to

A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3047-3068
DOI: 10.1039/D0OB00078G, Paper
Ramona Schütz, Maximilian Meixner, Iris Antes, Franz Bracher
A modular short-step synthesis of the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine was developed employing N-acyl-Pictet–Spengler reaction and Ullman diaryl ether synthesis as central steps.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Diversity oriented multi-component reaction (DOS–MCR) approach to access natural product analogues: regio- and chemo-selective synthesis of polyheterocyclic scaffolds via one-pot cascade reactions

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3082-3092
DOI: 10.1039/D0OB00368A, Paper
Lakshmanan Palanivel, Vasuki Gnanasambandam
Skeletally diverse and complex polyheterocyclic hybrid scaffolds have been accessed via one-pot three-component reaction by exploiting the build/couple/pair strategy of diversity oriented synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Photochemical rearrangement of diarylethenes: synthesis of functionalized phenanthrenes

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3098-3103
DOI: 10.1039/D0OB00296H, Paper
A. V. Zakharov, A. V. Yadykov, A. G. Lvov, E. A. Mitina, V. Z. Shirinian
The photocyclization of diarylethenes bearing naphthalene units was explored and a convenient protocol for the synthesis of functionalized phenanthrenes was proposed.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Metal-free cascade reactions of aziridines with arylalkynes and aryldiazoniums: facile access to arylazopyrrolines

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3149-3157
DOI: 10.1039/D0OB00346H, Paper
Jing Rong, Hao Jiang, Sijing Wang, Zhenni Su, Huiyan Wang, Chuanzhou Tao
A novel and facile approach to synthesize arylazopyrroline scaffolds via metal-free cascade reactions of aziridines with arylalkynes and aryldiazoniums has been developed, providing access to a variety of 4-arylazo-2-pyrrolines in a highly concise fashion.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3142-3148
DOI: 10.1039/D0OB00407C, Paper
Kun Huang, Andrea Marchesi, Kristian Hollingsworth, Peter Both, Ashley P. Mattey, Edward Pallister, Helene Ledru, Simon J. Charnock, M. Carmen Galan, W. Bruce Turnbull, Fabio Parmeggiani, Sabine L. Flitsch
A new α1,4 galactosyltransferase has been characterised and used for the synthesis of natural and non-natural cell surface trisaccharide antigens.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Rh(III)-Catalyzed regioselective C4 alkylation of indoles with allylic alcohols: direct access to β-indolyl ketones

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3038-3042
DOI: 10.1039/D0OB00396D, Communication
Changduo Pan, Gao Huang, Yujia Shan, Yiting Li, Jin-Tao Yu
A Rh(III)-catalyzed direct C4 alkylation of indoles with allylic alcohols to access β-indolyl ketones was developed.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3135-3141
DOI: 10.1039/D0OB00252F, Paper
Chiao Wen Chen, Ching Chi Wang, Xin Ru Li, Henryk Witek, Kwok-Kong Tony Mong
Polymethylhydrosiloxane (PMHS): a sub-stoichiometric reducing agent for reductive etherification of carbohydrate substrates and its application for one-pot protecting group manipulation
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Synthesis, radiolabelling and initial biological characterisation of 18F-labelled xanthine derivatives for PET imaging of Eph receptors

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3104-3116
DOI: 10.1039/D0OB00391C, Paper
Marc Pretze, Christin Neuber, Elisa Kinski, Birgit Belter, Martin Köckerling, Amedeo Caflisch, Jörg Steinbach, Jens Pietzsch, Constantin Mamat
Two new fluorine-18-labelled xanthine derivatives with high binding affinity were synthesised as PET-radioligand candidates for Eph receptors.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Asymmetric synthesis of (−)-solanidine and (−)-tomatidenol

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3169-3176
DOI: 10.1039/D0OB00457J, Paper
Yun Wang, Guanxin Huang, Yong Shi, Wei-sheng Tian, Chunlin Zhuang, Fen-Er Chen
The asymmetric synthesis of (−)-solanidine (1) and (−)-tomatidenol (2) has been achieved by employing a cascade ringswitching reaction and a cascade azide reduction/intramolecular reductive amination with 32% and 18.7% overall yields respectively.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Experimental results and computational insight into sequential reactions of β-(2-aminophenyl)-α,β-ynones with aryl isocyanates/benzoyl isothiocyanate

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3177-3189
DOI: 10.1039/D0OB00087F, Paper
Antonio Arcadi, Massimiliano Aschi, Marco Chiarini, Fabio Marinelli, Vincenzo Marsicano, Gustavo Portalone
The selective formation of quinazoline vs. benzoxazine  and benzothiazine derivatives from β-(2-aminophenyl)-α,β-ynones and aryl isocyanates/benzoyl isothiocyanate was explored. DFT calculations provide a plausible rationale.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3012-3016
DOI: 10.1039/D0OB00155D, Communication
Alexander S. Henderson, John F. Bower, M. Carmen Galan
The practical synthesis of pseudo-enantiomeric carbohydrate-based NHC–Rh complexes bearing C1 or C3 sterically differentiated positions is reported. We show that steric bulk at either C1 or C3 leads to enantiotopic discrimination in the hydrosilylation of acetophenone.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Synthesis and aggregation behaviour of single-chain, 1,32-alkyl-branched bis(phosphocholines) – part 2: lateral chain length triggers self-assembling from sheets to fibres to vesicles

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00534G, Paper
Kai Gruhle, Max Tuchtenhagen, Sindy Müller, Gerd Hause, Annette Meister, Simon Drescher
The synthesis of six single-chain, alkyl-branched bolalipids and first investigations of the lyotropic behaviour of these lipids are reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00582G, Communication
Maxime Manneveau, Saori Tanii, Fanny Gens, Julien Legros, Isabelle Chataigner
(3 + 2) Dearomatizing cycloaddition of 3-cyanoindoles occurs in smooth conditions with a non-stabilized azomethine ylide, to yield tricyclic indolines in only 1 min under microflow conditions using 3 equiv of the dipole precursor vs. 6 equiv. in a batch reactor.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Photocatalytic xanthate-based radical addition/cyclization reaction sequence toward 2-biphenyl isocyanides: synthesis of 6-alkylated phenanthridines

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00136H, Communication
Pedro López-Mendoza, Luis D. Miranda
A photocatalytic xanthate-based radical addition/cyclization reaction cascade toward 2-biphenylisocyanides is described as a practical and modular approach to 6-alkylated phenanthridines.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Study on the ArI-catalyzed intramolecular oxy-cyclization of 2-alkenylbenzamides to benzoiminolactones

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00612B, Communication
Huixia Liu, Xiaojun Deng, Xie Huang, Nan Ji, Wei He
A metal-free synthetic method toward the preparation of benzoiminolactones through oxy-cyclization of 2-alkenylbenzamides mediated by a catalyst/oxidant (ArI/mCPBA) system was developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Visible light promoted continuous flow photocyclization of 1,2-diketones

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00532K, Paper
Francesco Secci, Stefania Porcu, Alberto Luridiana, Angelo Frongia, Pier Carlo Ricci
A continuous flow Norrish–Yang photocyclization of 1,2-diketones has been developed and applied to the synthesis of functionalized 2-hydroxycyclobutanones, under blue light irradiation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Ni(II)-Catalyzed vinylic C–H functionalization of 2-acetamido-3-arylacrylates to access isotetronic acids

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00557F, Paper
Biswajit Roy, Eshani Das, Avijit Roy, Dipakranjan Mal
A ligand-free Ni(II)-catalyzed cascade annulation reaction for the synthesis of 4-aryl-substituted isotetronic acids from 2-acetamido-3-arylacrylates via vinylic C–H functionalization is reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00253D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hadyn L. Parker, Ruben M. F. Tomás, Christopher M. Furze, Collette S. Guy, Elizabeth Fullam
Chemoenzymatic synthesis of azido-functionalised asymmetric trehalose analogues that are resistant to enzymatic degradation to probe carbohydrate processing pathways in mycobacteria.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Acylation of oxindoles using methyl/phenyl esters via mixed Claisen condensation – An access to 3-alkylideneoxindoles

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00789G, Communication
Ramdas Sreedharan, Purushothaman Rajeshwaran, Pradeep Kumar Reddy Panyam, Saurabh Yadav, C. M. Nagaraja, THIRUMANAVELAN GANDHI
Predominantly, aggressive acid chlorides and stoichiometric coupling reagents are employed in the acylating process for synthesizing carbonyl tethered heterocycles. Herein, we report simple acyl sources, viz. methyl and phenyl esters...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/C9OB02724F, Communication
Yohei Arai, Shota Torigoe, Takanori Matsumaru, Sho Yamasaki, Yukari Fujimoto
We achieved the first synthesis of phosphatidylinositol mannoside Ac1PIM1, and a very potent agonist of an innate immune receptor DCAR is demonstrated.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Donor–acceptor fluorophores as efficient energy transfer photocatalysts for [2 + 2] photodimerization

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/C9OB02735A, Paper
Qing-An Wu, Feng Chen, Chen-Chao Ren, Xue-Fen Liu, Hao Chen, Liang-Xuan Xu, Xiao-Cong Yu, Shu-Ping Luo
Donor–acceptor fluorophores can act as efficient energy transfer photocatalysts to activate enone substrates, realizing photodimerization and isomerization reaction of enone substrates without precious metal photocatalysts.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Catalyst- and Solvent-Free Efficient Access to N-Alkylated Amines via Reductive Amination using HBPin

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00740D, Communication
ARNAB RIT, Vipin Kumar Pandey, Somnath Bauri
A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Discrimination of cellular developmental states focusing on glycan transformation and membrane dynamics by using BODIPY-tagged lactosyl ceramides

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00547A, Paper
Kenta Arai, Atsuko Ohtake, Shusaku Daikoku, Katsuhiko Suzuki, Yukishige Ito, Kazuya Kabayama, Koichi Fukase, Yoshimi Kanie, Osamu Kanie
Different cellular states were discriminated by analysing either the glycan transformation of exogenously introduced fluorescently tagged probe molecules or fluorescence recovery after photobleaching before conversion.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Rhodium-Catalyzed ortho-Acrylation of Aryl Ketone O-Methyl Oximes with Cyclopropenones

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00064G, Communication
Yafeng Liu, Yuan Tian, Kexin Su, Xin Guo, Baohua Chen
An efficient Rh-catalyzed ortho-acrylation reaction for the synthesis of chalcones from O-methyl ketoximes and cyclopropenones via C–H bond activation has been described. This cross-coupling reaction exhibits high functional group tolerance...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Electrochemically enabled functionalization of indoles or anilines to synthesis of hexafluoroisopropoxy indole and anilinederivatives

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00157K, Communication
Zu-yu Mo, Xin-Yu Wang, Yu-zhen Zhang, Li Yang, Hai-Tao Tang, Ying-Ming Pan
An environmentally benign electrochemically enabled site-selective functionalization of indole or aniline derivatives with hexafluoroisopropanol in the presence of tetrabutyl ammonium hexafluorophosphate as redox catalyst and electrolyte was demonstrated in this...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Synthesis of Glycosyl Sulfoximines by a Highly Chemo- and Stereoselective NH- and O-Transfer to Thioglycosides

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00647E, Paper
Arianna Tota, Claudia Carlucci, Luisa Pisano, Giuliano Cutolo, Guy James Clarkson, Giuseppe Romanazzi, Leonardo Degennaro, James A Bull, Patrick Rollin, Renzo Luisi
A synthesis of unprecedented and stable glycosyl sulfoximines is reported. The developed strategies represent the first examples of highly stereoselective sulfoximine formation directly from thioglycosides. X-ray analysis confirmed the structure...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Synthesis of unsymmetrical benzils via palladium-catalysed α-arylation–oxidation of 2-hydroxyacetophenones with aryl bromides

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00575D, Paper
Open Access
Takanori Matsuda, Souta Oyama
Unsymmetrical benzils are synthesised by a one-pot tandem palladium-catalysed α-arylation and oxidation of 2-hydroxyacetophenones with aryl bromides.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Synthesis and photophysical properties of selenopheno[2,3-b]quinoxaline and selenopheno[2,3-b]pyrazine heteroacenes

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00718H, Paper
Amol Sonawane, Atsushi Shimozuma, Taro Udagawa, Masayuki Ninomiya, Mamoru Koketsu
In this paper, we report the novel synthesis of three different heterocycles namely 2-arylselenopheno[2,3-b]quinoxaline, 3-(aryl/alkylselanyl)-2-arylselenopheno[2,3-b]quinoxaline and 6-phenyl-7-(arylselanyl)selenopheno[2,3-b]pyrazine derivatives from the corresponding 2,3-dichloroquinoxaline and 2,3-dichloropyrazine derivatives. Further, photophysical properties were investigated...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Insights into the secondary structures of lactam N-substituted stapled peptides

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00767F, Communication
Aldrin Vasco Vidal, Celia Gonzalez, Stefan Gröger, W Brandt, Jochen Balbach, Carlos Perez, Ludger A. Wessjohann, Daniel G. Rivera
Stapled peptides derived from the Ugi macrocyclization comprise a special class of cyclopeptides with an N-substituted lactam bridge cross-linking two amino acid side chains. Herein we report a comprehensive analysis...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3229-3233
DOI: 10.1039/D0OB00265H, Communication
Ying Han, Yifan Da, Mingjia Yu, Yaping Cheng, Xin Wang, Jiale Xiong, Guoying Guo, Yan Li, Xianxing Jiang, Xiaoqing Cai
An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic–inorganic inhibitors

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3288-3296
DOI: 10.1039/C9OB02682G, Paper
Matthew B. Minus, Haopei Wang, Jaime O. Munoz, Alexandra M. Stevens, Alicia E. Mangubat-Medina, Michael J. Krueger, Wei Liu, Moses M. Kasembeli, Julian C. Cooper, Mikhail I. Kolosov, David J. Tweardy, Michele S. Redell, Zachary T. Ball
Recurrence and drug resistance are major challenges in the treatment of acute myeloid leukemia (AML) that spur efforts to identify new clinical targets and active agents.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Synthesis, structures and photophysical properties of hexacoordinated organosilicon compounds with 2-(2-pyridyl)phenyl groups

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3239-3242
DOI: 10.1039/D0OB00484G, Communication
Shohei Furuta, Toshiaki Mori, Yusuke Yoshigoe, Kohei Sekine, Yoichiro Kuninobu
We synthesised novel air-, water-, heat-, acid-, and base-stable hexacoordinated organosilicon compounds, which contain two C,N-bidentate ligands and form two silafluorene equivalent moieties, with Lewis acid–base interactions.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Synthetic pathways to tetrahydrocannabinol (THC): an overview

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3203-3215
DOI: 10.1039/D0OB00464B, Review Article
Open Access
Victor R. L. J. Bloemendal, Jan C. M. van Hest, Floris P. J. T. Rutjes
This review summarises various synthetic pathways leading to tetrahydrocannabinol and structurally related cannabinoids.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

The quasi-irreversible inactivation of cytochrome P450 enzymes by paroxetine: a computational approach

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3334-3345
DOI: 10.1039/D0OB00529K, Paper
Emadeldin M. Kamel, Al Mokhtar Lamsabhi
The potency of paroxetine as a P450 inhibitor is mainly attributed to the availability of two active sites on its structure, its compatibility with P450's active site and the ease of its tight coordination to heme iron.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

A domino annulation approach to 3,4-diacylpyrrolo[1,2-a]pyrazines: decoration of pyrazine units

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3324-3333
DOI: 10.1039/D0OB00444H, Paper
Anuradha Dagar, Yohan Seo, Wan Namkung, Ikyon Kim
A new one-pot, sequential three-component access to 3,4-diacylpyrrolo[1,2-a]pyrazine was achieved from the reaction of an α-haloketone, azide, and N-substituted pyrrole-2-carboxaldehyde under mild reaction conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3354-3359
DOI: 10.1039/D0OB00419G, Paper
Amritha Rayaroth, Rajat Kumar Singh, Kalyanakrishnan A. V., Krishna Hari, Alagiri Kaliyamoorthy
1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs).
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Modular synthesis of oligoacetylacetones via site-selective silylation of acetylacetone derivatives

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3297-3302
DOI: 10.1039/D0OB00501K, Paper
Parantap Sarkar, Yuya Inaba, Hayato Shirakura, Tomoki Yoneda, Yasuhide Inokuma
Aliphatic oligoketones with tailored carbonyl and substituent sequences were modularly synthesized utilizing site-selective formation of enol silyl ethers. Their unique conformational preferences in solid-state were revealed by X-ray crystallography.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

A base-promoted tandem approach to bicyclic 8-membered ring ketones

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3249-3253
DOI: 10.1039/D0OB00618A, Communication
Emerson E. F. dos Santos, Gabriela F. P. de Souza, Deborah A. Simoni, Airton G. Salles
A base-promoted tandem route toward unprecedented bicyclic furan/8-membered ring ketones is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Dipyrazolodioxadiazocines as shelf-stable “ready-to-use” precursors for an in situ generation of enolate-iminium 1,4-dipoles: a straightforward atom-economical approach to pyrazolo[5,1-d][1,3,5]dioxazines

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, 18,3382-3391
DOI: 10.1039/D0OB00451K, Paper
Vladimir E. Zhulanov, Valeria A. Vigovskaya, Maksim V. Dmitriev, Pavel S. Silaichev, Andrey N. Maslivets, Michael Rubin
Generation of cyclic enolate-iminium 1,4-dipoles via thermolysis of dipyrazolodioxadiazocines in the presence of ketones allowed for efficient preparation of pyrazolo[5,1-d][1,3,5]dioxazines.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Controlling the liberation rate of the in situ release of a chemical fuel for the operationally autonomous motions of molecular machines

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00669F, Paper
Chiara Biagini, Giorgio Capocasa, Daniele Del Giudice, Valerio Cataldi, Luigi Mandolini, Stefano Di Stefano
Aminolysis of the anhydride of 2-cyano-2-phenylpropanoic acid can be employed to conveniently regulate the liberation rate of the related acid which, in turn, can be used as a fuel for acid–base operated molecular machines.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

A Selectfluor-promoted oxidative reaction of disulfides and amines: access to sulfinamides

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00720J, Paper
Haibo Mei, Jiang Liu, Romana Pajkert, Gerd-Volker Röschenthaler, Jianlin Han
An unprecedented metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Late-stage synthesis and application of photoreactive probes derived from direct benzoylation of heteroaromatic C–H bonds

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00336K, Communication
Kevin D. Hesp, Jun Xiao, Graham M. West
A synthetically-driven, late-stage C–H benzoylation strategy for the expedited preparation and evaluation of heterocyclic alternatives to more classical benzophenone photoreactive probes is reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Spiroconyone A, a new phytosterol with a spiro [5,6] ring system from Conyza japonica

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00666A, Paper
Long-Gao Xiao, Yu Zhang, Hong-Li Zhang, Ding Li, Qiong Gu, Gui-Hua Tang, Qian Yu, Lin-Kun An
The first rearranged phytosterol (spiroconyone A) with an unusual spiro [5,6] ring system and two new TDP1 inhibitors 7 and 10 showing a strong synergistic effect with topotecan were isolated from Conyza japonica.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Hierarchical Self-Assembly of Azobenzene Dyad with Inverted Amide Connection into Toroidal and Tubular Nanostructures

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00833H, Communication
Shiki Yagai, Takuho Saito
Inversion of the connectivity of amide groups in foldable azobenzene dyads with chiral side chains, which can self-assemble into toroids and nanotubes, significantly increases the thermal stability of these aggregates....
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Efficient synthesis of a galectin inhibitor clinical candidate (TD139) using a Payne rearrangement/azidation reaction cascade

By feeds.rsc.org
Published On ::

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00910E, Paper
Jacob St-Gelais, Vincent Denavit, Denis Giguère
Selective galectin inhibitors are valuable research tools and could also be used as drug candidates. In that context, TD139, a thiodigalactoside galectin-3 inhibitor, is currently being evaluated clinically for the...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

to

Urban Ministry questions Delhi govt's move to set up SEZs

By archive.indianexpress.com
Published On :: Wed, 05 Aug 2009 13:34:45 GMT

The Centre has questioned the legality of SEZs in absence of any provision for the same in the Master Plan Delhi (MPD) 2021.


Full Article

to

Aspiring actor-cum-model arrested for killing IT professional

By archive.indianexpress.com
Published On :: Thu, 06 Aug 2009 14:26:17 GMT

A 20-year-old aspiring actor- cum-model was arrested in the national capital for allegedly murdering a young woman IT professional a week ago after she refused to heed to his demand for money.


Full Article

to

CISF needs 4,500 addl personnel to man new 'Metro' routes

By archive.indianexpress.com
Published On :: Fri, 07 Aug 2009 11:37:35 GMT

With the Delhi Metro expanding its wings beyond Delhi, the CISF will require additional 4,500 personnel to guard the new operations of the mass rapid transport system.


Full Article

to

Pak politicians want to resolve Kashmir — military won't allow this: Arif Jamal

By timesofindia.indiatimes.com
Published On :: Sun, 22 Jun 2014 00:06:17 IST

Arif Jamal is a Pakistani journalist and South Asia expert based in America.


Full Article

to

There’s no power politics, customer is king, Piyush Goyal says

By timesofindia.indiatimes.com
Published On :: Thu, 26 Jun 2014 00:28:06 IST

The responsibility of lighting up the country today rests on Piyush Goyal’s shoulders. Just a month into his new job, the minister for power, coal and renewable energy has set an electric pace to energize the sector.


Full Article