Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03374D, Paper

Rui Dong, Hamad Rafique, Qianwen Niu, Xin Zeng, Maria Cristina Messia, Li Yuan, Lin Shi, Liang Zou, Lu Li, Xinzhong Hu
Interaction of oat bran (OB) diet and moderate intensity exercise training (MlET) reinforced the positive effect on skeletal muscle function.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03234A, Review Article

Jiao Pang, Chunshuo Yang, Jiaqi Liu, Zhilin Wang, Xueshu Tao, Zhipeng Cao
Polymorphisms in key genes in the vitamin D metabolic pathway affect susceptibility to cardiovascular disease (CVD) and play potential roles in the pathogenesis of CVD.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00940A, Review Article

Yanan Liu, Yuanqiang Jia, Yingying Wu, Huijuan Zhang, Feiyue Ren, Sumei Zhou
The value and mechanism of highland barley in the prevention of diabetes and its application in food products.
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Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03052D, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ana Pilar Tobajas, Ana Agulló-García, Jose Luis Cubero, Carlos Colás Sanz, Alba Civera, Clara Esteban, L. Sanchez, M. D. Perez
Pru p 3, a member of the Lipid Transfer Protein family, is considered a major allergen from peach and it often induces serious allergic reactions in peach allergic individuals. The...
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO01900H, Review Article

Yusong Luo, Ruolan Liu, Guoqiang Yuan, Yawen Pan
Molecular mechanisms of the antioxidant effects of polyphenols in stroke.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03614J, Paper

Shengjun Dong, Mengxin Jiang, Qinglei Sun, Junqing Xu, Lei Zhang, Lei Han, Yan-na Li, Zhengtong Zhou, Yingjiang Xu
We evaluated the potential effects of aspartate on brown adipose tissue function.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04028G, Paper

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Christopher G. Green, Marilyn L. Y. Ong, Samantha N. Rowland, Tindaro Bongiovanni, Lewis J. James, Tom Clifford, Stephen J. Bailey, Liam M. Heaney
HPMC capsules containing acetate, propionate, and butyrate salts exhibit peak serum concentrations of each short-chain fatty acid within 60 min and a return to baseline within 120 min. Seven days of repeated intake does not alter basal serum levels.
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Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03709J, Paper

Shijie Dou, Xuening Yu, Yuewen Xu, Xiaoyang Liu, Fawen Yin, Deyang Li, Da-Yong Zhou
The Maillard reaction products, as a kind of glycosylation-based reaction, possess the metal-chelating ability. In this study, the white shrimp hydrolysate (WH) and xylooligosaccharides (XOS) were used to prepare the...
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02942A, Paper

Naomi May, Jiahua Shi, Helen Clunas, Julianna Lys de Sousa Alves Neri, Celine Kelso, Jody Morgan, Yinghua Yu, Karen Charlton, Katrina Weston-Green
Phytochemicals, including phenolic compounds and terpenes, are of interest for the treatment and prevention of conditions with oxidative stress, inflammatory and neurodegenerative pathologies.
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Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04667F, Paper

Yuanlin Niu, Tingting Zhao, Zhenjiang Liu, Diantong Li, Dongxu Wen, Bin Li, Xiaodan Huang
Hypobaric hypoxia causes oxidative stress and inflammatory responses and disrupts the gut microbiome and metabolome. In this study, we developed a synbiotic fermented whey beverage, combining kefir and Brassica rapa...
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04024D, Review Article

Yujia Niu, Wancong Yu, Xiaohong Kou, Shuqi Wu, Mengyi Liu, Chenlong Chen, Jiaxin Ji, Ying Shao, Zhaohui Xue
The melanocortin system is regulated by long-term and short-term regulatory hormones and nutrients. Bioactive compounds influence appetite through multiple pathways: central nervous system, peripheral hormones, and intestinal microbiota.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03130J, Paper

Azza Dabous, Antonietta Stellavato, Donatella Cimini, Valentina Vassallo, Maria D'Agostino, Chiara Schiraldi
Freeze-dried formula containing three probiotic strains and hydroxyectoine reduces LPS-induced inflammation in Caco-2 cells, assessed via RT-PCR, western blot, ELISA, and immunofluorescence for tight junction integrity.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04067H, Paper

Feng Gao, Xin Zhang, Zhiming Xu, Kang Zhang, Fusheng Quan
Intestinal injury is often accompanied by epithelial barrier dysfunction, oxidative stress, and apoptosis.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03889D, Paper

Yixin Cheng, Xiaofan Liu, Yingao Hao, Shixu Wang, FangFang Wu, Lingzhuo Zhao, Du Peng, Du Yawen, Sun Sheng, Li Jianguo, Guangxu Ren
Selenium element improves dexamethasone-induced skeletal muscle atrophy by affecting enterotype.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03997A, Paper

Feng Liu, Yi Liu, Suyun Zhang, Gang Liu, Christos Ritzoulis, Yue Zhang
Protein molecules such as soy protein isolate (SPI) and egg white (EW) are highly promising materials for developing hydrogels (especially micro/nanogels) for the encapsulation, protection and controlled release of bioactive substances.
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Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04198D, Paper

Yifan Zhang, Qiang Yu, Peng Tan, Shimin Tian, Jun-zhi Lin, Mengqi Li, Li Han, Haozhou Huang, Ding-kun Zhang
Phyllanthi Fructus (PF) is a tropical fruit with the potential to effectively reduce postprandial blood glucose, making it highly promising for the development of functional foods. However, the lack of...
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Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04626A, Paper

Laipeng Xu, Xuan Li, Shuibing Han, Chunlong Mu, Wei-Yun Zhu
Intestinal mucin offers a physical barrier to maintain host-commensal homeostasis. Glycosylation is essential for appropriate function of mucin. Galacto-oligosaccharides (GOS) have been used as a prebiotic with proved intestinal benefits,...
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00364K, Paper

Gang Yu, Jianxin He, Zhongshan Gao, Linglin Fu, Qiaozhi Zhang
Protein-bound advanced glycation end-products (AGEs) induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism.
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Food Funct., 2024, 15,11115-11128
DOI: 10.1039/D4FO03167A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Maria Torrecillas-Lopez, Fernando Rivero-Pino, Paula Trigo, Rocio Toscano-Sanchez, Teresa Gonzalez-de la Rosa, Alvaro Villanueva, M. Carmen Millan-Linares, Sergio Montserrat-de la Paz, Carmen M. Claro-Cala
Hemp protein hydrolysate is capable of alleviating neuroinflammation by reducing the expression of pro-inflammatory cytokines, which could have promising effects in Parkinson's disease.
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Food Funct., 2024, 15,11047-11059
DOI: 10.1039/D3FO04672A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Patrícia Dias, Rudy Salam, Jana Pourová, Marie Vopršalová, Lukáš Konečný, Eduard Jirkovský, Jurjen Duintjer Tebbens, Přemysl Mladěnka
One of important metabolites of dietary polyphenols is 4-methylcatechol (4-MC). This compounds causes vasodilation likely due to an effect on voltage-dependent potassium channels (K_V) as suggested by our ex vivo and in silico docking study.
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Food Funct., 2024, 15,11129-11140
DOI: 10.1039/D4FO01635A, Paper

Xiaorui Zhao, Weiwei He, Louise M. A. Jakobsen, Farhad M. Panah, Banny Silva Barbosa Correia, Dennis Sandris Nielsen, Axel K. Hansen, Hanne Christine Bertram
This study investigated if the prebiotic efficacy of inulin depends on the dairy matrix used as vehicle.
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Food Funct., 2024, 15,10987-11004
DOI: 10.1039/D4FO02975E, Paper

Yue Ma, Chuanbing Hu, Jing Zhang, Cong Xu, Lizhi Ma, Yunhe Chang, Muhammad Altaf Hussain, Jiage Ma, Juncai Hou, Zhanmei Jiang
Ulcerative colitis (UC), an inflammatory bowel disease, seriously affects people's quality of life.
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Food Funct., 2024, 15,11020-11035
DOI: 10.1039/D4FO02479F, Paper

Huan Zhang, Zhigang Zhu, Wenjing Wei, Zekun Liu, Huiji Zhou, Yueling Gong, Xinlei Yan, Jun Du, Houkai Li, Liang Chen, Lili Sheng
Aronia melanocarpa (AM) was shown to promote the lifespan and health-span of C. elegans via the PMK-1 pathway, highlighting the potential of AM as a dietary supplement for delaying aging.
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Food Funct., 2024, 15,11005-11019
DOI: 10.1039/D4FO03591G, Paper

Chao Miao, Linge Wang, Huabing Wang, Yu Shen, Chaoxin Man, Wei Zhang, Yu Zhang, Qianyu Zhao, Yujun Jiang
Postbiotics prepared by ultrasound and pasteurization are used for the alleviation of obesity.
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Food Funct., 2024, 15,11072-11082
DOI: 10.1039/D4FO02588A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Chunhua Zhou, Jiawei Geng, Hanyi Huang, Lintao Dan, Zhipeng Wu, Xixian Ruan, Yao Zhang, Jie Chen, Jing Sun, Duowu Zou
The role of diet on the risk of chronic pancreatitis (CP) is understudied.
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Food Funct., 2024, 15,11060-11071
DOI: 10.1039/D4FO03841J, Paper

Xinran Lv, Wenyu Wu, Shuilin Liu, Lili Ding, Anqi Ren, Le An, Fengling Bai, Jianrong Li, Xuepeng Li, Shumin Yi
This study aimed to examine the dynamic changes in the gel properties, microbial diversity, and volatile flavor compounds (VFCs) of Spanish mackerel sausages inoculated with Lactiplantibacillus plantarum CY1-2 during fermentation.
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Food Funct., 2024, 15,11083-11095
DOI: 10.1039/D4FO03543G, Paper

Wenshan Nan, Jialin Yin, Wenhao Hao, Huali Meng, Junduo Wu, Xiao Yin, Hao Wu
Cardamonin inhibited macrophage M1 polarization in diabetic cardiomyopathy by binding to KEAP1, leading to the dissociation of NRF2 from KEAP1. This promoted NRF2 nuclear translocation and antioxidant gene expression in M1 polarized macrophages.
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Food Funct., 2024, 15,11096-11114
DOI: 10.1039/D4FO01870B, Paper

Xiaofei Xu, Xiaofei Liu, Liyan Liu, Jin Chen, Jingjing Guan, Donghui Luo
Tremella fuciformis polysaccharides exhibit hypoglycemic and hypotriglyceridemic activities through altering the taxonomic and functional attributes of the gut microbiota and modulating gene expression in the liver.
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Food Funct., 2024, 15,11220-11235
DOI: 10.1039/D4FO03326D, Paper

Elisa Di Stefano, Nico Hüttmann, Pieter Dekker, Monic M. M. Tomassen, Teresa Oliviero, Vincenzo Fogliano, Chibuike C. Udenigwe
In vitro gastrointestinal digestion, brush border enzyme activity, and microbial fermentation with Lactiplantibacillus plantarum influenced the peptidome of green lentils and peptide transport across the intestinal Caco-2 cell monolayer.
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Food Funct., 2024, 15,11206-11219
DOI: 10.1039/D4FO03898C, Paper

Jia-Yi Dou, Sai-Hu Liu, Jia Guo, Chen-Yu Wang, Xu Dai, Li-Hua Lian, Zhen-Yu Cui, Ji-Xing Nan, Yan-Ling Wu
Pterostilbene (PTE), a natural stilbene found in small berries, exhibits multiple pharmacological activities, particularly antioxidant and anti-inflammatory activities.
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Food Funct., 2024, 15,10956-10980
DOI: 10.1039/D4FO03549F, Review Article

Joy I. Obeme-Nmom, Raliat O. Abioye, Samanta S. Reyes Flores, Chibuike C. Udenigwe
Several nutraceutical compounds, such as polyphenols and peptides, modulate the enzymatic antioxidant defence system, providing an avenue for the development of multifunctional functional foods.
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Food Funct., 2024, 15,11236-11251
DOI: 10.1039/D4FO03355H, Paper

Yan Shao, Fei Li, Bo Zou, Yanling Jin, Xiaoyang Wang, Liting Wang, Youying Huang, Yu Xie, Wei Sun, Jing X. Kang, Kai Liu, Yi Huang, Wei Huang, Bin Wang
Our study showed that MAG upregulation might be the new regulatory mechanism for omega-3 PUFAs to exert AD protective effects, which is helpful for expanding our understanding of the health-promoting effects of omega-3 PUFAs.
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Food Funct., 2024, 15,11280-11290
DOI: 10.1039/D4FO03646H, Paper

Cristian Martínez Fajardo, Lucía Morote, Elena Moreno-Giménez, Susana López-López, Ángela Rubio-Moraga, María José M. Díaz-Guerra, Gianfranco Diretto, Alberto J. López Jiménez, Oussama Ahrazem, Lourdes Gómez-Gómez
Exosomes have garnered attention as a potential cell-free therapy for inflammatory diseases due to their immunomodulatory and anti-inflammatory properties.
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Food Funct., 2024, 15,10981-10986
DOI: 10.1039/D4FO02844A, Communication

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ziqi Li, Rachel E. Kopec
Coenzyme Q10 (CoQ10), a key component of the electron transport chain, is better micellarized and absorbed by intestinal cells following novel encapsulation with MCTs + phospholipid.
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Food Funct., 2024, 15,11252-11265
DOI: 10.1039/D4FO03851G, Paper

Xinzhang Chen, Shengjun Yang, Zhengtao Guo, Bailiang Li, Zhongjiang Wang, Lianzhou Jiang
Human milk oligosaccharides (HMOs) and the milk fat globule membrane (MFGM) represent novel treatments for cow's milk allergy (CMA).
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Food Funct., 2024, 15,11266-11279
DOI: 10.1039/D4FO02741H, Paper

Roshanak Zolqadri, Zahra Akbarbaglu, Khashayar Sarabandi, Seyed Hadi Peighambardoust, Seid Mahdi Jafari, Amin Mousavi Khaneghah
In this study, the techno-functional characteristics and nutritional value of coconut meal protein (CMP) and the obtained polypeptides by alcalase (H-Alc), trypsin (H-Try), pancreatin (H-Pan), and pepsin (H-pep) were investigated.
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Food Funct., 2024, 15,11036-11046
DOI: 10.1039/D4FO03582H, Paper

Hongbo Li, Lin Yang, Jiayi Li, Quan Gao, Tiantian Liu, Yang Zou, Xiaohong Chen, Hongjuan Li, Jinghua Yu
We developed an extensively hydrolyzed infant formula (EHF) with a protein composition similar to breast milk (whey protein-to-casein ratio of 6 : 4) and evaluated its sensitization in vitro and in vivo.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03449J, Review Article

Xin Xia, Jinkai Zhang, Xinfang Wang, Ke Xiong, Zhaobao Pan, Jinyu Wang
Our systematic review and meta-analyses showed that vegetarian diets significantly reduced blood lipids and blood glucose and had null effects on blood pressure.
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Food Funct., 2024, 15,11141-11157
DOI: 10.1039/D4FO01342E, Paper

Zhaojuan Shi, Jun Wu, Xingting Wang, Tongqiao Nie, Qingmei Zeng, Chuanxun Yuan, Risheng Jin
Candelilla wax reinforced the stability of Pickering W/O emulsions with a three-dimensional crystal network. The oil phase volume fraction of the emulsions showed dramatic differences in protecting probiotic viability from environmental stresses.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02548B, Paper

Yannan He, Lin Chen, Miao Miao, Yongmei Dai, Li Qin, Jing Lin, Yumei Qi, Huijuan Xiao, Yajun Qiu, Xiaohong Zhang, Hailan Sun, Jianing Wang, Meng-yan Xu, Ping Tan, Bo Yang, Guiju Sun, Feng Zhao, Duo Li
Fatty acids are essential components in breast milk with mutable characteristics.
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Food Funct., 2024, 15,11158-11168
DOI: 10.1039/D4FO03186E, Paper

Ann Liya Sajan, Jenat Pazheparambil Jerom, Bhagyasree Rajasekharan Nair, Devanandana Dileep Kumar Sajitha, Reshma Soman, Ajmal Jalal, Raveendran Harikumaran Nair
Supplementation with whey protein is effective for treating hypothyroidism-associated oxidative stress by enhancing the antioxidant system, reducing lipid peroxidation and maintaining cellular ionic balance.
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Food Funct., 2024, 15,11169-11185
DOI: 10.1039/D4FO03844D, Paper

Qiuyun Gu, Qiujv Du, Lina Xia, Xiaoting Lu, Xiaoqing Wan, Ying Shao, Jieyi He, Peiying Wu
Epigallocatechin gallate (EGCG) has demonstrated potential effects on obesity-induced precocious puberty, but the underlying mechanisms remain unclear.
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Food Funct., 2024, 15,10927-10955
DOI: 10.1039/D4FO03671A, Review Article

Sangkaran Pannerchelvan, Leonardo Rios-Solis, Helmi Wasoh, Mohamad Zulfazli Mohd Sobri, Fadzlie Wong Faizal Wong, Mohd Shamzi Mohamed, Rosfarizan Mohamad, Murni Halim
Functional yogurt contains a variety of nutritional components that offer numerous health benefits, with limitations that can potentially be overcome.
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Food Funct., 2024, 15,11186-11205
DOI: 10.1039/D4FO03985H, Paper

Hongbo Zhang, Min Luo, Yinuo Li, Lu Liu, Ji Bian, Lan Gong, Caian He, Lin Han, Min Wang
EA enhanced the abundance of beneficial bacteria as well as their derived metabolites, thereby inhibiting chronic alcohol-induced neuroinflammation via regulation of the gut microbiota-mediated CCL21-CCR7 axis, ultimately ameliorating AICSD.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02704C, Paper

Fenfen Wei, Huibin Jiang, Chuang Zhu, Lingyue Zhong, Zihan Lin, Yan Wu, Lihua Song
A high-fat diet (HFD) is associated with various adverse health outcomes, including cognitive impairment and an elevated risk of neurodegenerative conditions.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04321A, Review Article

Yao-Bo Zeng, Xun Deng, Li-Sha Shen, Yong Yang, Xing Zhou, Lianbao Ye, Sibao Chen, Da-Jian Yang, Guo-Qing Chen
Plant-derived extracellular vesicles (PDEVs) are nanoscale vesicles released from plant cells into the extracellular space.
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Food Funct., 2024, 15,11291-11304
DOI: 10.1039/D4FO03161J, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sawsan Amara, Maureen Gerlei, Carole Jeandel, Moulay Sahaka, Frédéric Carrière, Michel Linder
Marine liposomes are more resistant than triacylglycerol emulsion to lipolysis under gastric condition. They can protect LC-PUFA (EPA and DHA) and are a better gastric-stable delivery system for their intestinal absorption than TAG.
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Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04161E, Paper

Andrea del Saz-Lara, Alicia Saz-Lara, Iván Cavero-Redondo, Carlos Pascual-Morena, Carmen Mazarío-Gárgoles, Francesco Visioli, María-Carmen López de las Hazas, Alberto Dávalos
Fourteen studies were systematically reviewed and seven were included in the meta-analysis. Consumption of OO is associated with a reduction of cardiovascular mortality (16%), all-cause mortality (15%) and cancer mortality (11%) in adult population.
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Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO02968B, Paper

Yessica Rubí Hernández-García, Ivan Luzardo-Ocampo, Gaytán-Martínez Marcela, G. Loarca-Pina, Estela Vázquez Barrios, Rocio Campos-Vega
The poor disposal and lack of corncob (CC) and cornsilk (CS) utilization generate environmental problems. This research aimed to develop CC and CS-based ingredients (1:1, 1:2, and 2:1 mixtures), evaluate...
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Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO01929F, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Eduard Flores Ventura, Manuel Bernabeu, Belén Callejón Leblic, Raúl Cabrera-Rubio, Laxmi Yeruva, Javier Estañ-Capell, Cecilia Martínez-Costa, Tamara García-Barrera, Maria Carmen Collado
Background: The profile of metal (loid)s in human milk is essential for infant growth and development, yet its impact on the development of the infant microbiota remains unclear. Elements such...
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