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Surface Polymer Imprinted Optical Fibre Sensor for Dose Detection of Dabrafenib

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00434K, Paper
Chenyang He , Ulises Hernandez Ledezma , Pratik Gurnani, Thais Fedatto Abelha, Kristofer James Thurecht, Ricardo Goncalves Correia , Steve Morgan, Poulam Patel, Cameron Alexander, Sergiy Korposh
Dabrafenib is one of the most widely used of the new generation of targeted anti-cancer drugs. However, its therapeutic window varies for different patients and so there is an unmet...
The content of this RSS Feed (c) The Royal Society of Chemistry




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An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00721H, Paper
Open Access
Xiaoxiao Guo, Jodie R Malcolm, Marrwa M Ali, Goreti Ribeiro Morais, Steve Shnyder, Paul Loadman, L H Patterson, Robert Andrew Falconer
The polysialyltransferases (polySTs) catalyse the polymerisation of polysialic acid, which plays an important role in tumour metastasis. While assays are available to assess polyST enzyme activity, there is no methodology...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Influence of Hair Treatments on Detection of Antiretrovirals by Mass Spectrometry Imaging

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00478B, Paper
Mac Gilliland, Nicole R White, Bryan Yam, Joseph N Mwangi, Heather MA Prince, Ann Marie K Weideman, Angela DM Kashuba, Elias Rosen
Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair...
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] A Coculture Based Tyrosine-Tyrosinase Electrochemical Gene Circuit for Connecting Cellular Communication with Electronic Networks

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00469




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[ASAP] <italic toggle="yes">In Vivo</italic> Production of Five Crocins in the Engineered <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00039




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[ASAP] A Synthetic Malonyl-CoA Metabolic Oscillator in <italic toggle="yes">Komagataella phaffii</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00378




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[ASAP] Blue-Light-Switchable Bacterial Cell–Cell Adhesions Enable the Control of Multicellular Bacterial Communities

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00054




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[ASAP] A Novel Biosynthetic Pathway for the Production of Acrylic Acid through ß-Alanine Route in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00019




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[ASAP] Correction to EcoFlex: A Multifunctional MoClo Kit for <italic toggle="yes">E. coli</italic> Synthetic Biology

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00177




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[ASAP] SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00059




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[ASAP] Engineering Prokaryotic Transcriptional Activator XylR as a Xylose-Inducible Biosensor for Transcription Activation in Yeast

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00122




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[ASAP] Introduction of the Menaquinone Biosynthetic Pathway into <italic toggle="yes">Rhodobacter sphaeroides</italic> and <italic toggle="yes">de Novo</italic> Synthesis of Menaquinone for Incorporation into He

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00066




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[ASAP] One-Day Construction of Multiplex Arrays to Harness Natural CRISPR-Cas Systems

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00489




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[ASAP] Extending SynBioHub’s Functionality with Plugins

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00056




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[ASAP] Determinants for Efficient Editing with Cas9-Mediated Recombineering in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00440




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[ASAP] Engineering Stable <italic toggle="yes">Pseudomonas putida</italic> S12 by CRISPR for 2,5-Furandicarboxylic Acid (FDCA) Production

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00006




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[ASAP] Facilitating Protein Expression with Portable 5'-UTR Secondary Structures in <italic toggle="yes">Bacillus licheniformis</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00355




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[ASAP] MAPPS: A Web-Based Tool for Metabolic Pathway Prediction and Network Analysis in the Postgenomic Era

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00397




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[ASAP] Transcript Barcoding Illuminates the Expression Level of Synthetic Constructs in <italic toggle="yes">E. coli</italic> Nissle Residing in the Mammalian Gut

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00040




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[ASAP] Truncating the Structure of Lipopolysaccharide in <italic toggle="yes">Escherichia coli</italic> Can Effectively Improve Poly-3-hydroxybutyrate Production

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00071




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[ASAP] A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00476




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[ASAP] Analyzing and Engineering the Product Selectivity of a 2-Methylenebornane Synthase

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00432




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[ASAP] Multiplex Generation, Tracking, and Functional Screening of Substitution Mutants Using a CRISPR/Retron System

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00002




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[ASAP] Translation Related Factors Improve the Productivity of a <italic toggle="yes">Streptomyces</italic>-Based Cell-Free Protein Synthesis System

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00140




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[ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00028




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[ASAP] Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00038






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[ASAP] MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <italic toggle="yes">Mycobacterium tuberculosis</italic>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00003




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[ASAP] Molecule Property Analyses of Active Compounds for <italic toggle="yes">Mycobacterium tuberculosis</italic>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02075




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[ASAP] Imidazo[1,2-<italic toggle="yes">a</italic>]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01910




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[ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02164




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[ASAP] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00035




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[ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02161




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[ASAP] Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02092




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[ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00227




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[ASAP] Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02097




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[ASAP] Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <italic toggle="yes">In Vivo</italic> Antitumor Activity

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00547




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[ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02035




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[ASAP] Discovery of (2<italic toggle="yes">R</italic>)-<italic toggle="yes">N</italic>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<italic toggle="yes">H</italic>-indol-7

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01392




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[ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00202




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[ASAP] Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00015




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[ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01936




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[ASAP] Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00491




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[ASAP] Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01937




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[ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02126




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[ASAP] A Chemical Switch for Transforming a Purine Agonist for Toll-like Receptor 7 to a Clinically Relevant Antagonist

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00011




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[ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00395




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[ASAP] p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02038




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[ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00215