The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.

A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.

In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an aspect, the invention relates to compositions and methods of permeabilizing the membranes of cancer cells or microbial cells.

The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.

A digital television system is connected to a mobile computing and communication device through an ad hoc communication link. A program broadcasted by the television system includes a plurality frames delivered in a sequential manner. A user can freeze a frame by employing the mobile device. The frame can then be transmitted to the mobile device and be redisplayed on the mobile device. The redisplayed frame includes visible symbols pointing to displayed items associated with advertising messages. The frame can also be stored in a photograph folder for the user to view the frame and associated advertising messages in a later time.

Disclosed herein is a system and method for simultaneously broadcasting video components (VSs). In one example, a method includes an automation-system (AS) selecting a log entry including (i) a first identifier that maps to a first VC, and (ii) a second identifier that maps to a second VC; a recording-and-playout device (RAPD) retrieving the first VC; the RAPD sending the retrieved first-VC to an encoder; the encoder generating a first transport-stream (TS) having (i) program-identification (PID) data, and (ii) payload data including the sent first-VC; the encoder sending the generated first-TS to a first outbound-broadcast device (OBD); the encoder sending the generated first-TS to a transport-stream splicer; the AS loading the splicer with the second VC; the splicer generating a second TS having (i) the PID data of the generated first-TS, and (ii) payload data including the loaded second-VC; and the splicer sending the generated second-TS to a second OBD.

Methods, systems, and computer readable media for measuring multicast latency are disclosed. According to one method, the method includes emulating one or more Internet protocol television (IPTV) user devices by generating channel leave and join requests. The method further includes monitoring network responses to the channel leave and join requests and calculating, during a cycle of channel leave and join requests for a user device and prior to repeating the cycle, at least one metric of latency associated with the channel leave and join requests.

Methods, devices, and computer program products for providing instant messaging in conjunction with an audiovisual, video, or audio program are provided. The methods include providing an audiovisual, video, or audio program to a user. Viewer/listener input is received requesting activation of a program-based instant messaging function. A viewer/listener identifier corresponding to the viewer/listener is associated with a program identifier that uniquely identifies the audiovisual, video, or audio program being provided to the user to thereby generate a program viewer/listener record. The program viewer/listener record is transmitted to an electronic database. A list of other users who are viewing or listening to the program in addition to the viewer/listener is acquired from the electronic database. The list of other users is transmitted to the viewer/listener.

Systems and methods for optimizing system performance of capacity and spectrum constrained, multiple-access communication systems by selectively discarding packets are provided. The systems and methods provided herein can drive changes in the communication system using control responses. One such control responses includes the optimal discard (also referred to herein as “intelligent discard”) of network packets under capacity constrained conditions. Some embodiments inspect a video stream to determine priorities for various elements of the video stream. The elements may be discarding using the priorities. In various embodiments, the elements include frames, slices, macroblocks, and data partitions.

Provided is an adhesive composition for a protective film including an acrylic emulsion resin capable of providing contamination resistance on the film and low peel strength and minimizing generation of static electricity during peeling of the protective film. The acrylic emulsion resin includes a mixture including 80 to 99.9% by weight of a polymer of a (meth)acrylic acid ester monomer including a C1-C14 alkyl group and a (meth)acrylic acid ester monomer including an alkylene oxide unit, and 0.1 to 20% by weight of a monomer including a carboxyl group and/or a hydroxyl group or a combination thereof, and 5 to 30 parts by weight of a reactive emulsifier having a double bond structure radical-polymerizable with the polymer and including an alkylene oxide unit based on 100 parts by weight of the mixture.

In one aspect, hollow nanoparticles are described herein. In some embodiments, a hollow nanoparticle comprises a metal shell and a cavity substantially defined by the shell, wherein the shell has a thickness greater than or equal to about 5 nm and the cavity has a curved surface. In another aspect, methods of making hollow nanoparticles are described herein. In some embodiments, a method of making hollow nanoparticles comprises forming a plurality of gas bubbles and forming a shell on the surface of at least one of the plurality of gas bubbles, wherein at least one of the gas bubbles is electrochemically generated. In another aspect, composite particles are described herein. In some embodiments, a composite particle comprises at least one nanoparticle and a polycrystalline metal shell substantially encapsulating at least one nanoparticle, wherein at least one surface of at least one nanoparticle is not in contact with the shell.

An OLED device comprises a cathode, an anode, and located therebetween a light-emitting layer containing a host material and a tris-C^N-cyclometallated complex of Ir or Rh wherein at least one of the ligands comprises a substituted quinazoline moiety. The device provides useful emission and stability attributes.

The present invention relates to a triphenylene-based compound represented by the following Formula 1 and an organic electroluminescent device including the same, and the compound of the present invention has excellent hole injection and/or transporting ability, electron transporting ability, and/or light emitting ability, and particularly, green and red light emitting ability, and thus in an organic electroluminescent device containing the same as a light emitting host material, characteristics such as luminous efficiency, luminance, thermal stability, driving voltage, service life and the like may be improved. In the formula, each of A, L, X and R1 to R19 is the same as those as defined in Detailed Description.

The present invention discloses a new fluorene compound and organic EL device using the compound. The organic EL device employing the new fluorene compound as host material can lower driving voltage, prolong half-lifetime. The fluorene compound can functions as blue emitting host material of a light emitting layer and improve CIE color purity in blue emitting device. The fluorene compound are represented by the following formula(A): Wherein R1 to R6 are identical or different. R1 to R6 are independently selected from the group consisting of a hydrogen atom, a halide, alkyl group having 1 to 20 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkyl group having 6 to 30 carbon atoms, a substituted or unsubstituted heteroaryl group having 6 to 30 carbon atoms. R7˜R13 are identical or different R7 to R13 are independently selected from the group consisting of hydrogen atom, halide, alkyl group, aryl group, heteroaryl group. m and n are independently an integer of 0 to 3, X is selected from carbon or nitrogen.

A novel substance with which an increase in life and emission efficiency of a light-emitting element can be achieved is provided. A carbazole compound having a structure represented by General Formula (G1) is provided. Note that a substituent which makes the HOMO level and the LUMO level of a compound in which a bond of the substituent is substituted with hydrogen deep and shallow, respectively is used as each of substituents in General Formula (G1) (R1, R2, Ar3, and α3). Further, a substituent which makes the band gap (Bg) and the T1 level of a compound in which a bond of the substituent is substituted with hydrogen wide and high is used as each of the substituents in General Formula (G1) (R1, R2, Ar3, and α3).

A liquid crystalline polyester composition containing at least 100 parts by weight of liquid crystalline polyester (A) and 10 to 100 parts by weight of talc (B). The talc (B) has a ratio (a1/a2) of oil absorption (a1) ml/100 g to specific surface area (a2) m2/g in a range of 14.0 to 26.0 (ml·g)/(100 g·m2) and has a number-average particle diameter of 10 to 30 μm.

Embodiments of the present invention are directed to heterocyclic compounds and organic light-emitting devices including the heterocyclic compounds. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltages, high luminance and long lifespans.

The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.

A chimeric protein containing neutrophil inhibitory factor and hirugen, the chimeric protein having an amino acid sequence that includes FPRPGSGG (SEQ ID NO:21) Also provided is a pharmaceutical composition comprising the chimeric protein, which can be used for treating or preventing cerebral injury and cerebral edema, or for inhibiting platelet aggregation.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

The present invention relates to compositions and methods for inhibiting the activity of an enzyme, for example, Protein Kinase B, p70S6K and/or Abl using the catalytic subunit of Protein Kinase A (PKAc), or at least one PKAc fragment or variant PKAc fragment thereof. In this regard, methods for preventing or treating cancer or a neurodegenerative disease or disorder are also provided.

Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.

Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and byproducts, as well as other methods for the diagnosis, prevention, and treatment of disorders associated with Aze.

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

A fixing structure of an optical component is composed of a device chassis; a holder holding an optical component; first and second plate parts for joint to the device chassis and a connecting part of both the plate parts are formed in the holder; a plurality of joint holes are formed in the second plate part; a U-groove into which the connecting part of the holder is fitted and a plurality of through-holes are formed in the device chassis; and an adhesive that is extended in a circular columnar shape and is made by inserting the holder into the U-groove of the device chassis, and applying a UV-curing adhesive in such a manner that the UV-curing adhesive is bonded to the first plate part of the holder and is continuous to the inside of the joint hole via the inside of the through-hole, and radiating UV light along the through-hole.

A wobble determining apparatus is provided with: a calculating device for calculating (i) a first time required until reaching a number of revolutions of a motor which allows a predetermined linear velocity, and (ii) a second time required to move an optical head to a position which allows the predetermined linear velocity, on the basis of the number of revolutions of the motor and the position of the optical head; a judging device for judging whether to keep the optical head in accordance with the calculated first time and the calculated second time; and a controlling device for controlling a moving device not to move the optical head if it is judged to keep the optical head, and for controlling the moving device to move the optical head to the position which allows the predetermined linear velocity if it is judged not to keep the optical head.

There is provided a cartridge including a running portion which causes both end portions of a disc-shaped recording medium to run, and a pressing portion which presses one end portion of the disc-shaped recording medium to press the other end portion against the running portion. Static friction coefficients of a portion of the pressing portion coming in contact with the one end portion and a portion of the running portion coming in contact with the other end portion are different.

The airflow through a harvesting machine is adjusted by calculating a G-factor at a first point on an upper chaffer to determine if it is greater than 1+n, where n represents a desired factor. A blower is adjusted to reduce an airstream if the G-factor is greater than 1+n. A MOG factor is calculated if the G-factor is less than 1+n. The blower is adjusted to increase the airstream if the MOG-factor is less than 1+x, where x represents a desired factor. A MOG-factor is calculated at a second point if the MOG-factor at the point is greater than 1+x and the blower is adjusted to reduce the airstream if the MOG-factor at the second point is greater than 1+y, where y represents a desired factor or adjusted to increase the airstream if the MOG-factor at the second point is less than 1+y.

A grain conveyor for a combine harvester capable of increasing capacity and reducing component wear is disclosed. The grain conveyor includes a grain elevator, a transition chamber and an auger assembly. The grain elevator has an inlet for receiving a flow of grain. The transition chamber includes an inlet and an outlet in fluid communication with the transition chamber inlet and the grain elevator inlet. The transition chamber outlet has an asymmetric non-circular opening larger than the non-cylindrical opening of the transition chamber inlet. The auger assembly is operatively connected to the transition chamber and includes an inlet for receiving a flow of grain and an outlet in fluid communication with the transition chamber inlet.

A dual bin combine system for combine harvesters which increases the storage capacity of harvested grain products when compared with previous systems. The dual bin combine system generally includes a combine harvester having a frame and a first tank for storing material harvested by the combine harvester. A frame extension, which extends in a rearward direction from the frame, includes a second tank. A transferring conduit extends from the first tank to the second tank. When operating the harvester, material may be fed from both tanks to reduce downtime unloading and thus more efficiently harvest crops.

A grain cleaning system of an agricultural combine directs a flow of high velocity air in a first direction about an inlet end of a cleaning shoe. The system further monitors the cleaning shoe in order to detect a change in an operational parameter of the cleaning shoe, wherein the operational parameter is one of a transient effect of a sieve of the cleaning shoe, a flow rate about and exit end of the cleaning shoe and a flow velocity about an exit end of the cleaning shoe. Further, the flow of high velocity air about the inlet end of the cleaning shoe can be redirected in a second direction in response to a detected change in the operational parameter.

A spreader assembly for a combine harvester, the assembly including a pair of disks configured to be rotated such that chaff material dropped onto the disks is spread about the combine harvester, wherein each disk is operably connected to its own motor and a spreader frame assembly. The spreader frame assembly includes a first side support pivotably connected to a frame of the combine harvester, a second side support pivotably connected to the frame of the combine harvester, and at least one disk support configured to support at least one of the pair of disks. The spreader frame assembly further defines an opening configured such that when the combine harvester is windrowing material, no portion of the spreader frame assembly interferes with the flow of windrowing material.

An unload auger assembly for a combine harvester includes a drive coupler configured between adjacent first and second auger segments. The coupler includes a driver component and associated driver cog coupled to the first auger segment. A driven component and associated driven cog is coupled to the second auger segment. The driven cog is rotationally engaged by the driver cog to transmit rotational drive from the first auger segment to the second auger segment. A friction clutch is configured in-line between the driver component and driven component and rotationally couples the driver component to the driven up to a release torque value wherein the friction clutch disengages the driver component from the driven component.

A support assembly for supporting a moveable member of an agricultural combine is provided. The support assembly includes a moveable member, such as a foldable chaff pan assembly for spreading chaff and other crop residue from the rear of an agricultural combine, a support member and a resilient member connected to the support member for supporting the moveable member. The resilient member can be configured as an arched shaped or cylindrically shaped member.

An auger assembly for a combine harvester includes an auger trough having side walls with a length so as to extend laterally between opposed side sheets. Guide tracks are configured along bottom edges of the side walls. A flexible bottom cover member is slidably engaged within the guide tracks. The cover member is removably attached to the side walls by being slid into and out of the guide tracks from a longitudinal end of the side walls outboard of the side sheets for an auger clean-out procedure.

The invention concerns a harvested crop residue chopper and distribution arrangement for a combine (10) with a straw chopper (60) with a rotor (74) that can be brought into rotation about a horizontal axis (98) with chopper blades (76) fastened thereto that define an outer envelope (96), and with at least one impeller blower (82) arranged downstream of the straw chopper (60) with impeller blades (84) that can rotate about an axis of rotation (88) that extends vertically, in which the impeller blades (84) are provided with outer edges (94) that conform to the envelope (96) of the chopper knives (76) and follow it very closely and are not in contact with it.

An agricultural combine having an adjustable spreader assembly is provided that includes a spreader with one or a pair of regulators. The spreader includes a discharge opening about its lateral side. The regulator is pivotably connected to the lateral side of the spreader such that the regulator is in fluid communication with the discharge opening. The regulator can be configured to move from a retracted position to an extended position or to vary the direction of discharge of crop residue. The spreader can be a vertical spreader, a horizontal spreader, or a spread board.

A combine side-shaking control system and a method for controlling operation of a side-shaking mechanism in a combine. The control system includes at least one sieve for separating crop material from other materials and a movable side-shaking mechanism coupled to the at least one sieve and configured to move the at least one sieve in a side-to-side motion. The control system also includes at least one sensor for sensing at least one operating condition of a combine system. The control system further includes a controller for receiving the at least one operating condition and causing the side-shaking mechanism to stop moving the at least one sieve in the side-to-side motion or start moving the at least one sieve in the side-to-side motion based on the at least one operating condition.

An intake feeder system having a stone separator mounted between a crop elevator and the mouth of a threshing mechanism disposed longitudinally in a combine harvester. The stone separator includes a rotary feed beater and a sump disposed beneath the feed beater. The feed beater serves to advance crop raised by the elevator along a crop flow path towards the mouth of the threshing mechanism and to propel stones in the crop into the sump. A duct is provided in parallel with the crop flow path for connecting a space above the rotary feed beater to the mouth of the threshing mechanism.

A combine side-shaking control system includes a sieve for separating crop material from other materials and configured to move in a fore-aft direction. At least one side-shaking assembly includes a mounting device attached to a combine chassis, a lower plate configured to rotate about a lower plate axis and an upper plate configured to (i) have an upper plate rotational motion and rotate responsive to the rotation of the lower plate and (ii) have an upper plate substantially linear motion in a substantially linear direction. A fixed arm is rotatably coupled to the upper plate and attached to the sieve. An actuation device is configured to rotate the lower plate about the lower plate axis. Responsive to the rotation of the upper plate, the sieve is controlled to move diagonal to the fore-aft direction in the substantially linear direction of the upper plate substantially linear motion.

Example embodiments relate to a combine harvester including a straw chopper having an inlet for unchopped straw, an outlet for chopped straw in an essentially horizontal direction, and a spreader fan, connected downstream of the outlet of the straw chopper and having an essentially horizontal plane of rotation, for spreading the chopped straw over a ground surface. The combine harvester further includes a guide member, which is arranged to deflect at least a part of the stream of chopped straw material to an axial intake of the spreader fan such that a part of chopped straw material meets the blades of the spreader fan in the direction of transport of the chopped straw material through the spreader fan at an acute angle (α) relative to the plane of rotation of the spreader fan.

A combine side-shaking control system that includes a sieve for separating crop material from other material, located in a plane having an X dimension and a Y dimension and configured to move in a fore-aft direction in the X dimension, in a side-to-side direction in the Y dimension and in an up-down direction in a Z dimension. The system also includes a side-shaking assembly configured to move the sieve in the side-to-side direction in the Y dimension. The fixed arm is attached to the sieve and configured to move with the sieve in (i) the fore-aft direction in the X dimension, (ii) the side-to-side direction in the Y dimension and (iii) the up-down direction in the Z dimension. The side-shaking coupling portion comprises a moving portion configured to move in a diagonal direction having a fore-aft component in the X dimension and an up-down component in the Z dimension.

An agricultural combine has a threshing assembly for threshing a crop to produce chaff and grain, a cleaning assembly for removing the chaff from the grain, and a control system. The threshing assembly and the cleaning assembly operate at threshing and cleaning settings, respectively, for tending to produce a balance between a threshing load applied across the threshing assembly and a cleaning load applied across the cleaning assembly that tends to have a favorable influence on grain loss. The control system is for sensing an imbalance between the threshing load and the cleaning load tending to have an unfavorable influence on grain loss, and for concurrently adjusting the threshing and cleaning settings of the threshing and cleaning assemblies, respectively, for tending to convert the imbalance between the threshing and cleaning loads to a balance between the threshing and cleaning loads tending to have a favorable influence on grain loss.

A combine harvester comprises a separating apparatus arranged to receive a threshed crop stream and convey rearwardly. The separating apparatus comprises a grate for allowing grain and chaff to fall onto an underlying separator pan, the separator pan being driven in an oscillating manner to convey a grain/chaff stream forwardly for delivery to a cleaning unit. The separator pan comprises a first portion and a second portion disposed forwardly of the first portion. A rear edge of the second portion is releasably attached to a front edge of the first portion, the second portion being pivotable around a forward mounting around a transverse axis between an operating position in which the second portion is attached to the first portion forming a continuous pan surface, and a lowered position in which the second portion is detached from the first portion giving maintenance access to the underside of the separating apparatus.

A windrow door assembly for controlling a direction of flow of crop residue expelled from a combine is disclosed. The window door assembly may generally include a door panel extending between a first end and a second end. The door panel may be moveable between a closed position, wherein the crop residue being expelled from the combine is directed along the door panel into a spreader of the combine, and an opened position, wherein the crop residue is directed along the door panel towards a rear opening of the combine. In addition, the windrow door assembly may include a deflector panel rotatably coupled to the door panel. The deflector panel may be configured to alter the direction of flow of the crop residue when the door panel is in the opened position.