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[ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic>

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Published On :: Thu, 07 May 2020 04:00:00 GMT

ACS Synthetic Biology

DOI: 10.1021/acssynbio.0c00028

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[ASAP] Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids

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Published On :: Thu, 07 May 2020 04:00:00 GMT

ACS Synthetic Biology

DOI: 10.1021/acssynbio.0c00038

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Christians and the Coronavirus

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Published On ::

Do not be anxious and seek first the kingdom of God.

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[ASAP] MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <italic toggle="yes">Mycobacterium tuberculosis</italic>

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Published On :: Sun, 19 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00003

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[ASAP] Molecule Property Analyses of Active Compounds for <italic toggle="yes">Mycobacterium tuberculosis</italic>

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Published On :: Mon, 20 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02075

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[ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

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Published On :: Tue, 21 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02164

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[ASAP] Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties

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Published On :: Wed, 22 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00117

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[ASAP] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

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Published On :: Wed, 22 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00035

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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

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Published On :: Thu, 23 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00641

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[ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma

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Published On :: Thu, 23 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02161

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[ASAP] Correction to Toggling Preassembly with Single-Site Mutation Switches the Cytotoxic Mechanism of Cationic Amphipathic Peptides

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00608

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[ASAP] Molecular Interactions of Pyrazine-Based Compounds to Proteins

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02021

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[ASAP] Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00388

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[ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00227

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[ASAP] Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02097

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[ASAP] Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <italic toggle="yes">In Vivo</italic> Antitumor Activity

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00547

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[ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02035

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[ASAP] Discovery of (2<italic toggle="yes">R</italic>)-<italic toggle="yes">N</italic>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<italic toggle="yes">H</italic>-indol-7

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b01392

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[ASAP] Correction to Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00599

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[ASAP] Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b01336

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[ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00202

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[ASAP] Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00015

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[ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle>

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Published On :: Fri, 01 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02126

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[ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

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Published On :: Mon, 04 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00339

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[ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00215

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[ASAP] Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via <sup>15</sup>N Direct Detection Nuclear Magnetic Resonance

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00231

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[ASAP] Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00245

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[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00337

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[ASAP] Discovery of <italic toggle="yes">N</italic>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<italic toggle="yes">H</italic>-pyrrolo[2,3-<italic toggle=&q

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00628

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[ASAP] Discovery of a Silicon-Containing Pan-Genotype Hepatitis C Virus NS5A Inhibitor

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00082

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[ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00431

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[ASAP] Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00192

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[ASAP] Discovery and Optimization of Glucose Uptake Inhibitors

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02153

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[ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00441

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[ASAP] Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00005

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[ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00601

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[ASAP] Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00664

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[ASAP] Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor

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Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00665

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[ASAP] Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00669

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[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00045

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[ASAP] Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00041

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[ASAP] Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening

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Published On :: Fri, 03 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00076

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[ASAP] Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

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Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00111

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[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

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Published On :: Wed, 08 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00639

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[ASAP] Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor

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Published On :: Thu, 09 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00681

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[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00063

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[ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00594

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[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00129

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[ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00574

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[ASAP] Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00438