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Principles of pharmacology: the pathophysiologic basis of drug therapy / David E. Golan, MD, PhD, editor in chief ; Ehrin J. Armstrong, MD, MSc, April W. Armstrong, MD, MPH, associate editors

Hayden Library - RM301.P65 2017




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Drugs / editor, Ram N. Gupta ; consulting editor, Irving Sunshine

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Process systems engineering for pharmaceutical manufacturing / edited by Ravendra Singh and Zhihong Yuan

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Liposome-based drug delivery systems / editors, Wan-Liang Lu, Xian-Rong Qi

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NeuroPsychopharmacotherapy edited by Peter Riederer, Gerd Laux, Benoit Mulsant, Weidong Le, Toshiharu Nagatsu

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Current applications for overcoming resistance to targeted therapies / editors, Myron R. Szewczuk, Bessi Qorri and Manpreet Sambi

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Marine and freshwater toxins / editors, P. Gopalakrishnakone, Vidal Haddad Jr., William R. Kem, Aurelia Tubaro, Euikyung Kim

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The role of microstructure in topical drug product development Nigel Langley, Bozena Michniak-Kohn, David W. Osborne, editors

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Peptide therapeutics: strategy and tactics for chemistry, manufacturing, and controls / editor: Ved Srivastava

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Solid oral dose process validation Ajay Pazhayattil, Naheed Sayeed-Desta, Emilija Fredro-Kumbaradzi, Marzena Ingram, Jordan Collins

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Drug transporters in drug disposition, effects and toxicity Xiaodong Liu, Guoyu Pan, editors

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Adulteration in herbal drugs: a burning issue / Shabnum Shaheen, Sehrish Ramzan, Farah Khan, Mushtaq Ahmad

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Drug discovery in Japan: investigating the sources of innovation / Sadao Nagaoka, editor

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Kava: from ethnology to pharmacology / edited by Yadhu N. Singh

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Juzen-taiho-to (shi-quan-da-bu-tang): scientific evaluation and clinical applications / edited by Haruki Yamada, Ikuo Saiki

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Unit Operation in Downstream Processing / Husnul Azan Tajarudin, Mardiana Idayu Ahmad & Mohd Nazri Ismail

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Multiscale modeling of vascular dynamics of micro- and nano-particles: application to drug delivery system / Huilin Ye, Zhiqiang Shen and Ying Li

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Structure-activity relationships for development of neurokinin-3 receptor antagonists: reducing environmental impact / Koki Yamamoto

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Topical antimicrobial testing and evaluation / Darryl S. Paulson

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Psychoactive medicinal plants and fungal neurotoxins Amritpal Singh Saroya, Jaswinder Singh

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Novel drug delivery technologies: innovative strategies for drug re-positioning / Ambikanandan Misra, Aliasgar Shahiwala, editors

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The role of NIH in drug development innovation and its impact on patient access: proceedings of a workshop / Francis K. Amankwah, Alexandra Andrada, Sharyl J. Nass, and Theresa Wizemann, rapporteurs ; Board on Health Care Services ; Board on Health Scienc

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Strange trips: science, culture, and the regulation of drugs / Lucas Richert

Hayden Library - RM316.R53 2018




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Top Kashmiri Militant Is Killed, Sparking Protests and Rage

Over years of fighting, Riyaz Ahmad Naikoo recruited scores of young Kashmiris in an armed quest for independence from India. His death has set off a fresh wave of unrest.




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BCI Outraged by Planned Kill of Endangered Bats

BCI condemns the decision of the government of Mauritius to kill 13,000 individuals of the endangered Mauritius fruit bat (Pteropus niger). ....




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Protecting Homes and Food Sources of Two Critical Bat Species

 Lesser Long-Nosed and Mexican Long-Nosed Bats Receiving Support from Bat Conservation International’s New Program Supported by XTO Energy 




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Fostering the Future

We’re proud to announce the 2019 recipients of BCI’s Student Research Scholarship for Global Bat Conservation Priorities.             




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Helping Migratory Bats with Agave Planting Event

BCI announced today the launch of an agave planting initiative throughout Southwest, Tucson area, and Mexico to support the lesser long-nosed bat




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Fungus that causes bat-killing disease White-nose Syndrome is expanding in Texas

BCI announced today that early signs of the fungus Pseudogymnoascus destructans (Pd) have been detected at one of the world’s premier bat conservation sites, Bracken Cave Preserve




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Communities Encouraged to Take Action to Help Bats Across the Globe During Bat Week

Washington, DC (October 16, 2019) – A coalition of partners across North America announced the launch of Bat Week, an international celebration of




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Protecting America’s Rarest Bat with Opening of the FPL Bat Lab at Zoo Miami

Miami, Fla. – (Oct. 24, 2019) – The FPL Bat Lab at Zoo Miami officially opened today focused on providing solutions to protect the federally




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BCI Congratulates Our 2020 Student Scholars

BCI announced today the selection of the organization’s 2020 Student Scholars for global bat conservation priorities




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Coronavirus and changes to BCI’s Operations

We're thinking a lot about our community and hope you are staying safe.

As we confront the challenge of the coronavirus pandemic, we're making the health and safety of our staff and our supporters our top priority. In line with CDC guidance and Federal & state orders, we are taking several important steps to our operations:

  • Public Events
    In response to CDC guidance regarding avoidance of large public gatherings, we are postponing the Bracken bat flight season. We will resume bat flight events when public health experts determine that large public gatherings are again safe.

Similarly, we have postponed or canceled all upcoming bat walk events at this time.

  • Merchandise & Gift Fulfillments
    Our Austin, Texas headquarters is currently subject to a city-wide “Stay Home, Work Safe” order. With our Austin-based employees working from home, please allow several weeks for delivery of merchandise and adopt-a-bat purchases ordered after March 24. Please also allow extra time for the processing of gifts made through U.S. mail. We are grateful for your patience and ask you to consider making your contribution to BCI online via credit card on our website or through PayPal.

  • Staff Operations & Field Work
    We’re taking the necessary steps to protect our staff while minimizing any disruptions to our mission. These precautions include:
    • Adhering to all state “stay-at-home” orders. At this time, most state orders consider BCI’s work as non-essential.
    • Adhering to Federal CDC guidance including:
      • Avoiding large gatherings such as events, trainings, and conferences
      • Avoiding/postponing non-essential domestic and international travel
      • Working remotely
    • Adhering to National Wildlife Health Center and U.S. Fish and Wildlife Service guidance to avoid contact with bats to prevent a potential spillback of the novel coronavirus from humans to wildlife

As a result of these precautions, we have postponed all fieldwork during the coronavirus pandemic to comply with public policies. Also, due to the global shortage of PPE supplies, we have suspended bat survey activities that require PPE.

We will continue to do all we can to respond to expert public health guidance, take the actions necessary to keep our staff and supporters safe and healthy, and update you on any changes.

Thank you for your patience and understanding as we confront this shared challenge.

 

 

 




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Industrial Environmental Management: Engineering, Science, and Policy


 

Provides aspiring engineers with pertinent information and technological methodologies on how best to manage industry's modern-day environment concerns

This book explains why industrial environmental management is important to human environmental interactions and describes what the physical, economic, social, and technological constraints to achieving the goal of a sustainable environment are. It emphasizes recent progress in life-cycle sustainable



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Introducing Large Rivers


 

An accessible introduction to large rivers, including coverage of the geomorphology, hydrology, ecology, and environments of large river systems

This indispensible book takes a structured and global approach to the subject of large rivers, covering geomorphology, hydrology, ecology, and anthropogenic environment. It offers a thorough foundation for readers who are new to the field and presents enlightening discussions about issues of management at



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Exploring the Solar System, 2nd Edition


 

An Exciting and Authoritative Account of the Second Golden Age of Solar System Exploration Award-winning author Peter Bond provides an up-to-date, in-depth account of the sun and its family in the 2nd edition of Exploring the Solar System. This new edition brings together the discoveries and advances in scientific understanding made during the last 60 years of solar and planetary exploration, using research conducted by the world's leading geoscientists



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The Mediterranean Sea in the Era of Global Change 2: 30 Years of Multidisciplinary Study of the Ligurian Sea


 

Due to its particular characteristics, the Mediterranean Sea is often viewed as a microcosm of the World Ocean. Its proportionally-reduced dimensions and peculiar hydrological circulation render it susceptible to environmental and climatic constraints, which are rapidly evolving. The Mediterranean is therefore an ideal site to examine, in order to better understand a number of key oceanographic phenomena. This is especially true of the Ligurian Sea



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The Mediterranean Sea in the Era of Global Change 1: 30 Years of Multidisciplinary Study of the Ligurian Sea


 

Due to its particular characteristics, the Mediterranean Sea is often viewed as a microcosm of the World Ocean. Its proportionally-reduced dimensions and peculiar hydrological circulation render it susceptible to environmental and climatic constraints, which are rapidly evolving. The Mediterranean is therefore an ideal site to examine, in order to better understand a number of key oceanographic phenomena. This is especially true of the Ligurian Sea



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Bringing SSL To Your Private Network

In this entry I will describe and provide how to run a HTTPS server in your home network, in order to test new HTML5 APIs.




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TinyCDN: a portable blazing fast CDN

In this blog post I am introducing tinyCDN, a middle-ware module and a standalone static file server that does much more than others, and it has been designed from the scratch to work on most constrained, Internet of Things, environments, as well as production server.




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On Ignored Users Spoken Language

I think I've talked already few times about this problems but I don't see anything happening ... actually, it's getting worst and worst.

Who Is Directly Affected And Is Wasting Money

  • Companies paying for Online Advertisement
  • Companies selling online
  • Companies providing online services

Who Is Responsible

  • every service that is addressing users through their current IP address, without asking permission, and assuming if you travel to any country in this world you automatically speak that country language
  • every service that completely ignores Accept-Language on the server side, and navigator.language on the client side
This is an extract from the Accept-Language used for locale setting post directly from W3C website:
For a first contact, using the Accept-Language value to infer regional settings may be a good starting point, but be sure to allow them to change the language as needed and specify their cultural settings more exactly if necessary. Store the results in a database or a cookie for later visits.
...
By the way
Using the Accept-Language header is also a good starting point for determining the language of the user, rather than the locale ...
Accordingly, instead using users IP location to define their language, I'd rather prefer them to use my daily language of choice, which comes most likely from the fact that my entire Operating System speaks English, as example, so PLEASE, give me English content whenever I am!

It feels so straightforward simple thing, right? Wondering who is doing it right?

Nobody Is Doing It Right

I am in Germany these days, and suddenly I don't understand anything. I cannot even be "victim" of Ads, I'm rather disturbed by them.

Google

Before even asking to use my detailed location provided through the browser, if I type google.com in the URL bar I'm redirected to google.de. Why does that happen? Simple, they know by my IP I am in Germany ^_^.
If I choose the English language and I search for O2 DSL, imagining I'd like to sign for a contract, or need some help, this is the result:
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Exporting modules in JavaScript

In my latest entry I explain the difference about exporting a module between server side or CLI environments such Nashorn, SpiderMonkey, JSC, or micro controller and embedded engines such Duktape, Espruino, KinomaJS, and Desktop UI space via GJS.
Using this is a universal way to attach and export properties but when it comes to ES2015 modules, incompatible with CommonJS and with an undefined execution context.
Enjoy




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The missing analysis in JavaScript "Real" Mixins

I love hacks and unusual patterns! As logical consequence, I loved this post about "Real" Mixins!!!
The only hitch about that post is that I believe there are few points closer to a "gonna sell you my idea" discussion than a non disillusioned one.
Let's start this counter analysis remembering what are actually classes in latest JavaScript standard, so that we can move on explaining what's missing in there.

JavaScript embraces prototypal inheritance

It doesn't matter if ES6 made the previously reserved class keyword usable; at the end of the day we're dealing with a special syntactical shortcut to enrich a generic prototype object.

// class in ES2015
class A {
constructor() {}
method() {}
get accessor() {}
set accessor(value) {}
}

// where are those methods and properties defined?
console.log(
Object.getOwnPropertyNames(A.prototype)
// ["constructor", "method", "accessor"]
);
Accordingly, declaring a generic class consists in bypassing the following procedure:

function A() {}
Object.defineProperties(
A.prototype,
{
// constructor is implicitly defined
method: {
configurable: true,
writable: true,
value: function method() {}
},
accessor: {
configurable: true,
get: function get() {},
set: function set(value) {}
}
}
);
If you don't trust me, trust what a transpiler would do, summarized in the following code:

var A = (function () {
// the constructor
function A() {
_classCallCheck(this, _temporalAssertDefined(A, "A", _temporalUndefined) && A);
}
// the enriched prototype
_createClass(_temporalAssertDefined(A, "A", _temporalUndefined) && A, [{
key: "method",
value: function method() {}
}, {
key: "accessor",
get: function get() {},
set: function set(value) {}
}]);

return _temporalAssertDefined(A, "A", _temporalUndefined) && A;
})();
If there is some public static property in the definition, its assignment to the constructor would be the second bypassed part.

The super case

The extra bit in terms of syntax that makes ES6 special is the special keyword super. Being multiple inheritance not possible in JavaScript, we could think about super as the static reference to the directly extended prototype. In case of the previous B class, which extends A, we can think about super variable like if it was defined as such:

// used within the constructor
let super = (...args) => A.apply(this, arguments);

// used within any other method
super.method = (...args) => A.prototype.method.apply(this, args);

// used as accessor
Object.defineProperty(super, 'accessor', {
get: () => Object.getOwnPropertyDescriptor(
A.prototype, 'accessor'
).get.call(this),
set: (value) => Object.getOwnPropertyDescriptor(
A.prototype, 'accessor'
).set.call(this, value)
});
Now that we have a decent understanding on how inheritance works in JavaScript and what it means to declare a class, let's talk about few misleading points sold as pros or cons in the mentioned article.

Prototypes are always modified anyway!

We've just seen that defining a class technically means enriching its prototype object. This already invalidates somehow Justin point but there's more to consider.
When Justin exposes his idea on why current solutions are bad, he says that:
When using mixin libraries against prototype objects, the prototypes are directly mutated. This is a problem if the prototype is used anywhere else that the mixed-in properties are not wanted.
The way Justin describes this issue is quite misleading because mutating prototypes at runtime is a well known bad practice.
Indeed, I believe every single library he mentioned in that post, and he also forgot mine, is not designed to mutate classes prototypes at runtime ... like: not at all!
Every single mixin proposal that is capable of implementing mixins via classes is indeed designed to define these classes at definition time, not at runtime!
Moreover, whatever solution Justin proposed will not guard any class from being modified at runtime later on!
The same way he's defining his final classes during their definitions, mixins-for-classes oriented libraries have exactly the same goal: you define your class and its mixins during the class definition time!
The fact mixins add properties to a prototype is a completely hidden matter that at class definition time is everything but bad.
Also, no property is modified in place, because mixins are there to enrich, not to modify ... and having a prototype enriched means also that it's easier to spot name clashing and methods or properties conflicts ... but I'll come back to that later ...

super actually should NOT work!

The main bummer about the article is that it starts in a very reasonable way, describing mixins and classes, and also analyzing their role in a program.
The real, and only, difference between a mixin and normal subclass is that a normal subclass has a fixed superclass, while a mixin definition doesn't yet have a superclass.
Justin started right at the very beginning, and then degenerated with all sort of contradictions such:
Then finally he's back to Sanity Village with the following sentence:
super calls can be a little unintuitive for those new to mixins because the superclass isn't known at mixin definition, and sometimes developers expect super to point to the declared superclass (the parameter to the mixin), not the mixin application.
And on top of that, Justin talks about constructors too:
Constructors are a potential source of confusion with mixins. They essentially behave like methods, except that overriden methods tend to have the same signature, while constructors in a inheritance hierarchy often have different signatures.
In case you're not convinced yet how much messed up could be the situation, I'd like to add extra examples to the plate.
Let's consider the word area and its multiple meanings:
  • any particular extent of space or surface
  • a geographical region
  • any section reserved for a specific function
  • extent, range, or scope
  • field of study, or a branch of a field of study
  • a piece of unoccupied ground; an open space
  • the space or site on which a building stands
Now you really have to tell me in case you implement a basic Shape mixin with an area() method what the hack would you expect when invoking super. Moreoever, you should tell me if for every single method you are going to write within a mixin, you are also going to blindly invoke super with arbitrary amount of arguments in there ...

So here my quick advice about calling blindly a super: NO, followed by DON'T and eventually NEVER!

Oversold super ability

No kidding, and I can't stress this enough ... I've never ever in my life wrote a single mixin that was blindly trusting on a super call. That would be eventually an application based on mixins but that's a completely different story.
My feeling is that Justin tried to combine at all cost different concepts, probably mislead by his Dart background, since mentioned as reference, where composition in Dart was indeed classes based and the lang itself exposes native mixins as classes ... but here again we are in JavaScript!

instanceof what?

Another oversold point in Justin's article is that instanceof works.
This one was easy to spot ... I mean, if you create a class at runtime everytime the mixin is invoked, what exactly are you capable of "instanceoffing" and why would that benefit anyone about anything?
I'm writing down his very same examples here that will obviously all fail:

// a new anonymous class is created each time
// who's gonna benefit about the instanceof?
let MyMixin = (superclass) => class extends superclass {
foo() {
console.log('foo from MyMixin');
}
};

// let's try this class
class MyClass extends MyMixin(MyBaseClass) {
/* ... */
}

// Justin says it's cool that instanceof works ...
(new MyClass) instanceof MyMixin; // false
// false ... really, it can't be an instance of
// an arrow function prototype, isn't it?!
Accordingly, and unless I've misunderstood Justin point in which case I apologies in advance, I'm not sure what's the exact point in having instanceof working. Yes, sure the intermediate class is there, but every time the mixin is used it will create a different class so there's absolutely no advantage in having instanceof working there ... am I right?

Improving **Objects** Composition

In his Improving the Syntax paragraph, Justin exposes a very nice API summarized as such:

let mix = (superclass) => new MixinBuilder(superclass);

class MixinBuilder {
constructor(superclass) {
this.superclass = superclass;
}

with(...mixins) {
return mixins.reduce((c, mixin) => mixin(c), this.superclass);
}
}
Well, this was actually the part I've liked the most about his article, it's a very simple and semantic API, and it also doesn't need classes at all to be implemented for any kind of JS object!
How? Well, simply creating objects from objects instead:

let mix = (object) => ({
with: (...mixins) => mixins.reduce(
(c, mixin) => Object.create(
c, Object.getOwnPropertyDescriptors(mixin)
), object)
});
It could surely be improved in order to deal with classes too but you get the idea:

let a = {a: 'a'};
let b = {b: 'b'};
let c = {c: 'c'};
let d = mix(c).with(a, b);
console.log(d);
Since the main trick in Justin proposal is to place an intermediate class in the inheritance chain, defining at runtime each time the same class and its prototype, I've done something different here that doesn't need to create a new class with its own prototype or object each time, while preserving original functionalities without affecting them.

Less RAM to use, a hopefully coming soon native Object.getOwnPropertyDescriptors that should land in ES7 and make extraction faster, and the ability to use the pattern with pretty much everything out there, modern or old.
The gist is here, feel free to reuse.

As Summary ...

Wrapping up this post, with latter proposal we can actually achieve whatever Justin did with his intermediate classes approach but following different goals:
  1. Mixins are added to the prototype chain.
  2. Mixins are applied without modifying existing objects.
  3. Mixins do no magic, and don't define new semantics on top of the core language.
  4. super.foo property access won't hopefully work within mixins but it will with subclasses methods.
  5. super() calls won't hopefully work in mixins constructors because you've no idea what kind of arguments you are going to receive. Subclasses still work as expected.
  6. Mixins are able to extend other mixins.
  7. instanceof has no reason to be even considered in this scenario since we are composing objects.
  8. Mixin definitions do not require library support - they can be written in a universal style and be compatible with non classes based engines too.
  9. bonus: less memory consumption overall, there's no runtime duplication for the same logic each time
I still want to thanks Justin because he made it quite clear that still not everyone fully understands mixins but there's surely a real-world need, or better demand, in the current JavaScript community.

Let's hope the next version of ECMAScript will let all of us compose in a standard way that doesn't include a footgun like super through intermediate classes definition could do.
Thanks for your patience reading through this!




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Playing with Sockets and Geolocation

There is a little experiment I've created more than a year ago. It's incomplete and I never got time to make it an official product and finalize it. However, somebody told me it's a freaking cool idea so I've decided to share it with you.

A Dragon Ball Z Spirit Bomb like social App

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Surviving the Essex: the afterlife of America's most storied shipwreck / David O. Dowling

Hayden Library - G530.E77 D68 2016




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Mapping the country of regions: the Chorographic Commission of nineteenth-century Colombia / Nancy P. Appelbaum, the University of North Carolina Press, Chapel Hill

Hayden Library - GA693.7.A1 A77 2016




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The world and all the things upon it: native Hawaiian geographies of exploration / David A. Chang

Hayden Library - G222.C53 2016




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Wildlife tourism, environmental learning and ethical encounters: ecological and conservation aspects / edited by Ismar Borges de Lima, Ronda J. Green

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Springer handbook of global navigation satellite systems / Peter J.G. Teunissen, Oliver Montenbruck (Eds.)

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GIS and environmental monitoring: applications in the marine, atmospheric and geomagnetic fields / Stavros Kolios, Andrei V. Vorobev, Gulnara R. Vorobeva, Chrysostomos Stylios

Online Resource