Zibaii, Mohammad Babaei
At this time, little is known about the long-term effects of micro(nano)plastics on public health. In the present study, early warning signs of thyroid endocrine disruption were noticed in adult Wistar rats from the ingestion of virgin polystyrene nanoparticles.
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Environmental distribution of the neurotoxin L-BMAA in Paenibacillus species

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Toxicol. Res., 2019, 8,781-783
DOI: 10.1039/C9TX00203K, Viewpoint
Peter B. Nunn, Geoffrey A. Codd
The neurotoxic amino acid, 3-N-methyl-2,3-diaminopropanoic acid (BMAA), known in plants of the genus Cycas and in aquatic cyanobacteria and other organisms, is a component of antibiotic peptides in two species of Paenibacillus.
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Reply to the ‘Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use”’ by M. E. Mullins, M. C. Yarema, M. L. A. Sivilotti, M. Thompson, D. A. Algren, M. C. Beuhler and C. P. Holstege, Toxicol. Res., 2019, 8, DOI: 10.1039/C9T

By pubs.rsc.org
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Toxicol. Res., 2019, 8,1059-1059
DOI: 10.1039/C9TX00216B, Comment
Open Access
D. Nicholas Bateman, James W. Dear
Mullins et al. made a comment on our article (DOI: 10.1039/C9TX00002J) stating they noticed the omission of the one-bag, standard concentration protocol which is shared by several centers in North America when we discussed IV acetylcysteine protocols.
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Biogenic Aspergillus tubingensis silver nanoparticles’ in vitro effects on human umbilical vein endothelial cells, normal human fibroblasts, HEPG2, and Galleria mellonella

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Toxicol. Res., 2019, 8,789-801
DOI: 10.1039/C9TX00091G, Paper
Cristiane Angélica Ottoni, Durvanei Augusto Maria, Priscila Jane Romano de Oliveira Gonçalves, Welington Luiz de Araújo, Ana Olívia de Souza
Biogenic silver nanoparticles are ecofriendly and offers valuable possibilities of applications in several industrial areas.
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Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats

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Toxicol. Res., 2019, 8,939-952
DOI: 10.1039/C9TX00221A, Paper
Israa F. Mosa, Mokhtar Youssef, Maher Kamel, Osama F. Mosa, Yasser Helmy
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
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Mice with a Sertoli cell-specific knockout of the Ctr1 gene exhibit a reduced sensitivity to cisplatin-induced testicular germ cell apoptosis

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Toxicol. Res., 2019, 8,972-978
DOI: 10.1039/C9TX00142E, Paper
Open Access
Rashin Ghaffari, John H. Richburg
Exposure to the chemotherapeutic agent cis-diamminedichloroplatinum(II) (cDDP) is well known to instigate acute and prolonged testicular injury in male patients.
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Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials

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Toxicol. Res., 2019, 8,979-987
DOI: 10.1039/C9TX00227H, Paper
Saavia Alice Naame, Decheng Li, Ruixue Huang
Diabetes mellitus is of major public health concerns; its incidence is continuously increasing.
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Astilbin attenuates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB pathway

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Toxicol. Res., 2019, 8,1002-1008
DOI: 10.1039/C9TX00222G, Paper
Jing Li, Zhaowei Gu, Yue Liu, Yu Wang, Min Zhao
Ischemic stroke is the second most common cause of death worldwide and cerebral ischemia/reperfusion (I/R) injury also leads to serious tissue damage.
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Astaxanthin reduces perfluorooctanoic acid cytotoxicity in Saccharomyces cerevisiae

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Toxicol. Res., 2019, 8,1009-1015
DOI: 10.1039/C9TX00215D, Paper
S. J. Sudharshan, Raghavendra Tirupathi, Madhu Dyavaiah
Perfluorooctanoic acid (PFA) has been identified as an environmental contaminant of high concern for human health.
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Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae

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Toxicol. Res., 2019, 8,1035-1041
DOI: 10.1039/C9TX00139E, Paper
Abhishek Raj, Vasanthi Nachiappan
BQ exposure inhibited cell growth, increased the ROS-mediated apoptosis, and altered the phospholipids that resulted in membrane proliferation.
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Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

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Toxicol. Res., 2019, 8,1042-1049
DOI: 10.1039/C9TX00240E, Paper
Yuexiang Niu, Engong Tang, Qingan Zhang
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.
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AIIB extends $500 mn loan to India to deal with coronavirus crisis

By www.business-standard.com
Published On :: Fri, 08 May 2020 10:44:00 +0530

The bank's board of directors has approved a loan to India to strengthen the preparedness of the country's national health system


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Franklin Templeton issues apology to Sebi for global chief's remarks

By www.business-standard.com
Published On :: Fri, 08 May 2020 11:13:00 +0530

Stung by the comments made by the global chief, market regulator on Thursday issued a press release defending the new rules it introduced in October last year


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US Federal Reserve won't take rates negative, say fund managers, economists

By www.business-standard.com
Published On :: Fri, 08 May 2020 13:40:00 +0530

Fed funds futures, which are a gauge of where markets expect the Fed's benchmark overnight lending rate to be, are now pricing in a slightly negative rate environment beginning in December


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Only 13% of industrial units resume ops after Odisha eases lockdown

By www.business-standard.com
Published On :: Fri, 08 May 2020 17:29:00 +0530

Micro units in the state have not been able to resume operations to catch up with their larger peers


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Amarinder Singh asks administration to ensure welfare of migrant workers

By www.business-standard.com
Published On :: Fri, 08 May 2020 17:53:00 +0530

The chief minister asked the industry ministry to "aggressively" pursue the development of the four industrial parks already announced by the state government in the budget for this fiscal.


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CBDT orders tax officials to not issue scrutiny notices to taxpayers

By www.business-standard.com
Published On :: Fri, 08 May 2020 20:29:00 +0530

Move comes after a group of IRS created panic and tax policy uncertainty


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Lockdown period not to be counted for determining residency of NRIs: CBDT

By www.business-standard.com
Published On :: Fri, 08 May 2020 23:12:00 +0530

There were apprehensions that this extended stay could lead to these individuals becoming Indian residents as per Section 6 of the Income Tax Act


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Additional borrowing to widen fiscal deficit, but help govt perk up economy

By www.business-standard.com
Published On :: Fri, 08 May 2020 23:50:00 +0530

He did not think that the move will crowd out borrowings of the private sector, saying demand of the government and the private sector are not contradictory in these circumstances


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FM to discuss credit flow to NBFCs, businesses with banks on Monday

By www.business-standard.com
Published On :: Sat, 09 May 2020 00:00:00 +0530

The FM will take stock of the credit sanction and disbursement by the banks since March 1, 2020, and the Covid-19-related emergency credit lines opened by the lenders


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Covid-19: Relief for NRIs, foreign visitors as tax residency rules eased

By www.business-standard.com
Published On :: Sat, 09 May 2020 02:08:00 +0530

The government imposed a lockdown on March 24 and is yet to open up travel, including international flights.


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