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A quest to drug the undruggable

Listen to the latest Stereo Chemistry episode that explores why certain drug targets are so vexing, and the cutting edge approaches chemists are taking to finally crack them




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Existing treaty could help manage global plastic waste trade, researchers suggest

Basel Convention would help control flow of used material displaced by China’s ban




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Enzyme conjugate synthesizes DNA

Method is possible replacement for phosphoramidite-based DNA synthesis




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Sarepta’s Duchenne gene therapy shows promise in small study

The early peek at data from a Phase I/II study excited families, physicians, and investors 




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Oil and gas wastewater is a cheap fix for road dust but comes at a toxic cost

Treating roads with the wastewater may pollute the environment with radium and oil and gas compounds




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Potential alcohol addiction mechanism revealed

Researchers are using knowledge gained from rat studies to develop better therapeutics




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Chemistry in Pictures: Twisted crystals




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Attila E. Pavlath wins Parsons Award

ACS past president is honored for his work in promoting the public image of chemistry




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Volunteer service award to Carolyn Ribes

Chemist honored for her tireless efforts on behalf of diversity, inclusion, and volunteerism in the society




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Novacap to enter the U.S. by acquiring PCI Synthesis

French pharmaceutical services firm is latest to move into the U.S.




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When trapped, water becomes less polar

In confined spaces, water’s dielectric constant drops dramatically, according to new measurements




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U.S. report proposes lower safe level for perfluorochemical exposure

ATSDR daily dose numbers for PFOS and PFOA are one-tenth those of EPA




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Reactions




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Ineos Styrolution invests in France




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Unique silica enclosures form on micelles

Dodecahedral ‘silicages’ could carry drugs or diagnostic agents




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Covestro deploys novel chlor-alkali technology in Spain




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U.K. chemical firms must re-register for REACH




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Kuraray, partners plan a butadiene derivatives venture in Thailand




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Start-up Olaplex triumphs over L’Oréal in court case




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Winning at a chemistry innovation contest in Sweden

Technologies for wastewater treatment and glycidol production among winners at second annual competition




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When good bees go bad

Researchers identify neuropeptides linked to aggression in Africanized honeybees




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2-step synthesis yields large 2-D COF crystals

Separating crystal nucleation and growth processes is key to controlling crystal dimensions




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Study finds natural gas climate advantage nixed by methane loss

U.S. natural gas production loses 2.3% of methane to leaks




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LG launches innovation contest




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Recipharm acquires Sanofi’s inhalation assets




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Indorama pushes into Egypt with PET acquisition




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Roche pays $2.4 billion for rest of Foundation Medicine




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Trump proposes U.S. federal government reorganization

Food regulation, graduate education among changes put forward




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Some Chinese power plants may underreport sulfur dioxide emissions

Data from air pollution monitors don’t jibe with satellite measurements




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Polymer strips off-taste from wine

Magnetic property enables easy separation of sorption medium




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Expanding the glucose meter’s repertoire

Molecular logic gates allow personal glucose meters to respond to many other targets




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Oil and gas wastewater is a cheap fix for road dust, but it comes at a toxic cost

Treating roads with wastewater may pollute the environment with radium




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How the Women Chemists Committee stays relevant after 90 years




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Topological materials move from the world of theoretical physics to experimental chemistry

These exotic materials could find applications in electronics, catalysis, and quantum computing




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Project SEED scholar Ganesh Karunakaran

An early interest in science morphs into a career fueled by international finance and economics




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Setup may make transferring <i>tert</i>-butyl lithium and other pyrophoric reagents safer

Simple pieces of equipment decrease the danger of moving small volumes of chemicals prone to igniting




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Cellulose derivative accelerates organic chemistry in water

Additive facilitates numerous pharmaceutically relevant reactions through unknown mechanism




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LyondellBasell in talks to buy stake in Braskem

A deal would give LyondellBasell control of Brazil’s largest chemical maker




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Business Roundup




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256th ACS National Meeting

Boston, Mass., Aug. 19–23




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Decibel raises $55 million for hearing loss




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Gene therapy start-up Freeline Therapeutics raises $116 million




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BridgeBio licenses compounds from NeuroVive and launches Fortify Therapeutics




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Adventures with the periodic table




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Donald Ingber is leading efforts to develop organ-on-a-chip devices to replace animal tests

Widespread adoption of the chips will require mass production and finding the right questions to ask with the devices




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A U.K. option for a controlled substance

TPI Enterprises, an Australian poppy processor, enters the restrictive British codeine market via a contract with Sterling Pharma Solutions




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Out of the sea and into the factory for Acasti’s heart drug ingredient

Acasti picks CordenPharma to extract omega-3s from krill




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Theracos becomes increasingly reliant on contract manufacturing as its drug advances

Piramal sites on different continents have become involved in producing Theracos’s diabetes treatment




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Sea, land, factory: 3 tales of pharmaceutical outsourcing

Drugs can be made by more than just chemical synthesis. Here are stories of three from the sea, the land, and yes, the factory




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AbbVie invests in switchable CAR-T therapies for cancer

The drug company is partnering with Calibr to develop universal CAR T-cells directed to different tumors via antibody switches