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DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00383G, Paper
Debasish Bera, Rajib Sarkar, Tiyasa Dhar, Pinaki Saha, Prasanta Ghosh, Chhanda Mukhopadhyay
Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O coupling under oxidant-free conditions are outlined.
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Synthesis of alkenylphosphine oxides via Tf2O promoted addition–elimination of ketones and secondary phosphine oxides

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00318G, Communication
Jiangkai Ma, Lianjie Wang, Anjiang Qiao, Zhongxian Li, Fengqian Zhao, Junliang Wu
An efficient method for the synthesis of alkenylphosphine oxides via the addition-elimination of SPOs to ketones has been developed. The reaction exhibits good yields and compatibility. Several conversions have also proven the value of this method.
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Friedel–Crafts reactions for biomolecular chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00406J, Review Article
Open Access
Jun Ohata
This review demonstrates advances in Friedel–Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective synthesis of an elusive C-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor

Org. Biomol. Chem., 2024, 22,3059-3067
DOI: 10.1039/D3OB02050A, Paper
Marie M. Le Roy, Sandra Claes, Nathalie Saffon-Merceron, Dominique Schols, Thibault Troadec, Raphaël Tripier
A rare example of C,C'-linked bis-cyclam has been synthesized with controlled manner in mild conditions thanks to the “bis-aminal” tool, and its good CXCR4-recognition properties could be demonstated in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of alkynyl sulfides via base-promoted nucleophilic ring-opening of α-bromostyrene sulfonium salt

Org. Biomol. Chem., 2024, 22,2953-2957
DOI: 10.1039/D4OB00203B, Communication
Junqi Zhou, Ziyu Wang, Hanmiao Xu, Mengke Su, Jian Wen
An effective method for synthesizing various alkynyl sulfides has been developed using tetramethylene sulfoxide as a sulfur source through base-promoted nucleophilic ring-opening reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Photochromism of phenazine-2,3-diol derivatives through excited state intermolecular proton transfer based on keto–enol tautomerization

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kazuki Ohira, Kumpei Kozuka, Naoki Kaneda, Masahiro Yamamoto, Keiichi Imato, Yousuke Ooyama
It was found that phenazine-2,3-diol derivatives exhibit photochromism through excited state intermolecular proton transfer (ESInterPT) processes based on keto–enol tautomerization.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00040D, Paper
Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
Despite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.
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Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00015C, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. Mendes
An effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Recent developments in the enzymatic modifications of steroid scaffolds

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00327F, Review Article
Open Access
Huibin Wang, Ikuro Abe
This review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00167B, Paper
Open Access
Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. Smirnova
EPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00171K, Review Article
Bor-Cherng Hong, Ranadheer Reddy Indurmuddam
This review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00479E, Communication
Cao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen
A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.
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The content of this RSS Feed (c) The Royal Society of Chemistry




mo

Tab Discarding in Chrome: a Memory-Saving Experiment




mo

Why Mount Everest is a no-fly zone

Hurricane-force winds and frequent snowstorms are obstacles




mo

Demand for more flight schools soars

Pilot shortage is hurting airline operations in India, with the industry expected to need at least 1,000 to 1,500 pilots every year




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Electric aircraft set to transform urban mobility 

Investors are pouring in billions of dollars into eVTOL project (electric vertical take offs and landing aircraft) to ferry passengers




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Regaining momentum during turbulent times

Airlines must find a balances approach to navigating rising fuel costs




mo

Google brings AI-powered Gmail writing tools and ‘Polish’ to more users

Google is expanding its generative AI-powered email drafting tools to more users with new and enhanced shortcuts on web and mobile




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GitHub unveils multi-model Copilot, Spark for AI developers

Anthropic’s Claude 3.5 Sonnet will be available via GitHub Copilot starting today and Google’s Gemini 1.5 Pro will be available in the coming weeks




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Google’s moneymaking machine still pumping out massive profits despite multiple threats

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire




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Google expands AI Overviews in Search to more than 100 countries

Earlier this month, the search giant rolled out ads in AI Overviews on mobile but only in the U.S.




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Google CEO confirms the next Gemini model coming soon

Gemini 1.5, their last iteration had been released in February this year




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Chinese researchers develop AI model for military use on back of Meta's Llama

ChatBIT was fine-tuned and "optimised for dialogue and question-answering tasks in the military field", the paper said




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OpenAI CEO Sam Altman says next big AI model launch pushed due to compute challenges

Altman also said that the next update for DALL-E was still in the works with no release date yet




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Karnataka government plans to start 11 medical colleges under contentious PPP model

As of now, the State has 22 government medical colleges in 22 districts while 11 others have no government medical colleges; the PPP model however has been criticised by some experts




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High cataract rate among elderly in Mucherla, Meerkhanpet of Rangareddy district, says survey

HHF’s screening of 200 patients in Mucherla and Meerkhanpet found that 21% had senile cataracts, 18% had immature cataracts, and 15% had refractive errors




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Why did the Centre sanction a 50% hike in prices of commonly-used drugs?

According to the government the recent 50% hike in prices of eight drugs was sanctioned keeping in mind the larger public interest and to ensure continued availability of drugs




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30,000 critical care beds, regional centres for National Institute of Virology are among plans under PM-ABHIM: V.K. Paul

Expanding healthcare infrastructure plans also include integrated public health units in 600 districts and 30 branches of the National Centre for Disease Control, Niti Aayog member Dr. Paul has said




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Tuberculosis infected 8 million people last year, the most WHO has ever tracked

The World Health Organization says more than 8 million people were diagnosed with tuberculosis last year




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More than 50,000 vaccinated against mpox in DR Congo, Rwanda: WHO

The outbreak is still not under control, the African Union’s health watchdog has warned, appealing for resources to avoid a “more severe” pandemic than Covid-19




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Stop abuse of patent monopolies in rare diseases, say patient representatives and treatment activists 

They seek urgent intervention by government, courts, and lawmakers into the issue  




mo

'Once in a blue moon you get a lottery like Animal'

'It has never happened that all Top 5 songs on Spotify are from one film. On the Ormax list, the Top 9 are from Animal.''The music is good, sure. But everything has taken off with Animal the film.'




mo

'Emotion is missing in today's times'

'You have to fight your own battles and I fought mine.'




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'I didn't make any money through TV'

'I will never look down upon television. But do I want to do it again? I don't think so.'





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'Manthan Is My Most Influential Film'

'The censor board asked me for some strange cuts.''Otherwise, they would have given me an 'A' certificate.''One cut was where Girish Karnad was explaining artificial insemination in cattle.''These cuts never made any sense to me.'




mo

'Stars Don't Make A Movie But Vice-Versa'

'Stars have made stacks of wealth at the cost of the rest of the film industry.'




mo

'Can't Say Bigg Boss Promoting Polygamy'

'Ranvir will run out of steam pretty soon.''The way he is reacting or rather, overreacting to things, I am sure he will be exhausted soon.''You need to chill at times to play a game like Bigg Boss.'




mo

'I No Longer Need To Work For Money'

'I used to think I'll become a big heroine by 21-22, then I'll make a big, successful movie and then I would buy a house.''But when this was not happening for me, it was heartbreaking.'




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'Mom Was Very Scared Of...'

'When my mom saw my performance in Dhoka, she loved it.''She said, "I don't know why I stopped you for so many years. Ab jaa beta, jee le apni zindagi".'




mo

Modernizr 3: A beginners guide

Just in time for the launch of Modernizr 3 I’ve been working on a beginners course. This is aimed at people who are getting started in web development and want to know how they can use Modernizr in their workflows. I have 5 vouchers to give away that will give you free access to the … Continue reading "Modernizr 3: A beginners guide"




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An earth mosaic

So a while back I created a twitter bot @earthin24 that generates a video of earth, as seen from himawari8 satellite, every day. To see the year out I wanted to create a combined video into a mosaic. 🌏 Earth mosaic of all days captured so far for 2017 in 4k pic.twitter.com/VGf5qUct1M — Earth (@earthin24) … Continue reading "An earth mosaic"




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21-Day Mars, Moon simulation in Ladakh

The main aim or the analog mission in Ladakh is to explore new possibilities by mimicking the harsh conditions that are found on Mars and the Moon.




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Vibrant moves

Shruti Parthasarathy showed promise.




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‘Dance matters most’

Actress and up-and-coming dancer Mahalakshmi S. performs in the city today




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Magic once more with Surabhi

‘Maya Bazar’ and ‘Pataala Bhairavi’ attracted a lot of theatre lovers, says Velcheti Subrahmanyam.




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In forward motion

The third edition of the Prakriti Excellence in Contemporary Dance Awards unfolds on August 31.




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Verse in movement

Scintillating Odissi dance presentations highlighted the inextricable symbiosis of yoga and dance




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Of immortal love and familiar flair

Folk melodies with urban interpretations was the highlight of Lok Sangeet Sammelan, while versatility of gharanas was the hallmark of Ibtida.