ia News24 | SRD R370 grant beneficiaries approved in October still waiting for payment By www.news24.com Published On :: Tuesday Nov 12 2024 20:41:04 Nearly three weeks after they were supposed to be paid, a number of SRD grant beneficiaries who had their applications approved in October are still waiting for their payments. Full Article
ia News24 | SA Jewish Board of Deputies approaches Equality Court with social media hate speech complaint By www.news24.com Published On :: Wednesday Nov 13 2024 08:11:04 The Cape South African Jewish Board of Deputies has asked the Equality Court in Cape Town to declare politician Mehmet Vefa Dag's social media posts about about Jewish people hate speech. Full Article
ia News24 | Higher education minister clashes with NSFAS head over 'unexplained' suspension of 2 officials By www.news24.com Published On :: Wednesday Nov 13 2024 06:16:50 A formal disciplinary process, or lack thereof, around the suspensions of two high-ranking officials at the National Student Financial Aid Scheme (NSFAS) has pitted Higher Education and Training Minister Nobuhle Pamela Nkabane against NSFAS administrator Freeman Nomvalo. Full Article
ia Beyond Skills: Unlocking the Full Potential of Data Scientists By www.oreilly.com Published On :: Tue, 29 Oct 2024 10:25:04 +0000 Modern organizations regard data as a strategic asset that drives efficiency, enhances decision making, and creates new value for customers. Across the organization—product management, marketing, operations, finance, and more—teams are overflowing with ideas on how data can elevate the business. To bring these ideas to life, companies are eagerly hiring data scientists for their technical […] Full Article Data Data science Data-Driven Business Research
ia Jon Stewart on the bewildering denial in remaining an undecided voter By boingboing.net Published On :: Tue, 01 Oct 2024 15:10:43 +0000 Jon Stewart tears apart the denials and false claims Trump supporters make about their terrible candidate and wonders how anyone can remain undecided. At the top of this piece by Stewart sits the strange claim MAGAs keep making that Vice President Harris isn't clear about her plans. — Read the rest The post Jon Stewart on the bewildering denial in remaining an undecided voter appeared first on Boing Boing. Full Article Post Entertainment politics video
ia The science of vinegar: what happens to bacteria under a microscope By boingboing.net Published On :: Wed, 02 Oct 2024 11:15:00 +0000 I recently switched over to using a vinegar-based spray cleaner (just vinegar, water, and rubbing alcohol), to clean my kitchen. It works wonderfully for me, and I love that by using it I'm saving money and reducing my exposure to harsh chemicals. — Read the rest The post The science of vinegar: what happens to bacteria under a microscope appeared first on Boing Boing. Full Article Post bacteria microscope vinegar
ia AI artist appeals denial of copyright protection By boingboing.net Published On :: Wed, 02 Oct 2024 16:09:58 +0000 Jason M. Allen's "Theatre D'Opera Spatial" won an art competition at the 2022 Colorado State Fair, but the work was subsequently denied copyright protection due to his use of AI software to generate it and his unwillingness to disclaim that contribution to the whole. — Read the rest The post AI artist appeals denial of copyright protection appeared first on Boing Boing. Full Article Post ai art copyright slop slopcore aesthetic
ia Every day should be raccoon appreciation day By boingboing.net Published On :: Wed, 02 Oct 2024 16:14:48 +0000 October 1 was officially "International Raccoon Appreciation Day," for those of you who love to love the adorable trash panda. Around here, honestly, every day is raccoon appreciation day, so it's an "International Day" I can genuinely get behind. National Day Calendar explains the origins of the day: In 2002, a young girl in California wanted to highlight the good points about the raccoon instead of the bad ones. — Read the rest The post Every day should be raccoon appreciation day appeared first on Boing Boing. Full Article Post holidays that are most definitely made up International Days International Raccoon Appreciation Day National Days raccoons
ia IVT MediaPlatform 4.1 Sets New Standard for Enterprise Video Communications By communicationtransformation.blogspot.com Published On :: Wed, 06 May 2009 20:22:00 +0000 IVT released its latest upgrades to its MediaPlatform software.Click to view the announcement. Full Article
ia MediaPlatform Debuts WebCaster By communicationtransformation.blogspot.com Published On :: Wed, 12 May 2010 00:59:00 +0000 MediaPlatform Debuts WebCaster, a Fusion of Performance and UsabilityNew Addition to Webcasting Software Lineup Leverages Cloud Platform for Productivity and Connectivity NEW YORK - STREAMING MEDIA EAST - May 11, 2010 -MediaPlatform, Inc. (formerly IVT) today unveiled its latest product offering, MediaPlatform WebCaster, cloud-based webcasting software that packs leading edge event management, event customization, and production capabilities into a simple user experience. WebCaster has been built to serve the needs of demanding webcast production professionals as well as non-technical users"WebCaster is a heavyweight performer with a flyweight price and impact on corporate IT," said Jim McGovern, Chief Executive Officer of MediaPlatform. "Our team has worked hard for over a year to exceed client expectations in virtually every aspect of the webcasting experience."WebCaster offers a unique mix of best-in-class features, ranging from an intuitive, browser-based user interface and sophisticated reporting to multiple remote presenters and flexible producing teams. WebCaster also offers rich templates with options to customize, total operating system and browser independence, telephony to Flash® Audio input, and iPhone support."We went into the development process with a goal of enabling presentations from 'anywhere to anyone,'" said Greg Pulier, Founder and CTO of MediaPlatform, and head of WebCaster's development. "For every feature we considered, our constant question was, 'Will this provide the best possible experience for users at every step of the webcasting process? I am very proud of the work everyone has contributed to this outstanding offering."With WebCaster, MediaPlatform is further establishing itself as the preferred provider for digital media producers. As the business of producing webcasts for lead generation, training, and conferences continues to expand, MediaPlatform is serving a growing number of top tier digital media production firms. WebCaster is designed to provide producers with a webcasting toolset they can rely upon as they build their production businesses. WebCaster is the newest addition to MediaPlatform's growing portfolio of media production and management offerings.It complements the company's high-end webcasting product, now known as IVT MediaPlatform, as well as PrimeTime, MediaPlatform's video portal.About MediaPlatform, Inc. MediaPlatform, Inc. (formerly IVT) delivers best-in-class webcasting and media management technology to global enterprises and digital media producers. MediaPlatform's webcasting software enables high-impact presentations for lead generation, corporate communications and training. The company offers organizations the ability to take advantage of scalable cloud-based computing, as well as on-premises deployment, to present and manage rich media. With media management tools built on its platform, the company helps clients derive long term archive value from their investment in media content. Full Article
ia Amazon Enables MediaPlatform Migration to the Cloud By communicationtransformation.blogspot.com Published On :: Wed, 01 Dec 2010 21:58:00 +0000 Here is a link to the case study Amazon prepared about MediaPlatform's use of the Amazon Elastic Compute Cloud (EC2) and Simple Storage Solution (S3). http://aws.amazon.com/solutions/case-studies/mediaplatform/ MediaPlatform is the only streaming software solution that allows clients to access the obvious benefits of cloud computing while retaining the ability to maintain security, achieve integrations with Active Directory/LDAP, control remote encoders, etc. Combined with its groundbreaking approaches to multicasting Flash and leveraging the native caching abilities of WAN acceleration devices to stream HTTP, MediaPlatform's cloud offering represents the most innovative approach to enterprise webcasting available on the market today. Full Article
ia Interactive Media Strategies believes Microsoft could win big with Skype By communicationtransformation.blogspot.com Published On :: Fri, 13 May 2011 22:01:00 +0000 Interactive Media Strategies (IMS) is a market research firm that follows streaming media. They discuss the news of Microsoft’s $8.5 billion acquisition of Skype, and the prospects for Skype to emerge as a viable platform for business video communications. Their research compares usage levels for a range of social media and communications applications, including Skype, YouTube and Facebook. Here is a link to the video. They report that personal use of Facebook and YouTube is relatively high but that has not yet translated into comparable levels of corporate use. They believe this raises the question of whether YouTube and Facebook will be able to outgrow their focus on the consumer side of the business to compete in the enterprise market. Usage levels for Skype are significantly lower overall, but Skype’s penetration in business communications is higher than they see for other communications apps online among young users most likely to experiment with emerging technologies. IMS puts forth the opinion that if Microsoft could make it easier for technology laggards to embrace Skype - i.e. integrate Skype with the Microsoft Office suite - then Skype could achieve significant enterprise adoption. Full Article
ia From Savings to Student Loans: The Financial Realities of Single Female Home Buyers By www.nar.realtor Published On :: Tue, 20 Aug 2024 13:30:10 +0000 Financial Realities for Single Female Home Buyers Examining the different ways single female home buyers approach buying a home and the challenges they face. By: Amethyst Marroquin Demographic Groups, Working With Buyers, Student Loan Debt Full Article
ia Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights By conservativefiringline.com Published On :: Sun, 10 Nov 2024 04:15:48 +0000 The following article, Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights, was first published on Conservative Firing Line. (Natural News) Liberals have been working hard to portray Trump as a misogynist, and it worked on a lot of women – with some of them buying into the false narrative that he will work against women so wholeheartedly that they are now having very public meltdowns over his victory. Revolver put together some of the … Continue reading Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights ... Full Article Politics democrats election liberals rights Trump unhinged victory women
ia ‘Utterly Unacceptable’: After Helping Trump Win, Elon Musk Makes Crucial Endorsement For Senate Majority Leader By conservativefiringline.com Published On :: Mon, 11 Nov 2024 06:00:13 +0000 The following article, ‘Utterly Unacceptable’: After Helping Trump Win, Elon Musk Makes Crucial Endorsement For Senate Majority Leader, was first published on Conservative Firing Line. Despite a landslide victory for Donald Trump and his “Make America Great Again” agenda last week, a ferocious battle has suddenly broken out in the U.S. Senate over who will be the chamber’s new leader, with some saying outgoing Majority Leader Mitch McConnell is trying to thwart the plans of the president-elect. “What the hell … Continue reading ‘Utterly Unacceptable’: After Helping Trump Win, Elon Musk Makes Crucial Endorsement For Senate Majority Leader ... Full Article Politics Cornyn McConnell Musk Scott Thune Trump
ia Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik By www.adventurouskate.com Published On :: Wed, 04 Sep 2024 15:28:31 +0000 Cavtat, Croatia, might be the biggest surprise of your trip! This peaceful seaside town in the far south of Croatia is so close to Dubrovnik, and yet a world away. If you want to visit Dubrovnik but would rather stay somewhere with a quiet, more relaxing atmosphere — oh, and cheaper, too! — Cavtat (pronounced […] The post Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik appeared first on Adventurous Kate. Full Article Beaches Croatia
ia Technology, Humanity, and the Existential Test By battellemedia.com Published On :: Wed, 07 Aug 2024 15:58:51 +0000 I’m still digging through some of the pieces I posted at the now defunct NewCo Shift, and found this piece, adapted from a talk I gave at the Thrival Humans X Tech conference in Pittsburgh back in September of 2018. I was alarmed by trends that I saw intensifying – a push by the tech … Continue reading "Technology, Humanity, and the Existential Test" Full Article AI Columns Internet Big Five Joints After Midnight & Rants Media/Tech Business Models ai algorithms Capitalism policy politics technocapitalism technooptimism
ia Joe Rogan Officially Backs A Candidate… Could Be The Biggest Endorsement Yet By clashdaily.com Published On :: Tue, 05 Nov 2024 10:23:15 +0000 There is a reason Joe Rogan became the world's largest podcaster. He doesn't take his audience -- or his guests -- for granted. He wants MEANINGFUL conversations. The post Joe Rogan Officially Backs A Candidate… Could Be The Biggest Endorsement Yet appeared first on Clash Daily. Full Article News Clash
ia Convicted Jihadi Terrorist Hired As Social Justice Prof In Western University By clashdaily.com Published On :: Wed, 06 Nov 2024 04:39:39 +0000 For anyone thinking that 'social justice' is less about 'justice' and more about being a delivery system for a poisoned ideology, the story of Dr Hassan Diab, is the proverbial 'Exhibit A'. The post Convicted Jihadi Terrorist Hired As Social Justice Prof In Western University appeared first on Clash Daily. Full Article News Clash
ia BOOM: Trump’s Lawyers SAVAGE Letitia James… Threaten PRISON If She Plays More Of Her Games By clashdaily.com Published On :: Fri, 08 Nov 2024 11:05:28 +0000 If anyone could accuse Trump of being on 'defense' during his witch-hunt trials, he's going on full offense now. The post BOOM: Trump’s Lawyers SAVAGE Letitia James… Threaten PRISON If She Plays More Of Her Games appeared first on Clash Daily. Full Article Videos
ia Trump to Pick Senator Marco Rubio for Crucial Cabinet Position: Report By www.westernjournal.com Published On :: Tue, 12 Nov 2024 12:33:39 +0000 President-elect Donald Trump is expected to nominate Florida Sen. Marco Rubio as his secretary of state, reports late Monday indicate. According to The Wall Street Journal, while the nomination isn’t […] The post Trump to Pick Senator Marco Rubio for Crucial Cabinet Position: Report appeared first on The Western Journal. Full Article News Donald Trump Federal government Marco Rubio Trump administration U.S. News
ia Melania Trump to Give Jill Biden the Cold Shoulder This Week: Report By www.westernjournal.com Published On :: Tue, 12 Nov 2024 14:52:45 +0000 Melania Trump will not be traveling with her husband to Washington on Wednesday when President-elect Donald Trump and President Joe Biden have a formal transition meeting, according to multiple reports. […] The post Melania Trump to Give Jill Biden the Cold Shoulder This Week: Report appeared first on The Western Journal. Full Article News Jill Biden Melania Trump Trump administration U.S. News White House
ia Mark Milley Fears He Will Face a Court-Martial When Trump Enters White House By www.westernjournal.com Published On :: Tue, 12 Nov 2024 16:45:43 +0000 Retired Gen. Mark Milley is afraid of retribution. The former chairman of the Joint Chiefs of Staff and a four-star Army general made no bones about his feelings about former […] The post Mark Milley Fears He Will Face a Court-Martial When Trump Enters White House appeared first on The Western Journal. Full Article Commentary 2024 election Afghanistan China Donald Trump Mark Milley Military Politics Ukraine
ia Democratic Politician Crashes Her Car While Allegedly Drunk, Hurls Vile Insults at Responding Officer: Police Report By www.westernjournal.com Published On :: Tue, 12 Nov 2024 21:35:14 +0000 A Chicago-area Democrat hurled an insult at police Sunday after being charged with drunken driving, according to local news reports. Samantha Steele represents the Second District on the Cook County […] The post Democratic Politician Crashes Her Car While Allegedly Drunk, Hurls Vile Insults at Responding Officer: Police Report appeared first on The Western Journal. Full Article News Alcohol Chicago Democrats Investigation Police U.S. News
ia 'Warrior for Truth': Trump Has Chosen His Next CIA Director, Crediting Pick for 'Exposing Russian Collusion' Hoax By www.westernjournal.com Published On :: Tue, 12 Nov 2024 23:40:01 +0000 President-elect Donald Trump has chosen the next director of the CIA. Trump tapped former Texas congressman and director of national intelligence John Ratcliffe for the job. According to a statement […] The post 'Warrior for Truth': Trump Has Chosen His Next CIA Director, Crediting Pick for 'Exposing Russian Collusion' Hoax appeared first on The Western Journal. Full Article News 2024 election CIA Donald Trump Russia Trump administration U.S. News
ia Report Shows New Front-Runner for Trump's Press Secretary Spot: The Media Should Be Terrified By www.westernjournal.com Published On :: Wed, 13 Nov 2024 00:01:27 +0000 President-elect Donald Trump is reportedly considering lawyer Alina Habba to be the White House press secretary. Habba often spoke to the media while she was on the legal team representing […] The post Report Shows New Front-Runner for Trump's Press Secretary Spot: The Media Should Be Terrified appeared first on The Western Journal. Full Article Commentary 2024 election Donald Trump Kayleigh McEnany Trump administration White House
ia Breaking: Musk, Ramaswamy Officially Join Trump Administration - Their Job Is to Destroy Bureaucracy By www.westernjournal.com Published On :: Wed, 13 Nov 2024 00:59:12 +0000 Pro-Trump businessmen Elon Musk (the richest man in the world) and Vivek Ramaswamy have officially joined the incoming Trump administration. President-elect Donald Trump announced in a statement published Tuesday that […] The post Breaking: Musk, Ramaswamy Officially Join Trump Administration - Their Job Is to Destroy Bureaucracy appeared first on The Western Journal. Full Article News 2024 election Donald Trump Elon Musk Federal government Trump administration U.S. News Vivek Ramaswamy
ia Sport | It's been a long walk to Bafana for Sage Stephens: 'To have your first call up at 33 is special' By www.news24.com Published On :: Tuesday Nov 12 2024 05:00:32 With some of its infrastructure decaying and no premier division club using it, the somewhat abandoned Dobsonville Stadium offered the perfect setting for Sage Stephens to take his first steps as a Bafana Bafana player at the ripe age of 33. Full Article
ia Sport | BIG PREVIEW | SA v India: Jansen wary of India's blazing batters as Centurion run fest awaits By www.news24.com Published On :: Wednesday Nov 13 2024 05:01:33 Wednesday's third T20 between South Africa and India at SuperSport Park in Centurion is shaping up to be a run-drenched one, especially if the weather holds and SA's bowling centre doesn't. Full Article
ia Egyptian Government Television Episode About Farahat’s Book By cynthiafarahat.com Published On :: Mon, 31 Oct 2022 13:25:24 +0000 Cairo, Egypt Oct. 28, 2022 On Egyptian TV show, “Headlines,” Dr. Hossam Farouk dedicated an episode to discussing national and international coverage of the Secret Apparatus: The Muslim Brotherhood’s Industry of Death. It was a great honor having the book featured on this great show. Full Article Featured Articles
ia Newsroom: Insider Intelligence Slashes Ad Spending Forecast for Russia and Eastern Europe Amid Conflict By www.emarketer.com Published On :: Thu, 31 Mar 2022 04:01:00 GMT Total media ad spend in Russia to drop nearly 50%   March 30, 2022 (New York, NY) – Insider Intelligence expects the ongoing war in Ukraine to have a significant […] Full Article
ia The singularity probability of a random symmetric matrix is exponentially small By www.ams.org Published On :: Wed, 16 Oct 2024 14:24 EDT Marcelo Campos, Matthew Jenssen, Marcus Michelen and Julian Sahasrabudhe J. Amer. Math. Soc. 38 (), 179-224. Abstract, references and article information Full Article
ia A feminist and postcolonial approach to nuclear politics By www.chathamhouse.org Published On :: Wed, 20 Jul 2022 14:53:36 +0000 A feminist and postcolonial approach to nuclear politics Expert comment NCapeling 20 July 2022 The July issue of International Affairs includes eight articles on the global nuclear order and eight more covering Chinese lending, abortion rights, and global security. Disarmament and arms control has been a consistent area of debate in this journal for the past century, as underscored in our recent archive collection of research on a century of war and conflict. The July edition moves this debate forward with a collection of papers guest-edited by Shine Choi and Catherine Eschle. The section ‘Feminist interrogations of global nuclear politics’ includes work by nine authors exploring seven global case-studies that help rethink nuclear politics and feminism. As the guest editors note in their introduction, the section brings together research on nuclear power and nuclear weaponry to ‘begin the process of decentring 1980s white, western experiences of the global nuclear order in feminist IR’. The articles speak to three core themes: they provide evidence of the ongoing destructive nature of nuclear technologies, extend understanding of the gendered, racialized, and colonial dimensions of nuclear discourses, and unearth the impact of colonialism on the global nuclear order. Global nuclear politics Anne Sisson Runyan examines the gendered effects of uranium mining and nuclear waste dumping on North American Indigenous women, showing how the nuclear cycle tends to have a disproportionate effect on certain communities but also that the area of disposal remains problematic. This is a global problem – for example, the Royal Navy has yet to successfully dispose of a single redundant nuclear-powered submarine and is rapidly running out of space to store further vessels. Hebatalla Taha goes back to the early years of nuclear development and, using Egypt as a case-study, her article argues the early visualizations of the atomic age were fluid and ambivalent. She concludes – perhaps controversially – that feminizing nuclear politics and nuclear images will not lead to disarmament but rather reinforce the nuclearized world. The piece is a welcome addition to the emerging field of visuality within international relations. Gendered images, symbols and metaphors play a key role in narrating, imagining and criticizing, but also sustaining, the nuclear-armed world. Hebatalla Taha, Assistant Professor of International Relations, Department of Political Science, American University in Cairo Anand Sreekumar brings together feminist and Gandhian thinking to suggest a way for Narendra Modi’s government to move beyond the possession of nuclear weapons as symbols of power. In doing so, he also critiques the binary labels of ‘West’ and ‘non-West’ that often frame our understanding of the world. Lorraine Bayard de Volo revisits the Cuban missile crisis – a point in time where nuclear war looked likely. She compares the actions of Khrushchev, Castro, and Kennedy and finds the pursuit of masculinity led to the rejection of approaches considered more feminine, such as diplomacy and negotiation – the crisis was exacerbated by what might be referred to now as toxic masculinity. Sweden’s and Finland’s recent application to join the nuclear alliance NATO lends a particular urgency to Emma Rosengren’s article on the original Swedish decision to renounce the development of nuclear weapons during the Cold War. Her article concludes much of the emphasis on power in international relations has contributed to a gendered and racialized nuclear order. Similarly, Laura Rose Brown and Laura Considine’s article on the Non-Proliferation Treaty finds that ‘gender-sensitive’ approaches focus almost exclusively on women’s inclusion as opposed to feminist policy analysis. They end by making recommendations for future policymaking. Finally, Rebecca Hogue and Anais Maurer look at the anti-nuclear poetry of Pacific women. This article raises fundamental questions about what is currently considered to constitute evidence. They point to the role of oral history in many communities and the tendency of policymakers and social scientists to ignore this source of understanding. National politics with international implications This edition’s ‘Editor’s Choice’ is Jeffrey A. Friedman’s article which questions whether US grand strategy is dead in a post-Trump world. Running counter to much of the existing literature, he suggests there is a strong bilateral commitment to existing partnerships and alliances within the US political establishment. Bipartisan support for deep engagement is at least as strong today as it has been at any other point since the end of the Cold War. Jeffrey A. Friedman, Associate Professor of Government, Dartmouth College; Visiting Fellow at the Institute for Advanced Study, Toulouse Following the US Supreme Court decision over Roe vs Wade, it is important to note the issue of abortion rights can have an international dimension. Megan Daigle, Deirdre N. Duffy, and Diana López Castañeda reveal that, although Colombia now has the most progressive legal framework for abortion in Latin America, intense backlash persists as legacies of the civil war overshadow the issue and lead to barriers to safe abortion care. China Ric Neo and Chen Xiang look at Chinese public opinion and finds that citizens can be upset by foreign policies of other states even when they have no impact on their daily lives. It reminds us of the potency of nationalism and the importance of who controls the prevailing narrative. It was not the Chinese party-state’s grand strategy, or even a purposeful effort, to indebt Zambia. Deborah Brautigam, Bernard L. Schwartz Professor of International Political Economy and Director, China Africa Research Initiative, Johns Hopkins University School of Advanced International Studies (SAIS) Deborah Brautigam examines China’s role in creating Zambia’s debt crisis, arguing this has not been brought about by a centralized master plan which would give China control over Zambia. Instead, the crisis has been caused by the failure of Chinese bureaucracy with too many state organs offering funding in an uncoordinated fashion. Security and defence Using Iran as a case-study, Henrik Stålhane Hiim argues the development of nuclear-capable ballistic missiles is a key indicator when looking for potential nuclear proliferators. Eray Alim demonstrates the impact of an external great power interacting with local states. Russia’s involvement in the Syrian civil war has allowed it – sometimes through restrictive and punitive measures – to ensure Turkey and Israel do not harm its interests in the region. Nina Wilén draws on fieldwork in Niger to study how Security Force Assistance (SFA) impacts on Niger’s security sector and compares this to global trends in security. She finds these developments contribute to blurred borders and confusion regarding labour division in the security sector and points to wider questions for intervenors in developing local units. Full Article
ia Russia–China defence and security relations: Insights from the expert community By www.chathamhouse.org Published On :: Wed, 31 Aug 2022 13:22:13 +0000 Russia–China defence and security relations: Insights from the expert community 13 September 2022 — 3:00PM TO 4:00PM Anonymous (not verified) 31 August 2022 Online Experts share insights on Russia–China military, defence, and security relations. In the defence and security realms, Russia–China relations resemble more pragmatic cooperation based on shared, calculated interests than an alliance. This event presents and discusses key findings from a recent expert survey conducted by Chatham House with the aim to gather insights on Russia–China military, defence, and security relations. Survey responses helped identify areas of bilateral cooperation but also crucial friction points and obstacles that prevent the relationship from developing further, as well as policy pathways for the West. Full Article
ia Russia-China Defence and Security Relations By www.chathamhouse.org Published On :: Mon, 05 Sep 2022 11:16:50 +0000 Russia-China Defence and Security Relations This project explores the military and security linkages between Russia and China. jon.wallace 5 September 2022 The project seeks to provide a nuanced understanding of Russia-China relations in the defence and security realms. It also seeks to understand Russian political and security perceptions regarding Chinese inroads into what Russia considers its ‘near abroad’, as well as other sources of irritation and tension in the bilateral relationship. It offers recommendations to guide NATO policy responses. Full Article
ia Russia and China in Antarctica: Implications for the Five Eyes By www.chathamhouse.org Published On :: Fri, 02 Dec 2022 14:17:13 +0000 Russia and China in Antarctica: Implications for the Five Eyes 15 December 2022 — 11:00AM TO 12:00PM Anonymous (not verified) 2 December 2022 Online This event explores Russia’s and China’s postions on the Antarctic and offers a critical assessment of their actions in the region. Ever since the 1959 Antarctic Treaty System (ATS), signed at the height of Cold War, Antarctica has remained a demilitarized continent. Today, even though the ATS is not in immediate danger of collapse, Antarctica and the Southern Ocean are no longer insulated from wider geopolitical tension, with China and Russia posing challenges to regional governance. This event also discusses key recommendations for the Five Eyes regarding Russian and Chinese current and future efforts at undermining the ATS and Antarctic governance. The discussion is informed by Mathieu Boulègue’s paper ‘Russia and China in Antarctica and the Southern Ocean: Implications for the Five Eyes’ published by the Sea Power Centre of the Royal Australian Navy. Full Article
ia Beijing briefing: China aims for tech self-reliance By www.chathamhouse.org Published On :: Tue, 28 Mar 2023 09:44:39 +0000 Beijing briefing: China aims for tech self-reliance The World Today mhiggins.drupal 28 March 2023 Xi Jinping’s new appointments are tasked with a technology led recovery, but they face a daunting task to restore growth, writes Yu Jie. The three-day state visit to Moscow by President Xi Jinping in March may have eclipsed the National People’s Congress in Beijing a fortnight earlier, but as Xi seeks to establish a new global order with China at its centre, the political events in the Great Hall of People provide an important insight into the country’s longer-term economic plans. While a new cohort of cabinet members was appointed to sit on the State Council for the next five years, much of the attention remains on China’s economic stimulus plan to enable a rapid post-Covid recovery, as well as proposals to restructure central government. Mountainous task Three aspects of this year’s Congress deserve deeper scrutiny: Li Qiang’s confirmation as premier to succeed Li Keqiang’s decade-long subdued tenure under Xi; the extent to which Xi’s new cabinet sheds light on China’s economic and scientific self-reliance; and the unveiling of a major restructuring of central government administration in sectors such as finance and science. Local government debt and the volatile property market threaten huge economic uncertainty China’s new premier initially faces the mountainous task of restoring growth and market confidence. During a press conference much shorter than his predecessor would hold, Li Qiang praised China’s private business sector and repeated the words ‘China remains open to foreign business’ to address the growing anxieties among foreigners and Chinese private entrepreneurs. Beside the daunting task of economic recovery, Li Qiang faces another big challenge. Unlike his predecessors, he has never worked as a vice premier and overseen ministries under the State Council. The test for him will be to pursue a sound economic recovery plan while coordinating numerous central government agencies. He will also need to regulate relations among provincial heads who have a tendency to argue endlessly over the distribution of public finances. Even though Xi is secure in his third term, his involvement in shaping and implementing macro-economic policies is keenly felt. Li Qiang made explicit the State Council under his leadership will be the chief implementor of all policies approved by the president. This is a less equal working partnership with Xi than his predecessors on the State Council enjoyed in the past. Beijing published its official plan to restructure its central government administration announcing planned cuts of 5 per cent of its civil service. The newly established Central Commission on Finance intends to deal with systemic financial risks and to coordinate the financial regulatory bodies, central bank and Ministry of Finance. This is seen to reflect the Chinese leadership’s growing concern with the poor performance of local government loans and debt as well of the volatility of the property market, all of which threaten huge uncertainty for the economy. Beijing is responding to the tough US measures designed to dent China’s ambitions of technology supremacy As well as reorganizing the financial sector, Xi’s intention to pursue an integrated national strategy combining economic and scientific self-reliance has led to significant appointments following the Congress. As a starter, a new Central Commission for Science under the party leadership has been established. This commission will focus on providing a renewed impetus to accelerate China’s drive to achieve ‘scientific reliance’ and to ease the choke points in the economy, such as the supply chain for semiconductors. It remains unclear who will head this new commission or who will be on it, however, as scant detail has been made public. It is seen as a direct response to the tough measures adopted by the United States designed to dent China’s ambitions of technology supremacy. Departure from the past New appointees to the Politburo come with substantial backgrounds in science as well as a solid track record of running state-owned enterprises. This is a departure from the past. Instead of inserting financial specialists, Xi appointed two scientists, Liu Guozhong and Zhang Guoqing, as the vice premiers overseeing science, education and industrial policies. This signals that Xi intends to prioritize science and innovation during his third term. The appointment of technocrats to the State Council is seen as a move to strengthen innovation and prepare the Chinese economy, political system and society for potential external shocks. Full Article
ia India-China relations: Is the Quad the answer? By www.chathamhouse.org Published On :: Tue, 28 Mar 2023 15:16:51 +0000 India-China relations: Is the Quad the answer? Interview NCapeling 28 March 2023 The threat of China’s military aggression is being felt across the world, but this is a phenomenon India has been contending with for decades. India’s border with China became the site of tense conflict in 2020, which led to India reinvesting in the Quad. Arzan Tarapore discusses key issues from his International Affairs article, such as how India is responding to increased aggression at the border and how a reinvigorated Quad may hold answers to balancing China in the Indo-Pacific. What have India-China relations been like in the past? Relations between India and China have varied over the decades. In the years following World War Two there was some hope they would find common cause in their international outlooks but that was quite quickly extinguished with their border war of 1962. Since then, the two countries have oscillated between detente and tension. It took decades for them to normalize their relations and slowly build trust through several confidence-building agreements. This was a dynamic, iterative process, with incursions prompting India to accelerate its infrastructure development, which in turn probably prompted more incursions by China More recently it seemed the two countries were both willing to set aside their border dispute in order to profit from their burgeoning economic relationship – as, for both, there is no question development and economic growth is the primary national objective. The question has been the extent to which their unresolved sovereignty and security issues undermine those goals as, at the same time, they both began paying more attention to the security of their territorial claims. China in particular matched its explosive economic growth with startling military modernization and assertiveness. Its long-standing military doctrine and terrain advantages means it relies heavily on quality military infrastructure on the Tibetan plateau and it has accelerated the pace of those infrastructure upgrades and expansion. In the 2010s, India belatedly began to improve its own transport infrastructure near the border, which threatened to reduce China’s military advantages. The earlier quiet on the border began to crack and China began launching border incursions with increasing frequency and scale. This was a dynamic, iterative process, with incursions prompting India to accelerate its infrastructure development, which in turn probably prompted more incursions by China. What happened around 2020 to change their relationship? The cycle of competitive security policies on the border reached a tipping point in 2020 with Chinese incursions at multiple points simultaneously in Ladakh, apparently designed to establish a new status quo on the Line of Actual Control (LAC) separating Indian and Chinese-controlled territory. The Indian political leadership played down the incursions but both Indian and Chinese militaries rushed to reinforce their positions near the border. They held multiple rounds of military talks which made halting progress. On 15 June 2020, a skirmish resulted in the loss of 20 Indian troops, and an unknown number of Chinese troops. In the weeks that followed, both sides further reinforced their positions in a scramble to gain positional advantage. How has India responded to China’s increasing military might? The Indian government’s response to the Chinese landgrab was to threaten the entire bilateral relationship. In a reversal of decades of policy, it argued China had demolished the painstakingly constructed confidence-building measures on the border, and so the relationship could not continue as normal until the border crisis was resolved. It imposed new restrictions on Chinese investment in India – even as overall trade continued to increase – and adopted a more assertive diplomatic posture. Strategically, the 2020 border crisis had two major effects. First, it reinforced the Indian proclivity to see its northern borders as the primary threat to Indian national security. India has heavily reinforced the border, reassigning some major formations and making numerous new investments in military capability to manage the threat. The significance of this however is that, in the context of budget scarcity, these military improvements come at the cost of potential increases in India’s capability in the Indian Ocean region – ultimately a more consequential zone of competition in the Indo-Pacific. The Indian government may yet change course and reallocate resources for power projection but, at this stage, I see no evidence of that. The second major strategic effect of the crisis was to unleash Indian cooperation with its partners, especially the US and the reinvigorated Quad grouping of Australia, India, Japan and the US. India has generally avoided formal international alliances, and the Quad was in hiatus for years – why has India invested in it now? India had always been mindful not to embrace external partners too closely so as to maintain its freedom of action and to not provoke a Chinese reaction. But since the Ladakh crisis, New Delhi has a newfound willingness to work more closely with the US, Japan, and Australia – because it calculates correctly that these partnerships enhance its freedom to act, and that China has already adopted the aggressive posture India feared. It is important to note however that the border crisis was not the only driver of India’s strategic adjustment. The crisis coincided with the COVID-19 pandemic which highlighted to India the ineffectiveness of existing international institutional arrangements. For New Delhi, then, the twin crises of Ladakh and the pandemic stressed the need for new international arrangements, and the Quad offered the best combination of agility and capability to meet the most pressing challenges of the Indo-Pacific region. What do the Quad partners hope to achieve in their renewed partnership? Beginning in 2021, the Quad assumed far greater significance. The first national leader summits happened – which have since continued at regular intervals – and its members have all agreed to a continually expanding agenda of work. It seeks to provide international public goods, and everything from climate action to telecommunications regulations. Critically, it has limited its security role to some niche and relatively unprovocative areas, such as humanitarian assistance and maritime domain awareness – issues which benefit the Indo-Pacific as a whole and do not intensify security competition. It has certainly eschewed military cooperation. Interestingly, the four Quad countries have also separately accelerated their military cooperation, bilaterally, trilaterally, and even quadrilaterally. But that cooperation lies outside the formal mechanisms of the Quad. What impact will these Quad actions have on Chinese aggression and the Indo-Pacific region? This Quad approach, which I call ‘zone balancing’ in my article, is specifically designed to build the capacity and resilience of regional states, and to not inflame dyadic security competition. The relatively uncompetitive character of these activities helps to deflate Chinese claims that the Quad is an antagonistic new bloc, and to ameliorate southeast Asian states’ concerns over the potential intensification of strategic competition. New Delhi has a newfound willingness to work more closely with the US, Japan, and Australia – because it calculates correctly that these partnerships enhance its freedom to act But the Quad’s agenda is not fixed and not bounded. It has expanded year on year and may continue to extend into new areas. This gives it a degree of flexibility and coercive leverage as Beijing cannot be confident about the Quad’s future direction. This slate of activities has a lot of utility in building the Quad’s regional legitimacy and habits of cooperation among its members. But it conspicuously does not address the region’s most pressing security challenges. It is not, in its current form, equipped to manage the challenge of territorial disputes or aggression. So the Quad will not address India’s unresolved border dispute with China, potential crises over Taiwan, or the South China Sea. I would argue, however, that the four members of the Quad have unparalleled advantages of capacity and geography. With further military cooperation, even outside the formal structures of the Quad, they have the potential to deter Chinese aggression, but that remains subject to their political preferences. Will other countries in different parts of the world adopt similar balancing strategies? Zone balancing could be an attractive strategy for other countries which want to either avoid the costs of hard military balancing, or to not provoke their rivals. It has been used in the past – such as the Marshall Plan during the early Cold War – and I would not be surprised if other countries competing with China, or even China itself, use it. Full Article
ia Structure, mechanism, and regulation of mitochondrial DNA transcription initiation [Enzymology] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 Mitochondria are specialized compartments that produce requisite ATP to fuel cellular functions and serve as centers of metabolite processing, cellular signaling, and apoptosis. To accomplish these roles, mitochondria rely on the genetic information in their small genome (mitochondrial DNA) and the nucleus. A growing appreciation for mitochondria's role in a myriad of human diseases, including inherited genetic disorders, degenerative diseases, inflammation, and cancer, has fueled the study of biochemical mechanisms that control mitochondrial function. The mitochondrial transcriptional machinery is different from nuclear machinery. The in vitro re-constituted transcriptional complexes of Saccharomyces cerevisiae (yeast) and humans, aided with high-resolution structures and biochemical characterizations, have provided a deeper understanding of the mechanism and regulation of mitochondrial DNA transcription. In this review, we will discuss recent advances in the structure and mechanism of mitochondrial transcription initiation. We will follow up with recent discoveries and formative findings regarding the regulatory events that control mitochondrial DNA transcription, focusing on those involved in cross-talk between the mitochondria and nucleus. Full Article
ia The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2 [Computational Biology] By www.jbc.org Published On :: 2020-12-25T00:06:30-08:00 The QT interval is a recording of cardiac electrical activity. Previous genome-wide association studies identified genetic variants that modify the QT interval upstream of LITAF (lipopolysaccharide-induced tumor necrosis factor-α factor), a protein encoding a regulator of endosomal trafficking. However, it was not clear how LITAF might impact cardiac excitation. We investigated the effect of LITAF on the voltage-gated sodium channel Nav1.5, which is critical for cardiac depolarization. We show that overexpressed LITAF resulted in a significant increase in the density of Nav1.5-generated voltage-gated sodium current INa and Nav1.5 surface protein levels in rabbit cardiomyocytes and in HEK cells stably expressing Nav1.5. Proximity ligation assays showed co-localization of endogenous LITAF and Nav1.5 in cardiomyocytes, whereas co-immunoprecipitations confirmed they are in the same complex when overexpressed in HEK cells. In vitro data suggest that LITAF interacts with the ubiquitin ligase NEDD4-2, a regulator of Nav1.5. LITAF overexpression down-regulated NEDD4-2 in cardiomyocytes and HEK cells. In HEK cells, LITAF increased ubiquitination and proteasomal degradation of co-expressed NEDD4-2 and significantly blunted the negative effect of NEDD4-2 on INa. We conclude that LITAF controls cardiac excitability by promoting degradation of NEDD4-2, which is essential for removal of surface Nav1.5. LITAF-knockout zebrafish showed increased variation in and a nonsignificant 15% prolongation of action potential duration. Computer simulations using a rabbit-cardiomyocyte model demonstrated that changes in Ca2+ and Na+ homeostasis are responsible for the surprisingly modest action potential duration shortening. These computational data thus corroborate findings from several genome-wide association studies that associated LITAF with QT interval variation. Full Article
ia 30 Years of Non-Maghreb: What next for Algeria-Morocco relations? By www.chathamhouse.org Published On :: Tue, 13 Aug 2024 16:27:13 +0000 30 Years of Non-Maghreb: What next for Algeria-Morocco relations? 10 September 2024 — 2:00PM TO 3:15PM Anonymous (not verified) 13 August 2024 Online Experts discuss Algeria-Morocco relations and implications for regional actors. In 1989, the establishment of the Arab Maghreb Union (UMA) brought a promise of economic integration and strengthening of ties between Algeria, Libya, Mauritania, Morocco and Tunisia for the benefit and prosperity of their societies.Decades on, very little has been accomplished in developing the Maghreb project, and the region remains one of the least integrated in the world, despite significant social and cultural similarities between member countries. The last time the full UMA leadership met was back in 1994, with August 2024 marking 30 years of closed borders between Algeria and Morocco.Relations between the two largest Maghreb countries have deteriorated further since 2020 due to disagreements over issues of Western Sahara, and, most recently, the Abraham Accords, with Algeria cutting diplomatic ties with Morocco in 2021.In this webinar, experts will discuss:Which primary obstacles are hindering Maghreb integration and Algeria-Morocco relations?What are the costs and implications for regional countries?What are the positions of Libya, Tunisia, and Mauritania?What is required for a rapprochement and how can external partners support this? Full Article
ia Islamic radicalisation in Central Asia By www.chathamhouse.org Published On :: Tue, 20 Aug 2024 15:47:13 +0000 Islamic radicalisation in Central Asia 18 September 2024 — 10:00AM TO 11:30AM Anonymous (not verified) 20 August 2024 Chatham House and Online Experts analyse rising foreign recruitment, current counter-radicalisation efforts and challenge past Chatham House predictions made of the Central Asia region. In 2014, Chatham House released a report titled The Myth of Post-Soviet Muslim Radicalisation in the Central Asian Republics. At that time, a significant, Western-funded counter-radicalisation industry was addressing what was believed to be a major issue of Islamic violent extremism in the region.Over the past decade, two key developments have occurred. First, Western interest in the region has declined in favour of traditional geopolitical concerns. Second, while violent extremism incidents within Central Asia remain rare, there has been a notable recruitment of Central Asians by foreign groups, with several attacks carried out by Central Asians overseas.In this event, the original report’s authors, John Heathershaw and David Montgomery, will discuss whether the report’s arguments are still valid and how we might answer these questions today.This raises several questions:What did the report accurately predict, and where did it fall short?How can we explain the lack of violent extremist organisations (VEOs) within Central Asia but the presence of Central Asians in VEOs abroad?Could repression by Central Asian states both domestically and transnationally have contributed to this issue?What, if anything, can the counter-radicalisation industry do today to address this problem more effectively?Please note that in-person places are limited. Please wait for confirmation before participating. Full Article
ia Member’s question time: Is Russia losing the South Caucasus? By www.chathamhouse.org Published On :: Mon, 02 Sep 2024 16:12:14 +0000 Member’s question time: Is Russia losing the South Caucasus? 22 October 2024 — 1:00PM TO 1:30PM Anonymous (not verified) 2 September 2024 Online Join us and ask Chatham House Senior Research Fellow, Natalie Sabanadze anything about the situation in the Caucasus. Submit your questions in advance. Whilst Russia focuses on its illegal invasion of Ukraine, the situation at its southern border is evolving. Relations between the three states in the South Caucasus and Moscow have never been easy as Russia tried to maintain its dominance by leveraging vulnerabilities, playing one side against another to keep conflicts simmering and even engaging in open military aggression. Although the violence seen in the 1990s and early 2000s has abated, the war in Ukraine has had an indirect impact on the region, bringing a change to the status quo.Russia abandoned its long-standing support for Armenia, allowing for the collapse of Nagorny-Karabakh and the restoration of the territorial integrity of Azerbaijan with the backing of Turkey. As a result, Azerbaijan has emerged as a dominant regional player with Baku recently declaring its interest to join BRICS. Turkey’s influence has grown, while Armenia frustrated by Russia’s change of heart has been turning cautiously towards the EU and the US.In Georgia, meanwhile, the ruling party has been consolidating its grasp on power, rolling back democratic reforms and pivoting away from the West. Georgia’s long-awaited European integration process has been suspended, following the adoption of the Russian-style foreign agents legislation.Join us as our Senior Research Fellow in the Russia and Eurasia Programme answers your questions in this quick-fire session assessing the extent to which the Russian influence has changed since the start of the invasion of Ukraine and who is there to fill the vacuum; how geopolitical contestation in the region is going to impact aspirations of Armenia, Azerbaijan and Georgia; and much more.Submit your questions to Natalie Sabanadze in advance of the event. Your questions will drive the conversation. Full Article
ia In conversation with Valerii Zaluzhnyi, Ukrainian Ambassador to the UK By www.chathamhouse.org Published On :: Mon, 16 Sep 2024 19:47:13 +0000 In conversation with Valerii Zaluzhnyi, Ukrainian Ambassador to the UK 17 October 2024 — 10:00AM TO 11:00AM Anonymous (not verified) 16 September 2024 Chatham House and Online The former Commander-in-Chief of the Armed Forces of Ukraine offers insight into the evolution of Russia’s war against his country, and what to expect next. More than two and a half years since Russia launched its full-scale invasion, Ukraine has consistently adapted to Moscow’s advances by implementing new strategies.Ukraine’s recent incursion into Russia’s Kursk region demonstrated operational tactical ingenuity, surprising both Russia and Ukraine’s Western supporters. Success against the Russian Black Sea Fleet has already showcased how Ukraine can skilfully beat back Russian aggression. And increasing numbers of targeted strikes on Russian supply depots and airfields are disrupting Russian operations behind the front lines.Critical Western supplies continue to resource Ukraine’s military. But questions linger over the quantity and sustainability of these supplies. Kyiv will be watching the US presidential election in November as its biggest backer goes to the polls with the possibility of an outcome that could seriously affect the war. Meanwhile, Russian forces continue to edge forward in Donbas, despite heavy casualties, and strike at Ukrainian towns and cities from the air, demonstrating that President Putin has no intention of relinquishing the fight.Amid these complexities, Ambassador Zaluzhnyi will discuss how the war is changing both sides, advances on the battlefield, and what dangers lie ahead for Ukraine in the coming months. Other key questions include:What kind of enemy is Russia today and how to secure its strategic defeat in Ukraine;How have new strategies, such as the recent incursion into the Kursk region, affected the state of play on the battlefield?What technologies and armaments does Ukraine need from its Western allies in both the short and long term?Individual membership provides you with the complete Chatham House experience, connecting you with a unique global policy community. Find out more about membership. Full Article
ia US domestic polarization and implications for the presidential election By www.chathamhouse.org Published On :: Thu, 19 Sep 2024 09:07:13 +0000 US domestic polarization and implications for the presidential election 30 September 2024 — 5:00PM TO 6:00PM Anonymous (not verified) 19 September 2024 Online This webinar explores the rise of polarization amongst the US public and implications for the upcoming election. Domestic polarization has been on the rise in the US in recent years, with Democrats and Republicans moving further away from the centre on key policy issues. As polarization increases, so too do concerns about the state of US democracy and prospects of political violence surrounding the upcoming presidential election. This expert panel discusses key questions including:What are the driving forces of the growing political divide in the US?How far apart are voters on key election issues, from healthcare to immigration to national security?How is partisan polarisation altering the effectiveness of US foreign policy and influencing America’s role in the world? Full Article
ia Looking ahead to the 2024 US Presidential Election By www.chathamhouse.org Published On :: Mon, 23 Sep 2024 18:07:13 +0000 Looking ahead to the 2024 US Presidential Election 2 October 2024 — 6:00PM TO 7:00PM Anonymous (not verified) 23 September 2024 Chatham House and Online This panel explores the state of the US presidential election following the vice presidential debate. With only weeks to go, this panel looks at the state of the 2024 US presidential election.Harris and Trump are campaigning to drive up voter enthusiasm and bring undecided voters to their side.What are the key issues shaping voter’s preferences and how may this impact voter turnout? What can we expect in the weeks ahead? Full Article
ia Iraq Initiative Conference 2024 By www.chathamhouse.org Published On :: Fri, 04 Oct 2024 10:12:13 +0000 Iraq Initiative Conference 2024 20 November 2024 — 9:30AM TO 5:00PM Anonymous (not verified) 4 October 2024 Chatham House and Online Our sixth annual Iraq Initiative conference will convene Iraqi and international policymakers, experts and civil society in London to discuss the critical questions for Iraq’s future, and the country’s trajectory in the year ahead. Over two decades following regime change, Iraq appears to be on a path to recovery and growth. With the support of high oil prices, Prime Minister Mohammed Shia’ al-Sudani’s government is implementing an ambitious plan to develop critical infrastructure, enhance ties with neighbouring countries, and renegotiate relationships with international partners like the US and UN. The political system has rebounded from a series of shocks and is in the process of consolidating and centralising power in Baghdad under the governing Shia Coordination Framework.However, underlying political, economic, security, and regional challenges, if not addressed, threaten this apparent stability and frustrate longer-term hope for a better future. Despite the country’s wealth, many young Iraqis struggle to find jobs while the space for civic activism shrinks. Meanwhile, the escalation of violence across the region threatens to engulf Iraq in further conflict. With the 2025 parliamentary election approaching, infighting within the governing coalition also suggests political turmoil in the year ahead.The key questions explored through each session include:How can the Sudani government tackle the roots of these obstacles to ensure that development can be sustained over time?What are the key steps to coherent and effective state-building?And how can regional and international actors support this process?This conference is part of Chatham House’s Iraq Initiative.This year’s conference features RE-PLAY – a video art exhibition curated by Dr Tamara Chalabi of the Ruya Foundation. The artists featured in this exhibition, spanning multiple generations both within Iraq and in the Iraqi diaspora, use their work to grapple with complex notions of Iraqi identity through the thematic issues of heritage, exile, disconnection, freedom of expression, and other persistent issues explored in this show.Simultaneous English-Arabic interpretation will be available for all conference sessions. This event is part of Chatham House’s Iraq Initiative. Iraq Initiative conference 2024 agenda [English] (PDF, 2.97MB) Iraq Initiative conference 2024 agenda [Arabic] (PDF, 2.29MB) RE-PLAY Video Art Exhibition [English] (PDF, 0.23MB) RE-PLAY Video Art Exhibition [Arabic] (PDF, 0.22MB) The institute occupies a position of respect and trust, and is committed to fostering inclusive dialogue at all events. Event attendees are expected to uphold this by adhering to our code of conduct. Full Article
ia Civilian priorities for ending the war in Sudan By www.chathamhouse.org Published On :: Tue, 08 Oct 2024 08:17:13 +0000 Civilian priorities for ending the war in Sudan 31 October 2024 — 12:30PM TO 1:30PM Anonymous (not verified) 8 October 2024 Chatham House and Online Dr Abdalla Hamdok, former prime minister of Sudan and chairperson of the Coordination of Civil Democratic Forces (Tagadum), will discuss the prospects for conflict resolution in Sudan. The intensification of fighting across Sudan demonstrates that both warring parties and their allies are continuing to pursue an outright military victory in the war, with little regard for the human cost. Diplomatic efforts, including the US-led Geneva talks in August, have produced little progress towards a ceasefire. Meanwhile, the conflict has resulted in widespread devastation, mass displacement, and an escalating hunger crisis.Civilian perspectives on ending the war, their vital efforts in providing lifesaving humanitarian assistance, and the aspiration of many Sudanese for a more inclusive and democratic Sudan, have been sidelined by the interests and actions of the belligerent parties.At this event, Dr Abdalla Hamdok will discuss options for reaching a ceasefire and seeking a peaceful political resolution to the conflict. He will also address the urgent need for an international response to what has become the world’s largest humanitarian crisis.Please note that in-person attendance for this event will be balloted. Guests looking to join in-person must ‘register interest’ in joining. Full confirmations to successful applicants will be sent on Monday 28 October at 15:00.Individual membership provides you with the complete Chatham House experience, connecting you with a unique global policy community. Find out more about membership. Full Article
ia [4Fe-4S] cluster trafficking mediated by Arabidopsis mitochondrial ISCA and NFU proteins [Enzymology] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 Numerous iron-sulfur (Fe-S) proteins with diverse functions are present in the matrix and respiratory chain complexes of mitochondria. Although [4Fe-4S] clusters are the most common type of Fe-S cluster in mitochondria, the molecular mechanism of [4Fe-4S] cluster assembly and insertion into target proteins by the mitochondrial iron-sulfur cluster (ISC) maturation system is not well-understood. Here we report a detailed characterization of two late-acting Fe-S cluster-carrier proteins from Arabidopsis thaliana, NFU4 and NFU5. Yeast two-hybrid and bimolecular fluorescence complementation studies demonstrated interaction of both the NFU4 and NFU5 proteins with the ISCA class of Fe-S carrier proteins. Recombinant NFU4 and NFU5 were purified as apo-proteins after expression in Escherichia coli. In vitro Fe-S cluster reconstitution led to the insertion of one [4Fe-4S]2+ cluster per homodimer as determined by UV-visible absorption/CD, resonance Raman and EPR spectroscopy, and analytical studies. Cluster transfer reactions, monitored by UV-visible absorption and CD spectroscopy, showed that a [4Fe-4S]2+ cluster-bound ISCA1a/2 heterodimer is effective in transferring [4Fe-4S]2+ clusters to both NFU4 and NFU5 with negligible back reaction. In addition, [4Fe-4S]2+ cluster-bound ISCA1a/2, NFU4, and NFU5 were all found to be effective [4Fe-4S]2+ cluster donors for maturation of the mitochondrial apo-aconitase 2 as assessed by enzyme activity measurements. The results demonstrate rapid, unidirectional, and quantitative [4Fe-4S]2+ cluster transfer from ISCA1a/2 to NFU4 or NFU5 that further delineates their respective positions in the plant ISC machinery and their contributions to the maturation of client [4Fe-4S] cluster-containing proteins. Full Article
ia Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways [Molecular Bases of Disease] By www.jbc.org Published On :: 2020-12-04T00:06:06-08:00 The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardiac anomalies are incompletely understood. In this study, we investigated whether and how calpain activation promotes myocardial abnormalities under simulated microgravity conditions. Simulated microgravity was induced by tail suspension in mice with cardiomyocyte-specific deletion of Capns1, which disrupts activity and stability of calpain-1 and calpain-2, and their WT littermates. Tail suspension time-dependently reduced cardiomyocyte size, heart weight, and myocardial function in WT mice, and these changes were accompanied by calpain activation, NADPH oxidase activation, and oxidative stress in heart tissues. The effects of tail suspension were attenuated by deletion of Capns1. Notably, the protective effects of Capns1 deletion were associated with the prevention of phosphorylation of Ser-345 on p47phox and attenuation of ERK1/2 and p38 activation in hearts of tail-suspended mice. Using a rotary cell culture system, we simulated microgravity in cultured neonatal mouse cardiomyocytes and observed decreased total protein/DNA ratio and induced calpain activation, phosphorylation of Ser-345 on p47phox, and activation of ERK1/2 and p38, all of which were prevented by calpain inhibitor-III. Furthermore, inhibition of ERK1/2 or p38 attenuated phosphorylation of Ser-345 on p47phox in cardiomyocytes under simulated microgravity. This study demonstrates for the first time that calpain promotes NADPH oxidase activation and myocardial abnormalities under microgravity by facilitating p47phox phosphorylation via ERK1/2 and p38 pathways. Thus, calpain inhibition may be an effective therapeutic approach to reduce microgravity-induced myocardial abnormalities. Full Article