el State Library Council Awards declared, M. Leelavathy wins I.V. Das award for overall contributions By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:44:33 +0530 Full Article Kerala
el Watch: Which are the smaller parties in the fray in Maharashtra? | Election Cheatsheet By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:02:53 +0530 We take a look at the various political alliances in the Maharashtra ahead of the Assembly elections in the State. Full Article Videos
el New rest norms for pilots will reduce their salary, Air India tells DGCA By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:12:20 +0530 Meeting held as part of mediation ordered by Delhi High Court between pilots and airlines Full Article India
el Revise OBC creamy layer limit, say MPs at House panel meeting By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:27:44 +0530 They say that many OBC candidates have been unable to join the Civil Services despite clearing the exam Full Article India
el Children’s Day: public meet, rally led by girls to be held in Thiruvananthapuram By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:41:04 +0530 25,000 students from 200 schools will be part of the rally Full Article Kerala
el Try to stand on your own legs, Supreme Court tells NCP led by Ajit Pawar to stop using Sharad Pawar’s pictures, videos By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:49:46 +0530 The Bench asked the Ajit Pawar camp to circulate an online message among its leaders, party workers and representatives against using the pictures or video/audio clips of Sharad Pawar, whether old or new Full Article India
el BJP accuses Congress of releasing election manifesto during “silence” period in Jharkhand By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:40:16 +0530 Mr. Patra claimed that the Congress wanted to give 4% reservation to the Muslim organisations and contractors in public tenders Full Article Jharkhand Assembly
el Mamata calls for unity of hills and plains; focuses on development in north Bengal By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:55:01 +0530 This is her first official visit to Darjeeling in two years; she did not go to the hills even during the 2024 Lok Sabha election campaigns Full Article West Bengal
el Telangana BJP seeks judicial probe into Vikarabad incident By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:57:40 +0530 Full Article Telangana
el ISB Insights Forum 2024 to be held on November 15 By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:33:55 +0530 Full Article Telangana
el Govt. charges BRS with hatching conspiracies to stall development projects for political gains By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:17:30 +0530 Dy CM says involvement of BRS leader in Lagacharla incident exposes the party’s intentions Full Article Telangana
el KTR in Delhi to strike a deal with BJP to escape Formula-E probe: Bhatti By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:47:03 +0530 Deputy Chief Minister points to BRS call to Maharashtra voters not to vote for Congress Full Article Telangana
el US Deputy Secretary of State Kurt Campbell to attend inaugural US India Indian Ocean Dialogue in Delhi By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 10:42:54 +0530 During his visit, on November 13-14, Campbell will also participate in the Critical and Emerging Technologies (iCET) Intersessional to further expand cooperation between the United States and India on technological innovation and production Full Article News
el 'Any relief on bank guarantee will be provided across the sector': Scindia on Vodafone Idea request for waiver of bank guarantees for spectrum By www.newkerala.com Published On :: Wed, 13 Nov 2024 17:36:01 +0530 Full Article
el India IT spending to reach USD 160 billion in 2025 fueled by application and infrastructure software market growth: Gartner By www.newkerala.com Published On :: Wed, 13 Nov 2024 17:38:01 +0530 Full Article
el EU, Belgium, Denmark and Germany envoys visit Adani's Khavda, Mundra businesses, Gautam Adani says It was a privilege By www.newkerala.com Published On :: Wed, 13 Nov 2024 17:42:02 +0530 Full Article
el Integrated manufacturing cluster to be developed in Bihar's Gaya By www.newkerala.com Published On :: Wed, 13 Nov 2024 17:56:03 +0530 Full Article
el Centre to deliberate on plans to achieve 500 GW green energy target by 2030 By www.newkerala.com Published On :: Wed, 13 Nov 2024 18:02:02 +0530 Full Article
el India set to become 'major producer' of electric vehicles like China: Mark Mobius By www.newkerala.com Published On :: Wed, 13 Nov 2024 18:50:02 +0530 Full Article
el India could save 91,000 crore rupees on import bill through biofuel blending: Hardeep Singh Puri By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:04:01 +0530 Full Article
el Vistara's last flight from Odisha takes off for Delhi ahead of merger with Air India By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:06:02 +0530 Full Article
el Assam: Army celebrates 'National Education Day' with students in Tinsukia By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:08:01 +0530 Full Article
el UP: Devotees celebrate 'Tulsi Vivah' at Balua Ghat in Prayagraj, marking sacred union of Lord Vishnu, Vrinda By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:10:02 +0530 Full Article
el Defence Space Agency hosts first ever space exercise 'Antariksha Abhyas - 2024' in Delhi By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:14:02 +0530 Full Article
el Assam Governor attends Sainik school Goalpara's Diamond Jubilee celebrations By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:42:03 +0530 Full Article
el All cases related to loan fraud at Perumbavoor Urban Cooperative Society to be handed over to Crime Branch By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:46:46 +0530 Police say 29 cases have been registered. Probe by district joint registrar of Cooperative department finds 26 persons, mostly members of previous director boards, accountable for irregularities to the tune of ₹33.33 crore Full Article Kerala
el No gaps in management of biodegradable waste, Kerala tells NGT By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:23:47 +0530 Full Article Kerala
el French lower house rejects massively amended 2025 budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:53:03 +0530 Prime Minister Michel Barnier's minority government now has a largely free hand in submitting a cleaned-up text to the Senate upper house Full Article World
el COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article Environment
el Lebanon media claims Israeli strike hit apartment south of Beirut By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:10:43 +0530 Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet Full Article World
el IndiGo, Air India cancel flights to Bali following volcanic eruption By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:06 +0530 The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds Full Article India
el In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3778-3794DOI: 10.1039/D4MD00281D, Research ArticleCarolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. PilliA novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3795-3799DOI: 10.1039/D4MD00458B, Research ArticleKazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki TamaokiA photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cis–trans photoisomerization with blue-green light and fast thermal relaxation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el IIT-M students develop robot for O.P. Jindal university’s Constitution Museum By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:27 +0530 It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says Full Article Tamil Nadu
el Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:14:04 +0530 Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m. Full Article Delhi
el Delhi airport sees seven flight diversions owing to bad weather By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:39:37 +0530 The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi Full Article Delhi
el DUSU election results to be announced on November 21 By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:18:26 +0530 The counting of votes for both the central panel and college representatives will begin at 8:30 a.m. on November 21 at the DU Conference Centre Full Article Delhi
el Delhi High Court upholds ban on two-wheelers on Expressways By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:18:26 +0530 Two-wheelers, three-wheelers, and other slow-moving vehicles, such as tractors, are prohibited as per the Gazette Notifications dated June 14, 2018, and January 15, 2021 Full Article Delhi
el Delhi’s air quality turns ‘severe’ for first time this season: CPCB By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:52:21 +0530 According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418 Full Article Delhi
el Wall Street makes wagers on the likely winners and losers in a second Trump term By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:55:27 +0530 Wall Street is already making big bets on what take two for a White House led by Donald Trump will mean for the economy and markets Full Article Business
el Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:16:07 +0530 Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year. Full Article Business
el Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:31 +0530 Full Article Andhra Pradesh
el India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:20:06 +0530 In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months Full Article Real Estate