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Injections of botulinum conjugate relieves chronic pain in mice

Modified toxin targets and silences nerves that transmit pain, offering a potential nonaddictive alternative to opioids




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Chemical toxicity assessments by U.S. EPA to be reshaped, if bill passes

Congressional committee votes to give industry and other agencies greater input and to shift responsibility for IRIS program from research office




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Vinyl cation busts some new moves

By tweaking its counter ion, classic carbocation inserts into C-H bonds




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Insect sodium channels visualized with cryo-electron microscopy

Structures of voltage-gated channel with toxins suggest strategies for drug development




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Chemistry in Pictures: Forming good habits




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GSK, 23andMe to apply personal genetics to drug discovery

New partnership is part of GSK’s R&D face-lift, which includes an increased focus on immune system targets




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Hope and skepticism abound around Biogen and Eisai Alzheimer’s trial

An antibody called BAN2401 cleared amyloid-β proteins and slowed cognitive decline in people with mild Alzheimer’s disease




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Women chemists still face discrimination in academia

Survey shows little has changed in the decade since female professors were last asked about their careers




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Mercury finds a long-term home in marine ooze

Diatom data in the Southern Ocean suggests human activity may have emitted more of the toxic metal than previously estimated




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KKR buys firm accused of causing Taiwan explosion




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Lilly to spin off Elanco Animal Health in IPO




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Lilly, Anima link for translation control




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PTC buys gene-therapy-focused Agilis




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Sangamo acquires TxCell for cell therapy




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Listen in on X-ray laser science

Now witness the firepower of the (almost) fully armed and operational European X-ray Free Electron Laser




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New mechanism proposed for old diabetes drug

Type 2 diabetes drug metformin impedes glucose overproduction in a redox-dependent manner, researchers say




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The unexpected source of that luxury feel in car interiors

Japanese firms are the major players in synthetic suede used in high-end vehicle seats




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Zaida Morales-Martínez wins mentoring award




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Call for nominations for Akron Section Award




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Rachael Farber wins graduate research award




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Andrew Herring wins Storch Award




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Sandra Rosenthal wins Herty Award




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Reactions




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Cambrex to acquire dosage-form drug contractor Halo

With purchase, manufacturer of active pharmaceutical ingredients will move downstream into finished drugs




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Business Roundup




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BASF and Arkema invest in 3-D printing




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Celanese divests ethanol technology to Chinese partner




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Ingevity sues BASF over vapor control




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Platform sells crop chemicals business to UPL




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Gilead CEO Milligan to step down




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AkzoNobel partners with Renmatix on paint additives




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BASF to supply human milk oligosaccharide




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China tariff plan slammed by chemical industry

Chemical producers claim customs duties will harm U.S. competitiveness, threaten employment




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Science is in the (baseball) cards and comic books




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DARPA announces first round of $1.5 billion grants to revitalize electronics industry




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India updates rules to curb predatory journals




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U.S. pediatricians group calls for tougher food additive regulation by FDA




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FDA considers imports to tackle high U.S. drug prices




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Liquid water detected beneath Mars ice cap

Discovery confirms decades-old hypothesis




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Paper describing piperlongumine anticancer activity retracted

Some coauthors dissent from withdrawal of report, for which key findings have been independently confirmed




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Membrane knocks out antibiotic-resistant bacteria

Combining UV disinfection with a photocatalytic membrane helps reduce the bacteria and their genes in wastewater




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Easy-to-make polymer stretches, sticks, self-heals

Material’s features attributed to bonds that readily break and re-form




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Cerium photocatalysis conquers light hydrocarbon chemistry

Method turns challenging gaseous alkanes into liquid products




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One-pot, cell-free method makes glycoproteins

Technology is a step on the path to on-demand manufacturing of biologics




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Modernizing CEPA’s approach to supporting ACS members in their professional lives




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Your guide to the ACS national meeting in Boston




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Meet the exosome, the rising star in drug delivery

Companies are hoping to use the vesicles to package small-molecule, protein, and RNA drugs or even use them as therapies themselves




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C&EN’s Global Top 50 chemical companies

Chemical profits continue to rise as the global economy booms




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Sponsored content: Packing the right molecules for the great outdoors

Cutting-edge chemistry makes recreation in the wild more enjoyable—and more comfortable. 




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Sponsored content: Interdisciplinary innovation

Chemists at ShanghaiTech University are championing academic collaboration and eschewing traditional subject-matter divisions