They are counted among the Unmercenary Physicians. Cyrus was a physician living in Alexandria. A pious Christian, he healed not only bodies but souls, bringing many to Christ, and often healing through prayer rather than the use of his medicines. He often said to his patients, 'If you want to keep clear of illness, take care not to sin, because more often than not illness is a result of sin.' When Diocletian's persecution broke out, Cyrus was denounced to the pagan governor and fled to Arabia, where he became a monk. He gained great renown there by healing many ailments using only the sign of the Cross.   John was a soldier from Edessa who heard of Cyrus' deeds and, leaving the army, sought him out. They met in Egypt, where John became a monk and Cyrus' disciple, joining him in the practice of the virtues and in healing illnesses by prayer.   They heard of the arrest of a Christian lady named Athanasia and her daughters Theoctista and Eudoxia. Concerned that the tender maidens might renounce Christ under torture, the two monks sought them out to encourage them in their confession of the Faith. They themselves were captured, and the governor decided to have them tortured in front of the women, assuming that this would break their spirit. Instead, Cyrus and John bore their sufferings so patiently and boldly that the women were only strengthened in their resolve. Seeing that he had failed, the governor had all five of them beheaded. Their bodies were placed in the Church of St Mark in Alexandria.   In the fifth century the relics of Sts Cyrus and John were enshrined in a church at Aboukir near Alexandria by St Cyril (June 9). There they were the source of abundant healings and miracles, and the shrine became one of the greatest places of pilgrimage in the Christian world.

These twelve holy Martyrs suffered in the reign of Diocletian.   "The first of these, Pamphilius, was priest in the church at Caesarea in Palestine; a learned and devout man, he corrected the mistakes of various copiers in the text of the New Testament. He himself copied this saving Book and gave it to any who desired it. The second was a deacon, Valentine, old in years and white with wisdom. He was a great expert in the Holy Scriptures, knowing them by heart. The third was Paul, a respected and eminent man, who had on a previous occasion been cast into the fire for the sake of Christ. With them were five Egyptians, brothers both in blood and soul, who were returning to their native land from serving a sentence in the mines of Cilicia. As they reached the gate of the town of Caesarea they said that they were Christians, and were therefore brought to trial. When asked their names, they replied: 'We have cast away the pagan names given us by our mother, and are called Elias, Isaiah, Jeremiah, Samuel and Daniel.' when asked where they were from, they replied: 'From Jerusalem that is above.' They were all beheaded, and a young man called Porphyrius, who had searched for their bodies to give them burial, suffered soon afterwards. Him they burned. An officer, Seleucus, who had come up to the martyrs and embraced them before the sword descended on their heads, was also burned, and an old man, Theodulus, a servant of the Roman judge, who had embraced one of the martyrs while they were under escort. Lastly Julian, who had kissed the dead bodies of the martyrs and honoured them, followed them in death. So they exchanged the small for the greater, the tawdry for the precious and death for immortality, and went to the Lord in 308." (Prologue)   The Synaxarion concludes, "After the martyrdom of Pamphilius, the leader of the glorious cohort, the impious governor gave orders that his body and those of his companions should be left where they lay as food for carnivorous animals. However by God's Providence, no animal came near their holy relics, which the Christians were able to lay to rest with due honour." The account of these Martyrs was written by Eusebius of Caeserea, Pamphilius' disciple.

Chrysanthos was the only son of Polemon, a prominent pagan in Rome. As befit his status, he was given every opportunity for secular learning, but seemed unable to acquire worldly wisdom. By God's providence, copies of the Gospels and the Acts of the Apostles came into his possession and, reading them avidly, he was enlightened and desired above all to be a Christian. He found a priest, Carpophorus, who instructed him in the Faith and baptised him. When his father discovered Chrysanthos' conversion, he was angry and did everything he could to turn his son back to paganism, using even threats and imprisonment. When none of these measures worked, Polemon arranged for his son to be married to a beautiful and learned young pagan woman named Daria, hoping that affection for her would draw his son away from Christ. But instead, Chrysanthus persuaded Daria of the truth of Christianity, and she was secretly baptised.   When his father died, Chrysanthus and his wife began to confess Christ openly and to live publicly as Christians. They were soon arrested and grievously tortured for their faith. The torturer, whose name was Claudius, was so moved by their endurance and patience that he himself embraced the Faith, along with his whole household. For this they were executed: Claudius by drowning, his two sons by beheading, and his wife by hanging. Finally Chrysanthus and Daria were buried alive in a pit and covered with stones. This was during the reign of the Emperor Numerian.

Calliopius was the only son of a senator from Pamphylia and his wife Theoclea, who had long prayed to God for a child. The devout Theoclea reared her son in purity of life and love for God from infancy. When persecution of Christians broke out under Maximian, Theoclea put Calliopius aboard a ship bound for Pompeiopolis to save him from the persecutors. But Calliopius, as soon as he disembarked, encountered a pagan festival, where he was arrested when he refused to make sacrifice to the idols. Brought before the governor Maximus, he freely confessed that he was a Christian. For this he was cruelly tortured and thrown into prison. His mother, hearing of his torments, sold her goods and hurried to comfort him and encourage him in his martyrdom.   Calliopius was sentenced to death by crucifixion, as it happened on Holy Thursday; but the holy Theoclea bribed the officials to postpone the execution by one day, so that her son might imitate the Lord's Crucifixion on the day that He endured it; she also prevailed upon the torturers to crucify Calliopius upside-down (like St Peter) in humility toward the Lord. When her son's lifeless body was taken down from the cross, Theoclea cast herself upon it and died.

The Holy Symeon was bishop of the royal cities of Seleucia and Ctesiphon in Persia, during a great persecution under King Sapor II. The king had been incited by (Zoroastrian) Magi jealous of the growth of the Faith in their territory, and by some Jews living in Persia. The king was already displeased with the holy bishop: his eunuch, Ustazan, a secret Christian, had denied Christ, but when reprimanded by Symeon, had confessed the Faith before the King, for which he was executed. On Holy Friday of 343 Symeon, along with at least a hundred other servants of the Church, was sent out to be slain. Symeon exhorted each to be of good courage, and was himself slain last. One year later, again on Holy Friday, the King's eunuch Azat was executed for Christ, along with a great number of the faithful. It is said that more than 1,000 Christians died as martyrs during this persecution.   The Zoroastrians still live in parts of Iran as a small, somewhat persecuted minority under the Islamic government.

These martyrs gave glorious witness to Christ during the persecutions of Diocletian. St Januarius, Bishop of Benevento in Italy, was arrested and cast into a burning furnace, but he stood in the midst of the flames, singing praises to God, and emerged unharmed. After other cruel tortures, he was bound and cast in prison in Pozzuoli, along with his deacon Faustus and his reader Desiderius. With them in prison were two deacons from Pozzuoli, Proclus and Sossus, and two laymen, Eutychius and Acutius. All seven were cast to wild beasts; but when the animals came near the Saints, they fell affectionately at their feet and refused to harm them. Finally, all seven Christians were beheaded. Some Christians from Naples secretly took the body of Januarius and buried it in their church. Countless wonders have been worked at his grave, including the restoration of a dead man to life.

He came from a noble Gothic family. Like St George, he was an officer in the imperial army. He lived a life of great purity, fasted greatly, and often visited imprisoned Christians. Because of this his Christian faith became known, and when he was summoned before the Emperor, he boldly confessed his faith. He was tortured in many ways, but emerged unharmed. Seeing this miracle, seventy of his fellow-soldiers confessed Christ and were beheaded at the Emperor's command. Sabbas himself was condemned to death by drowning, and gave his soul to God in 272.

Theodotus was a married inn-keeper in Ancyra during the persecutions of Diocletian. He used his inn-keeping trade as a means of secretly helping the persecuted Christians, many of whom used his inn as a refuge in time of need. One of his holy works was to retrieve the bodies of martyred Christians and give them burial. At that time, seven maidens were tried and tortured for their faith in Christ, then killed by being thrown into a lake. One of them, St Tecusa, appeared to St Theodotus and asked him to retrieve the bodies of her and her sisters in Christ. Under cover of night Theodotus, guided by an Angel, was able to find all seven bodies and bury them honorably. But a friend whom he had asked to help him in this work betrayed him, and he was arrested and subjected to cruel tortures. Finally he was sentenced to be beheaded. As he went to the block, he said to the many Christians who had gathered to weep for him: 'Do not weep for me, brethren, but glorify our Lord Jesus Christ, by whose aid I am finishing my course and overcoming the enemy.' A church dedicated to him was later built on the site of his burial.

'Saint Patrick was Bishop of Prusa, a city in Bythinia (the present-day Brusa or Bursa). Because of his Christian faith, he was brought before Julius (or Julian) the Consul, who in his attempts to persuade Patrick to worship as he himself did, declared that thanks was owed to the gods for providing the hot springs welling up from the earth for the benefit of men. Saint Patrick answered that thanks for this was owed to our Lord Jesus Christ, and explained that when He, Who is God, created the earth, He made it with both fire and water, and the fire under the earth heats the water which wells up, producing hot springs; he then explained that there is another fire, which awaits the ungodly. Because of this, he was cast into the hot springs, but it was the soldiers who cast him in, and not he, who were harmed by the hot water. After this St Patrick was beheaded with the presbyters Acacius, Menander, and Polyaenus. Most likely this was during the reign of Diocletian (284-305).' (Great Horologion)

The holy Thalelaeus is counted as one of the Unmercenary Physicians. He was a physician, born in Lebanon to a Berucius (a bishop) and Romylia. During the persecutions by the Emperor Numerian, he fled to Cilicia, but was captured and brought before Theodore, the governor. When Thalelaeus boldly confessed Christ, the cruel governor ordered two soldiers, Alexander and Asterius, to bore holes through his leg-bones, pass a rope through them, and hang him from a tree. But the executioners, by the power of God, were momentarily deprived of their wits and bored through a wooden plank instead, which they hung in the tree. The governor angrily ordered that the soldiers be flogged; during their flogging they cried out: 'The Lord is alive to us; from now on, we are become Christians. We believe in Christ, and suffer for Him.' Hearing these words, the governor ordered that both be beheaded. He then seized their awl and attempted to bore through Thalelaeus' legs himself; but his hand suddenly became paralyzed. The compassionate physician prayed to Christ and healed his persecutor' hand. His heart still hardened, the governor next ordered that the Saint be thrown into water and drowned; but he survived. Next he was thrown to wild beasts, but they licked his feet and rubbed tamely against him. Finally the holy Martyr was beheaded.