i

​First responder: On Maldives-India ties

India and Maldives let subtle diplomacy surpass muscular posturing 




i

​Respect the mandate: On the 2024 Jammu and Kashmir elections

With elections done and dusted, J&K now must return to statehood




i

Biology transformed: On the Nobel Prize in chemistry

Nobel for determining protein structure recognises a big advance




i

Take the gauntlet: On safety and the Indian Railways

‘Kavach’ implementation is a priority but will not be a silver bullet




i

A Korean win: On the 2024 Nobel Prize in Literature

A Nobel raises Korean prose to success levels of its drama and music 




i

Taking guard: On the RBI and growth concerns

The central bank’s price worries may be warranted but growth concerns are emerging




i

Deeper role: On the U.S. and West Asia conflicts   

The escalating conflict cycle in West Asia could have disastrous consequences




i

​Sufferers, awarded: On the 2024 Nobel Peace Prize

The Nobel Peace for the selfless Nihon Hidankyo should help stir debates on nuclear disarmament




i

Abject failure: On India’s Global Hunger Index ranking

India’s ranks 105 out of 127 countries in the Global Hunger Index, 2024




i

Canadian frostbite: On the India-Canada diplomatic war

India must consider the impact of its next steps on its diplomacy and image




i

The endgame: On the injunction against Google

The U.S. district court injunction against Google could end its app dominance




i

Battle of wits: On the Maharashtra and Jharkhand elections 

The Maharashtra and Jharkhand polls will witness intense political battles




i

Fate of nations: On the 2024 Economics Nobel

The 2024 Nobel recognises the need for ‘inclusive’ institutions




i

Israel versus the UN: On Tel Aviv’s move and India’s response

India’s stand must keep in mind the UN’s importance in the global order




i

​Governor vs Government: On the hostilities in Tamil Nadu

Mr. Ravi must be withdrawn for needlessly wading into controversies




i

​Complicit: On India and the U.S and Canada cases

India must come clean on its stance on transnational killings 




i

​Allow for deliberation: On the legitimate demands of Ladakh

The lack of a legislature and regional autonomy in Ladakh has led to the current protests




i

Culture and society: On upholding Section 6A of the Citizenship Act

Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems




i

​West versus the rest: On western conduct and India

The West must not tolerate terror threats in the name of free speech 




i

​Over the borderline: On the India-China deal 

The agreement between India and China opens new opportunities  




i

​Celebration and vigil: On India, kala-azar and trachoma

India must not let its guard down on kala-azar




i

Growth prescription: On the latest World Economic Outlook 

The IMF’s ‘mediocre’ medium-term outlook merits policy attention




i

​Building blocks: On the 16th BRICS Summit in Kazan  

The BRICS Summit showed that Russia was not without friends




i

Neck and neck: On the U.S. presidential election

Trump and Harris offer U.S. voters vastly different choices 




i

​Fair trade: On the 29th COP and India’s carbon market

India must develop a transparent carbon trade policy 




i

At a loss: On the New Zealand-India three-match series

India batters frittered away the home advantage against New Zealand 




i

​Beyond intoxication: On alcohol regulation, judicial verdict

Batting for States, the Supreme Court of India holds federal balance on regulating alcohol




i

​Escalation ladder: On conflict between Israel and Iran

Iran should show strategic restraint; and the world should rein in Israel




i

Western front: On the parties and their prospects in the Maharashtra polls

Granular factors can determine the outcome in Maharashtra 




i

​Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference  

Actor Vijay seems to be targeting both the BJP and the DMK 




i

​Tough task: On the battle lines in the Jharkhand Assembly election

Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand




i

Sun signs: On extreme heat and Tamil Nadu’s policy decision

States should prepare to assist the vulnerable during extreme heat events




i

Towards Europe: On the India visits by the leaders of Germany, Spain

India used visits by leaders of Germany and Spain to balance ties in Europe 




i

Watch: When Jimmy Sheirgill Got Violent

'As a storyteller, one always looks to create something for the audience which is thrilling, engaging and entertaining and that is exactly what we have endeavoured with Sikandar Ka Muqaddar.'




i

What Makes <I>Andaz Apna Apna</I> Such Fun Even Today

Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie.




i

Why Kriti Is So Grateful

Kriti Kharbanda took a trip down memory lane when her rom-com Shaadi Mein Zaroor Aana clocked seven years since its release.




i

Alia-Ranbir's Daughter Raha Turns 2

Alia Bhatt and Ranbir Kapoor's little girl Raha turned two on November 6, and we were treated to the most adorable pictures on social media.




i

The Raj & DK Line-Up You Cannot Miss

Sukanya Verma looks at their eclectic career of over two decades as their latest offering Citadel: Honey Bunny, the Indian leg of the Russo Brothers globetrotting spy universe series, drops on Amazon Prime Video on November 7.




i

Why Abhishek Missed Aishwarya's Birthday

When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.




i

The Woman Who Lost Everything

When the landslide hit, Sruthi's house was washed away, along with its inhabitants.




i

'He Doesn't Have The Air He Is Raj Thackeray's Son'

'I love to meet people.'




i

Look Who Just Met Tom Cruise!

Kartik wants to savour Litti Chokha in Patna... Amyra holidays in Phuket... Karishma in Italy...




i

Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




i

Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
The content of this RSS Feed (c) The Royal Society of Chemistry




i

The role of silicon in drug discovery: a review

RSC Med. Chem., 2024, 15,3286-3344
DOI: 10.1039/D4MD00169A, Review Article
Open Access
Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van Otterlo
This review aims to highlight the role of silicon in drug discovery.
The content of this RSS Feed (c) The Royal Society of Chemistry




i

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




i

Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells

RSC Med. Chem., 2024, 15,3418-3432
DOI: 10.1039/D4MD00170B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van Tran
Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
The content of this RSS Feed (c) The Royal Society of Chemistry