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Encapsulated DNase Improving the Killing Efficiency of Antibiotics in Staphylococcal Biofilms

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00441C, Communication
Chenhui Liu, Yu Zhao, Wanqi Su, Jingshan Chai, Lina Xu, Jingjing Cao, Yang Liu
We developed a polymer-encapsulated DNase, n(DNase), which can efficiently accumulate in biofilm and expose the DNase to cleave the eDNA of biofilm. CLSM and crystal violet results demonstrated an effective...
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Mechanically robust enzymatic degradable shape memory polyurethane urea with rapid recovery response induced by NIR

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00798F, Paper
Xin Li, Wenkai Liu, Yaomin Li, Wanling Lan, Daiguo Zhao, Hecheng Wu, Yuan Feng, Xueling He, Zhen Li, Jiehua Li, Feng Luo, Hong Tan
Biodegradable shape memory polymers have great potential using in minimally invasive surgical procedures. Herein, a series of shape memory polyurethanes (SMPUs) containing chymotrypsin-inspired chain extenders with adjustable mechanical properties and...
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Design principles and fundamental understanding of biosensors for amyloid-β detection

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00344A, Review Article
Yanxian Zhang, Baiping Ren, Dong Zhang, Yonglan Liu, Mingzhen Zhang, Chao Zhao, Jie Zheng
Aβ as biomarker in Alzheimer’s disease (AD) drives the significant research efforts for developing different biosensors with different sensing strategies, materials, and mechanisms for Aβ detection.
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Development of mucoadhesive cationic polypeptide micelles for sustained cabozantinib release and inhibition of corneal neovascularization

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00874E, Paper
Haijie Han, Qichuan Yin, Xiajing Tang, Xiaoning Yu, Qiang Gao, Yelei Tang, Andrzej Grzybowski, Ke Yao, Jian Ji, Xingchao Shentu
Corneal neovascularization (CNV) is one of the leading risk factors for vision loss. Anti-angiogenic drugs can theoretically be extended to the treatment of CNV. However, the application of these drugs...
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The rise of bio-inspired polymer compartments responding to pathology related signals

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00475H, Perspective
Open Access
Luisa Zartner, Moritz Sylvester Muthwill, Ionel Adrian Dinu, Cora-Ann Schoenenberger, Cornelia G. Palivan
Self-organized nano- and microscale polymer compartments (polymersomes, GUVs, PICsomes and LbL capsules) have increasing potential in many sensing applications. In this review, we highlight the key role they play in...
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Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00083C, Paper
Huaibin Zhang, Shaowei Bo, Kai Zeng, Jie Wang, Yu Li, Zhigang Yang, Xin Zhou, Shizhen Chen, Zhong-Xing Jiang
A modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics for cancer therapy.
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Thin platelet-like COF nanocomposites for blood brain barrier transport and inhibition of brain metastasis from renal cancer

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00724B, Paper
Guiyang Zhang, Bo Jiang, Chunyong Wu, Yanfeng Liu, Yidan He, Xin Huang, Wei Chen, Kai Xi, Hongqian Guo, Xiaozhi Zhao, Xudong Jia
A drug-loaded polymer–COF nanocomposite has been developed to cross the blood brain barrier and treat brain metastasis from renal cancer.
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Bioinspired polydopamine nanoparticles: synthesis, nanomechanical properties, and efficient PEGylation strategy

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02769F, Paper
Islam Zmerli, Jean-Philippe Michel, Ali Makky
We established tightly controlled experimental conditions to synthesize polydopamine nanoparticles with well-defined and reproducible physicochemical properties such as size, yield and nanomechanics.
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A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02156F, Paper
Mohammad-Ali Shahbazi, Neha Shrestha, Malgorzata Karolina Pierchala, Firoz Babu Kadumudi, Mehdi Mehrali, Masoud Hasany, Véronique Préat, Sander Leeuwenburgh, Alireza Dolatshahi-Pirouz
A polymeric gum has been developed herein, which combines high stretchability and self-healing capacity with a bioactivity that can target and eliminate bacterial infections and inflammations.
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Phosphates-responsive 2D-Metal─Organic-Framework-Nanozymes for Colorimetric Detection of Alkaline Phosphatase

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/C9TB02542A, Paper
Xiaoyu Wang, Xiaoqian Jiang, Hui Wei
In this study, a simple colorimetric method with tunable dynamic range for alkaline phosphatase (ALP) activity assay was developed by using peroxidase-mimicking two-dimensional-metal─organic-framework (2D-MOF). Phosphates including pyrophosphate (PPi), ATP, and...
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Seedless Synthetic Branched Gold Nanoshell for Chemo-thermal Antitumor Therapy

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00891E, Paper
Lei Li, Yihan Fu, Zichuang Xu, Xuwu Zhang, Zining Hao, Yaqian He, Wenbin Gao, Dawei Gao
Gold nanomaterials (GNMs) were used in photothermal therapy due to their superior optical properties and excellent biocompatibility. However, the complex preparation process of seed-mediated growth limits further clinical applications of...
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Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00875C, Paper
Lisa White, Jessica E. Boles, Nyasha Allen, Luke Alesbrook, J. Mark Sutton, Charlotte Hind, Kira Hilton, Laura R. Blackholly, Rebecca Ellaby, George Williams, Daniel P Mulvihill, Jennifer Ruth Hiscock
SSAs are a class of Supramolecular Self-associating Amphiphilic salt, the anionic component of which contains a covalently bound hydrogen bond donor-acceptor motif. This results in a monomeric unit which can...
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Unique Sequence-Dependent Properties of Trinucleotide Repeat Monolayers: Electrochemical, Electrical, and Topographic Characterization

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00507J, Paper
Narges Asefifeyzabadi, Motahareh Taki, Madison Funneman, Tingjie Song, Mohtashim Hassan Shamsi
Trinucleotide repeat (TNR) sequences widely exist in nature and their overgrowth is associated with two dozen neurodegenerative diseases in humans. These sequences have unique helical flexibility which affects their biophysical...
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In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00499E, Paper
Zhaowen Ding, Nana Luo, Hua Yue, Yongjun Gao, Guanghui Ma, Wei Wei
2D PEGylated graphene oxide showed stealth-but-immune-activating capacity on macrophages, along with specific intraperitoneal immunological response in vivo.
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A waterborne polyurethane 3D scaffold containing PLGA with a controllable degradation rate and an anti-inflammatory effect for potential applications in neural tissue repair

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00656D, Paper
Bohong Du, Hang Yin, Yue Chen, Weiwei Lin, Yanchao Wang, Daiguo Zhao, Gang Wang, Xueling He, Jiehua Li, Zhen Li, Feng Luo, Hong Tan, Qiang Fu
3D connected porous LGPU scaffolds with adjustable degradation and a strong anti-inflammatory effect were prepared for neural tissue repair.
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Multivalent cationic dendrofullerenes for gene transfer: synthesis and DNA complexation

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00113A, Paper
Beatriz M. Illescas, Alfonso Pérez-Sánchez, Araceli Mallo, Ángel Martín-Domenech, Ignacio Rodríguez-Crespo, Nazario Martín
Non-viral nucleic acid vectors able to display high transfection efficiencies with low toxicity and overcoming the multiple biological barriers are needed to further develop the clinical applications of gene therapy.
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Alendronate/folic acid-decorated polymeric nanoparticles for hierarchically targetable chemotherapy against bone metastatic breast cancer

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J. Mater. Chem. B, 2020, 8,3789-3800
DOI: 10.1039/D0TB00046A, Paper
Shih-Hong Chen, Te-I Liu, Cheng-Lin Chuang, Hsin-Hung Chen, Wen-Hsuan Chiang, Hsin-Cheng Chiu
Through hierarchically targeting bone matrix and tumor cells, PTX-carrying ALN/FA-nanoparticles substantially accumulate in bone metastases and improve mice survival rate.
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Nanoclay-functionalized 3D nanofibrous scaffolds promote bone regeneration

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J. Mater. Chem. B, 2020, 8,3842-3851
DOI: 10.1039/C9TB02814E, Paper
Qingqing Yao, Kirby E. Fuglsby, Xiao Zheng, Hongli Sun
A nanoclay-enriched 3D nanofibrous biomimetic scaffold with strong bone regenerative ability by virtue of its improved mechanical properties, osteoconductivity, and drug binding capacity was developed.
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Macrocyclic polyamine [12]aneN3 modified triphenylamine-pyrazine derivatives as efficient non-viral gene vectors with AIE and two-photon imaging properties

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J. Mater. Chem. B, 2020, 8,3869-3879
DOI: 10.1039/D0TB00321B, Paper
Le-Le Ma, Ming-Xuan Liu, Xu-Ying Liu, Wan Sun, Zhong-Lin Lu, Yong-Guang Gao, Lan He
[12]aneN3 modified triphenylamine-pyrazines as non-viral gene vectors with AIE and two-photon imaging properties.
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A near-infrared light-responsive multifunctional nanocomposite hydrogel for efficient and synergistic antibacterial wound therapy and healing promotion

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J. Mater. Chem. B, 2020, 8,3908-3917
DOI: 10.1039/D0TB00361A, Paper
Na Yang, Ming Zhu, Guochao Xu, Ning Liu, Cong Yu
A multifunctional nanocomposite hydrogel for synergistic antibacterial wound therapy and healing promotion.
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New forms of electrospun nanofiber materials for biomedical applications

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J. Mater. Chem. B, 2020, 8,3733-3746
DOI: 10.1039/D0TB00271B, Review Article
Shixuan Chen, Johnson V. John, Alec McCarthy, Jingwei Xie
This review article discusses new forms of electrospun nanofiber materials and their biomedical applications.
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Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

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J. Mater. Chem. B, 2020, 8,3880-3885
DOI: 10.1039/D0TB00407C, Paper
Sara Amorim, Iva Pashkuleva, Celso A. Reis, Rui L. Reis, Ricardo A. Pires
We developed hyaluronic acid (HA):poly-L-lysine (PLL) layer-by-layer (LbL) constructs whose viscoelastic properties and bioactivity can be finely tuned by using polyanions of different molecular weight and/or crosslinking.
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Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

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J. Mater. Chem. B, 2020, 8,3939-3948
DOI: 10.1039/D0TB00327A, Paper
Boya Zhang, Shiyu Wan, Xinyu Peng, Mingying Zhao, Sai Li, Yuji Pu, Bin He
A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.
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H2S-Donating trisulfide linkers confer unexpected biological behaviour to poly(ethylene glycol)–cholesteryl conjugates

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J. Mater. Chem. B, 2020, 8,3896-3907
DOI: 10.1039/C9TB02614B, Paper
Francesca Ercole, Yuhuan Li, Michael R. Whittaker, Thomas P. Davis, John F. Quinn
A comprehensive in vitro study into trisulfide-bearing PEG-conjugates was conducted. For these materials the combination of a cholesteryl group and an H2S donating moiety is required to confer cytoprotective and ROS-mitigating effects.
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Ternary hydrogels with tunable mechanical and self-healing properties based on the synergistic effects of multiple dynamic  bonds

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02885D, Paper
Kun Li, Jingxi Wang, Ping Li, Yubo Fan
Ternary hydrogels with tunable mechanical properties were prepared based on the synergistic effects of hydrogen bonds and imine bonds.
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Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00735H, Paper
Long Wu, Wei Xie, Hui-Ming Zan, Zhongzhong Liu, Ganggang Wang, Yanfeng Wang, Wei Liu, Wenfei Dong
Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.
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Boron-based nanosheets for combined cancer photothermal and photodynamic therapy

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00070A, Paper
Yong Kang, Xiaoyuan Ji, Zhengjun Li, Zhiguo Su, Songping Zhang
Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods.
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A fiber-shaped neural probe with alterable elastic moduli for direct implantation and stable electronic–brain interfaces

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00508H, Communication
Chengqiang Tang, Songlin Xie, Mengying Wang, Jianyou Feng, Zhengqi Han, Xiaoying Wu, Liyuan Wang, Chuanrui Chen, Jiajia Wang, Liping Jiang, Peining Chen, Xuemei Sun, Huisheng Peng
A fiber-shaped neural probe with alterable elastic moduli allows direct implantation and enables adaptive electronic–tissue interfaces post implantation.
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Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00357C, Paper
Shuiling Jin, Lanling Weng, Zhi Li, Zhenzhen Yang, Lili Zhu, Jianxiang Shi, Wenxue Tang, Wang Ma, Hong Zong, Wei Jiang
Chemodynamic therapy (CDT) has been critically challenged by insufficient H2O2 in cancer tissues and inefficient reactive oxygen species (ROS) production.
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A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00561D, Paper
Yu Zhang, Jun Yang, Jun Zhang, Shuangwen Li, Lisi Zheng, Yanlong Zhang, Huipeng Meng, Xinge Zhang, Zhongming Wu
A bio-inspired injectable hydrogel as a cell platform for real time glycemic regulation by mimicking the function of native islet β cells.
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One-pot synthesis of trypsin-based magnetic metal–organic frameworks for highly efficient proteolysis

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02315A, Paper
Chao Zhong, Zhixian Lei, Huan Huang, Mingyue Zhang, Zongwei Cai, Zian Lin
A facile approach was developed for one-pot synthesis of trypsin-based magnetic ZIF-8, which could be applied as an immobilized enzyme microreactor for rapid digestion of proteins.
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Regulation of cell binding and entry by DNA origami mediated spatial distribution of aptamers

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00663G, Communication
Ke Liu, Cong Xu, Jinyao Liu
Customizing the spatial distribution of aptamers on DNA origami nanoboxes can regulate the internalization and proliferation of cancer cells.
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A decellularized scaffold derived from squid cranial cartilage for use in cartilage tissue engineering

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00483A, Paper
Thou Lim, Qian Tang, Zhen-Zhong Zhu, Yong Feng, Shi Zhan, Xiao-Juan Wei, Chang-Qing Zhang
Decellularized cartilage scaffold (DCS) is an emerging substitute for cartilage defect application.
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Shape memory materials for electrically-powered soft machines

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00392A, Review Article
Xiaonan Huang, Michael Ford, Zach J. Patterson, Masoud Zarepoor, Chengfeng Pan, Carmel Majidi
We review the recent progress of electrically-powered artificial muscles and soft machines using shape memory alloy and liquid crystal elastomer.
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Preparation and biological evaluations of collagen-like hierarchical Ti surface with superior osteogenic capabilities

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00799D, Paper
Weiwei Lao, Qiaojie Luo, Yadong Chen, Wei Yao, Jiajia Xu, Lijie Fan, Xiaodong Li
The construction of multiscale Ti surfaces of high osteogenic ability always attracts numerous attentions in oral implantology and implantable biomaterial field. However, so far, the absence of solid understanding of...
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Covalent Organic Framework as Nanocarrier for Synergistic Phototherapy and Immunotherapy

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00679C, Paper
Ying Zhou, Sainan Liu, Chunling Hu, Lihan Cai, Maolin Pang
As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumor, but can't inhibit tumor extensive metastasis and local recurrence. Herein, in order to prevent...
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Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00052C, Paper
Javad Foroughi, Sepehr Talebian , In Kyoung Shim, Kara Vine, Song Cheol Kim, Geoffrey M Spinks
Biopolymer-based hydrogels have emerged as promising platforms for drug delivery systems (DDSs) due to their inherent biocompatibility, tunable physical properties and controllable degradability. Yet, drug release in majority of these...
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Surface functionalization strategies of extracellular vesicles

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00744G, Review Article
Sagar Rayamajhi, Santosh Aryal
Physical, biological, and chemical strategies of surface functionalization can add vital functionality in extracellular vesicles (EVs) for diverse biomedical applications.
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The Circadian Clock Gene PER2 Enhances Chemotherapeutic Efficacy in Nasopharyngeal Carcinoma When Combined with a Targeted Nanosystem

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00595A, Paper
Li Hou, Hailiang Li, Haiyan Wang, Dede Ma, Jing Liu, liqiong Ma, Zhihua Wang, Zhihua Yang, Faxuan Wang, Hechun Xia
Treatment failure occurs in more than 40% of advanced nasopharyngeal carcinoma (NPC) patients including local recurrence and distant metastasis due to chemoradioresistance. Circadian clock genes were identified as regulating cancer...
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Ag@S-nitrosothiols core-shell nanoparticles for chemo and photothermal synergistic tumor target therapy

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00734J, Paper
Xinlin Yang, Tuanwei Liu, Xiao Li, Jinan Wang, Ping Zhang, Xiaoying Huang, Zhide Zhang, Dian-Shun Guo
Along with development of the controlled delivery systems for target therapy, ‘single-strategy’ therapy often fails to achieve the desired performance in real body internal environment. In such case, it is...
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Hydrogels toughened by biominerals as energy-dissipative sacrificial bonds

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00833H, Communication
Kazuki Fukao, Kazuki Tanaka, Ryuji Kiyama, Takayuki Nonoyama, Jian Ping Gong
Inspired by bone tissues, hydrogels toughened by hydroxyapatite (HAp) working as energy-dissipative sacrifical bonds is created. The contribution of dissipated energy from HAp mineral was over 500 % higher than...
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Diblock Copolypeptoids: A Review of Phase Separation, Self-Assembly and Biological Applications

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00477D, Review Article
Sunting Xuan, Ronald N Zuckermann
Polypeptoids are biocompatible, synthetically accessible, chemically and enzymatically stable, chemically diverse, and structurally controllable. As a bioinspired and biomimetic material, it has attracted considerable attention due to its great potential...
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Calcium alendronate-coated composite scaffolds promote osteogenesis of ADSCs via integrin and FAK/ERK signalling pathways

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00571A, Paper
Lei Liu, Xianling Gao, Xiaoyu Li, Guanglin Zhu, Nanying Li, Xuetao Shi, Yingjun Wang
Bioceramic-biopolymer composites have been used extensively as bone tissue engineering scaffolds due to their bioactive properties. However, composite scaffolds are insufficient in inducing osteogenic differentiation of stem cells. In this...
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High-performance non-enzymatic glucose detection: using conductive Ni-MOF as an electrocatalyst

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00131G, Communication
Yanxia Qiao, Qian Liu, Siyu Lu, Guang Chen, Shuyan Gao, Wenbo Lu, Xuping Sun
Conductive metal−organic frameworks (MOFs) are studied extensively in applications like water electrolysis, gas storage, and supercapacitors due to their high conductivity and large pore volume, etc. In this communication, we...
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Br(e)aking the news : journalism, politics and new media / Janey Gordon, Paul Rowinski and Gavin Stewart (eds)

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Psychoanalysis and ethics in documentary film / Agnieszka Piotrowska

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Piotrowska, Agnieszka, author


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The interplay of influence : news, advertising, politics, and the Internet / Kathleen Hall Jamieson, Karlyn Kohrs Campbell

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Jamieson, Kathleen Hall


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Social media law and marketing : fans, followers and online infamy / Geoffry Holland, Kathryn Crossley, Wenee Yap

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Holland, Geoffrey M, author


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Herding cats : the evolution of the ADF's media embedding program in operational areas / by Jason Logue

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Logue, Jason, author


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Analyzing media messages : using quantitative content analysis in research / Daniel Riffe, Stephen Lacy and Frederick Fico

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Riffe, Daniel


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