ul Beyond intoxication: On alcohol regulation, judicial verdict By www.thehindu.com Published On :: Mon, 28 Oct 2024 00:20:00 +0530 Batting for States, the Supreme Court of India holds federal balance on regulating alcohol Full Article Editorial
ul Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:10:00 +0530 Actor Vijay seems to be targeting both the BJP and the DMK Full Article Editorial
ul Why Kriti Is So Grateful By www.rediff.com Published On :: Kriti Kharbanda took a trip down memory lane when her rom-com Shaadi Mein Zaroor Aana clocked seven years since its release. Full Article
ul Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3495-3506DOI: 10.1039/D4MD00275J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. RussellThe optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3433-3443DOI: 10.1039/D4MD00468J, Research ArticleMeijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing LiA synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3529-3557DOI: 10.1039/D4MD00481G, Research ArticleMohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai AdelDiscovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3485-3494DOI: 10.1039/D4MD00246F, Research ArticleShouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng XuA novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3609-3615DOI: 10.1039/D4MD00501E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. VealeRationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3616-3624DOI: 10.1039/D4MD00306C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. SheldrakeCyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00673A, Review ArticleJuhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong JunPotential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Design and Synthesis of coumarin-based amphoteric antimicrobials with the biofilm interference and immunoregulation effects By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00721B, Research ArticleQun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan HanBacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00662C, Research ArticleRajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank SchweizerWe describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Synthesis and evaluation of tetrahydropyrrolo[1,2-a]quinolin-1(2H)-ones as new tubulin polymerization inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00541D, Research ArticleMikhail N. Anisimov, Maksim A. Boichenko, Vitaly V. Shorokhov, Julia N. Borzunova, Marina Janibekova, Vadim V. Mustyatsa, Ilya A. Lifshits, Andrey Yu. Plodukhin, Ivan A. Andreev, Nina K. Ratmanova, Sergey S. Zhokhov, Elena A. Tarasenko, Daria A. Ipatova, Alexander R. Pisarev, Ivan A. Vorobjev, Igor V. Trushkov, Olga A. Ivanova, Nikita B. GudimchukNew 1,5-disubstituted pyrrolidin-2-ones 1, 2 and 5-aryl-3,3a,4,5-tetrahydropyrrolo[1,2-a]quinoline-1(2H)-ones 3 were explored as inhibitors of tubulin polymerization.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00617H, Research ArticleAida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü BeydemirIn this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00553H, Research ArticleStefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro CosconatiNon-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ul U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory By www.thehindu.com Published On :: Tue, 05 Nov 2024 12:48:36 +0530 Full Article U.S. Elections
ul Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:44:09 +0530 Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago Full Article Tamil Nadu
ul Doctor assaulted inside Tiruchi ESI Hospital By www.thehindu.com Published On :: Tue, 05 Nov 2024 18:29:04 +0530 Full Article Tiruchirapalli
ul Three arrested for assaulting doctor in ESI hospital By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:23:47 +0530 Full Article Tiruchirapalli
ul Ernakulam Express to stop at Muthupettai during Kandhoori festival By www.thehindu.com Published On :: Thu, 07 Nov 2024 18:51:18 +0530 Full Article Tiruchirapalli
ul Consultant to be appointed soon to design Kalaignar grand library in Tiruchi By www.thehindu.com Published On :: Fri, 08 Nov 2024 18:41:18 +0530 The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events Full Article Tiruchirapalli
ul Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:25:49 +0530 Full Article Tiruchirapalli
ul ‘State should retain primary agricultural cooperative societies under its purview’ By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:23:59 +0530 Full Article Tiruchirapalli
ul Students and agriculture officials grapple with logistical, technical issues during digital crop survey By www.thehindu.com Published On :: Sat, 09 Nov 2024 20:32:48 +0530 Full Article Tiruchirapalli
ul Live Cricket Scores, Cricket News, Analysis, Results & More | The Hindu By www.thehindu.com Published On :: Full Article
ul 563: Getting Pulled by the Algorithm, AI Training Data, and SVG Drawing By shoptalkshow.com Published On :: Mon, 01 May 2023 08:51:30 +0000 There's a special guest on the show who takes aim at the billionaires in web dev, do we know better than the algorithm for news, why is AI training data such a secret, Chris and Dave discover JetBrains, monorepo struggles, and SVG drawing tools. Full Article All Episodes AI JetBrains PHP
ul 567: Full Stack Dev, Load Bearing Developer, and Being Zod Curious By shoptalkshow.com Published On :: Mon, 29 May 2023 09:00:16 +0000 What do you do if your computer dies? Chris applies to work at Luro, Dave applies at CodePen, Dave's Zod curious, TypeScript, sorting out a 10MB blog post, and how much do you miss jQuery? Full Article All Episodes full stack Jquery Zod
ul Change and culture By www.thehindu.com Published On :: Fri, 12 Dec 2014 20:06:36 +0530 We can’t just adopt renewable energy models imported from Europe. Any change has to address Chennai’s unique cultural and economic baggage Full Article Green Living
ul Unsuccessful malls on the verge of closure By www.thehindu.com Published On :: Fri, 04 Sep 2015 15:40:22 +0530 Poor management practices have resulted in many malls across the country becoming unviable spaces. Full Article Property Plus
ul Studying the ‘real’ pulse By www.thehindu.com Published On :: Fri, 04 Sep 2015 16:54:05 +0530 Where is the Bengaluru market heading to? What are the factors that could help bring down the unsold inventory? Full Article Property Plus
ul Make full use of wastewater By www.thehindu.com Published On :: Fri, 19 Feb 2016 15:11:48 +0530 In many small and medium towns, domestic wastewater is already being put to use by farmers. A look by S. Vishwanath Full Article Green Living
ul F1: Verstappen pulls off stunning win By www.rediff.com Published On :: Red Bull's Max Verstappen dealt Lando Norris a shattering blow in their Formula One title battle by winning a wet and chaotic Sao Paulo Grand Prix from 17th on the grid. Full Article
ul Could Maini be India's next F1 driver? By www.rediff.com Published On :: India could finally have a driver on the F1 grid after 13 long years. Full Article
ul A doctor-AI collab for detailed, patient consultations By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 Jivi.ai taps GenAI to optimise available medical resources and widen healthcare access Full Article Emerging Entrepreneurs
ul The last thing business founders need is a wasteful public spat By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 As entrepreneurship explodes in India, we need more iconic founders who not only build sustainable firms but also retain their humility Full Article Emerging Entrepreneurs
ul Senior feline resident: Defib stays at his ambulance station By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:19:43 +0530 Online petition halts re-homing of 16-year-old cat in London Full Article Pulse
ul How to report faulty glucose monitors, insulin pumps By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:30:00 +0530 UK regulator has a reporting scheme to identify safety concerns in diabetes-care devices Full Article Pulse
ul What you should know before you install rooftop solar By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 19:19:12 +0530 From picking the right module to asking the right questions on quality and maintenance, a shopping guide for rooftop solar systems Full Article Clean Tech
ul Mislabelled agri loans face culling By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:25:05 +0530 Why some banks are under the RBI’s lens for demanding gold surety for small-value farm credit Full Article Current Account
ul Economic results in a year of elections By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:31:09 +0530 Nearly half the world voted this year to choose governments and fiscal roadmaps Full Article Current Account
ul GalaxEye: A multi-sensor peek at earth from outer space By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:36:55 +0530 Startup sets out to fill a crucial gap in satellite imagery for real-world applications Full Article Emerging Entrepreneurs
ul Police rule out communal angle in clash near Jahangirpuri temple By www.thehindu.com Published On :: Wed, 06 Nov 2024 00:15:57 +0530 Full Article Delhi
ul Delhi’s air pollution: vehicular emissions top contributor, says study By www.thehindu.com Published On :: Thu, 07 Nov 2024 01:07:48 +0530 Full Article Delhi
ul AAP MLA ‘assaults’ MCD official, case registered By www.thehindu.com Published On :: Thu, 07 Nov 2024 01:10:03 +0530 Full Article Delhi
ul Cannot change rules of the game once recruitment to public services commences: SC By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:49:04 +0530 The Constitution Bench says laws, rules and procedure governing recruitments to public services must be governed by the overarching principles of fundamental rights of equality and non-discrimination Full Article India
ul ‘Threat culture’ in Centre for West Asian Studies of JNU: former seminar coordinator By www.thehindu.com Published On :: Thu, 07 Nov 2024 23:09:18 +0530 Sima Baidya also says she has lodged a complaint against the chairperson of the centre and has sought security from the university authorities as she has been intimidated Full Article India
ul BJP calls Kejriwal ‘biggest symbol of VVIP culture’ By www.thehindu.com Published On :: Sat, 09 Nov 2024 00:53:04 +0530 Mr. Bhatia dredged up a 2013 social media post of Mr. Kejriwal in which he had lashed out at the then CM Sheila Dikshit saying she had 10 ACs, including in bathrooms. Full Article Delhi
ul Accused in five-year-old case of sexual assault on minor held By www.thehindu.com Published On :: Mon, 11 Nov 2024 00:46:26 +0530 Full Article Delhi