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LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression




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NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




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MicroRNA let-7c (MIRLET7C; let-7c), miR-99a and miR-125b as prognostic markers of luminal breast cancer

Studies in patient samples and cell culture suggest let-7c, miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor–positive luminal breast cancers.




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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VEGF receptor (VEGFR)

Zebrafish studies suggest VEGFR inhibitors could help treat tuberculosis.




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HIV reverse transcriptase

In vitro studies have identified indolylarylsulfone derivatives that could help treat HIV infection.




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Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




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Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




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Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




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Resurrecting a magic bullet

Heidelberg Pharma has resuscitated a long-dead ADC toxin with updated conjugation techniques, and its partner Roche has thrown the company a lifeline that could help validate the platform.




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis




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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




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Nature Cell Biology




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Reviewer Recognition




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53




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Author Correction: Quantum wave–particle superposition in a delayed-choice experiment




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Strain creates a trion factory




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Nature Photonics




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




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An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




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Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




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Head-to-head trials in inflammatory bowel disease: past, present and future




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Microbiota and colorectal cancer: colibactin makes its mark




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Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions




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Inducing senescence sensitizes pancreatic tumours to therapies




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Universal screening for hepatitis C virus infection should be linked to universal treatment access




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Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities




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Nature Reviews Gastroenterology & Hepatology




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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys




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A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Nesfatin-1 puts the brakes on reward-based feeding




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




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Author Correction: Insights into parathyroid hormone secretion




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Obesity and impaired metabolic health in patients with COVID-19




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Nature Reviews Endocrinology




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Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




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Publisher Correction: Optomechanical detection of vibration modes of a single bacterium




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Nature Nanotechnology