What unheralded prospect could break out in 2019? Beat reporter Gregor Chisholm answers that and more in this edition of the Inbox.

The Blue Jays spent the past two years clinging to the past. Now, they're embracing the future.

The start of Spring Training is almost here and it's time for the annual tradition of predicting the Blue Jays' 25-man roster. MLB.com will revisit these projections midway through camp, and then again at the end of Spring Training to see how close we came.

As MLB.com continues its annual Around the Horn series, it's time to take a closer look at the Blue Jays' starting rotation. It looks different now than it did a few months ago and it probably won't be long before the same thing will be said again because these changes are far from over.

Vladimir Guerrero Jr. hasn't even reported for duty yet and already he has become the main talking point at Blue Jays Spring Training. General manager Ross Atkins was bombarded with questions about MLB Pipeline's top prospect during his first media availability of the spring on Thursday.

The Blue Jays officially added another veteran to their bullpen Saturday morning by signing right-hander John Axford to a Minor League deal with an invitation to Spring Training. Axford hasn't received any guarantees with the short-term contract, but he is a strong candidate to make Toronto's 25-man roster and head north at the end of camp.

Who do the Blue Jays have in the pipeline? Get scouting reports, video, stats, projected ETAs and more for Toronto's Top 30 Prospects on MLB Pipeline's Prospect Watch.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

Freddy Galvis conceded things might eventually change, but the veteran infielder is under the impression that he will be the Blue Jays' everyday shortstop at the start of the season.

Donald Trump did not win the 2020 election, but asserting that he did became a prerequisite for Republicans standing for nomination to Congress or the Senate to win their primaries. An entire party became a vehicle for disinformation.1 Trump did win the 2024 presidential election, and key to that victory was building on the success of that lie. If you control enough of the information ecosystem, truth no longer matters.Another telling example: Haitian migrants in Springfield, Ohio, are not eating cats and dogs. US vice president elect, JD Vance, the source of that claim, admitted as much even as he justified it. “If I have to create stories so that the American media actually pays attention to the suffering of the American people, then that’s what I'm going to do,” he said.2Disinformation in politics is nothing new. History is replete with claims that were fabricated to advance political aims. Although...

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

For the past two years OM South Africa SportsLink has attended a prestigious rugby tournament to spread the good news to players, coaches and staff.

Marleen was challenged to create reading curriculum for kids by what she saw while climbing Mount Everest in Nepal.

How OM Founder George Verwer's visit to Siberia impacted local churches.

A Dutch team member shares her mission trip experience praying with a man in Siberia.

Despite not openly being allowed to speak about Jesus, an outreach team finds ways to be instruments in God's hands.

Forty new students registered for OM Philippines-Cebu’s Alternative Learning System (ALS) programme in June, and by faith, their financial needs have been met.

"...if they don’t believe you, you have to keep on talking and talking and talking until it gets stuck in their head," said Lansipe.

Kanat, which means 'wings' in Turkish, is the biannual worship arts camp run by the Taco team in Turkey.

An Uzbek girl living in Istanbul, Turkey enters into relationship with Jesus after having a dream.

A family in Turkey is impacted by the gospel through contacts with the Bible Correspondence Course.

An OMer sharing the gospel at a police station in Turkey is asked to return and carry on the conversation.

After experiencing answered prayer, a Syrian woman finds faith through gifts of the "Jesus Film" and a Bible.

In partnership with a local church, OM Lifehope teaches truths about God and the Bible to children at their recent Easter holiday club.

Twice a week Lourie Ferreira heads out into rural Zambian communities to show God's love through dentistry.

Dimas, the headman of a small village along the shores of Lake Tanganyika, shares about the challenges of being a headman and Christian.

OM Zambia develops women through skills training in sewing, cooking, embroidery and more to bring change to communities.

Cecilia dreamt of being able to provide a safe place for at-risk girls. In January 2016 that dream was realised in Hope House.

How God changed the lives of each team member of OM in Kasama to bring hope to the vulnerable children.

It’s common for the OMers in Kapembwa to have people associated with witchcraft coming for deliverance, but Wilson wanted more than that.

Kasama is known for sports and vulnerable kids; two subjects that OMer Noel is passionate about.

Rosie from OM Greece helps at a project for homeless people run by local believers in Athens. She describes how one regular 'guest' is progressing towards faith in God.

How OM is partnering with Greek churches to address the growing immigrant and trafficking situation

Women caught in the sex industry find new life through Nea Zoi, a partner organisation, which reaches out to sex workers in Athens.

OM seeks to love refugees like family members through starting sports ministry and cooking meals in camps.

“What a feeling it is to know you can be someone’s miracle…” shares a short-term worker after outreach with the OM Transit team in Romania.

Faith is strengthened when OMers learn how the Lord watches over them, not allowing harm to come to the people or the ministry.

OM Italy makes increasing use of their excellent facility, Forterocca, as a base for sports and arts ministries.

The coordinator of OM Italy’s anti-trafficking ministry describes the birth of the ministry through meeting a Nigerian woman forced into prostitution in Rome.

As they seek to establish a church, God gives OM Spain the opportunity to minister to the community, break down barriers and share the gospel.

In this second update from the Serbia/Croatia border, OM leader Volker Sachse describes moments of God’s peace that transforms people in a dire situation.

In his third update from Serbian/Croatian border, Volker Sachse says that in spite of increasingly difficulties, he can see God’s peace touch local people.

Michel Di Feliciantonio and three other Italian Christians spent a week in Šid, Serbia, helping refugees on their way into Europe.

During their visits in Serbia, Moldova and Montenegro the two MDT Love Europe teams had many experiences, as well as opportunities to share God’s love.

The Agency is a first-of-its-kind interactive mission experience that’s set on top of OM’s newly-launched Riverboat.

“Every movie, book or song tells a story. They all have a beginning and an end. When a song ends, the story seems over. When the killer is found at the end of that thriller, the movie ends. When the couple is finally together and they kiss on the last page of that romance novel, the book ends,” says OMer Anja. “But in life, the end of a story is never the end of it. It always goes on. When that book or movie is over, time seems to freeze and life as we know it seems to stay exactly the same.”

Time spent giving and receiving blessings is a special highlight for the participants of a weekly children's meeting.

In 1963, the first OM team travelled overland from Europe to India, sharing the gospel along the way and initiating a movement that would reached millions with the gospel.