ai Judge anger on $10 art claim By www.theaustralian.com.au Published On :: Wed, 11 Jan 2017 13:00:00 GMT A judge has issued a stinging rebuke to separating couples who expect the courts to decide frivolous disputes. Full Article
ai Le stress chronique affaiblit le système immunitaire By www.journaldemontreal.com Published On :: Sun, 15 Sep 2024 17:00:00 EDT Une étude rapporte que la perturbation de l’équilibre du microbiote intestinal par le stress dérègle la fonction des cellules immunitaires. Full Article
ai Les fromages en portions individuelles au banc d’essai By www.journaldemontreal.com Published On :: Sun, 06 Oct 2024 17:00:00 EDT Les fromages vendus en portions individuelles sont des plus pratiques pour l’école et le bureau. Full Article
ai Nutrition et cancer de l’ovaire By www.journaldemontreal.com Published On :: Sun, 27 Oct 2024 18:00:00 EDT En 2024, on estime que 3000 Canadiennes recevront un diagnostic de cancer de l’ovaire. Full Article
ai Union Ayush secretary to inaugurate 61st Ayurveda Seminar at Kottakkal Aryavaidyasala in Kerala on November 10 By www.pharmabiz.com Published On :: Thursday, November 7, 2024 08:00 IST The secretary of the Union Ayush Ministry, Dr Rajesh Kotecha, will inaugurate the 61st Ayurveda Seminar organized by the Kottakkal Aryavaidyasala (Kottakkal AVS) on November 10 at Kottakkal in Full Article
ai AIOCD urges DCGI to immediately stop partnership between Swiggy & PharmEasy for rapid drug delivery By www.pharmabiz.com Published On :: Friday, November 8, 2024 08:00 IST Raising deep concern over the partnership between Swiggy Instamart and PharmEasy for a rapid drug delivery model, the All India Organization of Chemists and Druggists (AIOCD) has apprised the Drug Controller Full Article
ai NABL to usher in accreditation insights for reference material producers in Raipur and Hyderabad By www.pharmabiz.com Published On :: Tuesday, November 12, 2024 08:00 IST Two exclusive conferences focusing on "Reference Material (RM) Producers" organized by National Accreditation Board for Testing and Calibration Laboratories (NABL) are scheduled to be held on January 10, Full Article
ai Inter─ministerial committee calls for amendment in FSSAI Act on nutraceuticals By www.pharmabiz.com Published On :: Wednesday, November 13, 2024 08:00 IST An inter─ministerial committee formed by the Union health ministry has recommended amendments to the Food Safety and Standards Act, 2006 and regulations on nutraceuticals and health supplements, to shift regulation of Full Article
ai Industry hails DoP's new scheme for strengthening of medical devices industry By www.pharmabiz.com Published On :: Wednesday, November 13, 2024 08:00 IST The centrally sponsored scheme for strengthening of medical devices industry (SMDI), launched by the Central government last week, was widely welcomed by the medical devices industry in the country. Full Article
ai NABL announces joint technical training programme with MANTRA on medical textiles testing By www.pharmabiz.com Published On :: Wednesday, November 13, 2024 08:00 IST The National Accreditation Board for Testing and Calibration Laboratories (NABL), under the Quality Council of India (QCI), has announced a collaborative effort with Man─Made Textile Research Association (MANTRA) in Surat to deliver a specialized technical training programme on medical textiles testing. Full Article
ai Q&A: Bringing sustainability into the medical industry By www.medicalplasticsnews.com Published On :: Tue, 05 Nov 2024 16:00:00 -0000 Brightmark CEO Bob Powell discusses Plastics Renewal technology and how to bring sustainability into the medical industry. Full Article
ai How are contract manufacturers driving sustainability? By www.medicalplasticsnews.com Published On :: Mon, 11 Nov 2024 16:30:00 -0000 Nick Guerin, CSP, director of environmental, health & safety at Tessy Plastics highlights how contract manufacturers are driving sustainability in the medical plastics industry. Full Article
ai Catastrophic Floods in Spain Kill at Least 95 People By www.scientificamerican.com Published On :: Thu, 31 Oct 2024 16:00:00 +0000 Torrential rain, made worse by climate change, has lashed Spain, with Valencia bearing the brunt of the floodwaters Full Article
ai How the Brain Summons Deep Sleep to Speed Healing By www.scientificamerican.com Published On :: Fri, 01 Nov 2024 13:00:00 +0000 A heart attack unleashes immune cells that stimulate neurons in the brain, leading to restorative slumber Full Article
ai We Need Scientific Brainstorming about Shared Global Dangers By www.scientificamerican.com Published On :: Thu, 07 Nov 2024 11:00:00 +0000 It is difficult to disentangle Russian and Chinese scientists from international science cooperation. That is a good thing Full Article
ai Rainwater Could Help Satisfy AI’s Water Demands By www.scientificamerican.com Published On :: Thu, 07 Nov 2024 13:00:00 +0000 A few dozen ChatGPT queries cost a bottle’s worth of water. Tech firms should consider simpler solutions, such as harvesting rainwater, to meet AI’s needs Full Article
ai Consciousness Might Hide in Our Brain’s Electric Fields By www.scientificamerican.com Published On :: Fri, 08 Nov 2024 11:00:00 +0000 A mysterious electromagnetic mechanism may be more important than the firing of neurons in our brain to explain our awareness Full Article
ai Available for Preorder: The 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors By feeds.feedblitz.com Published On :: Tue, 17 Sep 2024 10:30:00 +0000 On October 8, 2024, Drug Channels Institute will release our 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors. This report—our fifteenth edition—remains the most comprehensive, fact-based tool for understanding and analyzing the large and growing U.S. pharmaceutical distribution industry. 9 chapters, 350+ pages, 178 exhibits, 750+ endnotes: There is nothing else available that comes close to this valuable resource. We are providing you with the opportunity to preorder this thoroughly updated, revised, and expanded 2024-25 edition at special discounted prices. This means that you can be among the first to access our new report. Those who preorder will receive a download link before October 8. Review pricing/license options and place a preorder Download a free pre-publication report overview (including key industry trends, What's New in this edition, the Table of Contents, and a List of Exhibits) You can pay online with all major credit cards (Visa, MasterCard, American Express, and Discover) or via PayPal. Click here to contact us if you would like to pay by corporate check or ACH. Special preorder and launch pricing discounts will be valid through October 23, 2024. Read on for more details. Read more » Full Article Biosimilars Buy-and-Bill Channel Management Group Purchasing Organizations (GPOs) Industry Trends Inflation Reduction Act of 2022 Physicians Specialty Drugs Wholesalers
ai Innovative Models for Improving Access and Visibility for Specialty-Lite and Retail Therapies By feeds.feedblitz.com Published On :: Fri, 04 Oct 2024 11:23:00 +0000 Today’s guest post comes from Timothy Nielsen, Vice President of Customer Success at AssistRx. Timothy discusses the affordability and patient journey challenges of specialty-lite products for patients, manufacturers, and health care providers. He explains how AssistRx's Advanced Access Anywhere (AAA) solution streamlines processes for specialty-lite products and facilitates enrollment via a digital hub. To learn more, register for AssistRx's free webinar on October 8: Meet Your Patients Where They Are & Gain Visibility: Even at Retail. Read on for Timothy’s insights. Read more » Full Article Guest Post Sponsored Post
ai NOW AVAILABLE: 2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors By feeds.feedblitz.com Published On :: Tue, 08 Oct 2024 10:30:00 +0000 I am pleased to announce Drug Channels Institute's new 2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors, available for purchase and immediate download. Download a free report overview (including key industry trends, the Table of Contents, and a List of Exhibits) Review pricing/license options and download the full 2024-25 report We’re offering special discounted pricing if you order before October 23, 2024. 2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors—our 15th edition--remains the most comprehensive, fact-based tool for understanding and analyzing the large and growing U.S. pharmaceutical distribution industry. This 2024-25 edition includes substantial new material—outlined on page vii of the report overview. 9 chapters, 380+ pages, 178 exhibits, more than 750 endnotes: There is nothing else available that comes close to this valuable resource. You can pay online with all major credit cards (Visa, MasterCard, American Express, and Discover) or via PayPal. Click here to contact us if you would like to pay by corporate check or ACH.Email Paula Fein (paula@drugchannels.net) if you’d like to bundle your report purchase with access to DCI’s video webinars. If you preordered the report, you should have already received an email with download instructions last week. Please contact us if you did not receive your email. Read on for some additional details. Read more » Full Article Industry Trends Wholesalers
ai Drug Channels News Roundup, October 2024: Humira Price War Update, PA vs. Providers, IRA vs. Physicians, My AI Podcast, New DCI Jobs, and Dr. G on Copayments By feeds.feedblitz.com Published On :: Tue, 29 Oct 2024 10:30:00 +0000 Eeek! It's time for Drug Channels’ Halloween roundup of terrifying tales to share with your ghoulish fiends. This month’s tricks and treats: Spooky! Blue Shield of California frightens away the gross-to-net bubble with its Humira biosimilar strategy Vampiric! Prior authorization sinks its fangs into providers’ time Wicked! How the IRA will put a stake through specialty physician practices Eerie! Google’s monstrous AI podcasts leave me petrified Zoinks! Join the vampire hunters at Drug Channels Institute Plus, Dr. Glaucomflecken tells us a frightening tale of copayments. P.S. Stretch out your arms and join the ever-growing zombie horde who shamble after me on LinkedIn. You’ll find my ghostly rantings along with commentary from the undead hordes in the DCI community. Read more » Full Article Average Sales Price (ASP) Biosimilars Buy-and-Bill Gross-to-Net Bubble Inflation Reduction Act of 2022 PBMs Physicians
ai New On-Demand Training Platform By regulatoryrx.blogspot.com Published On :: Mon, 02 May 2022 12:00:00 +0000 I am pleased to announce the availability of on-demand training about FDA's regulation of advertising and promotion. So, you are now able to learn about the wonderful world of FDA ad-promo from the comfort of your home, office, or campsite. At PhillyCooke.Thinkific.com, you can see the courses that are currently available and sign up. In the video above, there's a special discount code to celebrate the launch of this new platform.If you are interested in providing access to the training for your full team, then please email me at DCooke@PhillyCooke.com or fill out the contact form on the website. I can provide all of the information about the corporate licensing. Every course comes with access for a full year. You can view, and review, the content as often as you like. In addition, every module on the platform is reviewed in its entirety at least twice per year. If something changes, new modules will replace the old ones, and students will be notified of the update. Those new modules will be available at no additional cost! That way you can rest assured that the information you are learning is always current with the latest developments in the world of ad-promo. Full Article APLB FDA On-demand OPDP SEM SEO training
ai California Adopts a Bundle of AI & Privacy Laws, Most Controversial Bills Vetoed (Updated) By cohealthcom.org Published On :: Mon, 30 Sep 2024 19:05:07 +0000 Sorry, but you do not have permission to view this content. Full Article Artificial Intelligence (AI) Data Privacy Legislative child data privacy CO Colorado consumer privacy data privacy legislation Jim Potter
ai Former CHC Board Chairs Sharon Callahan and Nick Colucci Named as 2025 MAHF Inductees By cohealthcom.org Published On :: Fri, 25 Oct 2024 20:39:55 +0000 Two former board chairs of the Coalition for Healthcare Communication (CHC) were named as the Medical Advertising Hall of Fame (MAHF) 2025 inductees – Sharon Callahan, former Chief Client Officer at Omnicom Health Group (OHG), and Nick Colucci, former Chairman and CEO of Publicis Health/COO of Publicis Groupe North America. The inductees will be honored […] Full Article CHC News chc MAHF Nick Colucci Sharon Callahan
ai Don’t Confuse the Art and Science of Medicine: PCI vs CABG for Left Main Disease By www.cardiobrief.org Published On :: Thu, 20 Aug 2020 15:56:47 +0000 It is often said that medicine is both an art and a science. In an imperfect world this is both inevitable and desirable. But it is extremely important that the two should not be confused with each other. In particular, because the “science” side of the equation has achieved overwhelming prestige and authority, it is...Click here to continue reading... Full Article Interventional Cardiology & Surgery People Places & Events Policy & Ethics CABG guidelines left main disease LMCA PCI
ai Medicines for Europe 23rd Regulatory Affairs Conference 2025 By www.gabionline.net Published On :: Tue, 05 Nov 2024 09:04:58 +0000 <p> <b>23rd Regulatory Affairs Conference 202</b><b>5</b><br /> <b>27</b><b>‒</b><b>28 February 2025</b><br /> Hilton Amsterdam Airport Schiphol<br />Amsterdam, The Netherlands</p> Full Article
ai MHRA to consult on making two progestogen-only contraceptives available without a prescription By www.pharmaceutical-journal.com Published On :: Mon, 15 Feb 2021 12:22 GMT Consultations on the reclassification of two progestogen-only contraceptive pills from prescription-only to pharmacy medicines have been launched. Full Article
ai Waiver of Informed Consent - proposed changes in the 21st Century Cures Act By www.placebocontrol.com Published On :: Tue, 14 Jul 2015 20:21:00 +0000 Adam Feuerstein points out - and expresses considerable alarm over - an overlooked clause in the 21st Century Cures Act: Waive informed consent requirement for clinical trials?!?! Unbelievable but true if #Path2Cures becomes law. pic.twitter.com/dqmWPpxPdE — Adam Feuerstein (@adamfeuerstein) July 14, 2015 In another tweet, he suggests that the act will "decimate" informed consent in drug trials. Subsequent responses and retweets did nothing to clarify the situation, and if anything tended to spread, rather than address, Feuerstein's confusion. Below is a quick recap of the current regulatory context and a real-life example of where the new wording may be helpful. In short, though, I think it's safe to say: Waiving informed consent is not new; it's already permitted under current regs The standards for obtaining a waiver of consent are stringent They may, in fact, be too stringent in a small number of situations The act may, in fact, be helpful in those situations Feuerstein may, in fact, need to chill out a little bit (For the purposes of this discussion, I’m talking about drug trials, but I believe the device trial situation is parallel.) Section 505(i) - the section this act proposes to amend - instructs the Secretary of Health and Human Services to propagate rules regarding clinical research. Subsection 4 addresses informed consent: …the manufacturer, or the sponsor of the investigation, require[e] that experts using such drugs for investigational purposes certify to such manufacturer or sponsor that they will inform any human beings to whom such drugs, or any controls used in connection therewith, are being administered, or their representatives, that such drugs are being used for investigational purposes and will obtain the consent of such human beings or their representatives, except where it is not feasible or it is contrary to the best interests of such human beings. [emphasis mine] Note that this section already recognizes situations where informed consent may be waived for practical or ethical reasons. These rules were in fact promulgated under 45 CFR part 46, section 116. The relevant bit – as far as this conversation goes – regards circumstances under which informed consent might be fully or partially waived. Specifically, there are 4 criteria, all of which need to be met: (1) The research involves no more than minimal risk to the subjects; (2) The waiver or alteration will not adversely affect the rights and welfare of the subjects; (3) The research could not practicably be carried out without the waiver or alteration; and (4) Whenever appropriate, the subjects will be provided with additional pertinent information after participation. In practice, this is an especially difficult set of criteria to meet for most studies. Criterion (1) rules out most “conventional” clinical trials, because the hallmarks of those trials (use of an investigational medicine, randomization of treatment, blinding of treatment allocation) are all deemed to be more than “minimal risk”. That leaves observational studies – but even many of these cannot clear the bar of criterion (3). That word “practicably” is a doozy. Here’s an all-too-real example from recent personal experience. A drug manufacturer wants to understand physicians’ rationales for performing a certain procedure. It seems – but there is little hard data – that a lot of physicians do not strictly follow guidelines on when to perform the procedure. So we devise a study: whenever the procedure is performed, we ask the physician to complete a quick form categorizing why they made their decision. We also ask him or her to transcribe a few pieces of data from the patient chart. Even though the patients aren’t personally identifiable, the collection of medical data qualifies this as a clinical trial. It’s a minimal risk trial, definitely: the trial doesn’t dictate at all what the doctor should do, it just asks him or her to record what they did and why, and supply a bit of medical context for the decision. All told, we estimated 15 minutes of physician time to complete the form. The IRB monitoring the trial, however, denied our request for a waiver of informed consent, since it was “practicable” (not easy, but possible) to obtain informed consent from the patient. Informed consent – even with a slimmed-down form – was going to take a minimum of 30 minutes, so the length of the physician’s involvement tripled. In addition, many physicians opted out of the trial because they felt that the informed consent process added unnecessary anxiety and alarm for their patients, and provided no corresponding benefit. The end result was not surprising: the budget for the trial more than doubled, and enrollment was far below expectations. Which leads to two questions: 1. Did the informed consent appreciably help a single patient in the trial? Very arguably, no. Consenting to being “in” the trial made zero difference in the patients’ care, added time to their stay in the clinic, and possibly added to their anxiety. 2. Was less knowledge collected as a result? Absolutely, yes. The sponsor could have run two studies for the same cost. Instead, they ultimately reduced the power of the trial in order to cut losses. Bottom line, it appears that the modifications proposed in the 21st Century Cures Act really only targets trials like the one in the example. The language clearly retains criteria 1 and 2 of the current HHS regs, which are the most important from a patient safety perspective, but cuts down the “practicability” requirement, potentially permitting high quality studies to be run with less time and cost. Ultimately, it looks like a very small, but positive, change to the current rules. The rest of the act appears to be a mash-up of some very good and some very bad (or at least not fully thought out) ideas. However, this clause should not be cause for alarm. Full Article 21st Century Cures Act Adam Feuerstein informed consent
ai The first paid research subject in written history? By www.placebocontrol.com Published On :: Mon, 21 Nov 2016 20:31:00 +0000 On this date 349 years ago, Samuel Pepys relates in his famous diary a remarkable story about an upcoming medical experiment. As far as I can tell, this is the first written description of a paid research subject. According to his account, the man (who he describes as “a little frantic”) was to be paid to undergo a blood transfusion from a sheep. It was hypothesized that the blood of this calm and docile animal would help to calm the man. Some interesting things to note about this experiment: Equipoise. There is explicit disagreement about what effect the experimental treatment will have: according to Pepys, "some think it may have a good effect upon him as a frantic man by cooling his blood, others that it will not have any effect at all". Results published. An account of the experiment was published just two weeks later in the journal Philosophical Transactions. Medical Privacy. In this subsequent write-up, the research subject is identified as Arthur Coga, a former Cambridge divinity student. According to at least one account, being publicly identified had a bad effect on Coga, as people who had heard of him allegedly succeeded in getting him to spend his stipend on drink (though no sources are provided to confirm this story). Patient Reported Outcome. Coga was apparently chosen because, although mentally ill, he was still considered educated enough to give an accurate description of the treatment effect. Depending on your perspective, this may also be a very early account of the placebo effect, or a classic case of ignoring the patient’s experience. Because even though his report was positive, the clinicians remained skeptical. From the journal article: The Man after this operation, as well as in it, found himself very well, and hath given in his own Narrative under his own hand, enlarging more upon the benefit, he thinks, he hath received by it, than we think fit to own as yet. …and in fact, a subsequent diary entry from Pepys mentions meeting Coga, with similarly mixed impressions: “he finds himself much better since, and as a new man, but he is cracked a little in his head”. The amount Coga was paid for his participation? Twenty shillings – at the time, that was exactly one Guinea. [Image credit: Wellcome Images] Full Article benefits of clinical trials ethics Guinea Pigs PRO sample size
ai Patrick Dempsey aims to raise awareness of cancer disparities and encourage screening By www.npr.org Published On :: Mon, 11 Nov 2024 05:18:50 -0500 NPR's Leila Fadel talks with actor Patrick Dempsey about his efforts to raise money for cancer treatment and prevention. Full Article
ai Online yoga classes prove helpful for back pain in new study By www.npr.org Published On :: Tue, 12 Nov 2024 08:00:00 -0500 Participant reported relief from chronic low back pain and reduced need for pain-relief medications. Full Article
ai With Trump coming into power, the NIH is in the crosshairs By www.npr.org Published On :: Tue, 12 Nov 2024 13:16:08 -0500 The National Institutes of Health, the crown jewel of biomedical research in the U.S., could face big changes under the new Trump administration, some fueled by pandemic-era criticisms of the agency. Full Article
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ai Noise Cancellation for Your Brain By spectrum.ieee.org Published On :: Tue, 04 Jun 2024 13:06:40 +0000 Elemind, a 5-year-old startup based in Cambridge, Mass., today unveiled a US $349 wearable for neuromodulation, the company’s first product. According to cofounder and CEO Meredith Perry, the technology tracks the oscillation of brain waves using electroencephalography (EEG) sensors that detect the electrical activity of the brain and then influence those oscillations using bursts of sound delivered via bone conduction.Elemind’s first application for this wearable aims to suppress alpha waves to help induce sleep. There are other wearables on the market that monitor brain waves and, through biofeedback, encourage users to actively modify their alpha patterns. Elemind’s headband appears to be the first device to use sound to directly influence the brain waves of a passive user. In a clinical trial, says Perry [no relation to author], 76 percent of subjects fell asleep more quickly. Those who did see a difference averaged 48 percent less time to progress from awake to asleep. The results were similar to those of comparable trials of pharmaceutical sleep aids, Perry indicated.“For me,” Perry said, “it cuts through my rumination, quiets my thinking. It’s like noise cancellation for the brain.”I briefly tested Elemind’s headband in May. I found it comfortable, with a thick cushioned band that sits across the forehead connected to a stretchy elastic loop to keep it in place. In the band are multiple EEG electrodes, a processor, a three-axis accelerometer, a rechargeable lithium-polymer battery, and custom electronics that gather the brain’s electrical signals, estimate their phase, and generate pink noise through a bone-conduction speaker. The whole thing weighs about 60 grams—about as much as a small kiwi fruit.My test conditions were far from optimal for sleep: early afternoon, a fairly bright conference room, a beanbag chair as bed, and a vent blowing. And my test lasted just 4 minutes. I can say that I didn’t find the little bursts of pink noise (white noise without the higher frequencies) unpleasant. And since I often wear an eye mask, feeling fabric on my face wasn’t disturbing. It wasn’t the time or place to try for sound sleep, but I—and the others in the room—noted that after 2 minutes I was yawning like crazy.How Elemind tweaks brain wavesWhat was going on in my brain? Briefly, different brain states are associated with different frequencies of waves. Someone who is relaxed with eyes closed but not asleep produces alpha waves at around 10 hertz. As they drift off to sleep, the alpha waves are supplanted by theta waves, at around 5 Hz. Eventually, the delta waves of deep sleep show up at around 1 Hz.Ryan Neely, Elemind’s vice president of science and research, explains: “As soon as you put the headband on,” he says, “the EEG system starts running. It uses straightforward signal processing with bandpass filtering to isolate the activity in the 8- to 12-Hz frequency range—the alpha band.”“Then,” Neely continues, “our algorithm looks at the filtered signal to identify the phase of each oscillation and determines when to generate bursts of pink noise.” To help a user fall asleep more quickly [top], bursts of pink noise are timed to generate a brain response that is out of phase with alpha waves and so suppresses them. To enhance deep sleep [bottom], the pink noise is timed to generate a brain response that is in phase with delta waves.Source: ElemindThese auditory stimuli, he explains, create ripples in the waves coming from the brain. Elemind’s system tries to align these ripples with a particular phase in the wave. Because there is a gap between the stimulus and the evoked response, Elemind tested its system on 21 people and calculated the average delay, taking that into account when determining when to trigger a sound.To induce sleep, Elemind’s headband targets the trough in the alpha wave, the point at which the brain is most excitable, Neely says.“You can think of the alpha rhythm as a gate for communication between different areas of the brain,” he says. “By interfering with that communication, that coordination between different brain areas, you can disrupt patterns, like the ruminations that keep you awake.”With these alpha waves suppressed, Neely says, the slower oscillations, like the theta waves of light sleep, take over.Elemind doesn’t plan to stop there. The company plans to add an algorithm that addresses delta waves, the low-frequency 0.5- to 2-Hz waves characteristic of deep sleep. Here, Elemind’s technology will attempt to amplify this pattern with the intent of improving sleep quality.Is this safe? Yes, Neely says, because auditory stimulation is self-limiting. “Your brain waves have a natural space they can occupy,” he explains, “and this stimulation just moved it within that natural space, unlike deep-brain stimulation, which can move the brain activity outside natural parameters.”Going beyond sleep to sedation, memory, and mental healthApplications may eventually go beyond inducing and enhancing sleep. Researchers at the University of Washington and McGill University have completed a clinical study to determine if Elemind’s technology can be used to increase the pain threshold of subjects undergoing sedation. The results are being prepared for peer review.Elemind is also working with a team involving researchers at McGill and the Leuven Brain Institute to determine if the technology can enhance memory consolidation in deep sleep and perhaps have some usefulness for people with mild cognitive impairment and other memory disorders. Neely would love to see more applications investigated in the future.“Inverse alpha stimulation [enhancing instead of suppressing the signal] could increase arousal,” he says. “That’s something I’d love to look into. And looking into mental-health treatment would be interesting, because phase coupling between the different brain regions appears to be an important factor in depression and anxiety disorders.”Perry, who previously founded the wireless power startup UBeam, cofounded Elemind with four university professors with expertise in neuroscience, optogenetics, biomedical engineering, and artificial intelligence. The company has $12 million in funding to date and currently has 13 employees.Preorders at $349 start today for beta units, and Elemind expects to start general sales later this year. The company will offer customers an optional membership at $7 to $13 monthly that will allow cloud storage of sleep data and access to new apps as they are released. Full Article Alpha waves Elemind Neuromodulation Sleep Startup Wearable
ai Is AI Search a Medical Misinformation Disaster? By spectrum.ieee.org Published On :: Thu, 13 Jun 2024 13:00:04 +0000 Last month when Google introduced its new AI search tool, called AI Overviews, the company seemed confident that it had tested the tool sufficiently, noting in the announcement that “people have already used AI Overviews billions of times through our experiment in Search Labs.” The tool doesn’t just return links to Web pages, as in a typical Google search, but returns an answer that it has generated based on various sources, which it links to below the answer. But immediately after the launch users began posting examples of extremely wrong answers, including a pizza recipe that included glue and the interesting fact that a dog has played in the NBA. Renée DiResta has been tracking online misinformation for many years as the technical research manager at Stanford’s Internet Observatory.While the pizza recipe is unlikely to convince anyone to squeeze on the Elmer’s, not all of AI Overview’s extremely wrong answers are so obvious—and some have the potential to be quite harmful. Renée DiResta has been tracking online misinformation for many years as the technical research manager at Stanford’s Internet Observatory and has a new book out about the online propagandists who “turn lies into reality.” She has studied the spread of medical misinformation via social media, so IEEE Spectrum spoke to her about whether AI search is likely to bring an onslaught of erroneous medical advice to unwary users.I know you’ve been tracking disinformation on the Web for many years. Do you expect the introduction of AI-augmented search tools like Google’s AI Overviews to make the situation worse or better?Renée DiResta: It’s a really interesting question. There are a couple of policies that Google has had in place for a long time that appear to be in tension with what’s coming out of AI-generated search. That’s made me feel like part of this is Google trying to keep up with where the market has gone. There’s been an incredible acceleration in the release of generative AI tools, and we are seeing Big Tech incumbents trying to make sure that they stay competitive. I think that’s one of the things that’s happening here. We have long known that hallucinations are a thing that happens with large language models. That’s not new. It’s the deployment of them in a search capacity that I think has been rushed and ill-considered because people expect search engines to give them authoritative information. That’s the expectation you have on search, whereas you might not have that expectation on social media.There are plenty of examples of comically poor results from AI search, things like how many rocks we should eat per day [a response that was drawn for an Onion article]. But I’m wondering if we should be worried about more serious medical misinformation. I came across one blog post about Google’s AI Overviews responses about stem-cell treatments. The problem there seemed to be that the AI search tool was sourcing its answers from disreputable clinics that were offering unproven treatments. Have you seen other examples of that kind of thing?DiResta: I have. It’s returning information synthesized from the data that it’s trained on. The problem is that it does not seem to be adhering to the same standards that have long gone into how Google thinks about returning search results for health information. So what I mean by that is Google has, for upwards of 10 years at this point, had a search policy called Your Money or Your Life. Are you familiar with that?I don’t think so.DiResta: Your Money or Your Life acknowledges that for queries related to finance and health, Google has a responsibility to hold search results to a very high standard of care, and it’s paramount to get the information correct. People are coming to Google with sensitive questions and they’re looking for information to make materially impactful decisions about their lives. They’re not there for entertainment when they’re asking a question about how to respond to a new cancer diagnosis, for example, or what sort of retirement plan they should be subscribing to. So you don’t want content farms and random Reddit posts and garbage to be the results that are returned. You want to have reputable search results.That framework of Your Money or Your Life has informed Google’s work on these high-stakes topics for quite some time. And that’s why I think it’s disturbing for people to see the AI-generated search results regurgitating clearly wrong health information from low-quality sites that perhaps happened to be in the training data.So it seems like AI overviews is not following that same policy—or that’s what it appears like from the outside?DiResta: That’s how it appears from the outside. I don’t know how they’re thinking about it internally. But those screenshots you’re seeing—a lot of these instances are being traced back to an isolated social media post or a clinic that’s disreputable but exists—are out there on the Internet. It’s not simply making things up. But it’s also not returning what we would consider to be a high-quality result in formulating its response.I saw that Google responded to some of the problems with a blog post saying that it is aware of these poor results and it’s trying to make improvements. And I can read you the one bullet point that addressed health. It said, “For topics like news and health, we already have strong guardrails in place. In the case of health, we launched additional triggering refinements to enhance our quality protections.” Do you know what that means?DiResta: That blog posts is an explanation that [AI Overviews] isn’t simply hallucinating—the fact that it’s pointing to URLs is supposed to be a guardrail because that enables the user to go and follow the result to its source. This is a good thing. They should be including those sources for transparency and so that outsiders can review them. However, it is also a fair bit of onus to put on the audience, given the trust that Google has built up over time by returning high-quality results in its health information search rankings.I know one topic that you’ve tracked over the years has been disinformation about vaccine safety. Have you seen any evidence of that kind of disinformation making its way into AI search?DiResta: I haven’t, though I imagine outside research teams are now testing results to see what appears. Vaccines have been so much a focus of the conversation around health misinformation for quite some time, I imagine that Google has had people looking specifically at that topic in internal reviews, whereas some of these other topics might be less in the forefront of the minds of the quality teams that are tasked with checking if there are bad results being returned.What do you think Google’s next moves should be to prevent medical misinformation in AI search?DiResta: Google has a perfectly good policy to pursue. Your Money or Your Life is a solid ethical guideline to incorporate into this manifestation of the future of search. So it’s not that I think there’s a new and novel ethical grounding that needs to happen. I think it’s more ensuring that the ethical grounding that exists remains foundational to the new AI search tools. Full Article Ai search Google Disinformation Generative ai Large language models Health Medicine Search
ai Next-Gen Brain Implant Uses a Graphene Chip By spectrum.ieee.org Published On :: Sat, 20 Jul 2024 13:00:02 +0000 A Barcelona-based startup called Inbrain Neuroelectronics has produced a novel brain implant made of graphene and is gearing up for its first in-human test this summer. The technology is a type of brain-computer interface. BCIs have garnered interest because they record signals from the brain and transmit them to a computer for analysis. They have been used for medical diagnostics, as communication devices for people who can’t speak, and to control external equipment, including robotic limbs. But Inbrain intends to transform its BCI technology into a therapeutic tool for patients with neurological issues such as Parkinson’s disease.Because Inbrain’s chip is made of graphene, the neural interface has some interesting properties, including the ability to be used to both record from and stimulate the brain. That bidirectionality comes from addressing a key problem with the metallic chips typically used in BCI technology: Faradaic reactions. Faradaic reactions are a particular type of electrochemical processes that occurs between a metal electrode and an electrolyte solution. As it so happens, neural tissue is largely composed of aqueous electrolytes. Over time, these Faradaic reactions reduce the effectiveness of the metallic chips.That’s why Inbrain replaced the metals typically used in such chips with graphene, a material with great electrical conductivity. “Metals have Faraday reactions that actually make all the electrons interact with each other, degrading their effectiveness...for transmitting signals back to the brain,” said Carolina Aguilar, CEO and cofounder of Inbrain. Because graphene is essentially carbon and not a metal, Aguilar says the chip can inject 200 times as much charge without creating a Faradic reaction. As a result, the material is stable over the millions of pulses of stimulation required of a therapeutic tool. While Inbrain is not yet testing the chip for brain stimulation, the company expects to reach that goal in due time.The graphene-based chip is produced on a wafer using traditional semiconductor technology, according to Aguilar. At clean-room facilities, Inbrain fabricates a 10-micrometer-thick chip. The chip consists of what Aguilar terms “graphene dots” (not to be confused with graphene quantum dots) that range in size from 25 to 300 micrometers. “This micrometer scale allows us to get that unique resolution on the decoding of the signals from the brain, and also provides us with the micrometric stimulation or modulation of the brain,” added Aguilar.Testing the Graphene-Based BCIThe first test of the platform in a human patient will soon be performed at the University of Manchester, in England, where it will serve as an interface during the resection of a brain tumor. When resecting a tumor, surgeons must ensure that they don’t damage areas like the brain’s language centers so the patient isn’t impaired after the surgery. “The chip is positioned during the tumor resection so that it can read, at a very high resolution, the signals that tell the surgeon where there is a tumor and where there is not a tumor,” says Aguilar. That should enable the surgeons to extract the tumor with micrometric precision while preserving functional areas like speech and cognition.Aguilar added, “We have taken this approach for our first human test because it is a very reliable and quick path to prove the safety of graphene, but also demonstrate the potential of what it can do in comparison to metal technology that is used today.”Aguilar stresses that the Inbrain team has already tested the graphene-based chip’s biocompatibility. “We have been working for the last three years in biocompatibility through various safety studies in large animals,” said Aguilar. “So now we can have these green lights to prove an additional level of safety with humans.”While this test of the chip at Manchester is aimed at aiding in brain tumor surgery, the same technology could eventually be used to help Parkinson’s patients. Toward this aim, Inbrain’s system was granted Breakthrough Device Designation last September from the U.S. Food & Drug Administration as an adjunctive therapy for treating Parkinson’s disease. “For Parkinson’s treatment, we have been working on different preclinical studies that have shown reasonable proof of superiority versus current commercial technology in the [reduction] of Parkinson’s disease symptoms,” said Aguilar.For treating Parkinson’s, Inbrain’s chip connects with the nigrostriatal pathway in the brain that is critical for movements. The chip will first decode the intention message from the brain that triggers a step or the lifting of the arm—something that a typical BCI can do. But Inbrain’s chip, with its micrometric precision, can also decode pathological biomarkers related to Parkinson’s symptoms, such as tremors, rigidity, and freezing of the gait. By determining these biomarkers with great precision, Inbrain’s technology can determine how well a patient’s current drug regimen is working. In this first iteration of the Inbrain chip, it doesn’t treat the symptoms of Parkinson’s directly, but instead makes it possible to better target and reduce the amount of drugs that are used in treatment.“Parkinson’s patients take huge amounts of drugs that have to be changed over time just to keep up with the growing resistance patients develop to the power of the drug,” said Aguilar. “We can reduce it at least 50 percent and hopefully in the future more as our devices become precise.” Full Article Graphene Brain computer interface Parkinson's disease Neurotechnology Brain implants
ai What My Daughter’s Harrowing Alaska Airlines Flight Taught Me About Healthcare By medcitynews.com Published On :: Wed, 06 Nov 2024 15:11:00 +0000 As a leader who has committed much of his career to improving healthcare — an industry that holds millions of people’s lives in its hands — I took from this terrifying incident a new guiding principle. Healthcare needs to pursue a zero-failure rate. The post What My Daughter’s Harrowing Alaska Airlines Flight Taught Me About Healthcare appeared first on MedCity News. Full Article Daily Health IT MedCity Influencers Medical Education Providers clinician burnout failure health IT medical errors
ai AI is Revolutionizing Healthcare, But Are We Ready for the Ethical Challenges? By medcitynews.com Published On :: Thu, 07 Nov 2024 15:09:00 +0000 Navigating the regulatory and ethical requirements of different medical data providers across many different countries, as well as safeguarding patient privacy, is a mammoth task that requires extra resources and expertise. The post AI is Revolutionizing Healthcare, But Are We Ready for the Ethical Challenges? appeared first on MedCity News. Full Article Artificial Intelligence Daily Health IT MedCity Influencers AI AI bias bias challenges discrimination ethics health IT
ai Inside Providence’s Health Equity & Medicaid Strategy By medcitynews.com Published On :: Sun, 10 Nov 2024 20:10:11 +0000 Whitney Haggerson — vice president of health equity and Medicaid at Providence — discussed the significance of her role, as well as how her health system is working to give all employees, regardless of title, the skills needed to help reduce health inequities. The post Inside Providence’s Health Equity & Medicaid Strategy appeared first on MedCity News. Full Article Health Tech Hospitals Providers health equity HLTH HLTH 2024 HLTH Events Medicaid Providence
ai Biden Administration Should Prioritize Fight Against Superbugs By www.pewtrusts.org Published On :: Wed, 16 Dec 2020 11:00:00 -0500 The Pew Charitable Trusts joined dozens of research, health care, and nonprofit stakeholders in urging President-elect Joe Biden to prioritize and strengthen the national response to antibiotic resistance. Full Article
ai Relaxed Federal Regulations Amid Pandemic Can Help Jails Better Treat Opioid Use Disorder By www.pewtrusts.org Published On :: Tue, 22 Dec 2020 12:50:58 -0500 Few correctional facilities in the United States have treatment programs for individuals with opioid use disorder (OUD), despite clear evidence that certain medications reduce the risk of overdose and death. Even in facilities where treatment is available, the COVID-19 pandemic has complicated efforts to provide such care. Full Article
ai Extended Medicaid Coverage Would Help Postpartum Patients With Treatment for Opioid Use Disorder By www.pewtrusts.org Published On :: Thu, 14 Jan 2021 13:02:00 -0500 Between 1999 and 2014, opioid use disorder (OUD) among pregnant women more than quadrupled, risking the health of the women—before and after giving birth—and their infants. As states grapple with COVID-19’s exacerbation of the opioid crisis, several are taking innovative steps to address the needs of high-risk groups, including low-income, postpartum patients with OUD. Full Article
ai Pew Applauds Michigan for Enacting Bipartisan Legislation to Safely Reduce Jail Populations By www.pewtrusts.org Published On :: Thu, 14 Jan 2021 15:00:29 -0500 The Pew Charitable Trusts today commended Michigan Governor Gretchen Whitmer (D), state Senate Majority Leader Mike Shirkey (R), and Lee Chatfield (R)—whose term as state House Speaker ended last month—for passing and signing a bipartisan package of bills aimed at protecting public safety while reducing the number of people in county jails. Full Article
ai Antibiotic Sales for Use in Food Animals Increased Again in 2019 By www.pewtrusts.org Published On :: Thu, 21 Jan 2021 16:33:00 -0500 Sales of medically important antibiotics for use in food-producing animals increased 3% in 2019, according to recent data from the U.S. Food and Drug Administration. This is the second year in a row that the quantities of antibiotics sold for animal use have risen, underscoring the need for further FDA action to ensure judicious use of these lifesaving drugs. Full Article
ai Pain Management in Crisis: Why Hospitals Are Limiting Pain Medications and What This Means for Patients By worldofdtcmarketing.com Published On :: Fri, 01 Nov 2024 12:45:01 +0000 Hospitals across the U.S. have significantly restricted the use of pain medications containing narcotics. This shift comes amid […] The post Pain Management in Crisis: Why Hospitals Are Limiting Pain Medications and What This Means for Patients appeared first on World of DTC Marketing. Full Article Bad practices Focus on patients Pain Medication
ai Why Biotech Companies Fail: Lessons for CEOs By worldofdtcmarketing.com Published On :: Tue, 12 Nov 2024 10:56:35 +0000 We’re seeing an alarming increase in the number of failed biotech companies. While the biotechnology industry holds enormous […] The post Why Biotech Companies Fail: Lessons for CEOs appeared first on World of DTC Marketing. Full Article in the news Working in the industry Failing Biotechs