Background:

The Center to Reduce Cancer Health Disparities (CRCHD), NCI, implemented Screen to Save, NCI's Colorectal Cancer Outreach and Screening Initiative to promote awareness and knowledge of colorectal cancer in racial/ethnic and rural populations.

While smoking is inextricably linked to oral/head and neck cancer (HNSCC), only a small fraction of smokers develop HNSCC. Thus, we have sought to identify other factors, which may influence the development of HNSCC in smokers including microbiology. To determine microbial associations with HNSCC among tobacco users, we characterized oral microbiome composition in smokers with and without HNSCC. 16S rRNA MiSeq sequencing was used to examine the oral mucosa microbiome of 27 smokers with (cases) and 24 without HNSCC (controls). In addition, we correlated previously reported levels of DNA damage with the microbiome data. Smokers with HNSCC showed lower microbiome richness compared with controls (q = 0.012). Beta-diversity analyses, assessed as UniFrac (weighted and unweighted) and Bray–Curtis distances, showed significant differences in oral mucosal microbiome signatures between cases and controls (r² = 0.03; P = 0.03) and higher interindividual microbiome heterogeneity in the former (q ≤ 0.01). Higher relative abundance of Stenotrophomonas and Comamonadaceae and predicted bacterial pathways mainly involved in xenobiotic and amine degradation were found in cases compared with controls. The latter, in contrast, exhibited higher abundance of common oral commensals and predicted sugar degradation pathways. Finally, levels of DNA damage in the oral cavity were correlated with the microbiome profiles above. Oral microbiome traits differ in smokers with and without HNSCC, potentially informing the risk of eventual HNSCC and shedding light into possible microbially mediated mechanisms of disease. These findings present data that may be useful in screening efforts for HNSCC among smokers who are unable to quit.

Cruciferous vegetables have been of special interest due to the rich presence of bioactive compounds such as sulforaphane which show promising potential on cancer prevention and therapy as an epigenetic dietary strategy. Abnormal epigenetic alteration as one of the primary contributors to tumor development is closely related to breast cancer initiation and progression. In the present study, we investigated the effect of dietary broccoli sprouts (BSp), a common cruciferous vegetable, on prevention of estrogen receptor (ER)-negative mammary tumors at three different temporal exposure windows using a spontaneous breast cancer mouse model. Our findings indicate that maternal BSp treatment exhibited profound inhibitory and preventive effects on mammary cancer formation in the nontreated mouse offspring. The BSp diet administered to adult mice also showed suppressive effects on mammary cancer but was not as profound as the maternal BSp preventive effects. Moreover, such protective effects were linked with differentially expressed tumor- and epigenetic-related genes, as well as altered global histone acetylation, DNA methylation, and DNA hydroxymethylation levels. We also found that the expression changes of tumor-related genes were associated with the levels of histone methylation of H3K4 and H3K9 in the gene promoter regions. In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNA methyltransferases, and histone deacetylases in ERα-negative breast cancer cell lines. Collectively, these results suggest that maternal exposure to key phytochemicals may contribute to ER-negative mammary tumor prevention in their offspring through epigenetic regulations.

BACKGROUND AND PURPOSE:

The massa intermedia is a normal midline transventricular thalamic connection. Massa intermedia aberrations are common in schizophrenia, Chiari II malformation, X-linked hydrocephalus, Cornelia de Lange syndrome, and diencephalic-mesencephalic junction dysplasia, among others. We have noticed that massa intermedia abnormalities often accompany other midline malformations. The massa intermedia has never been formally evaluated in a group of exclusively pediatric patients, to our knowledge. We sought to compare and contrast the prevalence, size, and location of the massa intermedia in pediatric patients with and without congenital midline brain abnormalities.

BACKGROUND AND PURPOSE:

Endovascular embolization only has been advocated for treatment of brain arteriovenous malformations in recent trials. Our aim was to evaluate the results of embolization only in a cohort of patients who were enrolled in the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) study at 39 clinical sites in 9 countries.

SUMMARY:

Use of mechanical thrombectomy for stroke has increased since the publication of trials describing outcome improvement when used in the anterior circulation. These results, however, cannot be directly translated to the posterior circulation. While a high NIHSS score has demonstrated an association with poor outcomes in posterior stroke, the NIHSS is weighted toward hemispheric disease, and complex scores potentially delay definitive imaging diagnosis. We performed a retrospective analysis to ascertain whether any rapidly obtainable demographic or clinical and imaging data have a correlation with patient outcome postthrombectomy. Seventy-three cases were audited between September 2010 and October 2017. Presenting with a Glasgow Coma Scale score of >13 meant that the odds of reaching the primary end point of functional independence (defined as a 90-day modified Rankin Scale score of 0–2) were 5.70 times greater; similarly, presenting with a posterior circulation ASPECTS of >9 resulted in the odds of reaching the primary end point being 4.03 times greater. Older age correlated to a lower odds of independence (0.97, p = .04).

BACKGROUND AND PURPOSE:

The increased severity of white matter disease is associated with worse outcomes and an increased rate of intracerebral hemorrhage in patients with ischemic stroke undergoing thrombolytic treatment. However, whether white matter disease is associated with outcomes in patients undergoing endovascular treatment remains unclear.

A recent survey conducted by KB Financial Group Research Institute on 400 South Korean billionaires showed Vietnam is the most preferred country for real estate investments.

Normally, you have to sell the current property if you need the money to buy a new one. But there are occasions when it makes practical or financial sense to keep the old home.

Every home seller wants to sell it fast and reach as many buyers as possible. Here are some tips to make your listing stand out to potential buyers from the crowd.

City of Windsor payouts on personal injury and property damage claims totaled $2.1 million in 2019, the lowest number in eight years. The total — for settlements as well as court decisions — was well below the $3 million budgeted for the hundreds of claims made each year against the city for everything from trip-and-falls, […]

Windsor’s tech community came together Friday to share all the ways they are making the most of the COVID-19 pandemic. During an online event, leaders of seven local tech companies explained how they are dealing with, and capitalizing on the current pandemic. From the ability to scan facial temperatures, checking your blood for COVID-19 immunity, […]

The US Army has built a prototype device that allows wearers to go glove-free in freezing conditions. It works by heating the forearm, which helps keep the fingertips warm

Ironbark is one of 2020’s anticipated movies. Benedict Cumberbatch plays the MI6 handler of a Russian spy who may have helped prevent nuclear war

Concerns about adversaries hacking democracy abound, but it’s sheer incompetence we should really be worried about, writes Annalee Newitz

The super-sensitive smelling ability of American grasshoppers has been used to create biological bomb sniffers, which could prove useful for security purposes

A secret US Navy project known only as CLAWS will equip armed robot submarines with sensors and algorithms enabling them to destroy targets without explicit human control

Robots are being developed to help with tasks like fixing the sea cages where fish are farmed, and their size seems to be all that affects how the fish react

An AI can detect the presence of smells and even distinguish between scents like ammonia or carbon monoxide, which could be useful for detecting hazardous odours

A 3D printed grate can be used to make a smart window that blocks heat from sunlight out in the summer while letting it through in the winter, conserving energy

A robot that uses artificial intelligence to find and remove weeds could eventually be used as an alternative to chemical insecticides

Why? Because that’s our reality here in the year 2020.

Sony has managed to best its top-of-the-line noise cancelling earbuds with a new, improved, and best of all, cheaper model.

By Rachana Pradhan and Fred Schulte | Kaiser Health News

The Trump administration has sent hundreds of millions of dollars in pandemic-related bailouts to health care providers with checkered histories, including a Florida-based cancer center that agreed to pay a $100 million criminal penalty as part of a federal antitrust investigation.

At least half of the top 10 recipients, part of a group that received $20 billion in emergency funding from the Department of Health and Human Services, have paid millions in recent years either in criminal penalties or to settle allegations related to improper billing and other practices, a Kaiser Health News review of government records shows.

Read more at The Daily Beast.

The UFC is set to return to return to action this weekend.

Mercury is mostly iron, which may be because a series of close encounters with a young Venus billions of years ago stripped away its rocky outer layers

Two stars in the constellation Sagitta are predicted to smash together in the year 2083, producing an explosion that will outshine every star in the sky

How can we get a picture of the whole Milky Way if we are inside it? Good sleuthing is needed to combine all the clues, writes Chanda Prescod-Weinstein

A spacecraft designed to study re-entry into Earth's atmosphere has a nose coated in cork, a cheap and lightweight alternative to other materials

NASA’s InSight lander has been on the surface of Mars for over a year now – here are five of its strangest and most fascinating discoveries from the Red Planet

Astronomers have spotted an asteroid that has been captured by Earth's gravity, making it a temporary mini-moon. It will probably fly away again in April

Our measurements of the Hubble constant can't seem to come up with a consistent answer. What we learn next may alter our view of the cosmos, writes Chanda Prescod-Weinstein

The leading hypothesis for how the moon formed involves a collision between a Mars-sized object and Earth that would have boiled away elements like carbon, making its discovery on the moon a mystery

Start harnessing the power of data today – learn how in this whitepaper

Startup Cerebras has built a wafer-size chip for AI, but it isn’t the only one possible

Blue Frog Robotics CEO Rodolphe Hasselvander on the future of Buddy

The fastest, safest, and most exciting way to launch a quadrotor may be ballistically

“I didn’t ‘sell out’ by making my dreams come true.”

New Zealand’s competition watchdog has cited areas of overlap from a Fairfax-APN merger.

Agents are being offered double the normal commission to help shift apartments throughout capital cities.

Because with enough time spent at home you can accomplish anything, no matter how incredibly inconsequential, this is a video of a guy with a dog bed full of golf tees successfully flipping one into a bottle's pour spout. I wonder how many tries it really took. And, wait -- is that olive oil? It's not even liquor?! So let me get this straight -- you're spending quarantine trying to flip golf tees into a bottle pour spout sober? Well thank God we didn't get trapped in the same house when the rona hit. "Why's that, GW?" You can't get drunk on olive oil. "Nope, no matter how much you drink." Or balsamic vinegar, I've tried. Keep going for the actual video (with a much more respectable frame rate), complete with "Let's go! Let's go!" celebration, although I'm fairly certain this guy isn't actually going anywhere.

Global data on Fukushima challenge Japanese estimates.