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A highly selective probe engineered to detect polarity and distinguish normal cells and tumor cells in tissue sections

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00438H, Paper
Sai Zhu, Lixuan Dai, Xiaoli Zhong, Weiying Lin
We have designed a polarity fluorescent probe (DCI-Cou-polar) with high selectivity for diagnosing cancer.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Monolith stationary phases prepared via cyclic anhydride ring-opening polymerization as tunable platforms for chromatographic applications

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00251B, Paper
Ahmad Aqel, Ayman Ghafr, A. Yacine Badjah-Hadj-Ahmed, Zeid Abdullah ALOthman
Polymer monolithic stationary phases were prepared based on a cyclic anhydride as a reactive and tunable platform via ring-opening post-polymerization using primary amines; octadecylamine and benzylamine. The characterization techniques indicated...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02200E, Paper
Qiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan Gao
Tuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Solutions and Tools for Dealing with Broken Links in Web Pages

A couple of months ago a post by Leo Blanchette got to the front page of Hacker News and there was an interesting discussion on dealing with broken links and external content – the main problem being links that become out of date due to paywalls, altered content, or content getting taken down.

I’ve been running this blog since May 2008. If you’ve run a content-driven site for even a fraction of that, you know that link rot is a problem. In this post I’ll go over some of the suggestions in that thread along with some tools to use to check for broken links.

The post Solutions and Tools for Dealing with Broken Links in Web Pages appeared first on Impressive Webs.



  • HTML5
  • Web Design Articles

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Fading in a Page on Load with CSS & JavaScript

When I visit a page, I get annoyed when I try to interact with elements while the website is still loading. Often stuff is moving around, fonts aren’t quite loaded, and it feels broken.

I know nowadays we’re obsessed in this industry with gaining every millisecond in page performance. But in a couple of projects that I recently overhauled, I added a subtle and clean loading mechanism that I think makes the experience nicer, even if it does ultimately slightly delay the time that the user is able to start interacting with my page.

The post Fading in a Page on Load with CSS & JavaScript appeared first on Impressive Webs.




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Are These the Most Interesting Front-end Developer Tools for 2021?

When I come to the end of any given year, it’s always interesting to look back through the click-through stats for my weekly newsletter Web Tools Weekly to see which tools got the most attention.

This year wasn’t all that different from previous years. I’ve learned that clicks happen for basically one of two reasons:

The post Are These the Most Interesting Front-end Developer Tools for 2021? appeared first on Impressive Webs.



  • Roundups and Resources

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Detecting Specific Text Input with HTML and CSS

Recently I came across a CodePen demo by a developer/engineer named Jane that was Tweeted out by Šime Vidas. The demo has a neat collection of HTML and CSS tricks rolled into one that I thought was worth examining in detail.

The page displays a secret message based on specific text input. Ok, that’s no big deal, right? Well this is done using pure HTML and CSS – no JavaScript. I’ve seen stuff like this before, but I thought it would be cool to break down exactly how this works. There are a few notable things happening in the code so I’ll break down each of the parts.

The post Detecting Specific Text Input with HTML and CSS appeared first on Impressive Webs.




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A Review of ipwhois.io for Reliable Geolocation Data

[Sponsored] If you’re building an app that requires delivering a dynamic experience based on the user’s location or other location-related data, a fast and easy-to-use Geolocation API will certainly come in handy. One such option is ipwhois.io. The service, which is free for small non-commercial projects that need fewer than 10,000 requests per month, is easy to integrate with your tech stack.

As usual, it’s always best to look at a few examples so you can see it in action. Their documentation is short and easy to follow, so I’ll demonstrate using the following example request:

The post A Review of ipwhois.io for Reliable Geolocation Data appeared first on Impressive Webs.




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How to Disable JavaScript in Almost Any Browser

In 2022 I think it’s still important as a web developer to test your how your websites look and function when users disable JavaScript in their browser. Developing in this way used to be a cornerstone of Progressive Enhancement and can be handy on both desktop or mobile.

I still find myself wanting disabling JavaScript on pages I visit. Sometimes it’s to test a page I’m working on, but in other instances it’s simply to visit a web page that’s not functioning correctly and I want to see if JavaScript is the culprit.

The post How to Disable JavaScript in Almost Any Browser appeared first on Impressive Webs.




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Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content

[Sponsored] If you’re building an app that requires a lot of user-generated content and media that needs to be processed, tagged, filtered, or otherwise manipulated in real-time, you definitely want a solution that’s fast and seamless and doesn’t get in the way of your app’s primary functionality. Filestack is a service you’ll want to consider. Here’s what Filestack offers:

The post Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content appeared first on Impressive Webs.




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Don’t Let ChatGPT Write Your Code

We can all agree it's ridiculous to suggest that we should ignore a modern tool that makes it exponentially easier to finish our work.

But as I've learned in 20+ years of writing code, there's always going to be a drawback to using any tool that "makes life easier". In this case, AI-based tools that use ChatGPT or some other AI-based foundation are similar to the frameworks we've been using for years.

The post Don’t Let ChatGPT Write Your Code appeared first on Impressive Webs.



  • Web Design Articles

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YouTube’s Time-Based UX Problem for Live Sports

I like to play beach volleyball here in the Toronto area. I also watch beach volleyball on YouTube, which includes a lot of live streams from the AVP league in the US. It's a fun sport that I recommend to anyone looking for a new athletic competition to follow.

In most leagues and tournaments, beach volleyball games have a 3-set format, with each set finishing when a team reaches 21 points (or higher if they're not yet ahead by 2). The third set (played if needed) will go up to 15 points (again, win by 2). Some leagues/tournaments will play all three sets up to 15. It depends on the venue, tournament, etc.

The post YouTube’s Time-Based UX Problem for Live Sports appeared first on Impressive Webs.



  • UX
  • Web Design Articles

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Upward bound




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More 'dead' mobile services?




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A better Twitter app for Android, at last




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Facebook Home is here. Now what?




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Meet capella star Alaa Wardi




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How mobile data can help rationalise bus routes




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Losing a friend, virtually




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NPR and Aadhaar - a confused process




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The not-so-smart use of mobiles




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Location tracking - do you need it?




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Worsening Aadhaar conundrum




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Pictures from the dear departed




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It's a snapchatty world




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The transformation of BSNL




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BSNL customer service changing for the better




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Good, but not enough: On the extended coverage of the Ayushman Bharat scheme

Extension of free health coverage to all over 70 years is good, but more needs to be done  




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​Weather gods: On ‘Mission Mausam’

Attempts at controlling the weather are still in the realm of uncertainty




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​Last mile woes: On inflation data and the challenges

Inflation should not be allowed to undermine the economic momentum 




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​Unrealistic expectations: On India and Russia-Ukraine peace

India’s efforts at peacemaking between Russia and Ukraine have limited potential




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​For a fair probe: On the Kejriwal bail order and CBI conduct

Kejriwal bail order is a reminder to CBI to dispel perception of bias




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Clarity of vision: On eye drops for presbyopia and ‘claims’

A useful drug is undone by fantastic claims about its efficacy




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Down to the wire: On the run-up to the U.S. presidential election

The U.S. presidential race is poised on a knife’s edge




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Third front: On the expanding nature of the conflict in West Asia

Israel’s fighting three enemy militias at once highlights the pressing need for a ceasefire




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A way out: On the government and doctor-led protests in West Bengal

The West Bengal government must enable the changes doctors want to see




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A fair share: On the concerns of high performing States

The Sixteenth Finance Commission must address the concerns of high-performing States




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Party on the move: On the Aam Aadmi Party, its leader

AAP’s Arvind Kejriwal continues to surprise, also outlining his political ambitions




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Wrong notion: On simultaneous elections

The idea of simultaneous elections is inherently anti-federal




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 Milestones and U-turns: On the government in its third term

The optics of the 100-day mark cannot conceal changed dynamics for the BJP




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Pivot to watch: On the U.S. Fed’s rate reduction, its impact




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Staunch the breach: On India, Pakistan and the Indus Waters Treaty

India and Pakistan need to drop their hard line stances on the Indus Waters Treaty




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Sri Lanka’s verdict: On the Island nation’s ninth Presidential election

The spirit of the mandate of the presidential poll was clear — for change




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Unwarranted curbs: On the Centre’s move on a ‘fact-checking unit’

Fact-checking cannot be an excuse to impose censorship




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Triumph squared: On India’s chess double win in Budapest

India’s chess double win was fashioned by its young generation of players




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Politicising the laddu: On the Tirupati laddu and its ‘adulteration’

The Tirupati laddu issue should be limited to one of quality control




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It is an offence: On Supreme Court clarification on online content on child sex abuse

Court has done well to clarify law on online content showing child sex abuse




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Visit wrap-up: On PM Modi’s U.S. visit, announcements

The Modi U.S. visit announcements will see New Delhi being put to the test




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​Rogue state: On Israel’s conflict with Hezbollah  

Israel is choosing war over peace, escalation over compromise 




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​Kashmir conflict: On the J&K elections

The political divide between national parties and regional parties is clear