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Digital transformation solutions player UST named Workday services deployment partner 

UST will leverage its cross-platform SaaS expertise, Generative AI thought leadership, industry solutions, and automation tools to enable customers get the most from their Workday experience




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Nvidia’s Jensen Huang bets on India’s AI future

Announces a slew of partnerships with Indian companies to enable AI infra




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Qualcomm bullish on India’s automotive growth, eyes major expansion in auto tech

At the recent Snapdragon Summit, Qualcomm launched the Snapdragon Cockpit Elite and Ride Elite platforms, designed to enhance in-car entertainment and automated driving experiences




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Revolutionising data security: IBM introduces Guardium Data Security Centre with GenAI capabilities

The centre incorporates GenAI features for generating risk summaries and improving productivity among security teams.




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Cyient acquires 27.3% stake in Azimuth AI

The investment aligns with India’s initiatives to boost domestic semiconductor innovation and follows Cyient’s establishment of a fully owned semiconductor subsidiary in July 2024




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DENSO, T-Hub tie up to promote automotive start-ups

DENSO would support T-Hub in conducting hackathons and innovation challenges targeting automotive technologies




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With Trump win, DoT gears up to sort out issues related to Elon Musk’s Starlink

The department of telecommunications is looking into security aspects while considering the demands made by two American companies — Starlink and Amazon (project Kuiper), say sources




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Sonata Software optimistic about revenue growth in H2FY25; eyes $1.5 billion revenue by FY27

The company’s international services revenue in the September-ended quarter stood at ₹707.9 crore




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OpenAI's ChatGPT back up after brief outage

Outage tracking website Downdetector.com said ChatGPT's services were down for about half an hour, affecting over 19,403 users as of 7:13 p.m. ET (0013 GMT on Saturday)




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Cyient to carve out semiconductor arm in Q1 2025: Ramya Mohan

The new company will primarily focus on four industry segments for its ASIC turnkey offerings – automotive, industrial, telecommunications, and healthcare: Cyient VP




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Time out

Check out this fun and easy way to learn yoga.




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Nature’s beauty




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The Substitute Teacher: A sudden disappearance

No warning and no goodbyes... was this how VI C wanted the ST chapter to end?




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Synthesis of 3,5-disubstituted isoxazoles by domino reductive Nef reaction/cyclization of β-nitroenones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00232F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Muhammad Ehtisham Ibraheem Khan, Tomas Lighuen Cassini, Marino Petrini, Alessandro Palmieri
β-Nitroenones were converted into 3,5-disubstituted isoxazoles via a domino reaction promoted by tin(II) dichloride. The protocol efficiently works under both microwave and flow conditions.
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Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00312H, Paper
I. Caroline Vaaland Holmgard, Aday González-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández-Bolaños, José M. Padrón, Óscar López, Emil Lindbäck
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.
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Dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00190G, Paper
Kai-Cheng Yang, Shi-Lu Zheng, Zhong Wen, Yu-Shan Zhang, Hai-Liang Ni, Long Chen
A HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes was developed, which represents a brand-new procedure for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones.
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Kinetic resolution of 1,1'-binaphthyl-2,2'-diamine derivatives by chiral calcium phosphate-catalyzed acylation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00355A, Paper
Tatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama
Chiral calcium phosphate-catalyzed kinetic resolution of BINAM derivatives.
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An efficient synthesis of mono-, di-, and tri-substituted 1,3-thiazoles employing functionalized thioamides as thiocarbonyl precursors

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00229F, Paper
Kalleshappa Sheela, Chikkappaiahnayaka Santhosh, Krishna Ravi Singh, Kalleshappa Sharath, Maralinganadoddi P. Sadashiva
Herein, we report an efficient strategy to synthesize functionalized 1,3-thiazoles using alkyl 2-amino-2-thioxoacetates.
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Generation of sulfones utilizing β-sulfinyl esters as masked aryl sulfinates under redox-neutral conditions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00238E, Communication
Yixin Zhang, Zhu Yang, Hongjun Yang, Xuefeng Li, Lu Yang
A method for generation of SVI sulfones from β-sulfinyl esters (SIV) under transition-metal-free non-oxidative mild conditions is presented.
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Correction: Recent progress of core-substituted naphthalenediimides: highlights from 2010

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB90045F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sheshanath V. Bhosale, Sidhanath V. Bhosale, Suresh K. Bhargava
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Structural flexibility of favipiravir and its structural analogues in solutions: experimental and computational insight

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00404C, Paper
Tatiana P. Gerasimova, Almaz A. Zagidullin, Anastasiia N. Nikolaeva, Robert R. Fayzullin, Aliya M. Saitova, Vasili A. Miluykov, Stefan Grimme, Sergey A. Katsyuba
Keto-enol transformations of 6-R-3-hydroxy-2-pyrazinecarboxamides in solutions are accompanied by deprotonation of enol tautomers and the formation of corresponding anionic species. The key factors determining these processes have been identified.
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Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield

Org. Biomol. Chem., 2024, 22,3009-3018
DOI: 10.1039/D4OB00211C, Paper
Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
A single-point mutation of 7α-HSDH achieved the highest activity and synergistically improved substrate tolerance, thermal stability, cofactor affinity, and conversion rate.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Albumin–ruthenium catalyst conjugate for bio-orthogonal uncaging of alloc group

Org. Biomol. Chem., 2024, 22,2992-3000
DOI: 10.1039/D4OB00234B, Paper
Kimberly S. Taylor, Madison M. McMonagle, Schaelee C. Guy, Ariana M. Human-McKinnon, Shumpei Asamizu, Heidi J. Fletcher, Bradley W. Davis, Takashi L. Suyama
An organo–ruthenium catalyst conjugated to albumin efficiently unmasks an alloc group under physiologically relevant conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Additive-free oxychlorination of unsaturated C–C bonds with tert-butyl hypochlorite and water

Org. Biomol. Chem., 2024, 22,3080-3085
DOI: 10.1039/D4OB00003J, Paper
Duyi Shen, Chaoyue Sun, Yun Han, Zhen Luo, Ting Ren, Qin Zhang, Wenting Huang, Jianru Xie, Ying Jia, Mianran Chao
A facile oxychlorination of various alkynes and alkenes with tBuOCl as an alternative chlorine source and H2O as a green oxygen source.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Photochromism of phenazine-2,3-diol derivatives through excited state intermolecular proton transfer based on keto–enol tautomerization

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kazuki Ohira, Kumpei Kozuka, Naoki Kaneda, Masahiro Yamamoto, Keiichi Imato, Yousuke Ooyama
It was found that phenazine-2,3-diol derivatives exhibit photochromism through excited state intermolecular proton transfer (ESInterPT) processes based on keto–enol tautomerization.
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3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00391H, Communication
Alexander A. Lukoyanov, Svetlana A. Aksenova, Andrey A. Tabolin, Alexey Yu. Sukhorukov
3-Halo-1,2-oxazine N-oxide derivatives act as surrogates of vinyl nitrile oxides in tandem [3 + 2]-cycloaddition/[3 + 2]-cyclofragmentation with arynes leading to benzisoxazoles.
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Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00397G, Paper
Angel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. Möller
Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00140K, Communication
R. Vara Prasad, Yogendra Kumar, R. Arun Kumar, Tohira Banoo, Subbiah Nagarajan
The use of a simple carbohydrate-derived eutectogel facilitating a LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yields is reported.
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Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00171K, Review Article
Bor-Cherng Hong, Ranadheer Reddy Indurmuddam
This review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.
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Rolling out Public Key Pinning with HPKP Reporting




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As the price of aviation turbine fuel soars, airlines’ finances spin out of control




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In case the engine gives out

If an aircraft’s engine fails, the pilot has nearly half an hour to find a landing spot




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Evolution of security in aviation

Data and technology need to be adopted




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Yoke vs. sidestick: Jury still out on what works best for pilots

Why do Airbus commercial aircraft have sidesticks and Boeing have yokes as control units?




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Blockchain: Piloting the future of aviation

Enables effective solutions that positively impact industry players and end consumers




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5 things Indian airlines must do to break their way out of pandemic blues

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 




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Air infrastructure plans should be future-proof

India’s aviation story is full of delayed, untapped and under-utilised potential




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Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




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Google to develop AI that takes over computers: Report

Google is developing AI technology that takes over a web browser to complete tasks such as research and shopping, The Information reported




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Meta builds AI search engine to cut Google, Bing reliance, the Information reports

The Facebook-owner currently relies on Google and Bing search engines to give users answers on news, stocks and sports




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Google’s moneymaking machine still pumping out massive profits despite multiple threats

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire




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Crypto firm Consensys to cut 20% of workforce amid macroeconomic, regulatory headwinds

The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment”




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ChatGPT will now work as a search engine as OpenAI partners with some news outlets

OpenAI is launching a ChatGPT-powered search engine that could put the artificial intelligence company in direct competition with search giant Google




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OpenAI CEO Sam Altman says next big AI model launch pushed due to compute challenges

Altman also said that the next update for DALL-E was still in the works with no release date yet




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Out-of-pocket expenditure on health in Kerala is highest in country despite increased State investments

National Health Accounts figures show the per capita out-of-pocket expenditure on health in Kerala stands at ₹7,889. However, Kerala also tops the list when it comes to the per capita government spending on health, at ₹4,338




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Will not allow dilution of AIIMS brand: Union Health Minister J. P. Nadda

The Health Minister said no compromises will be made in faculty recruitments or standards of teaching at any of the new AIIMS institutes being set up across the country




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Should men be allowed into operation theatres when their wives are having a baby? Doctors weigh in after YouTuber’s video sparks controversy

YouTuber Irfan recently posted a video on social media that showed him cutting the umbilical cord of his newborn, in the operation theatre of a private hospital in Chennai; consent of the medical personnel involved to being videoed was another aspect doctors say needs discussion




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Acute Flaccid Paralysis surveillance as a crucial defence against polio in India | Explained

India needs to continue efforts to maintain its polio-free status, and AFP surveillance has to remain a cornerstone of its strategy




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Air pollution: Centre warns of the rising ill-effects of deteriorating air quality

In a letter to States and UTs, the Director General of Health Services Atul Goel has said to discourage stubble and waste burning, and spread awareness among people about reducing firecrackers during festivities