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Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol

Interview with Sangeeta Mehta, MD, author of Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol




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Prevalence of Nonrefractive Visual Impairment in US Adults and Associated Risk Factors, 1999-2002 and 2005-2008

Interview with David S. Friedman, MD, MPH, PhD, author of Prevalence of Nonrefractive Visual Impairment in US Adults and Associated Risk Factors, 1999-2002 and 2005-2008




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Prevalence of and Risk Factors for Autopsy-Determined Atherosclerosis Among US Service Members, 2001-2011

Interview with Bryant J. Webber, MD, author of Prevalence of and Risk Factors for Autopsy-Determined Atherosclerosis Among US Service Members, 2001-2011




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Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial

Interview with Timothy McAlindon, DM, MPH, author of Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial




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Robotically Assisted vs Laparoscopic Hysterectomy Among Women With Benign Gynecologic Disease

Interview with Jason D. Wright, MD, author of Robotically Assisted vs Laparoscopic Hysterectomy Among Women With Benign Gynecologic Disease




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Bariatric Surgery Complications Before vs After Implementation of a National Policy Restricting Coverage to Centers of Excellence

Interview with Justin B. Dimick, MD, MPH, author of Bariatric Surgery Complications Before vs After Implementation of a National Policy Restricting Coverage to Centers of Excellence




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Association Between the Initiation of Anti-Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster

Interview with Kevin L Winthrop, MD, MPH, author of Association Between the Initiation of Anti-Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster




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Long-term Mortality After Stroke Among Adults Aged 18 to 50 Years

Interview with Frank-Erik de Leeuw, MD, PhD and Loes C. A. Rutten-Jacobs, MSc, authors of Long-term Mortality After Stroke Among Adults Aged 18 to 50 Years




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Melatonin Secretion and the Incidence of Type 2 Diabetes

Interview with Ciaran J. McMullan, MD, author of Melatonin Secretion and the Incidence of Type 2 Diabetes




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Magnetic Resonance Imaging Screening to Identify Spinal and Paraspinal Infections Associated With Injections of Contaminated Methylprednisolone Acetate

Interview with Anurag N. Malani, MD, author of Magnetic Resonance Imaging Screening to Identify Spinal and Paraspinal Infections Associated With Injections of Contaminated Methylprednisolone Acetate




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Time to Treatment With Intravenous Tissue Plasminogen Activator and Outcome From Acute Ischemic Stroke

Interview with Jeffrey L. Saver, MD, author of Time to Treatment With Intravenous Tissue Plasminogen Activator and Outcome From Acute Ischemic Stroke




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Effect of Home Blood Pressure Telemonitoring and Pharmacist Management on Blood Pressure Control: A Cluster Randomized Clinical Trial

Interview with Karen L. Margolis, MD, MPH, author of Effect of Home Blood Pressure Telemonitoring and Pharmacist Management on Blood Pressure Control: A Cluster Randomized Clinical Trial




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The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors

Interview with Christopher J. L. Murray, MD, DPhil, author of The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors




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Risk Factors Associated With Suicide in Current and Former US Military Personnel

Interview with Cynthia A. LeardMann, MPH, author of Risk Factors Associated With Suicide in Current and Former US Military Personnel




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The Regulatory Challenge of Electronic Cigarettes

Interview with Neal L. Benowitz, MD, author of The Regulatory Challenge of Electronic Cigarettes




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Effects of a Fixed-Dose Combination Strategy on Adherence and Risk Factors in Patients With or at High Risk of CVD: The UMPIRE Randomized Clinical Trial

Interview with Simon Thom, MB,BS, MD, author of Effects of a Fixed-Dose Combination Strategy on Adherence and Risk Factors in Patients With or at High Risk of CVD: The UMPIRE Randomized Clinical Trial




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Industry-Sponsored Clinical Trials in Emerging Markets: Time to Review the Terms of Engagement

Interview with Stephen MacMahon, DSc, FMedSci, author of Industry-Sponsored Clinical Trials in Emerging Markets: Time to Review the Terms of Engagement




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Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women's Health Initiative Randomized Trials

Interview with JoAnn E. Manson, MD, author of Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women's Health Initiative Randomized Trials




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Association of National Initiatives to Improve Cardiac Arrest Management With Rates of Bystander Intervention and Patient Survival After Out-of-Hospital Cardiac Arrest

Interview with Christian Torp-Pedersen, MD, DSc, author of Association of National Initiatives to Improve Cardiac Arrest Management With Rates of Bystander Intervention and Patient Survival After Out-of-Hospital Cardiac Arrest




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Metoclopramide in Pregnancy and Risk of Major Congenital Malformations and Fetal Death

Interview with Björn Pasternak, MD, PhD, author of Metoclopramide in Pregnancy and Risk of Major Congenital Malformations and Fetal Death




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Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels

Interview with Michael Ho, MD, PhD, author of Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels




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Complications of Daytime Elective Laparoscopic Cholecystectomies Performed by Surgeons Who Operated the Night Before

Interview with Christopher Vinden, MD, author of Complications of Daytime Elective Laparoscopic Cholecystectomies Performed by Surgeons Who Operated the Night Before




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The Anatomy of Health Care in the United States

Interview with Hamilton Moses III, MD, author of The Anatomy of Health Care in the United States




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JEffect of Weight Reduction and Cardiometabolic Risk Factor Management on Symptom Burden and Severity in Patients With Atrial Fibrillation: A Randomized Clinical Trial

Interview with Prashanthan Sanders, MBBS, PhD, author of Effect of Weight Reduction and Cardiometabolic Risk Factor Management on Symptom Burden and Severity in Patients With Atrial Fibrillation: A Randomized Clinical Trial




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Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana

Interview with Marianna K Baum, PhD, author of Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana




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2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)

Interview with Paul A. James, MD, author of 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)




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Tobacco Control and the Reduction in Smoking-Related Premature Deaths in the United States, 1964-2012

Interview with Theodore R. Holford, PhD, author of Tobacco Control and the Reduction in Smoking-Related Premature Deaths in the United States, 1964-2012




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Effect of 3 to 5 Years of Scheduled CEA and CT Follow-up to Detect Recurrence of Colorectal Cancer: The FACS Randomized Clinical Trial

Interview with John N. Primrose, MD, FRCS, author of Effect of 3 to 5 Years of Scheduled CEA and CT Follow-up to Detect Recurrence of Colorectal Cancer: The FACS Randomized Clinical Trial




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Blood Pressure Trajectories in Early Adulthood and Subclinical Atherosclerosis in Middle Age

Interview with Norrina B. Allen, PhD, MPH, author of Blood Pressure Trajectories in Early Adulthood and Subclinical Atherosclerosis in Middle Age




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Ending Sales of Tobacco Products in Pharmacies

Interview with Troyen A. Brennan, MD, MPH, author of Ending Sales of Tobacco Products in Pharmacies




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Surgical Site Infections Following Ambulatory Surgery Procedures

Interview with Claudia A. Steiner, MD, MPH, author of Surgical Site Infections Following Ambulatory Surgery Procedures




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A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions

Interview with Nancy L. Keating, MD, MPH, author of A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions




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Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative

Interview with Gregg C. Fonarow, MD, author of Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative




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Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009

Interview with Dana Dabelea, MD, PhD, author of Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009




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Effect of Vitamin D3 on Asthma Treatment Failures in Adults With Symptomatic Asthma and Lower Vitamin D Levels

Interview with Mario Castro, MD, author of Effect of Vitamin D3 on Asthma Treatment Failures in Adults With Symptomatic Asthma and Lower Vitamin D Levels




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Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

Interview with Mark G. Kris, MD, author of Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs




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Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

Interview with Nynne Nyboe Andersen, MD, author of Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease




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Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography

Interview with Sarah M. Friedewald, MD, author of Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography




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Nonmyeloablative HLA-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Phenotype

Interview with John F. Tisdale, MD, author of Nonmyeloablative HLA-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Phenotype




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Does This Man With Lower Urinary Tract Symptoms Have Bladder Outlet Obstruction? The Rational Clinical Examination: A Systematic Review

Interview with Karen A. D'Silva, MD, MS, author of Does This Man With Lower Urinary Tract Symptoms Have Bladder Outlet Obstruction? The Rational Clinical Examination: A Systematic Review




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Use of and Mortality After Bilateral Mastectomy Compared With Other Surgical Treatments for Breast Cancer in California, 1998-2011

Interview with Allison W. Kurian, MD, MSc, author of Use of and Mortality After Bilateral Mastectomy Compared With Other Surgical Treatments for Breast Cancer in California, 1998-2011




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Obstetric Quality Indicators and Morbidity

Interview with Elizabeth A Howell, MD, MPP, author of Durability of Benefits of an Outpatient Antimicrobial Stewardship Intervention After Discontinuation of Audit and Feedback




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Trends and Outcomes of Intracytoplasmic Sperm Injection

Interview with Sheree L. Boulet, DrPH, MPH, author of Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection




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Hematopoietic Stem Cell Transplantation for Multiple Sclerosis

Interview with Richard K. Burt, MD, author of Association of Nonmyeloablative Hematopoietic Stem Cell Transplantation With Neurological Disability in Patients With Relapsing-Remitting Multiple Sclerosis




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Natural History of Benign Thyroid Nodules

Interview with Sebastiano Filetti, MD, author of The Natural History of Benign Thyroid Nodules




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Nontoxigenic Clostridium difficile for Prevention of Recurrent Infection

Interview with Dale N. Gerding, MD, author of Administration of Spores of Nontoxigenic Clostridium difficile Strain M3 for Prevention of Recurrent C difficile Infection: A Randomized Clinical Trial




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Oral Steroids for Acute Sciatica Due to Herniated Lumbar Disk

Interview with Harley Goldberg, DO, author of Oral Steroids for Acute Radiculopathy Due to a Herniated Lumbar Disk: A Randomized Clinical Trial




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Antibiotics vs Appendectomy for Uncomplicated Appendicitis Treatment

JAMA Topic Review: Edward Livingston, MD, FACS, AGAF, Deputy Editor of JAMA, explores how the study by Paulina Salminen, MD, PhD, supports treating appendicitis without surgery




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Trajectory of Cognitive Decline After Incident Stroke

Interview with Deborah A. Levine, MD, MPH, author of Trajectory of Cognitive Decline After Incident Stroke




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Testosterone and Atherosclerosis in Older Men

Interview with Shalender Bhasin, MBBS, author of Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial