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Synergetic effect of mild hypothermia and antioxidant treatment on ROS-mediated neuron injury under oxygen-glucose deprivation investigated by scanning electrochemical microscopy

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05977H, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junjie Zhang, Yulin Liu, Yuxiang Zhao, Siyu Zhang, Feng Xu, Fei Li
Ischemic stroke and reperfusion injury result in neuronal damage and dysfunction associated with oxidative stress, leading to overproduction of cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS). In...
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Triple-Function Porphyrin in Glycopolymeric Photosensitizer: From PhotoATRP to Targeted PDT

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06466F, Edge Article
Open Access
Jiahui Lin, Zhiyuan Ma, Weiwei Zuo, Meifang Zhu
Porphyrin derivatives serve as photocatalysts in reversible-deactivation radical polymerization and as photosensitizers in photodynamic therapy (PDT). Herein, a triple function porphyrin, ZnTPPC6Br, was synthesized as photocatalyst and initiator for photoATRP....
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Morphology of Lithium Halides in Tetrahydrofuran from Molecular Dynamics with Machine Learning Potentials

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04957H, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marinella de Giovanetti, Sondre H. Hopen Eliasson, Sigbjørn L. Bore, Odile Eisenstein, Michele Cascella
The preferred structures of lithium halides (LiX, with X = Cl, Br, I) in organic solvents have been the subject of a wide scientific debate, and a large variety of...
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Rapid, Potent, and Persistent Covalent Chemical Probes to Deconvolute PI3Kα Signaling

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05459H, Edge Article
Open Access
Lukas Bissegger, Theodora Alexandra Alexandra Constantin, Erhan Keles, Luka Raguž, Isobel Barlow-Busch, Clara Orbegozo, Thorsten Schaefer, Valentina Borlandelli, Thomas Bohnacker, Rohitha SriRamaratnam, Alexander Schäfer, Matthias Gstaiger, John E. Burke, Chiara Borsari, Matthias Wymann
Chemical probes have gained importance in the elucidation of signal transduction in biology. Insufficient selectivity and potency, lack of cellular activity and inappropriate use of chemical probes has major consequences...
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Photoactivated hydride therapy under hypoxia beyond ROS

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06576J, Edge Article
Open Access
Xia Wang, Yijian Gao, Ting Wang, Zhaobin Wang, He Hang, Shengliang Li, Fude Feng
As compared to oxidative phototherapy, studies on reactive reductive species-participating photodynamic therapy (PDT) are rare. Porphyrins are typical photosensitizers restricted with oxygen level, but efficacy and selectivity are always uncompatible...
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Rare-earth metal complexes bearing electrophilic and nucleophilic carbon centres and their unique reactivity patterns towards pyridine derivatives

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04197F, Edge Article
Open Access
weikang Wu, Thayalan Rajeshkumar, Shan Zhu, Fuxiang Chai, Dongjing Hong, ZeMing Huang, Qingbing Yuan, Laurent Maron, Shaowu Wang
The rare-earth metal dialkyl complexes (κ2-L1)RE(CH2SiMe3)2(THF)2 [RE = Lu(1a), Yb(1b), Er(1c), Y(1d), Dy(1e)] (L1 = 1-(2-N-C5H10NCH2CH2)-3-(2,6-iPr2C6H3N=CH)-C8H4N) and the rare-earth metal monoalkyl complexes (κ2-L1)2RE(CH2SiMe3)(THF)n [n = 0, RE = Lu(2a), Yb(2b);...
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Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s Disease

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05469E, Edge Article
Open Access
Jennifer Shyong, Jinliang Wang, Tran Quoc Dung Huynh, Marina Fayzullina, Bo Yuan, Ching-Kuo Lee, Thomas Minehan, Paul M. Seidler, Clay Wang
Alzheimer’s Disease (AD) is a neurodegenerative disorder proven to be caused by the aggregation of protein tau into fibrils, resulting in neuronal death. The irreparable neuronal damage leads to irreversible...
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Sequence-dependent Conformational Transitions of Disordered Proteins During Condensation

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05004E, Edge Article
Open Access
Jiahui Wang, Dinesh Devarajan, Keerthivasan Muthukumar, Youngchan Kim, Arash Nikoubashman, Jeetain Mittal
Intrinsically disordered proteins (IDPs) can form biomolecular condensates through phase separation. It is recognized that the conformation of IDPs in the dense and dilute phases, as well as at the...
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Depolymerisation of Poly(Lactide) Under Continuous Flow Conditions

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05891G, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sophie Ellis, Antoine Buchard, Tanja Junkers
Poly(L-lactic acid) (PLLA) is commercially successful bio-based plastic, where end-of-life materials can undergo industrial composting. To create a circular economy, a desirable alternative to composting is chemical recycling to monomer...
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Spin State Modulation and Kinetic Control of Thermal Contraction in a [Fe2Co2] Discrete Prussian Blue Analogue

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05792A, Edge Article
Open Access
Jyoti Yadav, Sanjit Konar
Stimuli-responsive switchable molecules represent an important category of magnetic materials with significant potential for functional devices. However, engineering complexes with controlled switchability remains challenging due to their sensitivity to lattice...
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12/14:46 EST Heatwave Warning (QLD)




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13/09:44 EST Flood Warning Summary for Queensland




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13/09:43 EST Final Flood Warning for the Logan River




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13/09:26 EST Minor Flood Warning for the Bremer River and Warrill Creek




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‘I’d like to think that one day I’ll be Chinese’

Committed Sinophile and one of the debut filmmakers at MAMI this year, Jordan Schiele is alsoan enthusiastic Mumbaikar discovers Satya Kandala




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Crushing on candy

Witness the theatrics of customised sweet-making at the city’s newest confectionery store




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The young and the restless

With top female stars pairing up with younger heroes, Hindi cinema is showing a marked change in the age gap debate




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The seven qualities of successful male playback singers




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Curating history through cinema

The New Medium, which debuted at MAMI, showcased a history of the moving picture and its formal innovation




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When a drummer sits down to write music

Rijul Victor’s experiments with EDM led him to start a solo project, which is now releasing his debut album as an electronic music producer




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Following a seven-day cinema diet

The Mumbai Film Festival this year had themes of suffocation, alienation, personal struggle, politics, rape, morality, gender, family…and a few characters we fell in love with, says Namrata Joshi




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An ear for music, an eye for art

Much sought-after exhibition designer Mark Prime’s first Indian solo art show is a playful mix of abstract patterns




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Curtains come down on MAMI

Diamond Island,Godless,Everything Else,Lady of the LakeandThe Narrow Pathamong big winners




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A fresh wind from the desert

Elite Zexer’s film about two Bedouin women was as warmly received in Mumbai as it was at Sundance and Berlin says Satya Kandala




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The future of flashbacks




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An auteur of diverse genres

Cary Fukunaga on his favourite version ofTrue Detective, the challenges of working onBeast of Nations, and why he’s a student of history




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Telecasting a strong message

AdhaFULL , a detective drama series on Doordarshan National, seeks to address the country’s coming-of-age issues




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Spicing it up further

Chef Anees Khan’s Bandra patisserie is now a café with a must try theccha burger, small eats, galangal ice tea and thick smoothies




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Standing apart: Shivam Pradhan




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The reluctant pop star




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The feminine mystique

The Prabal Gurung label is a staple in the wardrobes of celebrities ranging from Michelle Obama to Lady Gaga. The New York-based fashion designer, who was recently in India, spoke to T. Krithika Reddy about his association with Hillary Clinton, the DNA of his design, and what it takes to turn a dream into reality




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Bollywood’s divisive Diwali

It was a close battle at the box office with a romantic drama taking a slight financial edge over an action blockbuster.




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Who is Doctor Strange?

Here’s a primer to get acquainted with the Marvel’s superhero universe’s most unique character




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Beauty and a band of brothers

The Salaam Bombay Foundation adapts old favouriteChalti Ka Naam Gaadi for stage in a modern avatar to showcasethe talent of their underprivileged students




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The magical pull of the mask

It’s a dramatic weekend for Mumbaikars with the Berlin-based Familie Flöz all set to perform four shows of Hotel Paradiso




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Mr. Big of rock vocals

Eric Martin, the voice of the popular yesteryears band, will perform in the city this weekend




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Warrior prince and talking heads

The playfulness to the writing around Ravana and his ten perennially bickering heads could have made the film oddly amusing. But alas, the humour remains just a flash




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Industrial yet bespoke

Tucked away in the lanes of Ballard Estate is a roomy new restaurant that typifies the changing spaces in the city, courtesy the team that launched Indigo




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Making the raga game accessible

Sarod maestro Arnab Chakrabarty kick-starts a new series of classical music concerts that focuses on the enduring legacy of Indian classical instruments




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Rediscovering repositories of heritage

Often considered dull and uninviting, Indian museums are storehouses of history and culture, and deserve repeat visits saysShailaja Tripathi




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The Majrooh Sultanpuri of writers

Best known for musical blockbusters, legendary filmmaker Nasir Husain also wrote dialogues for his films. His words were true to the syntax of the timesthey were written in, whether it was forMunimjiorPaying Guestin the mid-1950s or forJo Jeeta Wohi Sikanderin the ’90s




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Mohammed Rafi and the rights of fictional characters




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From Sarita Devi’s corner

Suprita Das’s latest book captures the tale of boxer Sarita Devi, who refused to receive the bronze medal at the Incheon Asian Games 2014




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Making seminars seamless

Kaiwan Mehta and TARQ have joined forces to present a series of seminars on a set of subjects, each one fattened by a diversity of interdisciplinary approaches




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Subdued 62nd birthday for Kamal Haasan




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Fall, rise, repeat

After eight years, Dhruvi Acharya presents an achingly intimate solo show that explores her ownloss and looks at women as independent individuals




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Crime, lust and honey

An eight-minute film goes behind the scenes atMadhur Kathayen, adesicrime photo magazine run doggedly by its publisher Shailabh Rawat




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Acting career has a shelf life: Farhan




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An obstinate vision of music

Rahul Das of Sundog Project talks about the band’s upcoming album and the role that art plays in society




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Progressive forces to unite at Goa meet