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COVID-19 outcomes in patients with hematologic disease




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Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody




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NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma




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Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells




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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




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The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors




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QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




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LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression




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NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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Nanomolar-scale, high throughput chemical synthesis of drug-like molecules

A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds.




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Dermatophagoides pteronyssinus peptidase 1 (DERP1)

In vitro and rat studies suggest inhibiting the enzymatic activity of house dust mite (HDM) allergens could help treat allergic asthma.




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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




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Resurrecting a magic bullet

Heidelberg Pharma has resuscitated a long-dead ADC toxin with updated conjugation techniques, and its partner Roche has thrown the company a lifeline that could help validate the platform.




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Neutralizing the negatives of RNAi

The siRNN technology that Solstice licensed from UCSD could take RNAi-based therapies to tissues outside the liver and expand their use to a host of new diseases.




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SciBX: Science-Business eXchange




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53




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High-purity orbital angular momentum states from a visible metasurface laser




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Strain creates a trion factory




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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




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An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




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Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




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Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy




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Head-to-head trials in inflammatory bowel disease: past, present and future




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Feeding back on ingestion




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Microbiota and colorectal cancer: colibactin makes its mark




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Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions




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Inducing senescence sensitizes pancreatic tumours to therapies




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Universal screening for hepatitis C virus infection should be linked to universal treatment access




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Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities




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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys




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A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Nesfatin-1 puts the brakes on reward-based feeding




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Obesity affects skeletal muscle ketone oxidation