go Israeli High Court permits Benjamin Netanyahu to form government despite indictments By www.upi.com Published On :: Wed, 06 May 2020 18:59:47 -0400 A panel of 11 judges ruled that Israeli Prime Minister Benjamin Netanyahu can form a government after reaching a deal with rival Benny Gantz. Full Article
go Google-related company pulls plug on Toronto 'smart city' project By www.upi.com Published On :: Thu, 07 May 2020 13:41:47 -0400 A Google-related company has pulled the plug on its ambitious high-tech waterfront city project in Toronto, citing financial strains from the coronavirus, but the project had also run into local opposition. Full Article
go Diabetes and Aging: Unique Considerations and Goals of Care By care.diabetesjournals.org Published On :: 2017-04-01 Rita R. KalyaniApr 1, 2017; 40:440-443Emerging Science and Concepts for Management of Diabetes and Aging Full Article
go Metformin Therapy During Pregnancy: Good for the goose and good for the gosling too? By care.diabetesjournals.org Published On :: 2011-10-01 Denice S. FeigOct 1, 2011; 34:2329-2330Editorial (See Rowan et al., p. 2279) Full Article
go Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations By care.diabetesjournals.org Published On :: 2016-06-01 Francesco RubinoJun 1, 2016; 39:861-877Metabolic Surgery and the Changing Landscape for Diabetes Care Full Article
go Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A review of their efficacy and tolerability By care.diabetesjournals.org Published On :: 2011-05-01 Alan J. GarberMay 1, 2011; 34:S279-S284Diabetes Treatments Full Article
go Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From a Diabetes Care Editors Expert Forum By care.diabetesjournals.org Published On :: 2018-01-01 William T. CefaluJan 1, 2018; 41:14-31Diabetes Care Expert Forum Full Article
go Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like peptide 1 (GLP-1) recruits skeletal and cardiac muscle microvasculature, and this action is preserved in insulin-resistant rodents. We aimed to examine whether GLP-1 recruits microvasculature and improves the action of insulin in obese humans. RESEARCH DESIGN AND METHODS Fifteen obese adults received intravenous infusion of either saline or GLP-1 (1.2 pmol/kg/min) for 150 min with or without a euglycemic insulin clamp (1 mU/kg/min) superimposed over the last 120 min. Skeletal and cardiac muscle microvascular blood volume (MBV), flow velocity and blood flow, brachial artery diameter and blood flow, and pulse wave velocity (PWV) were determined. RESULTS Insulin failed to change MBV or flow in either skeletal or cardiac muscle, confirming the presence of microvascular insulin resistance. GLP-1 infusion alone increased MBV by ~30% and ~40% in skeletal and cardiac muscle, respectively, with no change in flow velocity, leading to a significant increase in microvascular blood flow in both skeletal and cardiac muscle. Superimposition of insulin to GLP-1 infusion did not further increase MBV or flow in either skeletal or cardiac muscle but raised the steady-state glucose infusion rate by ~20%. Insulin, GLP-1, and GLP-1 + insulin infusion did not alter brachial artery diameter and blood flow or PWV. The vasodilatory actions of GLP-1 are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. CONCLUSIONS In obese humans with microvascular insulin resistance, GLP-1’s vasodilatory actions are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. Full Article
go As Governments Build Advanced Surveillance Systems to Push Borders Out, Will Travel and Migration Become Unequal for Some Groups? By www.migrationpolicy.org Published On :: Tue, 10 Mar 2020 15:13:30 -0400 As governments seek to push their borders out by amassing ever more data on travelers and migrants, their creation of increasingly complex border surveillance systems and use of risk-assessment technologies could ease mobility for some while rendering other groups immobile based on hypothetical risk profiles and decisions that are not publicly known and cannot be challenged, as this article explores. Full Article
go Una nueva política migratoria para una nueva era: Una conversación con la Secretaria de Gobernación Olga Sánchez Cordero By www.migrationpolicy.org Published On :: Thu, 28 Feb 2019 18:28:45 -0500 Durante su primera visita oficial a Washington, DC, la Secretaria de Gobierno Olga Sánchez Cordero presento un discurso público sobre la nueva política migratoria de México en el Instituto de Políticas Migratorias. Full Article
go Chicago Dental Society donates thousands of supplies to dental school clinic, health care facilities By www.ada.org Published On :: Thu, 16 Apr 2020 10:49:00 -0500 The Chicago Dental Society and its members donated thousands of personal protective equipment to front-line health care workers in response to the COVID-19 pandemic. Full Article
go Oregon Dental Association dentists, volunteers donate PPE to help emergency relief By www.ada.org Published On :: Mon, 20 Apr 2020 10:37:00 -0500 Oregon Dental Association dentists, volunteers donate more than 600,000 pieces of PPE to help emergency relief efforts Full Article
go ADA advocates that third-party payers modify fee schedules as dentists consider going back to work By www.ada.org Published On :: Thu, 23 Apr 2020 14:19:00 -0500 The ADA is urging third-party payers to alter their fees to account for the increasing cost of personal protective equipment that dentists are using to protect themselves, their staff and patients. Full Article
go 3M granted injunction against New Jersey company in N95 price-gouging scheme By www.ada.org Published On :: Tue, 05 May 2020 14:18:00 -0500 A federal judge on May 4 granted 3M, the maker of N95 masks, an injunction against a New Jersey-based company accused of using 3M’s trademarks and deliberately inflating the price of the face masks. Full Article
go Venezuela’s Guaido to name new boards of PDVSA and Citgo By www.upi.com Published On :: Tue, 29 Jan 2019 06:56:47 -0500 Venezuela's President of the National Assembly, Juan Guaido, will name new director boards at state oil company PDVSA and its United States subsidiary Citgo. Full Article
go Oil prices rise amid ongoing concern about Venezuela By www.upi.com Published On :: Wed, 30 Jan 2019 09:12:39 -0500 Oil prices rose Wednesday amid expectations that Venezuelan oil shipments would see some disruption following U.S. sanctions. Full Article
go Novel Use of GLP-1 Receptor Agonist Therapy in HNF4A-MODY By care.diabetesjournals.org Published On :: 2020-04-07T07:46:27-07:00 Full Article
go Wilson Disease With Novel Compound Heterozygote Mutations in the ATP7B Gene Presenting With Severe Diabetes By care.diabetesjournals.org Published On :: 2020-04-14T15:58:25-07:00 OBJECTIVETo determine the relationship between ATP7B mutations and diabetes in Wilson disease (WD).RESEARCH DESIGN AND METHODSA total of 21 exons and exon-intron boundaries of ATP7B were identified by Sanger sequencing.RESULTSTwo novel compound heterozygous mutations (c.525 dupA/ Val176Serfs*28 and c.2930 C>T/ p.Thr977Met) were detected in ATP7B. After d-penicillamine (D-PCA) therapy, serum aminotransferase and ceruloplasmin levels in this patient were normalized and levels of HbA1c decreased. However, when the patient ceased to use D-PCA due to an itchy skin, serum levels of fasting blood glucose increased. Dimercaptosuccinic acid capsules were prescribed and memory recovered to some extent, which was accompanied by decreased insulin dosage for glucose control by 5 units.CONCLUSIONSThis is the first report of diabetes caused by WD. Full Article
go Use of Glucagon-Like Peptide 1 Receptor Agonists and Risk of Serious Renal Events: Scandinavian Cohort Study By care.diabetesjournals.org Published On :: 2020-04-28T10:59:59-07:00 OBJECTIVETo assess the association between use of glucagon-like peptide 1 (GLP-1) receptor agonists and risk of serious renal events in routine clinical practice.RESEARCH DESIGN AND METHODSThis was a cohort study using an active-comparator, new-user design and nationwide register data from Sweden, Denmark, and Norway during 2010–2016. The cohort included 38,731 new users of GLP-1 receptor agonists (liraglutide 92.5%, exenatide 6.2%, lixisenatide 0.7%, and dulaglutide 0.6%), matched 1:1 on age, sex, and propensity score to a new user of the active comparator, dipeptidyl peptidase 4 (DPP-4) inhibitors. The main outcome was serious renal events, a composite including renal replacement therapy, death from renal causes, and hospitalization for renal events. Secondary outcomes were the individual components of the main outcome. Hazard ratios (HRs) were estimated using Cox models and an intention-to-treat exposure definition. Mean (SD) follow-up time was 3.0 (1.7) years.RESULTSMean (SD) age of the study population was 59 (10) years, and 18% had cardiovascular disease. A serious renal event occurred in 570 users of GLP-1 receptor agonists (incidence rate 4.8 events per 1,000 person-years) and in 722 users of DPP-4 inhibitors (6.3 events per 1,000 person-years, HR 0.76 [95% CI 0.68–0.85], absolute difference –1.5 events per 1,000 person-years [–2.1 to –0.9]). Use of GLP-1 receptor agonists was associated with a significantly lower risk of renal replacement therapy (HR 0.73 [0.62–0.87]) and hospitalization for renal events (HR 0.73 [0.65–0.83]) but not death from renal causes (HR 0.72 [0.48–1.10]). When we used an as treated exposure definition in which patients were censored at treatment cessation or switch to the other study drug, the HR for the primary outcome was 0.60 (0.49–0.74).CONCLUSIONSIn this large cohort of patients seen in routine clinical practice in three countries, use of GLP-1 receptor agonists, as compared with DPP-4 inhibitors, was associated with a reduced risk of serious renal events. Full Article
go Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-05-07T07:52:43-07:00 OBJECTIVETo determine the effect of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptors, on biomarkers of nonalcoholic steatohepatitis (NASH) and fibrosis in patients with type 2 diabetes mellitus (T2DM).RESEARCH DESIGN AND METHODSPatients with T2DM received either once weekly tirzepatide (1, 5, 10, or 15 mg), dulaglutide (1.5 mg), or placebo for 26 weeks. Changes from baseline in alanine aminotransferase (ALT), aspartate aminotransferase (AST), keratin-18 (K-18), procollagen III (Pro-C3), and adiponectin were analyzed in a modified intention-to-treat population.RESULTSSignificant (P < 0.05) reductions from baseline in ALT (all groups), AST (all groups except tirzepatide 10 mg), K-18 (tirzepatide 5, 10, 15 mg), and Pro-C3 (tirzepatide 15 mg) were observed at 26 weeks. Decreases with tirzepatide were significant compared with placebo for K-18 (10 mg) and Pro-C3 (15 mg) and with dulaglutide for ALT (10, 15 mg). Adiponectin significantly increased from baseline with tirzepatide compared with placebo (10, 15 mg).CONCLUSIONSIn post hoc analyses, higher tirzepatide doses significantly decreased NASH-related biomarkers and increased adiponectin in patients with T2DM. Full Article
go Artificial tongue with gold taste buds to test maple syrup By www.upi.com Published On :: Tue, 05 May 2020 13:34:08 -0400 Scientists in Quebec have developed an artificial tongue that can taste the flavor profiles of maple syrup, researchers revealed in a paper published on Tuesday. Full Article
go Africa Deepens its Approach to Migration Governance, But Are Policies Translating to Action? By www.migrationpolicy.org Published On :: Thu, 02 Apr 2020 11:41:21 -0400 While migration once was a lower-priority topic for African governments, the last decade has seen a deepening in governance. Policymakers have integrated migration into their national development strategies and mainstreamed it across policy domains such as health and education. The actions are promising on paper, yet questions remain about the extent to which they will translate to more effective migration management. Full Article
go USS Montgomery, USNS Cesar Chavez enter South China Sea to support drill ship By www.upi.com Published On :: Fri, 08 May 2020 20:26:10 -0400 The USS Montgomery and the USNS Cesar Chavez sailed into the South China Sea this week in support of the West Capella drill ship, according to U.S. Indo-Pacific Command. Full Article
go South Dakota gov. orders tribes to remove checkpoints; U.S. death toll tops 77K By www.upi.com Published On :: Sat, 09 May 2020 12:58:07 -0400 South Dakota Gov. Kristi Noem has ordered two Sioux tribes to remove checkpoints designed to curb the coronavirus on tribal lands. Full Article
go Google brings back 'Pac-Man' game in latest Doodle By www.upi.com Published On :: Fri, 08 May 2020 07:21:05 -0400 Google's homepage features arcade classic "Pac-Man" in the latest Doodle. Full Article
go Podcast: It’s See You Later, Not Goodbye By psychcentral.com Published On :: Mon, 04 May 2020 10:30:47 +0000 All good things must come to an end. And today is one of those days. In this episode of The Not Crazy Podcast, we say a sad farewell to... Full Article General Not Crazy Podcast Podcast
go [ Law & Ethics ] Open Question : Law and Ethics: Do you think gore should be illegal? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:16:44 +0000 I certainly do, it doesn't make sense how someone crazy recording someone getting killed isn't illegal but CP is! That shouldn't be because, they should be either running away or trying to stop that super duper crazy person. Why can't both of them be illegal? Full Article
go [ Politics ] Open Question : Why do people in Chicago kill themselves for nothing? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:17:22 +0000 Full Article
go [ Religion & Spirituality ] Open Question : Does God love it when you call him Big Poppa? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:17:49 +0000 Full Article
go [ Politics ] Open Question : Is Camp David going to be the new Trump “White House“ since Melania’s White House is at the top of the avoidance list for germaphobes? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:18:09 +0000 Full Article
go [ Politics ] Open Question : Where would you prefer to live in New York,Chicago or Los Angeles? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:18:36 +0000 Full Article
go [ Politics ] Open Question : Is Trump going to have to invade California? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:19:40 +0000 The state leads the nation in poverty and homelessness while it's socialist elites live in absolute luxury. It's like some third world nation the US is obligated to invade on the basis of humanitarianism. Full Article
go [ Other - Australia ] Open Question : Where is the to go menu for Outback? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:22:03 +0000 Full Article
go [ Politics ] Open Question : Is it true many British and American banks and companies(Bank of England,UIC,Prescott Bush,etc) gave money and goods to Hitler secretly? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:24:02 +0000 Full Article
go [ Marriage & Divorce ] Open Question : 5 year old doesn’t want to go to her dads? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:24:30 +0000 My step daughter is 5 and her dad lives states away. He calls her maybe once a month (not even on holidays) he hasn’t had her since she was one (when they lived in the same state) he had told my wife if our daughter wanted to see him we could bring her to him but he wasn’t coming to our state. My wife asked him beginning of this year if he’d sign his rights over. He doesn’t talk to her and he was behind on child support. He said no and that we was going to finally pick her up. He is getting married and didn’t include the little one we told him if he is going to get her he needs to tell her that it’s not just him living there and he is getting married. Our daughter was hurt by it that he hid this from her (they’ve been engaged for 4 years). She’s been crying she doesn’t want to go and he isn’t willing to come stay the week here to visit. He said he is taking her back to his state for a month. Yes it’s in their agreement but is there anything we can do? She really doesn’t want to go to a “strangers” house is what my daughter says. Full Article
go [ Religion & Spirituality ] Open Question : How come there are different writers attributed to the Gospel of Mark.... why would Mark need different people to write his Gospel.? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:24:57 +0000 Full Article
go Why Exercise Is So Good For You By rss.sciam.com Published On :: Fri, 24 Apr 2020 23:23:00 GMT Health journalist Judy Foreman talks about her new book Exercise Is Medicine: How Physical Activity Boosts Health and Slows Aging. -- Read more on ScientificAmerican.com Full Article Health The Body Wellness Mind Mental Health The Sciences Biology
go Flamingos Can Be Picky about Company By rss.sciam.com Published On :: Fri, 08 May 2020 00:58:00 GMT They don’t stand on one leg around just anybody but often prefer certain members of the flock. -- Read more on ScientificAmerican.com Full Article Mind Behavior & Society Conservation The Sciences Evolution
go Using Science to Soothe the Agony of Defeat By www.washingtonpost.com Published On :: Mon, 26 Jun 2006 00:00:00 EDT Melissa Hunfalvay feels Claudio Reyna's pain. Not the pain caused by the sprain in Reyna's knee -- an injury the captain of the defeated U.S. World Cup soccer team sustained last week while conceding a goal in an all-important match against Ghana. Full Article Health Using Science to Soothe the Agony of Defeat
go Why We Don't Go for It By www.washingtonpost.com Published On :: Mon, 18 Jun 2007 00:00:00 EDT This year's National Basketball Association playoffs recently provided not one but two examples of a very interesting facet of human decision making. Even if you are not a sports fan, these moments tell you something about human nature. Full Article Opinions Why We Don't Go for It
go When Immigration Goes Up, Prices Go Down By www.washingtonpost.com Published On :: Mon, 15 Oct 2007 00:00:00 EDT Last week, a gallon of gas at an Exxon station in the tony suburb of Bethesda cost $2.99. Full Article Opinions When Immigration Goes Up Prices Go Down
go Go for It on Fourth Down, Coach? Maybe You Should Ask an Egghead. By www.washingtonpost.com Published On :: Mon, 05 Nov 2007 00:00:00 EST With just over five minutes to play in yesterday's game against the New York Jets, the Washington Redskins found themselves on their own 23-yard line facing a fourth and one. The team, which was ahead by just three points, elected to do what teams normally do in such situations: They played it safe... Full Article Opinions Go for It on Fourth Down Coach? Maybe You Should Ask an Egghead.
go Good Options Can Mask Bad Choices By www.washingtonpost.com Published On :: Mon, 14 Jan 2008 00:00:00 EST Take a step back from the Republican and Democratic presidential primary races and you will see a sharp difference between the two. Full Article Opinions Good Options Can Mask Bad Choices
go Why Being the GOP's No. 2 Isn't So Bad By www.washingtonpost.com Published On :: Mon, 18 Feb 2008 00:00:00 EST Through much of the Republican presidential primary, Sen. John McCain and former Massachusetts governor Mitt Romney could barely restrain their contempt for each other. During one Republican debate in New Hampshire in early January, McCain landed a zinger that summed up Romney's opportunistic... Full Article Opinions Why Being the GOP's No. 2 Isn't So Bad
go Subprime Mortgages and Race: A Bit of Good News May Be Illusory By www.washingtonpost.com Published On :: Mon, 30 Jun 2008 00:00:00 EDT Subprime mortgages have been linked to a meltdown in housing and questionable Wall Street practices, and they may have been the original domino that set off America's current economic crisis. Full Article Opinions Subprime Mortgages and Race: A Bit of Good News May Be Illusory
go Sideline Rage -- Sports Parents Go Berserk By www.washingtonpost.com Published On :: Mon, 14 Jul 2008 00:00:00 EDT Among psychologists who study sports, there is a code word for parents who lose their temper standing on the sidelines of their children's soccer, baseball and football games: THOSE parents -- Tempestuous, Harried, Overwrought, Self-absorbed and Emotional. Full Article Opinions Sideline Rage -- Sports Parents Go Berserk
go Seasonal Worker Programs in Europe: Promising Practices and Ongoing Challenges By www.migrationpolicy.org Published On :: Tue, 18 Feb 2020 14:18:40 -0500 Seasonal worker programs in the European Union have a long history, but have yet to find the sweet spot of working for migrants, employers, and countries of destination and origin alike. This policy brief explores some of the challenges common to these programs—drawing on examples in Europe, Australia, and New Zealand—and highlights promising practices. Full Article
go When Good People Write Bad Sentences, by Robert Harris By brooklynbooktalk.blogspot.com Published On :: Fri, 16 May 2014 20:06:00 +0000 All great writing starts with a sentence. But what is it that makes a sentence great? Could it be grammar, syntax, style, word choice, information, meaning, common sense, passion etc? According to one author, there is only one rule for writing a great sentence. And this is the rule: "whether you're Christian, Jew, Muslim, or a disciple of the church of Penn Jillette, when you sit down to write, the Reader is thy god." The rule is certainly thought-provoking but one has to wonder if one rule would be enough for writing a great sentence. Robert Harris, in his book, "When Good People Write Bad Sentences," offers "12 Steps to Verbal Enlightenment" that can cure any eager to learn "bad writing addict." Besides, the 12 steps don’t just provide solutions to well-known problems in the categories of punctuation, syntax, diction, and style but also help bad writers understand the emotional foundations and psychological forces behind those problems. Harris argues, not without humor, that only with this deep understanding can permanent changes take place. He identifies nine types of ineffective sentences that arise from unexamined emotions and self-destructive needs, and offers an integrated approach which could help writers learn to take a broader and healthier perspective on sentence construction. When it comes to the malady of writing badly, which he calls "malescribism,"--an uncontrollable urge to write carelessly and unpersuasively--Harris warns that this malady "is no respecter of status, nor does it take into account social, ethnic, or religious orientation." He also notes that malescribes could be black and white, male and female, believer and nonbeliever, liberal and conservative.Since we all would like to write better sentences consistently, let's look at the advice offered by Robert Harris, and also share some of the great sentences that we have come across in our reading. Full Article
go Governments in Europe & North America Need a New Social Contract for the Age of Spontaneous Migration By www.migrationpolicy.org Published On :: Tue, 14 Jan 2020 16:14:01 -0500 WASHINGTON — A new age of migration has been ushered in by large-scale spontaneous migration flows on both sides of the Atlantic, which have upended asylum adjudications systems and placed enormous stress on reception, housing and social services, particularly in Europe. Full Article
go Tarragon Vinegar By www.abc.net.au Published On :: Thu, 12 Nov 2015 10:52:00 +1100 This gourmet vinegar is often the choice for a vinaigrette dressing when making a classic French leafy green salad but it's so easy to make at home. It's worth using a good quality white wine vinegar. You could also use a local cider vinegar. Either way, the flavour is beautifully aromatic. Tarragon vinegar will last for well over a year. Be sure to use un-sprayed tarragon. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:All:All Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690