Springhall, John

Krupnik, Igor

Anglin, Douglas George

Stephen, Lynn

Barsky, Robert F

Mruk, Christopher J

Winkler, Ira

Pickover, Clifford A

Ring, Laura A., 1968-

Badger, Michael

Badger, Michael

Sawyer, R. Keith (Robert Keith)

Thompson, Katrina Daly, 1975-

Nyathi, Pathisa, 1951-

Rotenstreich, Nathan, 1914-1993

This cohort study compares the characteristics and management of acute heart failure in global regions comprising 44 countries.

This prespecified secondary analysis of the MOMENTUM 3 randomized clinical trial aims to determine whether clinical outcomes of patients with 2 different left ventricular assist devices differed based on preoperative categories of bridge to transplant/bridge to candidacy vs destination therapy.

Lowering low-density lipoprotein cholesterol (LDL-C) levels remains a mainstay of cardiovascular disease prevention, but gaps in treatment remain, even in persons with hypercholesterolemia and greatly elevated LDL-C levels. Although well-described gene variants in the apolipoprotein B (APOB), low-density lipoprotein receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes explain small but important fractions of monogenic hypercholesterolemia, recent attention has turned to prognostication of cardiovascular disease using polygenic risk scores (PRS) that incorporate common genetic variants derived from large-scale genome-wide association studies of lipid subfractions. Earlier PRS considered only variants with genome-wide significance, and newer studies have focused on methods that better capture the variance conferred by millions of variants, suggesting an ability to identify risk equivalent to monogenic mutations. There remains a gap in evidence from prospective observational studies or treatment trials regarding the appropriate placement of PRS in risk assessment and lipid treatment decisions relative to information on rare monogenic gene variants, particularly in multiethnic populations.

This cohort study uses the UK Biobank cohort data to compare the association of monogenic vs polygenic hypercholesterolemia with the risk of atherosclerotic cardiovascular disease among individuals with comparable levels of low-density lipoprotein cholesterol.

This randomized clinical trial assesses the effectiveness of an implantable loop recorder plus 24-hour Holter electrocardiographic monitoring vs standard 24-hour Holter electrocardiographic monitoring alone for detecting arrhythmias in pregnant women with structural heart disease and/or symptoms suggestive of arrhythmias.

To the Editor We read with interest the study by Sepehrvand et al, which described secular trends in the conduct of pragmatic or explanatory cardiovascular randomized clinical trials over 2 decades. We believe extension of this thoughtful analysis can provide additional insights into pragmatic vs explanatory trials.

In Reply We thank Fernandes et al for their interest in our study and agree that this field requires further exploration. Explanatory trials are primed to maximize the likelihood of finding efficacy of an intervention by testing it in an ideal setting, whereas pragmatic trials aim to test effectiveness of an intervention in a more generalizable setting. Hence, they are expected to generate more generalizable results, with the risk understood that there may be more variation in less tightly controlled environments, which may result in differing results.

This Special Communication analyzes the conclusions drawn from effective regurgitant orifice area analysis and end-diastolic volume analysis from 2 randomized clinical trials to assess disparities in the different clinical outcomes.

With a date span of 1779 through 1955, the McManus-Young Collection provides a rich survey of the literature of "illusion practices," which includes works on conjuring, ventriloquism, fortune-telling, spiritualism, witchcraft, gambling, hypnotism, automata, and mind reading comprised of a gathering of thousands of pamphlets and offprints. This ephemeral literature is the backbone of modern...

Lawyer and banker. Diaries, documenting Mitchell's July 3-August 31, 1914, automobile trip in France as World War I broke out.

Lawyer, assistant attorney general for the United States Department of Justice Civil Division, and acting director of the United States Federal Bureau of Investigation (FBI). Correspondence, memoranda, notes, writings, speeches, testimony, legal records, military records, photographs, printed matter, and other papers relating chiefly to Gray's time as acting director of the FBI during the...

Economist, government official, and director of the Congressional Budget Office. Correspondence, memoranda, reports, speeches and other writings, congressional testimony, printed materials, newspaper clippings, and photographs pertaining to Rivlin's career as an economist and government official.

Barker Library - PQ7298.422.U37 L67 2019

Online Resource

Hayden Library - PQ7082.P7 C23 2018

Dewey Library - PQ7409.2.H355 M8313 2018

Dewey Library - PQ7070.C65 2018

Dewey Library - PQ7082.P7 W45 2018

Hayden Library - PQ7123.W6 E88 2018

With the arrest of Tehsin Akhtar, thought to be Indian Mujahideen (IM) commander of India operations, security agencies have netted another big fish in the fight against terror.

The Congress manifesto is the polar opposite of policies pursued by UPA-II. It promises to undo measures that clogged the economy and make economic growth the "overriding priority".

Lacking a cohesive national campaign, Kejriwal has yet again taken recourse to insurgent tactics – projecting himself as Modi’s only rival when Congress is yet to declare its nominee for Varanasi.

The disappearance of inflammatory communal slogans from political speeches suggests development is the agenda for 2014.

Trinamool Congress appears ready to move forward from the ferocious acrimony of Mamata-Modi exchanges during the election campaign.