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Nano meets macro: social perspectives on nanoscale sciences and technologies / editors, Kamilla Lein Kjølberg, Fern Wickson

Online Resource




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Nanotechnology applications in dairy science: packaging, processing, and preservation / edited by Lohith Kumar Dasarahally-Huligowda, Megh R. Goyal, Hafiz Ansar Rasul Suleria

Online Resource




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School closures and the online preparedness of children during the COVID-19 pandemic [electronic resource] / by Marc Frenette, Kristyn Frank, and Zechuan Deng

[Ottawa] : Statistics Canada = Statistique Canada, 2020




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COVID-19 pandemic [electronic resource]: school closures and the online preparedness of children / by Marc Frenette, Kristyn Frank and Zechuan Deng

[Ottawa] : Statistics Canada = Statistique Canada, 2020




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Synthesis of Biaryl Ketones by Arylation of Weinreb Amides with Functionalized Grignard Reagents under Thermodynamic Control vs. Kinetic Control of N,N-Boc2-Amides

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00813C, Communication
Guangchen Li, Michal Szostak
A highly efficient method for chemoselective synthesis of biaryl ketones by arylation of Weinreb amides (N-methoxy-N- methylamides) with functionalized Grignard reagents is reported. This protocol offers rapid entry to functionalized...
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Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRASG12C and ARS compounds

Org. Biomol. Chem., 2020, 18,3069-3081
DOI: 10.1039/D0OB00071J, Paper
Maria G. Khrenova, Anna M. Kulakova, Alexander V. Nemukhin
Comprehensive molecular modeling and kinetic analysis reveal a novel mechanism of the inhibition of the oncogenic mutant of the “undruggable” KRAS protein.
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A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine

Org. Biomol. Chem., 2020, 18,3047-3068
DOI: 10.1039/D0OB00078G, Paper
Ramona Schütz, Maximilian Meixner, Iris Antes, Franz Bracher
A modular short-step synthesis of the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine was developed employing N-acyl-Pictet–Spengler reaction and Ullman diaryl ether synthesis as central steps.
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The silver catalyzed direct C–H functionalization of quinones with dialkyl amides

Org. Biomol. Chem., 2020, 18,3027-3031
DOI: 10.1039/D0OB00323A, Communication
Sakthivel Pandaram, Adarsh Krishna T. P., Andivelu Ilangovan
A novel and efficient strategy for the direct C–H amidoalkylation of quinones via a radical pathway has been achieved using readily available alkyl amides and an AgNO3-TBHP catalyst system. This is the first ever example of the synthesis of novel amidoquinone derivatives.
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Regio- and stereoselective synthesis of 1,4-enynes by iron-catalysed Suzuki–Miyaura coupling of propargyl electrophiles under ligand-free conditions

Org. Biomol. Chem., 2020, 18,3022-3026
DOI: 10.1039/D0OB00357C, Communication
Ryosuke Agata, Siming Lu, Hiroshi Matsuda, Katsuhiro Isozaki, Masaharu Nakamura
The first iron-catalysed cross coupling of propargyl electrophiles with lithium alkenylborates has been developed.
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The ruthenium(II)-catalyzed C–H olefination of indoles with alkynes: the facile construction of tetrasubstituted alkenes under aqueous conditions

Org. Biomol. Chem., 2020, 18,3158-3163
DOI: 10.1039/D0OB00508H, Paper
Ming Li, Tian-Yu Yao, Sheng-Zheng Sun, Ting-Xun Yan, Li-Rong Wen, Lin-Bao Zhang
An environmentally-friendly and facile protocol for the construction of tetrasubstituted alkenes has been established with Ru(II)-catalyzed C–H bond functionalizations under mild conditions.
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Metal-free cascade reactions of aziridines with arylalkynes and aryldiazoniums: facile access to arylazopyrrolines

Org. Biomol. Chem., 2020, 18,3149-3157
DOI: 10.1039/D0OB00346H, Paper
Jing Rong, Hao Jiang, Sijing Wang, Zhenni Su, Huiyan Wang, Chuanzhou Tao
A novel and facile approach to synthesize arylazopyrroline scaffolds via metal-free cascade reactions of aziridines with arylalkynes and aryldiazoniums has been developed, providing access to a variety of 4-arylazo-2-pyrrolines in a highly concise fashion.
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Catalyst and solvent switched divergent C–H functionalization: oxidative annulation of N-aryl substituted quinazolin-4-amine with alkynes

Org. Biomol. Chem., 2020, 18,3032-3037
DOI: 10.1039/D0OB00318B, Communication
Siddi Ramulu Meesa, Praveen Kumar Naikawadi, Kishan Gugulothu, K. Shiva Kumar
Catalyst and solvent controlled ortho/peri site-selective oxidative annulation of C–H bonds of N-aryl substituted quinazolin-4-amines with internal alkynes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides

Org. Biomol. Chem., 2020, 18,3142-3148
DOI: 10.1039/D0OB00407C, Paper
Kun Huang, Andrea Marchesi, Kristian Hollingsworth, Peter Both, Ashley P. Mattey, Edward Pallister, Helene Ledru, Simon J. Charnock, M. Carmen Galan, W. Bruce Turnbull, Fabio Parmeggiani, Sabine L. Flitsch
A new α1,4 galactosyltransferase has been characterised and used for the synthesis of natural and non-natural cell surface trisaccharide antigens.
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Rh(III)-Catalyzed regioselective C4 alkylation of indoles with allylic alcohols: direct access to β-indolyl ketones

Org. Biomol. Chem., 2020, 18,3038-3042
DOI: 10.1039/D0OB00396D, Communication
Changduo Pan, Gao Huang, Yujia Shan, Yiting Li, Jin-Tao Yu
A Rh(III)-catalyzed direct C4 alkylation of indoles with allylic alcohols to access β-indolyl ketones was developed.
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Enantioselective synthesis of chiral α-alkynylated thiazolidones by tandem S-addition/acetalization of alkynyl imines

Org. Biomol. Chem., 2020, 18,3117-3124
DOI: 10.1039/D0OB00365D, Paper
Mei-Xin Wang, Juan Liu, Zhen Liu, Yingcheng Wang, Qi-Qiong Yang, Wenyu Shan, Yu-Hua Deng, Zhihui Shao
A SPINOL-CPA catalyzed asymmetric [2 + 3]-annulation of in situ generated alkynyl imines and 1,4-dithiane-2,5-diol has been developed to afford enantiopure α-alkynylated thiazolidones.
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Synthesis and aggregation behaviour of single-chain, 1,32-alkyl-branched bis(phosphocholines) – part 2: lateral chain length triggers self-assembling from sheets to fibres to vesicles

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00534G, Paper
Kai Gruhle, Max Tuchtenhagen, Sindy Müller, Gerd Hause, Annette Meister, Simon Drescher
The synthesis of six single-chain, alkyl-branched bolalipids and first investigations of the lyotropic behaviour of these lipids are reported.
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Photocatalytic xanthate-based radical addition/cyclization reaction sequence toward 2-biphenyl isocyanides: synthesis of 6-alkylated phenanthridines

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00136H, Communication
Pedro López-Mendoza, Luis D. Miranda
A photocatalytic xanthate-based radical addition/cyclization reaction cascade toward 2-biphenylisocyanides is described as a practical and modular approach to 6-alkylated phenanthridines.
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Study on the ArI-catalyzed intramolecular oxy-cyclization of 2-alkenylbenzamides to benzoiminolactones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00612B, Communication
Huixia Liu, Xiaojun Deng, Xie Huang, Nan Ji, Wei He
A metal-free synthetic method toward the preparation of benzoiminolactones through oxy-cyclization of 2-alkenylbenzamides mediated by a catalyst/oxidant (ArI/mCPBA) system was developed.
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Visible light promoted continuous flow photocyclization of 1,2-diketones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00532K, Paper
Francesco Secci, Stefania Porcu, Alberto Luridiana, Angelo Frongia, Pier Carlo Ricci
A continuous flow Norrish–Yang photocyclization of 1,2-diketones has been developed and applied to the synthesis of functionalized 2-hydroxycyclobutanones, under blue light irradiation.
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Acylation of oxindoles using methyl/phenyl esters via mixed Claisen condensation – An access to 3-alkylideneoxindoles

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00789G, Communication
Ramdas Sreedharan, Purushothaman Rajeshwaran, Pradeep Kumar Reddy Panyam, Saurabh Yadav, C. M. Nagaraja, THIRUMANAVELAN GANDHI
Predominantly, aggressive acid chlorides and stoichiometric coupling reagents are employed in the acylating process for synthesizing carbonyl tethered heterocycles. Herein, we report simple acyl sources, viz. methyl and phenyl esters...
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The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/C9OB02724F, Communication
Yohei Arai, Shota Torigoe, Takanori Matsumaru, Sho Yamasaki, Yukari Fujimoto
We achieved the first synthesis of phosphatidylinositol mannoside Ac1PIM1, and a very potent agonist of an innate immune receptor DCAR is demonstrated.
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Catalyst- and Solvent-Free Efficient Access to N-Alkylated Amines via Reductive Amination using HBPin

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00740D, Communication
ARNAB RIT, Vipin Kumar Pandey, Somnath Bauri
A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and...
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A laccase-catalysed tyrosine click reaction

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00650E, Communication
Shinichi Sato, Keita Nakane, Hiroyuki Nakamura
The tyrosine click reaction of peptides/proteins with the tyrosine modification reagent, N-methyl luminol, was catalysed by a laccase in the presence of molecular oxygen (O2) at 37 °C.
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Rhodium-Catalyzed ortho-Acrylation of Aryl Ketone O-Methyl Oximes with Cyclopropenones

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00064G, Communication
Yafeng Liu, Yuan Tian, Kexin Su, Xin Guo, Baohua Chen
An efficient Rh-catalyzed ortho-acrylation reaction for the synthesis of chalcones from O-methyl ketoximes and cyclopropenones via C–H bond activation has been described. This cross-coupling reaction exhibits high functional group tolerance...
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Preparation of cage-shaped hexakis(spiroborate)s

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00518E, Paper
Hiroshi Danjo, Yuhki Masuda, Yuki Kidena, Masatoshi Kawahata, Kazuaki Ohara, Kentaro Yamaguchi
Direct construction of anionic hexakis(spiroborate) prismatic cages was realized by the reaction of hexahydroxytriphenylene, bis(dihydroxynaphthalene)s, and boric acid.
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Divergent syntheses of okaramines C, J, L, and S-U

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00587H, Communication
Xiao Wan Li, Tong xu Si, Ya-Ping Liu, Mingzhong Wang, Albert S. C. Chan
The total synthesis of six novel okaramines (C, J, L, and S-U) was accomplished with a precise synthesis scheme involving few steps and with practical yield of 6.7%-23.0%. The significance...
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Copper(I)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00546K, Paper
Hao Cui, Ke Li, Yue Wang, Manman Song, Congcong Wang, Donghui Wei, Er-Qing Li, Zheng Duan, François Mathey
A copper/Ganphos-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described, producing the spiro[pyrrolidin-3,3'-oxindole]s in good yields with high ee.
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Blue emissive dimethylmethylene-bridged triphenylamine derivatives appending cross-linkable groups

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00622J, Paper
Kangyu Zhou, Hongfei Pan, Yongjie Zhang, Houchen Wang, Xiaofei Dong, Xiangkui Ren, Xianggao Li, Shirong Wang, Zhijian Chen
Blue-emissive and cross-linkable dimethylmethylene-bridged triphenylamine derivatives were synthesized and their optical and electrochemical properties were investigated.
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Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides

Org. Biomol. Chem., 2020, 18,3354-3359
DOI: 10.1039/D0OB00419G, Paper
Amritha Rayaroth, Rajat Kumar Singh, Kalyanakrishnan A. V., Krishna Hari, Alagiri Kaliyamoorthy
1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs).
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Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines

Org. Biomol. Chem., 2020, 18,3263-3268
DOI: 10.1039/D0OB00491J, Communication
Hua Yao, Bo Xie, Xiaoyang Zhong, Shengzhou Jin, Sen Lin, Zhaohua Yan
A new synthetic method toward direct C–N bond formation through saturated C–H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed.
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A base-promoted tandem approach to bicyclic 8-membered ring ketones

Org. Biomol. Chem., 2020, 18,3249-3253
DOI: 10.1039/D0OB00618A, Communication
Emerson E. F. dos Santos, Gabriela F. P. de Souza, Deborah A. Simoni, Airton G. Salles
A base-promoted tandem route toward unprecedented bicyclic furan/8-membered ring ketones is reported.
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KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones

Org. Biomol. Chem., 2020, 18,3360-3366
DOI: 10.1039/D0OB00494D, Paper
Zhen Yang, Jing He, Yueting Wei, Weiwei Li, Ping Liu
A series of diverse fused [1,2,4]triazolo[3,4-c]quinoxalines was obtained by an efficient KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones.
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Chemo- and regioselective click reactions through nickel-catalyzed azide–alkyne cycloaddition

Org. Biomol. Chem., 2020, 18,3374-3381
DOI: 10.1039/D0OB00579G, Paper
Woo Gyum Kim, Seung-yeol Baek, Seo Yeong Jeong, Dongsik Nam, Ji Hwan Jeon, Wonyoung Choe, Mu-Hyun Baik, Sung You Hong
Nickel-catalyzed [3 + 2] cycloaddition reactions of unsymmetrical alkynes and organic azides afford substituted 1,2,3-triazoles with high levels of chemo- and regioselectivity.
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Gold(III)-catalyzed azide-yne cyclization/O–H insertion cascade reaction for the expeditious construction of 3-alkoxy-4-quinolinone frameworks

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00745E, Paper
Jingjing Huang, Han Su, Ming Bao, Lihua Qiu, Yuanqing Zhang, Xinfang Xu
A gold-catalyzed cascade reaction has been developed, and it provides an expeditious access to 3-alkoxy-4-quinolines and applications in alkaloid synthesis.
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Synthesis of gem-difluoroalkenes via nickel-catalyzed allylic defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00535E, Communication
Xiao-Yu Lu, Run-Chuang Jiang, Jia-Mei Li, Chuang-Chuang Liu, Qing-Qing Wang, Hai-Pin Zhou
A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed.
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Correction: Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB90052D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Liang Wang, Yaoyao Wang, Jun Shen, Qun Chen, Ming-Yang He
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TN woman seeks Rs 1 cr compensation from AIDS society

A housewife has moved the Madras High Court seeking Rs 1 crore as compensation and a public apology from the Tamil Nadu AIDS Control Society.




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Aspiring actor-cum-model arrested for killing IT professional

A 20-year-old aspiring actor- cum-model was arrested in the national capital for allegedly murdering a young woman IT professional a week ago after she refused to heed to his demand for money.




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DMRC delays inauguration of Yamuna Bank-Noida line

Delhi Metro has delayed the inauguration of the Yamuna Bank-Noida line by a month.




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Mumbaikars usher in Ganesh amidst flu scare

Terror alerts and swine flu scare did not dampen the spirit of Mumbaikars as they welcomed the elephant headed-god.




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People look at fairy tales in a limited way: Hudson Asia MD Tulika Tripathi

Tulika Tripathi is the managing director of a global talents solutions company, Hudson Asia.




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We’ll look back at 2014 as a new journey for India-Israel ties: Alon Ushpiz

India and Israel have signed a far-reaching agreement on homeland security where the two countries will collaborate on policing, forensics, counter-terrorism, etc. Israel's ambassador Alon Ushpiz spoke with Indrani Bagchi about shared concerns, PM Modi — and justice in the 2012 attack on an Israeli diplomat:




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'I'd have done anything else other than write this book': Akhil Sharma

New York-based writer Akhil Sharma 's novel Family Life has received rave reviews. The autobiographical book traces the journey of a family that moves to the US from India, its eldest son suddenly suffering a freak accident.




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Progress measures must include nature — think beyond GDP: Rachel Kyte

As India debates environmental health versus economic growth, Rachel Kyte, vice-president and special envoy for climate change at the World Bank Group, feels it is vital to think beyond basic GDP.




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Pak politicians want to resolve Kashmir — military won't allow this: Arif Jamal

Arif Jamal is a Pakistani journalist and South Asia expert based in America.




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There’s no power politics, customer is king, Piyush Goyal says

The responsibility of lighting up the country today rests on Piyush Goyal’s shoulders. Just a month into his new job, the minister for power, coal and renewable energy has set an electric pace to energize the sector.




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Women suffer sanitation absence most — also impacts economy: Bindeshwar Pathak

One month after the horrific Badaun gang rape exposed how gravely at risk women and minors lacking domestic toilets are.




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Upgraded fleet in India by 2016, Air France-KLM CEO says

Alexandre de Juniac, chairman and CEO of Air France-KLM, which on June 24 launched a €500 million aircraft upgrade project called BEST AND BEYOND with the inaugural flight of an advanced Boeing 777 on the Paris-New York route, says flyers from India can look forward to top-of-the-line seats by the end of 2016.




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Australia-India cricket rivalry has even bettered Ashes: John Harnden

CEO of the ICC World Cup 2015 John Harnden spoke with Amin Ali about ensuring excitement in cricket's mega-tournament, clamping down on racism, managing 'minnows' matches — and how Australia is sizing up India as a rival for the trophy.




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Officials to pay for illegal building: Venkaiah Naidu

The Centre will push for key reforms including the provision of incentivising civic agencies for good work & making officials concerned accountable for illegal construction or unauthorized development under their jurisdiction.