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Integrated device for plasma separation and nucleic acid extraction from whole blood toward point-of-care detection of bloodborne pathogens

Lab Chip, 2024, 24,5124-5136
DOI: 10.1039/D4LC00571F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Abigail G. Ayers, Christia M. Victoriano, Samuel K. Sia
This work presents PRECISE, a device that integrates plasma separation and nucleic acid extraction, enabling streamlined sample preparation of whole blood for point-of-care diagnostics without external equipment or electricity.
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Impact of microchannel width on axons for brain-on-chip applications

Lab Chip, 2024, 24,5155-5166
DOI: 10.1039/D4LC00440J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarina Vulić, Giulia Amos, Tobias Ruff, Revan Kasm, Stephan J. Ihle, Joël Küchler, János Vörös, Sean Weaver
Axon growth is influenced by the width and number of microchannels, with growth cone adaptability reaching its limit for constraints smaller than 350 nm. Tradeoffs between axon growth and control need to be made for neurofluidic devices.
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Optical tweezer-assisted cell pairing and fusion for somatic cell nuclear transfer within an open microchannel

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00561A, Paper
Yidi Zhang, Han Zhao, Zhenlin Chen, Zhen Liu, Hanjin Huang, Yun Qu, Yaowei Liu, Mingzhu Sun, Dong Sun, Xin Zhao
We developed a somatic cell nuclear transfer-electrofusion system for pairing and fusing oocytes and somatic cells with a thousand-fold volume difference. The system showed a 90.56% pairing efficiency, potentially boosting batch cloning efficiency.
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Dual-drive acoustic micromixer for rapid nucleation and ultrafast growth of perovskite nanoparticles

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00721B, Paper
Zhifang Liu, Yuwen Lu, Wei Tan, Guorui Zhu
An acoustic micromixer driven by bubbles and sharp edges, controlling the nucleation and growth of perovskite nanoparticles.
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Observing root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00659C, Paper
Open Access
Claudia Allan, Yiling Sun, Stephen C. Whisson, Michael Porter, Petra C. Boevink, Volker Nock, Claudia-Nicole Meisrimler
Using a bi-directional dual-flow RootChip with integrated force sensing micropillars, root growth and signalling responses to stress gradients and pathogens were studied in Arabidopsis thaliana, Nicotiana benthamiana and Solanum lycopersicum.
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Discretised microfluidics for noninvasive health monitoring using sweat sensing

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00763H, Paper
Open Access
Emma J. M. Moonen, Walther Verberne, Eduard Pelssers, Jason Heikenfeld, Jaap M. J. den Toonder
We present the first wearable device with integrated electrowetting, which collects and transports sweat from single glands and measures sweat rate for extremely low sweat rate. This enables non-invasive biomarker monitoring of hospitalized patients.
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An imaging scheme to study the flow dynamics of co-flow regimes in microfluidics: implications for nanoprecipitation

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00652F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wali Inam, Anton Vladyka, Joanna W. Pylvänäinen, Junel Solis, Dado Tokic, Pasi Kankaanpää, Hongbo Zhang
Herein, by presenting a novel imaging-based scheme for analyzing fluid interactions in co-flow regimes, we identify oscillatory and chaotic flow behaviors to optimize nanoprecipitation through controlled fluid manipulation.
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Microstring-engineered tension tissues: a novel platform for replicating tissue mechanics and advancing mechanobiology

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00753K, Paper
Zixing Zhou, Tingting Li, Wei Cai, Xiaobin Zhu, Zuoqi Zhang, Guoyou Huang
A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.
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SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00858H, Paper
Siyue Xiong, Chushu Zhu, Chengxuan Wang, Peitao Dong, Xuezhong Wu
Cortisol, known as the "stress hormone," is secreted by the adrenal cortex. Measuring cortisol levels in body fluids is essential for evaluating stress levels, adrenal function, hormone imbalances, and psychological...
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Man armed with machete creates tension in Aluva




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P.V. Thampy memorial award to forest guide

Sudhamma, a forest guide at Thattekkad Bird Sanctuary, is an authority on birds in the region and provides valuable information to visitors




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Man accused in 25 cases arrested for attempted theft at magistrate’s house in Ernakulam




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Multiple factors remain a hurdle in setting up centralised sewer networks, Kerala govt. informs NGT

Faecal sludge treatment plants proposed in a radius of 15 km on cluster basis in urban and rural local bodies




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Kerala State school sports meet off to a vibrant start with grand inaugural ceremony

The inaugural ceremony featured a march past with student athletes from 14 districts and the United Arab Emirates (UAE) parading from Durbar Hall Ground to the college ground




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A combat sport continues to attract Kerala’s youngsters

Nivediya L. Nair, a defending champion in the fencing Épée category, was drawn to the sport as an eight-year-old a decade ago. Nakshathra A.R. was captivated by the valiant display of sword play by C.A. Bhavani Devi, the first Indian fencer to qualify for an Olympics, at Tokyo Olympics held in 2021.




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KITE gives technological edge to coverage of State school sports meet




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Amicus curiae suggests restricting elephant parades to religious festivals

Parading of elephants should be strictly restricted to registered temples, churches, mosques, and rituals which are associated with these institutions. Any introduction of new rituals or reviving of dormant rituals should not be permitted.




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Two youngsters from Kochi determined to smash their disabilities on the badminton court

Atul Krishna and Jyothish Kumar defy physical limitations to excel in badminton, inspiring with their determination and talent.




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Biomining of legacy waste at Kalamassery likely to begin soon




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Malankara Metropolitan Joseph Gregorios to lead Jacobite Syrian Church temporarily




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No child will be left out of school sports meet in future, says Sivankutty




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Demand for wayside amenities along NHs, Centre’s policy may be of help

PWD pursuing the matter with NHAI, since such amenities will help drivers and others to take a break. ‘Humsafar policy’ of the Centre, launched a month ago, aims to accelerate development of wayside amenities beside highways, if need be with private participation




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ERCMPU set to become fully solar-powered dairy cooperative




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P.J. Joseph demands govt. intervention in Munambam issue




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Police officer arraigned as accused in accident case




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Police control room in Kochi gets bomb threat call




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Woman arrested on charge of job fraud




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RTO to probe operator’s failure to provide accommodation to students




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Drenched in sweat, student volunteers have a bittersweet experience at sports meet in Kochi




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HC holds that civil courts have jurisdiction to order execution of decree on Waqf disputes

Petitioners challenge a civil court’s dismissal of a petition filed by them seeking to execute the decree that was passed before the commencement of the Waqf Act. HC asks munsiff court to proceed with the execution petition and pass an order in three months




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Over 12,000 dengue cases reported in Ernakulam since January

Sources include illegal waste dumping sites, vacant plots, and mosquito-breeding grounds like discarded containers, used tyres, and pots




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Kerala HC adjourns hearing on plea against land acquisition for Wayanad township




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Kerala High Court quashes criminal case against filmmaker Sreekumar Menon




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Kerala School Sports & Games 2024: Athletics events to start on Thursday




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Standoff continues in archdiocese over ‘letter’ from Vatican




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Road safety class mandatory for driving licence applicants in Ernakulam from Dec. 2

“The sessions will include new road safety guidelines in keeping with advancements in automobiles and road construction and also amendments made to the Motor Vehicles Act in the recent past”




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Thammanam-Pullepady Road development: joint site inspection planned

Landowners along the stretch seek adequate compensation for small tracts of additional land that will be acquired in keeping with the revised alignment




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Civic authorities racing against time to save Central funds for Edakochi STP

The deadline for the ₹18.6-crore project is December 31, and failure to complete it in time will lead to the Corporation losing the Central share of ₹7.75 crore




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Union Minister Suresh Gopi inaugurates ‘Confluence-24’ in Kochi




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Allow only dolly workers with police verification certificate to carry pilgrims to Sabarimala: Kerala HC




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Hema Committee report: Preliminary inquiry in cases to be completed by December-end, Kerala govt tells HC

Submission made in a progress report filed by Kerala govt in response to public interest litigation in High Court filed in connection with Hema Committee report




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Laugh in life: Kochi-based comedians Abhishek and Akshay on their latest show, their inspirations and more

The duo has been performing stand-up comedy for around three years now.




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Interview | Meet Malayalam cinema’s newest villains in the Joju George film ‘Pani’

Actors Sagar Surya and Junaiz VP talk about becoming Don and Siju and working in the actor-director’s directorial debut




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Kerala State Sports & Games 2024: curiosity pulls in more people to baseball games

Though not a very popular game like cricket, more youngsters are getting drawn into the sport, says a baseball coach




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Two friends and their track of records

Mohammed Ameen and Mohammed Jaseel, Plus Two students from KKM Higher Secondary School, Cheekkode in Malappuram, contested the same event in the previous edition and finished exactly in the same positions




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CKCL, private players help fill gaps in non-biodegradable waste management in Ernakulam




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Media rights cannot be restricted: Kerala High Court

Expression by the media of any definitive opinion regarding the guilt or innocence of a party in an ongoing criminal investigation will not get protection under Article 19(1)(a), observes an HC bench




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A man’s love affair with a sport that gave him a life




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Tooth-brushing event held to create awareness about oral health among children




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A champion pole-vaulter aims to bow out on a high