In 2018, opioid overdoses in the United States caused one death every 11 minutes, resulting in nearly 47,000 fatalities. The most effective treatments for opioid use disorder (OUD) are three medications approved by the Food and Drug Administration (FDA): methadone, buprenorphine, and naltrexone.

Few correctional facilities in the United States have treatment programs for individuals with opioid use disorder (OUD), despite clear evidence that certain medications reduce the risk of overdose and death. Even in facilities where treatment is available, the COVID-19 pandemic has complicated efforts to provide such care.

Between 1999 and 2014, opioid use disorder (OUD) among pregnant women more than quadrupled, risking the health of the women—before and after giving birth—and their infants. As states grapple with COVID-19’s exacerbation of the opioid crisis, several are taking innovative steps to address the needs of high-risk groups, including low-income, postpartum patients with OUD.

As the coronavirus pandemic grips the world, the opioid epidemic continues to affect millions of Americans. Several states are developing innovative ways to tackle this public health issue. In this episode, we speak with Beth Connolly, who leads Pew’s research on substance use disorders, and Louisiana Representative Paula Davis, who helped ensure effective treatment in her state.

Modern innovation typically occurs one step-improvement at a time. Some clients initially question whether their new application of an existing technology is patentable. Usually, the answer is ‘yes.’ Under U.S. law (and most other jurisdictions), an innovation to an existing technology is patentable so long as at least one claim limitation is novel and non-obvious....… Continue Reading

This is not a drill. Companies and law enforcement agencies around the world have been left scrambling after the world’s most prolific ransomware attack hit over 500,000 computers in 150 countries over a span of only 4 days. The ransomware – called WannaCry, WCry, WannaCrypt, or WannaDecryptor – infects vulnerable computers and encrypts all of...… Continue Reading

Jardiance is a popular drug used to treat type 2 diabetes and help reduce cardiovascular risk. DTC campaigns […]

We’re seeing an alarming increase in the number of failed biotech companies. While the biotechnology industry holds enormous […]

This paper provides a high-level tour of five modern approaches to model building that are available in recent releases of SAS/STAT.

NEW YORK — McDonald's on Sunday (Oct 27) ruled out beef patties as a source of the E. coli outbreak linked to Quarter Pounder hamburgers, which has killed at least one person and sickened nearly 75 others. "We remain very confident that any contaminated product related to this outbreak has been removed from our supply chain and is out of all McDonald's restaurants," the fast-food chain's chief supply chain officer Cesar Pina said in a statement. The Colorado Department of Agriculture said that all subsamples from multiple lots of McDonald's brand fresh and frozen beef patties had tested negative for E. coli, adding that it had completed beef testing and does not anticipate receiving further samples. McDonald's said it would resume distribution of fresh supplies of the Quarter Pounder and that it is expected to be available in all restaurants in the coming week, according to the statement.

The US Centers for Disease Control and Prevention said on Wednesday that slivered onions served on McDonald's, opens new tab Quarter Pounder hamburgers and other menu items were the likely source of an E. coli outbreak that sickened 90 people. The outbreak linked to Quarter Pounder was first reported on Oct 22, and slivered onions were suspected to be the source of the infections. The US Food and Drug Administration and the company have confirmed that Taylor Farms was the supplier for the affected locations, and it has since recalled several batches of yellow onions produced in a Colorado facility. The FDA on Wednesday said it had initiated inspections at a Taylor Farms processing center in Colorado, a state where 29 people have fallen ill due to the outbreak. An onion grower of interest in Washington state is also being investigated, the FDA added. The CDC said the number of infected people has risen by 15 people from 75 and 27 persons have been hospitalised due to the illness, which has already killed one person.

David Duchovny and Gillian Anderson didn't speak to each other for "weeks at a time" when they worked on The X Files. The 64-year-old actor and Gillian, 56, enjoyed huge success with the iconic sci-fi series — but the duo actually had a turbulent relationship for many years. David said on the Fail Better podcast: "There was a long time, working on the show, where we were just not even dealing with one another off-camera. And there was a lot of tension. Which didn't matter, apparently, for the work cause we're both f****** crazy, I guess. We could just go out there and do what we needed to do." Gillian was amazed that they achieved so much success while their off-screen relationship was so tense.

South Korean actor Song Jae-rim died yesterday (Nov 12) at the age of 39. The Seongdong Police Station in Seoul confirmed that he was found deceased in his apartment at around 12.30pm. According to media reports, a friend whom he was supposed to meet for lunch had visited his home and reported the death. A two-page letter was reportedly found at the scene but the cause of death has not been confirmed. A police official, however, stated that there are "no signs of foul play". His wake was held at Yeouido St. Mary’s Hospital Funeral Hall at 5.30pm yesterday. His funeral will be held tomorrow at Seoul City Crematorium. Jae-rim gained popularity after starring in the 2012 drama The Moon Embracing the Sun and the 2014 reality series We Got Married. This year, he starred in two dramas — My Military Valentine and Queen Woo. Following news of his death, comedian Hong Seok-cheon and other celebrities posted tributes to Jae-rim on social media.

Donald Trump has begun the process of choosing a cabinet and selecting other high-ranking administration officials following his presidential election victory. Here are the early picks and top contenders for some of the key posts overseeing defence, intelligence, diplomacy, trade, immigration and economic policymaking. Some are in contention for a range of posts. Susie Wiles, chief of staff Susie Wiles reacts as Republican presidential nominee and former US President Donald Trump speaks, following early results from the 2024 US presidential election in Palm Beach County Convention Center, in West Palm Beach, Florida, US on Nov 6, 2024. PHOTO: Reuters Trump announced last week that Wiles, one of his two campaign managers, will be his White House chief of staff.

SEOUL - South Korea's military said it will hold a three-day joint exercise with the United States and Japan starting on Wednesday (Nov 13), featuring fighter jets and marine patrol aircraft as well as the US nuclear-powered aircraft carrier USS George Washington. The Freedom Edge exercise is a response to what the South Korean military said were threats from North Korea, which recently conducted an intercontinental ballistic missile test, drawing condemnation from Seoul, Tokyo and Washington. It also comes as the US State Department said North Korean troops have started engaging in combat operations in Russia's war with Ukraine. The exercise will include South Korean and Japanese fighter jets and maritime patrol aircraft, as well as the USS George Washington, Seoul's Joint Chiefs of Staff (JCS) said in a statement. The trilateral exercise follows a first round held earlier this year after the leaders of the three countries agreed at a summit in 2023 to hold annual training drills. Pyongyang has long condemned joint drills between South Korea and the United States, calling them a rehearsal for invasion.

JAKARTA — Indonesia said on Monday (Nov 11) it does not recognise China's claims over the South China Sea despite signing a joint maritime development deal with Beijing, as some analysts warned the agreement risked compromising the country's sovereign rights. Beijing has long clashed with its Southeast Asian neighbours over territory in the South China Sea, which it claims sovereignty over in almost its entirety via a "nine-dash line" on its maps that cuts into the exclusive economic zones (EEZ) of several countries. Joint agreements with China in the strategic waterway have for years been sensitive, with some claimant states wary of entering into deals they fear could be interpreted as legitimising Beijing's vast claims. An arbitral tribunal in 2016 said the Chinese claim, based on its old maps, has no basis under international law, a decision China refuses to recognise. A joint statement issued at the weekend during Indonesian President Prabowo Subianto's visit to Beijing mentioned the two countries had "reached important common understanding on joint development in areas of overlapping claims".

In July 2024, internet personality Bobby Saputra posted a video of himself living it up at what appeared to be the star-studded, ultra-lavish wedding of Radhika Merchant and Anant Ambani, the youngest child of Indian billionaire and Asia's richest man, Mukesh Ambani. The video featured clips of Saputra dancing, feasting and soaking up the "completely crazy" celebrations. He gushes in the voiceover: "It was like watching a Bollywood production." The video quickly went viral, racking up 6.6 million views on Instagram, 5.1 million on TikTok, and another 2.2 million on YouTube. Thousands left comments, including some celebrities who claimed they spotted him there. Except… he never set foot in the party. As it turns out, he had pieced together clips from a wedding he attended a few months prior — complete with him in full Indian attire, dancing with friends — and spliced in shots from the Ambani wedding that he found online. The result? Social media magic.

SEOUL — South Korean President Yoon Suk-yeol recently began practising golf, for the first time in eight years, in preparation for future meetings with US President-elect Donald Trump, Yoon's office confirmed on Tuesday (Nov 12). South Korean media said Yoon visited a golf course on Saturday for a sport his office said he had last played in 2016. "A lot of people close to President Trump... (told me) President Yoon and Trump will have good chemistry," Yoon told a press conference on Thursday, after congratulating Trump by telephone on his win. Former Trump administration officials and influential Republicans had offered to help build ties with the incoming president, he added. Analysts said Yoon may seek to find a way to capitalise on a personal friendship with Trump to advance Seoul's interests as Trump's "America First" foreign policy plans and his unpredictable style play out in his second term. South Korean companies rely heavily on trade with the United States, and during Trump's first term, the countries clashed over cost-sharing for the roughly 28,500 US troops stationed in South Korea as a legacy of the 1950-1953 Korean War.

CANBERRA — China is putting ever-greater pressure on the Philippines to cede its sovereign rights in the South China Sea, Secretary of National Defence Gilberto Teodoro said on Nov 12 after a meeting with his Australian counterpart in Canberra. "What we see is an increasing demand by Beijing for us to concede our sovereign rights in the area," he said, adding that the Philippines was a "victim of Chinese aggression". China and the Philippines have sparred repeatedly this year over disputed areas of the South China Sea, including the Scarborough Shoal, one of Asia's most contested features. Teodoro's meeting with his Australian counterpart Richard Marles, their fifth since August 2023, reflects growing security ties between the countries, both of whom have expressed concern about Chinese activity in areas of the South China Sea claimed by the Philippines and other Southeast Asian nations. The two nations signed a strategic partnership in September 2023 and held their first joint sea and air patrols in the South China Sea several months later. The Philippines also joined war games in Australia this year for the first time.

ISLAMABAD — Beijing is pushing Pakistan to allow its own security staff to provide protection to thousands of Chinese citizens working in the South Asian nation, during talks after a car bombing in Karachi that was seen as a major security breach, sources said. Last month's airport bombing in the southern port city that killed two Chinese engineers returning to work on a project after a holiday in Thailand was the latest in a string of attacks on Beijing's interests in Pakistan. The attacks, and Islamabad's failure to deter them, have angered China, which has pushed Pakistan to begin formal negotiations for a joint security management system. Reuters spoke to five Pakistani security and government sources with direct knowledge of the previously unreported negotiations and demands on condition of anonymity, as the talks are sensitive, and reviewed a written proposal sent by Beijing to Islamabad. "They (Chinese) want to bring in their own security," said one official, who sat in on a recent meeting, adding that Pakistan had not so far agreed to such a step.

May 11, 2022

When the U.S. military trains other states’ forces, it tries to impart liberal norms such as respect for human rights. But when liberal norms clash, these soldiers prioritize loyalty to their unit, the military, and shared goals.

Sep 28, 2022

As the best documented major crisis in history, in substantial part because Kennedy secretly taped the deliberations in which he and his closest advisers were weighing choices they knew could lead to a catastrophic war, the Cuban missile crisis has become the canonical case study in nuclear statecraft. Over the decades since, key lessons from the crisis have been adapted and applied by the successors of Kennedy and Khrushchev to inform fateful choices.

Feb 28, 2023

Policymakers need to act now and place child welfare professionals, not law enforcement actors, at the border to effectively screen and interview migrant children. Information sharing practices need to be improved, with a movement away from paper documents that can easily get lost to an approach that is digital, secure, and accessible by the child, their guardian, their lawyer, and their doctor. Further, the enforcement processing facilities need to undergo an immediate infrastructural transformation with the addition of new design features that are necessary and sensitive to the majority demographic that are held within facilities—children and families.

These actions are doable and require no legislative action. Migrant children deserve decisive action to ensure that their health, safety, and well-being is not jeopardized as they seek refuge in the United States.

Aug 1, 2023

Using the private journals of commission secretaries Henry Marie Brackenridge and Dr. William Baldwin, as well as Captain Sinclair, this chapter will explore the establishment of American naval identity through its diplomatic experiences in South America. It will also exhibit the role of the U.S. Navy in a proto framework of the Monroe Doctrine.

Mar 12, 2024

After a century of rebellion, South America experienced a rapid decline in revolts in the early 1900s. Historical narratives and an analysis of a comprehensive new dataset show that the decrease stemmed in large part from the expansion and professionalization of the region’s militaries, which were driven by an export boom and the threat of interstate conflict. 

In one of the first books I read, the writer had posed the question: ‘Who was the greatest all-rounder in the history of cricket?’, before providing this answer: ‘He was a left-arm bowler and a right-hand batsman, who was born in the village of Kirkheaton’. I now forget the title of the book, but remember [...]

My first editor, Rukun Advani, once described himself as ‘a composite hybrid of the Indian and the Anglo-European’, who sought to reconcile ‘within himself those varying cultural influences which chauvinistic nationalists could only see as contradictions.’ This self-characterization I might avow as my own. One mark of the Anglo-European in me is that, unlike members [...]

Pakistan's National Security Adviser to the Prime Minister, Mahmud Ali Durrani, on the 2008 bombing of the Indian Embassy in Kabul

‘India does not want to play into the hands of terrorists by shunning dialogue.'

During recent trips to southern Punjab, Principal Officer was repeatedly told that a sophisticated jihadi recruitment network had been developed in the Multan, Bahawalpur, and Dera Ghazi Khan Divisions.

Though the Northwest Frontier Province (NWFP) and Federally Administered Tribal Areas (FATA) continue to grab headlines for terrorist violence, poor and underdeveloped regions in the rest of "settled" Pakistan are increasingly the recruiting and training ground for extremism and militancy.

The average time spent on discussing a Bill dropped from 213 minutes in 2019 to 85 minutes in 2021

Who controls India’s water resources: Centre, States or both? How are inter-State river disputes settled? Who supplies drinking water to Indian citizens?

National parties’ unknown income rose from 66% to 71% in the three years before and after the scheme’s introduction

Jun 21, 2022

Simon Saradzhyan was invited to publicly brief the National Academy of Sciences (NAS) committee addressing the adequacy of strategies to prevent, counter, and respond to nuclear terrorism, and identify technical, policy, and resource gaps. The consensus study is a congressionally mandated analysis included in the 2021 National Defense Authorization Act (Section 1299I) sponsored by the Office of the Secretary of Defense (Policy).  Nearly 60 stakeholders concerned about this topic from the Department of Defense, US Department of Energy, National Nuclear Security Administration, State Department, National Security Council, US Congress, the National Labs, and many non-governmental organizations were in attendance. The briefings are available at the NAS event website. Video of the presentation can be found here.

Aug 10, 2016

"African countries are already at the forefront of harnessing these technologies. For example, Rwanda has set itself the ambitious goal of building the first drone airport in the world. An increasing number of African countries are leveraging drone technology to address a variety of resource mapping, delivery and agricultural services. It is through such efforts that salient basic research challenges are likely to emerge."

Dec 8, 2016

"The goal of the book was to invest in thinking. It doesn't have a list of recommendations but generates options for action that are backed by evidence. We chose to forgo credit by adopting this approach, but it’s been very encouraging to see some key impacts that acknowledge the book."

Dec 18, 2017

Our colleague Calestous Juma—who passed away on December 15 at age 64 after a long illness—was a pioneering, prolific, and influential scholar/practitioner in science and technology policy for sustainable well-being. He joined Harvard Kennedy School (HKS) in 1999 as Director of the Science, Technology, and Innovation Project (a joint venture of the Belfer Center for Science and International Affairs and the Center for International Development) and became Professor of the Practice of International Development in 2002, a position in which he maintained his exceptional productivity and engagement with policy, despite illness, up to the time of his death.

Oct 10, 2023

Michael Toffel, Senator John Heinz Professor of Environmental Management and Professor of Business Administration at Harvard Business School (HBS), discusses the many ways in which business and governments can and are working together to address climate change in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

Mar 7, 2024

Tarek Masoud, who questioned Iriqat’s views of Oct. 7 and how a two-state solution could be achieved during the event, said in an interview later on Thursday that he was “reasonably confident and hopeful” the discussion was an opportunity for learning, and added he appreciated that Iriqat “did not deny the atrocities of Oct. 7.” Understanding the Palestinian perspective is critical for moving toward peace and a two-state solution, Masoud said. Masoud and Iriqat agreed to discuss her controversial social media posts during the dialogue. Iriqat said that she did not intend to justify the violence on Oct. 7, which included kidnappings of children and elderly, beheadings, and massacres of civilians, but meant to place the attack in the context of a decades-long conflict. She was intensely critical of Israel throughout the conversation, saying the “settler-colonial project started 76 years ago.”

Jun 5, 2024

The war in Gaza has accelerated a major shift in Tunisia’s foreign policy. One of the first Arab countries to advocate for a two-state solution, Tunisia has now abandoned it. That shift has left Tunisia more isolated geopolitically, prompting it to now court Iran, China, and Russia.

Mar 13, 2024

Social media’s unregulated evolution over the past decade holds a lot of lessons that apply directly to AI companies and technologies.

Jun 13, 2024

In an era in which internet companies dominate both public and private life, both power and culture are increasingly corporate, write Kim Córdova and Bruce Schneier.

Apr 3, 2024

Only a small handful of people in the world have sat at the negotiating table with the North Koreans and extensively interacted with them. Yet, this knowledge is fragmented and has not been collected or analyzed in a systematic manner. This report captures the findings from in-depth, one-on-one interviews with former senior negotiators from the United States and South Korea, who gained unique knowledge about North Korean negotiating behavior by dealing directly with their high-level North Korean counterparts. 

These negotiators collectively represent a body of negotiation experience and expertise starting from the early 1990s to late 2019, when North Korea ceased all negotiations with the United States. During that time, the conditions for productive negotiation changed dramatically – indeed, the conditions for the 1994 U.S.-North Korea Agreed Framework negotiations were much more favorable than during the Six-Party Talks of the mid-2000s or the Season of Summits during 2018-2019. For the “Negotiating with North Korea: Key Lessons Learned from Negotiators’ Genesis Period” project, a spotlight was placed on former senior negotiators’ early-stage experience preparing for and engaging in negotiations with the North Koreans. In doing so, tacit knowledge was captured to serve as a resource for future negotiators to inform and accelerate their own genesis period.