al Surface Polymer Imprinted Optical Fibre Sensor for Dose Detection of Dabrafenib By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00434K, PaperChenyang He , Ulises Hernandez Ledezma , Pratik Gurnani, Thais Fedatto Abelha, Kristofer James Thurecht, Ricardo Goncalves Correia , Steve Morgan, Poulam Patel, Cameron Alexander, Sergiy KorposhDabrafenib is one of the most widely used of the new generation of targeted anti-cancer drugs. However, its therapeutic window varies for different patients and so there is an unmet...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
al An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00721H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaoxiao Guo, Jodie R Malcolm, Marrwa M Ali, Goreti Ribeiro Morais, Steve Shnyder, Paul Loadman, L H Patterson, Robert Andrew FalconerThe polysialyltransferases (polySTs) catalyse the polymerisation of polysialic acid, which plays an important role in tumour metastasis. While assays are available to assess polyST enzyme activity, there is no methodology...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
al Influence of Hair Treatments on Detection of Antiretrovirals by Mass Spectrometry Imaging By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00478B, PaperMac Gilliland, Nicole R White, Bryan Yam, Joseph N Mwangi, Heather MA Prince, Ann Marie K Weideman, Angela DM Kashuba, Elias RosenAnalysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
al [ASAP] A Coculture Based Tyrosine-Tyrosinase Electrochemical Gene Circuit for Connecting Cellular Communication with Electronic Networks By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00469 Full Article
al [ASAP] <italic toggle="yes">In Vivo</italic> Production of Five Crocins in the Engineered <italic toggle="yes">Escherichia coli</italic> By feedproxy.google.com Published On :: Tue, 07 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00039 Full Article
al [ASAP] A Synthetic Malonyl-CoA Metabolic Oscillator in <italic toggle="yes">Komagataella phaffii</italic> By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00378 Full Article
al [ASAP] Blue-Light-Switchable Bacterial Cell–Cell Adhesions Enable the Control of Multicellular Bacterial Communities By feedproxy.google.com Published On :: Wed, 15 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00054 Full Article
al [ASAP] A Novel Biosynthetic Pathway for the Production of Acrylic Acid through ß-Alanine Route in <italic toggle="yes">Escherichia coli</italic> By feedproxy.google.com Published On :: Wed, 15 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00019 Full Article
al [ASAP] Correction to EcoFlex: A Multifunctional MoClo Kit for <italic toggle="yes">E. coli</italic> Synthetic Biology By feedproxy.google.com Published On :: Fri, 17 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00177 Full Article
al [ASAP] SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions By feedproxy.google.com Published On :: Fri, 17 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00059 Full Article
al [ASAP] Engineering Prokaryotic Transcriptional Activator XylR as a Xylose-Inducible Biosensor for Transcription Activation in Yeast By feedproxy.google.com Published On :: Fri, 17 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00122 Full Article
al [ASAP] Introduction of the Menaquinone Biosynthetic Pathway into <italic toggle="yes">Rhodobacter sphaeroides</italic> and <italic toggle="yes">de Novo</italic> Synthesis of Menaquinone for Incorporation into He By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00066 Full Article
al [ASAP] One-Day Construction of Multiplex Arrays to Harness Natural CRISPR-Cas Systems By feedproxy.google.com Published On :: Wed, 22 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00489 Full Article
al [ASAP] Extending SynBioHub’s Functionality with Plugins By feedproxy.google.com Published On :: Thu, 23 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00056 Full Article
al [ASAP] Determinants for Efficient Editing with Cas9-Mediated Recombineering in <italic toggle="yes">Escherichia coli</italic> By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00440 Full Article
al [ASAP] Engineering Stable <italic toggle="yes">Pseudomonas putida</italic> S12 by CRISPR for 2,5-Furandicarboxylic Acid (FDCA) Production By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00006 Full Article
al [ASAP] Facilitating Protein Expression with Portable 5'-UTR Secondary Structures in <italic toggle="yes">Bacillus licheniformis</italic> By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00355 Full Article
al [ASAP] MAPPS: A Web-Based Tool for Metabolic Pathway Prediction and Network Analysis in the Postgenomic Era By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00397 Full Article
al [ASAP] Transcript Barcoding Illuminates the Expression Level of Synthetic Constructs in <italic toggle="yes">E. coli</italic> Nissle Residing in the Mammalian Gut By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00040 Full Article
al [ASAP] Truncating the Structure of Lipopolysaccharide in <italic toggle="yes">Escherichia coli</italic> Can Effectively Improve Poly-3-hydroxybutyrate Production By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00071 Full Article
al [ASAP] A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00476 Full Article
al [ASAP] Analyzing and Engineering the Product Selectivity of a 2-Methylenebornane Synthase By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00432 Full Article
al [ASAP] Multiplex Generation, Tracking, and Functional Screening of Substitution Mutants Using a CRISPR/Retron System By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00002 Full Article
al [ASAP] Translation Related Factors Improve the Productivity of a <italic toggle="yes">Streptomyces</italic>-Based Cell-Free Protein Synthesis System By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00140 Full Article
al [ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic> By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00028 Full Article
al [ASAP] Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00038 Full Article
al Franz Freiherr von Eckgher, Fürstbischofs von Freising, alphabetische Sammlung zur Genealogie des bayrischen Adels, Band 4 - BSB Cgm 2268(4 By daten.digitale-sammlungen.de Published On :: Wed, 01 Apr 2020 13:12:02 +0100 Autor: Johann Franz [Freising, Bischof] Erschienen 1695 BSB-Signatur Cgm 2268(4 URN: urn:nbn:de:bvb:12-bsb00003723-2 URL: http://daten.digitale-sammlungen.de/~db/0000/bsb00003723/images/ Full Article
al Genealogia Mändliana (der Freiherr Mändl von und zu Duntenhofen Ursprung und Aufnahme von 1613 - 1719) - BSB Cgm 2128 By daten.digitale-sammlungen.de Published On :: Thu, 16 Apr 2020 13:12:02 +0100 Autor: Erschienen 1701 BSB-Signatur Cgm 2128 URN: urn:nbn:de:bvb:12-bsb00132384-3 URL: http://daten.digitale-sammlungen.de/~db/0013/bsb00132384/images/ Full Article
al [ASAP] MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <italic toggle="yes">Mycobacterium tuberculosis</italic> By feedproxy.google.com Published On :: Sun, 19 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00003 Full Article
al [ASAP] Molecule Property Analyses of Active Compounds for <italic toggle="yes">Mycobacterium tuberculosis</italic> By feedproxy.google.com Published On :: Mon, 20 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02075 Full Article
al [ASAP] Imidazo[1,2-<italic toggle="yes">a</italic>]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells By feedproxy.google.com Published On :: Mon, 20 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01910 Full Article
al [ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02164 Full Article
al [ASAP] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation By feedproxy.google.com Published On :: Wed, 22 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00035 Full Article
al [ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma By feedproxy.google.com Published On :: Thu, 23 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02161 Full Article
al [ASAP] Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design By feedproxy.google.com Published On :: Fri, 24 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02092 Full Article
al [ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00227 Full Article
al [ASAP] Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02097 Full Article
al [ASAP] Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <italic toggle="yes">In Vivo</italic> Antitumor Activity By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00547 Full Article
al [ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02035 Full Article
al [ASAP] Discovery of (2<italic toggle="yes">R</italic>)-<italic toggle="yes">N</italic>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<italic toggle="yes">H</italic>-indol-7 By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01392 Full Article
al [ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00202 Full Article
al [ASAP] Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00015 Full Article
al [ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01936 Full Article
al [ASAP] Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00491 Full Article
al [ASAP] Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions By feedproxy.google.com Published On :: Fri, 01 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01937 Full Article
al [ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle> By feedproxy.google.com Published On :: Fri, 01 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02126 Full Article
al [ASAP] A Chemical Switch for Transforming a Purine Agonist for Toll-like Receptor 7 to a Clinically Relevant Antagonist By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00011 Full Article
al [ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00395 Full Article
al [ASAP] p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02038 Full Article
al [ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00215 Full Article