f Navy breaks ground on laser weapons test lab in California By www.upi.com Published On :: Thu, 07 May 2020 18:29:45 -0400 Navy leaders and private contractors broke ground this week on what will become the fleet's only dedicated facility to test, fire and evaluate complete laser weapon systems in a maritime environment. Full Article
f Boeing awarded $128.5M modification to GMD missile upgrade contract By www.upi.com Published On :: Thu, 07 May 2020 19:36:45 -0400 Boeing was awarded a $128.5 million modification to its Ground-based Midcourse Defense development and sustainment contract Thursday, according to the Pentagon. Full Article
f Raytheon nabs $19M for RAM missiles, GMLS launchers By www.upi.com Published On :: Thu, 07 May 2020 20:03:58 -0400 Raytheon Missile Systems was awarded a $19 million contract modification to exercise options for Navy Rolling Airframe Missile and Guided Missile Launching Systems, according to the Department of Defense. Full Article
f Gestational Diabetes Mellitus and Diet: A Systematic Review and Meta-analysis of Randomized Controlled Trials Examining the Impact of Modified Dietary Interventions on Maternal Glucose Control and Neonatal Birth Weight By care.diabetesjournals.org Published On :: 2018-07-01 Jennifer M. YamamotoJul 1, 2018; 41:1346-1361Reconsidering Pregnancy With Diabetes Full Article
f Type 1 Diabetes Mellitus and Cardiovascular Disease: A Scientific Statement From the American Heart Association and American Diabetes Association By care.diabetesjournals.org Published On :: 2014-10-01 Sarah D. de FerrantiOct 1, 2014; 37:2843-2863Scientific Statement Full Article
f Diuretic Treatment of Hypertension By care.diabetesjournals.org Published On :: 2011-05-01 Ehud GrossmanMay 1, 2011; 34:S313-S319Hypertension Full Article
f Investigation of the Accuracy of 18 Marketed Blood Glucose Monitors By care.diabetesjournals.org Published On :: 2018-08-01 David C. KlonoffAug 1, 2018; 41:1681-1688Emerging Technologies: Data Systems and Devices Full Article
f Diabetes and Aging: Unique Considerations and Goals of Care By care.diabetesjournals.org Published On :: 2017-04-01 Rita R. KalyaniApr 1, 2017; 40:440-443Emerging Science and Concepts for Management of Diabetes and Aging Full Article
f Table 1--Systeme International (SI) units for plasma, serum, or blood concentrations By care.diabetesjournals.org Published On :: 1994-04-01 Apr 1, 1994; 17:360-361Syst[egrave]me International (SI) Units Full Article
f Metformin Therapy During Pregnancy: Good for the goose and good for the gosling too? By care.diabetesjournals.org Published On :: 2011-10-01 Denice S. FeigOct 1, 2011; 34:2329-2330Editorial (See Rowan et al., p. 2279) Full Article
f Dalcetrapib Reduces Risk of New-Onset Diabetes in Patients With Coronary Heart Disease By care.diabetesjournals.org Published On :: 2020-05-01 Gregory G. SchwartzMay 1, 2020; 43:1077-1084Emerging Therapies: Drugs and Regimens Full Article
f Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial By care.diabetesjournals.org Published On :: 2019-05-01 Jordi Salas-SalvadóMay 1, 2019; 42:777-788Continuing Evolution of Nutritional Therapy for Diabetes Full Article
f Table 1--Systeme International (SI) units for plasma, serum, or blood concentrations By care.diabetesjournals.org Published On :: 1995-11-01 Nov 1, 1995; 18:1524-1525Syst[egrave]me International (SI) Units Full Article
f Professional Practice Committee: Standards of Medical Care in Diabetes--2019 By care.diabetesjournals.org Published On :: 2019-01-01 Jan 1, 2019; 42:S3-S3Professional Practice Committee Full Article
f Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030 By care.diabetesjournals.org Published On :: 2018-05-01 Christian BommerMay 1, 2018; 41:963-970The Costs Of Diabetes Full Article
f Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations By care.diabetesjournals.org Published On :: 2016-06-01 Francesco RubinoJun 1, 2016; 39:861-877Metabolic Surgery and the Changing Landscape for Diabetes Care Full Article
f HbA1c Levels Are Significantly Lower in Early and Late Pregnancy By care.diabetesjournals.org Published On :: 2004-05-01 Lene R. NielsenMay 1, 2004; 27:1200-1201Brief Reports Full Article
f Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association By care.diabetesjournals.org Published On :: 2015-10-01 Richard A. InselOct 1, 2015; 38:1964-1974Scientific Statement Full Article
f Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study By care.diabetesjournals.org Published On :: 2016-10-01 Khalid A. JadoonOct 1, 2016; 39:1777-1786Emerging Technologies and Therapeutics Full Article
f PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2019-09-01 Vanita R. ArodaSep 1, 2019; 42:1724-1732Emerging Therapies: Drugs and Regimens Full Article
f Disclosures: Standards of Medical Care in Diabetes--2020 By care.diabetesjournals.org Published On :: 2020-01-01 Jan 1, 2020; 43:S205-S206Disclosures Full Article
f Impact of Fat, Protein, and Glycemic Index on Postprandial Glucose Control in Type 1 Diabetes: Implications for Intensive Diabetes Management in the Continuous Glucose Monitoring Era By care.diabetesjournals.org Published On :: 2015-06-01 Kirstine J. BellJun 1, 2015; 38:1008-1015Type 1 Diabetes at a Crossroads Full Article
f The Pathophysiology of Hyperglycemia in Older Adults: Clinical Considerations By care.diabetesjournals.org Published On :: 2017-04-01 Pearl G. LeeApr 1, 2017; 40:444-452Emerging Science and Concepts for Management of Diabetes and Aging Full Article
f Current Challenges and Opportunities in the Prevention and Management of Diabetic Foot Ulcers By care.diabetesjournals.org Published On :: 2018-04-01 William J. JeffcoateApr 1, 2018; 41:645-652Perspectives in Care Full Article
f Dietary Sugar and Body Weight: Have We Reached a Crisis in the Epidemic of Obesity and Diabetes?: Health Be Damned! Pour on the Sugar By care.diabetesjournals.org Published On :: 2014-04-01 George A. BrayApr 1, 2014; 37:950-956Current Concepts of Type 2 Diabetes Prevention Full Article
f The Pros and Cons of Diagnosing Diabetes With A1C By care.diabetesjournals.org Published On :: 2011-05-01 Enzo BonoraMay 1, 2011; 34:S184-S190Diabetes Full Article
f The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview By care.diabetesjournals.org Published On :: 2014-01-01 David M. NathanJan 1, 2014; 37:9-16DCCT/EDIC 30th Anniversary Summary Findings Full Article
f Management of Inpatient Hyperglycemia and Diabetes in Older Adults By care.diabetesjournals.org Published On :: 2017-04-01 Guillermo E. UmpierrezApr 1, 2017; 40:509-517Emerging Science and Concepts for Management of Diabetes and Aging Full Article
f Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring By care.diabetesjournals.org Published On :: 2018-11-01 Richard M. BergenstalNov 1, 2018; 41:2275-2280Perspectives in Care Full Article
f DPP-4 Inhibitors: Impact on glycemic control and cardiovascular risk factors By care.diabetesjournals.org Published On :: 2011-05-01 Dror DickerMay 1, 2011; 34:S276-S278Diabetes Treatments Full Article
f Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A review of their efficacy and tolerability By care.diabetesjournals.org Published On :: 2011-05-01 Alan J. GarberMay 1, 2011; 34:S279-S284Diabetes Treatments Full Article
f Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From a Diabetes Care Editors Expert Forum By care.diabetesjournals.org Published On :: 2018-01-01 William T. CefaluJan 1, 2018; 41:14-31Diabetes Care Expert Forum Full Article
f Efficacy and Safety of Liraglutide 3.0 mg in Individuals With Overweight or Obesity and Type 2 Diabetes Treated With Basal Insulin: The SCALE Insulin Randomized Controlled Trial By care.diabetesjournals.org Published On :: 2020-05-01 W. Timothy GarveyMay 1, 2020; 43:1085-1093Emerging Therapies: Drugs and Regimens Full Article
f Oral Semaglutide Versus Empagliflozin in Patients With Type 2 Diabetes Uncontrolled on Metformin: The PIONEER 2 Trial By care.diabetesjournals.org Published On :: 2019-12-01 Helena W. RodbardDec 1, 2019; 42:2272-2281Emerging Therapies: Drugs and Regimens Full Article
f The Cost of Diabetes Care--An Elephant in the Room By care.diabetesjournals.org Published On :: 2018-05-01 Matthew C. RiddleMay 1, 2018; 41:929-932The Costs Of Diabetes Full Article
f Diabetes Technology Update: Use of Insulin Pumps and Continuous Glucose Monitoring in the Hospital By care.diabetesjournals.org Published On :: 2018-08-01 Guillermo E. UmpierrezAug 1, 2018; 41:1579-1589Diabetes Care Symposium Full Article
f Globalization of Diabetes: The role of diet, lifestyle, and genes By care.diabetesjournals.org Published On :: 2011-06-01 Frank B. HuJun 1, 2011; 34:1249-1257Kelly West Award Lecture Full Article
f International Consensus on Use of Continuous Glucose Monitoring By care.diabetesjournals.org Published On :: 2017-12-01 Thomas DanneDec 1, 2017; 40:1631-1640Continuous Glucose Monitoring and Risk of Hypoglycemia Full Article
f 2017 National Standards for Diabetes Self-Management Education and Support By care.diabetesjournals.org Published On :: 2017-10-01 Joni BeckOct 1, 2017; 40:1409-1419National Standards Full Article
f Effects of Coffee Consumption on Fasting Blood Glucose and Insulin Concentrations: Randomized controlled trials in healthy volunteers By care.diabetesjournals.org Published On :: 2004-12-01 Rob M. van DamDec 1, 2004; 27:2990-2992Brief Reports Full Article
f Treatment of Type 2 Diabetes: From "Guidelines" to "Position Statements" and Back: Recommendations of the Israel National Diabetes Council By care.diabetesjournals.org Published On :: 2016-08-01 Ofri MosenzonAug 1, 2016; 39:S146-S153II. Diabetes Treatment Options Full Article
f Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association By care.diabetesjournals.org Published On :: 2016-12-01 Deborah Young-HymanDec 1, 2016; 39:2126-2140Psychosocial Research and Care in Diabetes Full Article
f Table 1-Systeme International (SI) units for plasma, serum, or blood concentrations By care.diabetesjournals.org Published On :: 1995-08-01 Aug 1, 1995; 18:1223-1224Syst[egrave]me International (SI) Units Full Article
f Economic Costs of Diabetes in the U.S. in 2017 By care.diabetesjournals.org Published On :: 2018-05-01 American Diabetes AssociationMay 1, 2018; 41:917-928The Costs Of Diabetes Full Article
f Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range By care.diabetesjournals.org Published On :: 2019-08-01 Tadej BattelinoAug 1, 2019; 42:1593-1603International Consensus Report Full Article
f 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) By care.diabetesjournals.org Published On :: 2020-02-01 John B. BuseFeb 1, 2020; 43:487-493Consensus Report Update Full Article
f Professional Practice Committee: Standards of Medical Care in Diabetes--2020 By care.diabetesjournals.org Published On :: 2020-01-01 Jan 1, 2020; 43:S3-S3Professional Practice Committee Full Article
f Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report By care.diabetesjournals.org Published On :: 2019-05-01 Alison B. EvertMay 1, 2019; 42:731-754Continuing Evolution of Nutritional Therapy for Diabetes Full Article
f Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE The long-term influences of sex hormone administration on insulin sensitivity and incretin hormones are controversial. We investigated these effects in 35 transgender men (TM) and 55 transgender women (TW) from the European Network for the Investigation of Gender Incongruence (ENIGI) study. RESEARCH DESIGN AND METHODS Before and after 1 year of gender-affirming hormone therapy, body composition and oral glucose tolerance tests (OGTTs) were evaluated. RESULTS In TM, body weight (2.8 ± 1.0 kg; P < 0.01), fat-free mass (FFM) (3.1 ± 0.9 kg; P < 0.01), and waist-to-hip ratio (–0.03 ± 0.01; P < 0.01) increased. Fasting insulin (–1.4 ± 0.8 mU/L; P = 0.08) and HOMA of insulin resistance (HOMA-IR) (2.2 ± 0.3 vs. 1.8 ± 0.2; P = 0.06) tended to decrease, whereas fasting glucose (–1.6 ± 1.6 mg/dL), glucose-dependent insulinotropic polypeptide (GIP) (–1.8 ± 1.0 pmol/L), and glucagon-like peptide 1 (GLP-1) (–0.2 ± 1.1 pmol/L) were statistically unchanged. Post-OGTT areas under the curve (AUCs) for GIP (2,068 ± 1,134 vs. 2,645 ± 1,248 [pmol/L] x min; P < 0.01) and GLP-1 (2,352 ± 796 vs. 2,712 ± 1,015 [pmol/L] x min; P < 0.01) increased. In TW, body weight tended to increase (1.4 ± 0.8 kg; P = 0.07) with decreasing FFM (–2.3 ± 0.4 kg; P < 0.01) and waist-to-hip ratio (–0.03 ± 0.01; P < 0.01). Insulin (3.4 ± 0.8 mU/L; P < 0.01) and HOMA-IR (1.7 ± 0.1 vs. 2.4 ± 0.2; P < 0.01) rose, fasting GIP (–1.4 ± 0.8 pmol/L; P < 0.01) and AUC GIP dropped (2,524 ± 178 vs. 1,911 ± 162 [pmol/L] x min; P < 0.01), but fasting glucose (–0.3 ± 1.4 mg/dL), GLP-1 (1.3 ± 0.8 pmol/L), and AUC GLP-1 (2,956 ± 180 vs. 2,864 ± 93 [pmol/L] x min) remained unchanged. CONCLUSIONS In this cohort of transgender persons, insulin sensitivity but also post-OGTT incretin responses tend to increase with masculinization and to decrease with feminization. Full Article
f Steroid Metabolomic Signature of Insulin Resistance in Childhood Obesity By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE On the basis of urinary steroidal gas chromatography-mass spectrometry (GC-MS), we previously defined a novel concept of a disease-specific "steroid metabolomic signature" and reclassified childhood obesity into five groups with distinctive signatures. The objective of the current study was to delineate the steroidal signature of insulin resistance (IR) in obese children. RESEARCH DESIGN AND METHODS Urinary samples of 87 children (44 girls) aged 8.5–17.9 years with obesity (BMI >97th percentile) were quantified for 31 steroid metabolites by GC-MS. Defined as HOMA-IR >95th percentile and fasting glucose-to-insulin ratio >0.3, IR was diagnosed in 20 (of 87 [23%]) of the examined patients. The steroidal fingerprints of subjects with IR were compared with those of obese children without IR (non-IR). The steroidal signature of IR was created from the product of IR – non-IR for each of the 31 steroids. RESULTS IR and non-IR groups of children had comparable mean age (13.7 ± 1.9 and 14.6 ± 2.4 years, respectively) and z score BMI (2.7 ± 0.5 and 2.7 ± 0.5, respectively). The steroidal signature of IR was characterized by high adrenal androgens, glucocorticoids, and mineralocorticoid metabolites; higher 5α-reductase (An/Et) (P = 0.007) and 21-hydroxylase [(THE + THF + αTHF)/PT] activity (P = 0.006); and lower 11βHSD1 [(THF + αTHF)/THE] activity (P = 0.012). CONCLUSIONS The steroidal metabolomic signature of IR in obese children is characterized by enhanced secretion of steroids from all three adrenal pathways. As only the fasciculata and reticularis are stimulated by ACTH, these findings suggest that IR directly affects the adrenals. We suggest a vicious cycle model, whereby glucocorticoids induce IR, which could further stimulate steroidogenesis, even directly. We do not know whether obese children with IR and the new signature may benefit from amelioration of their hyperadrenalism. Full Article
