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State Library Council Awards declared, M. Leelavathy wins I.V. Das award for overall contributions




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Watch: Which are the smaller parties in the fray in Maharashtra? | Election Cheatsheet

We take a look at the various political alliances in the Maharashtra ahead of the Assembly elections in the State.




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New rest norms for pilots will reduce their salary, Air India tells DGCA

Meeting held as part of mediation ordered by Delhi High Court between pilots and airlines




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Revise OBC creamy layer limit, say MPs at House panel meeting

They say that many OBC candidates have been unable to join the Civil Services despite clearing the exam




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Children’s Day: public meet, rally led by girls to be held in Thiruvananthapuram

25,000 students from 200 schools will be part of the rally




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Try to stand on your own legs, Supreme Court tells NCP led by Ajit Pawar to stop using Sharad Pawar’s pictures, videos

The Bench asked the Ajit Pawar camp to circulate an online message among its leaders, party workers and representatives against using the pictures or video/audio clips of Sharad Pawar, whether old or new




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BJP accuses Congress of releasing election manifesto during “silence” period in Jharkhand

Mr. Patra claimed that the Congress wanted to give 4% reservation to the Muslim organisations and contractors in public tenders




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Mamata calls for unity of hills and plains; focuses on development in north Bengal

This is her first official visit to Darjeeling in two years; she did not go to the hills even during the 2024 Lok Sabha election campaigns




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Telangana BJP seeks judicial probe into Vikarabad incident




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ISB Insights Forum 2024 to be held on November 15




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Govt. charges BRS with hatching conspiracies to stall development projects for political gains

Dy CM says involvement of BRS leader in Lagacharla incident exposes the party’s intentions




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KTR in Delhi to strike a deal with BJP to escape Formula-E probe: Bhatti

Deputy Chief Minister points to BRS call to Maharashtra voters not to vote for Congress




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US Deputy Secretary of State Kurt Campbell to attend inaugural US India Indian Ocean Dialogue in Delhi

During his visit, on November 13-14, Campbell will also participate in the Critical and Emerging Technologies (iCET) Intersessional to further expand cooperation between the United States and India on technological innovation and production




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'Any relief on bank guarantee will be provided across the sector': Scindia on Vodafone Idea request for waiver of bank guarantees for spectrum




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India IT spending to reach USD 160 billion in 2025 fueled by application and infrastructure software market growth: Gartner




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EU, Belgium, Denmark and Germany envoys visit Adani's Khavda, Mundra businesses, Gautam Adani says It was a privilege




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Integrated manufacturing cluster to be developed in Bihar's Gaya




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Centre to deliberate on plans to achieve 500 GW green energy target by 2030




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India set to become 'major producer' of electric vehicles like China: Mark Mobius




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India could save 91,000 crore rupees on import bill through biofuel blending: Hardeep Singh Puri




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Vistara's last flight from Odisha takes off for Delhi ahead of merger with Air India




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Assam: Army celebrates 'National Education Day' with students in Tinsukia




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UP: Devotees celebrate 'Tulsi Vivah' at Balua Ghat in Prayagraj, marking sacred union of Lord Vishnu, Vrinda




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Defence Space Agency hosts first ever space exercise 'Antariksha Abhyas - 2024' in Delhi




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Assam Governor attends Sainik school Goalpara's Diamond Jubilee celebrations




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All cases related to loan fraud at Perumbavoor Urban Cooperative Society to be handed over to Crime Branch

Police say 29 cases have been registered. Probe by district joint registrar of Cooperative department finds 26 persons, mostly members of previous director boards, accountable for irregularities to the tune of ₹33.33 crore




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No gaps in management of biodegradable waste, Kerala tells NGT




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French lower house rejects massively amended 2025 budget

Prime Minister Michel Barnier's minority government now has a largely free hand in submitting a cleaned-up text to the Senate upper house




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COP29: India, other developing countries demand fair climate finance commitments

India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments




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Lebanon media claims Israeli strike hit apartment south of Beirut

Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet




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IndiGo, Air India cancel flights to Bali following volcanic eruption

The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds




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In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP

RSC Med. Chem., 2024, 15,3674-3694
DOI: 10.1039/D4MD00580E, Research Article
Jinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin Jin
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells

RSC Med. Chem., 2024, 15,3795-3799
DOI: 10.1039/D4MD00458B, Research Article
Kazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki Tamaoki
A photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cistrans photoisomerization with blue-green light and fast thermal relaxation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells

RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer

RSC Med. Chem., 2024, 15,3853-3861
DOI: 10.1039/D4MD00165F, Research Article
Jiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang Liu
The synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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IIT-M students develop robot for O.P. Jindal university’s Constitution Museum

It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says




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Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital

Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m.




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Delhi airport sees seven flight diversions owing to bad weather

The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi




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DUSU election results to be announced on November 21

The counting of votes for both the central panel and college representatives will begin at 8:30 a.m. on November 21 at the DU Conference Centre




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Delhi High Court upholds ban on two-wheelers on Expressways

Two-wheelers, three-wheelers, and other slow-moving vehicles, such as tractors, are prohibited as per the Gazette Notifications dated June 14, 2018, and January 15, 2021




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Delhi’s air quality turns ‘severe’ for first time this season: CPCB

According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418




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Wall Street makes wagers on the likely winners and losers in a second Trump term

Wall Street is already making big bets on what take two for a White House led by Donald Trump will mean for the economy and markets




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Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud

Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year.




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Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam




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India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield

In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months