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Good, but not enough: On the extended coverage of the Ayushman Bharat scheme

Extension of free health coverage to all over 70 years is good, but more needs to be done  




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A way out: On the government and doctor-led protests in West Bengal

The West Bengal government must enable the changes doctors want to see




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Staying the course: On the fight against air pollution in the Indo-Gangetic plains

The Centre and the States need to fight air pollution together 




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​Delay and bail: On former Tamil Nadu Minister V. Senthilbalaji’s case

Senthilbalaji’s release on bail was overdue, but he should not be made a Minister




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​Marina mayhem: On the IAF’s Chennai air show

The deaths at the air show in Chennai could have been prevented with better arrangements 




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Take the gauntlet: On safety and the Indian Railways

‘Kavach’ implementation is a priority but will not be a silver bullet




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What Makes <I>Andaz Apna Apna</I> Such Fun Even Today

Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie.




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Why Abhishek Missed Aishwarya's Birthday

When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.




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'He Doesn't Have The Air He Is Raj Thackeray's Son'

'I love to meet people.'




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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer

RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article
Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory




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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan

Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago




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Data crucial for building climate resilience, says ISRO scientist




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Tiruchi Today (November 7, 2024)




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Ensure time-bound implementation of development schemes, says Thirumavalavan




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Agro-tourism push needs industry-specific policies, say farmers




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TNSTC Kumbakonam Division mops up ₹17.13 crore in four days




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Govt. urged to extend last date to pay crop insurance premium by farmers




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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects




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Railways using treated water from its STP for maintaining green spaces

The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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Tiruchi Corporation office expansion plan witnesses more delay




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Nagapattinam MP presses for new express trains, railway line extensions




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Association holds protest against delay in Anna University’s staff absorption, promotions




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560: Oh Biscuits! Cascade Layers, Block Links, Emoji Lists, and more CSS!

After a brief visit from Hip Hop Dad Dave, we're talking cascade layers updates, block link practices, search element getting dropped, how to use cite, emoji list accessibility, scrollbar state, and trigonometric functions in CSS.




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568: Display Contents, Passkeys Follow Up, Yellow Fade Technique, and TOTK Talk

Macho Man Randy Standards stops by for a quick chat, Passkeys follow up, discussing the safety of Display: contents, the yellow fade technique, how hot CSS is right now (so hot), and a check in on how everyone's doing with Tears of the Kingdom.




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571: Searching vs AI, Getting Designers to Play Nice, and Web Components

Do you listen at 2x? Do Chris and Dave sound weird at normal speed IRL? How searching compares to using AI, chatbots kind of suck at context, getting a designer to work with developers at an agency, what happened to content visibility, and how to best build a design system using web components.




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579: One Day Builds, Spicy Slugs, and What Next for CSS?

Have you ever been an auctioneer? Sometimes when God closes a shed, he opens a sauna. Dave's working on the one day build theory, how to market with fake data, an update on the Discord, marketing with a spicy slug, what we want to see next in CSS, and thoughts on component libraries.




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591: Cascade Layers, CSS Functions, and more CSS with Miriam Suzanne

Miriam Suzanne stops by to talk about CSS updates and news on container queries, rolling out cascade layers, !important things to remember, custom properties, exit animations, CSS functions, state queries, and more.




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621: Setting Up Prettier and Linting, Comparing Colors, and Accessibility Overlays

We've got follow up on Cloudflare and Cara from last episode, a question about setting up Prettier and auto linting, a cool tool from a listener on comparing colors, a question about using tooling like Craft or more user friendly apps like Webflow when working with clients, and our takes on accessibility overlays.




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Laying a strong base

The Centre has various plans to meet the housing needs of the country, writes K.A. Martin




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Sunny days are here again

Despite the cost, a solar energy system is a great energy saver and a boon during power cuts, says Anamika Mukherjee




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Start green, stay green

A recent CSE study found that many green-certified buildings were not eco-friendly after all. Deepa Sathiaram, executive director, En3 Sustainability Solutions, tells us what exactly goes wrong.




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Are freeways viable?

Barring very few functionally useful ones, many elevated concrete structures with suboptimal utility have ripped the city apart, defiled and marred it.




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Say ‘no’ to joints and mortars

It would lead to lesser material consumption, zero wastage, faster construction and better aesthetics




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Galathea Bay: New major port can be game changer

Transshipment port at Galathea Bay is strategically located on the East-West international trade and shipping route




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Morning runs, protein-packed breakfast, and a rest day

The daily quest to balance work, health, and personal life




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How Ratan Tata pushed for evidence-led ayurveda 

Ratan Tata sought to promote research that could validate ayurveda through contemporary science




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Senior feline resident: Defib stays at his ambulance station 

Online petition halts re-homing of 16-year-old cat in London




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‘Our goal is beauty for each,’ says L’Oréal India chief

Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey




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Spotlight on ways to end violence against children




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Corporates look to tread the India Way  

Business leaders are realising that longevity may be a better marker for growth than shareholder value maximisation




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Jamiat cautions NDA partners, says ‘crutches’ cannot escape responsibility for Waqf Bill

The Jamiat Ulama-i-Hind urged NDA partners TDP and JD(U) to heed Muslim sentiments on the contentious issue surrounding the Waqf (Amendment) Bill, 2024




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Make Hindi universally acceptable: Amit Shah says at Kendriya Hindi Samiti meet

Speaking at the 32nd meeting of the Kendriya Hindi Samiti, Union Home Minister Amit Shah said it was necessary to translate all education curricula into Hindi and other Indian languages




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Govt., BJP spar over Chhath planning as festivities begin today